In this episode of The Human Upgrade, Dave Asprey sits down with award-winning journalist and author Olga Khazan to explore the radical idea that your personality isn’t fixed—it’s hackable. From rewiring chronic anxiety and neuroticism to building confidence, resilience, and better relationships, Olga reveals what happened when she set out to completely change her personality in her 30s.
Together, they unpack the science of behavior-based transformation, the myth of the “true self,” and why sleep, parenting, psychedelics, and even improv might hold the key to becoming the version of yourself you’ve always wanted to be.
What if you could rewrite the code of your personality—on command? Not just cope with anxiety, overthinking, or social exhaustion… but delete the traits holding you back and install better ones?
This episode challenges everything you’ve been told about identity. Dave dives deep into the science of personality change to reveal why your habits, moods, triggers, and even sense of self aren’t fixed—they’re fluid. And more importantly: they’re up for grabs.
Joining him is award-winning journalist from The Atlantic, Olga Khazan, author of Me, But Better, who spent years hacking her own mind—transforming high neuroticism, social avoidance, and chronic self-criticism into calm, confidence, and connection. Her personal experiment in identity rewiring became a roadmap for anyone who wants to feel different… and live differently.
You’ll uncover the hidden mechanisms behind neuroticism, reactivity, and emotional spirals—and how to override them with real-time upgrades.
What You’ll Learn in This Episode:
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Dave kicks off the conversation and sets the stage for Olga’s transformation journey.
Olga opens up about being over 9/10 on the neurotic scale—and how she started changing it.
The emotional and biological chaos of early motherhood sends Olga’s scores plummeting.
Olga confronts her Russian upbringing and why gratitude felt like tempting fate.
She breaks down how reframing people’s actions can completely change your emotional responses.
The difference between being agreeable and being a doormat—and how to draw the line.
How saying no the right way can improve your life and your relationships.
Why changing your personality is the most foundational upgrade of all.
SSRIs, Xanax, and what the science says about pharmaceutical personality shifts.
Dave and Olga explore how gut health, hormones, and inflammation shape identity.
Why sleep and food quality might affect who you are more than you think.
Can smart use of nicotine improve anxiety, focus, and self-perception?
What long-term therapy actually does to neuroticism—and how fast it works.
How small actions—done repeatedly—create massive identity shifts over time.
How love, marriage, and early partnerships reshape your traits.
The behavioral science behind what works—and what doesn’t.
Why facing fear on stage rewired Olga’s brain more than anything else.
Dave and Olga reflect on the meaning of identity and what it means to grow.
Resources:
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