Hacking Skin & Gut Issues – Interventions With Dave

Nancy Pellegrino

Learn to think about health problems differently, ask questions that lead to answers, and upgrade your biology.


In this Episode of The Human Upgrade™...

… Dave tackles multiple issues with former Upgrade Collective member Nancy Pellegrino so she can better manage psoriasis, gut health and anxiety.

Nancy’s been biohacking for a few years but can’t seem to land on the right combination. She does the hacks, uses the gadgets and tech, and takes the products and supplements. Instead of feeling better, she’s feeling overwhelmed with information. She talks with Dave to sort it out, focusing on skin and gut health.

Now in her mid-50s, Nancy’s post-menopausal and does bio-identical hormone replacement therapy. She experienced—and beat!—colorectal cancer in 2017. She routinely uses her Sunlighten sauna, an ozone machine and a ChiliSleep cooling mattress pad.

Her busy life as a teacher and mom to three daughters makes it hard for her to meditate and relax. She’s looking to ease some body distress, focus on solutions and find benefit in biohacks that work for her particular symptoms.

  • She hasn’t found a resolution to chronic psoriasis.
  • Despite following the Bulletproof Diet, drinking Bulletproof Coffee and regularly intermittent fasting, she continues to have unexplained digestive issues.
  • She wakes up in the night with feelings of anxiety.

If you struggle with similar conditions, take a listen to this episode for tips and resources.

“What I'm proposing here is a broad-spectrum, anti-inflammatory, antihistamine and anti-allergy strategy because that's what's underlying this.”

Dave Asprey

Note: The “Interventions With Dave” recommendations are designed to help you upgrade yourself and your biology so you can perform better at everything you do. They are not, however, a substitute for advice or treatment by a trained medical professional that may be needed for specific health conditions, illness or injury.

Listen to the other episodes in the Interventions With Dave series and don’t miss the “Links & Resources” section below for specific information. 

Enjoy the show!

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“Is she like me? How are we going to think about this?” What’s going on? What do you want to hack?  – 3:35

when you wake up with anxiety 3:00 or 4:00 in the morning?  – 7:28

You’ve done a little bit of lab work, which is worth considering. You’ve got your Viome results and one of the things that they can do is they can tell you how healthy is the balance of bacteria in your gut – 9:29

So you’re in a really old building now, and your psoriasis is getting worse. Any other changes in your GI in the new school? Better? Worse? Same?  – 14:52

Mass cells release about a hundred different inflammatory molecules that cause a whole host of symptoms, sometimes lifelong symptoms.  – 21:45

I love it that you’re on testosterone, and I want to see your thyroid stuff, but I’m getting a sense that you have an autoimmune thing going on because dry skin is a classic autoimmune thing.  – 29:16

The protocol you’re on is ayurvedic protocol that has a lot of liquid tinctures and all.  some really good stuff that your practitioners are recommending, like andrographis, which is a really powerful herb.  – 33:48

So now we’ve dialed it down. And so it’s much more likely to be in your GI tract. It doesn’t mean it has to be, because it’s a whole body detoxer, but that means it’s more likely to be lipopolysaccharide based. – 42:10


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