The Metabolism-Cancer Connection & How to Treat It – Dr. Charles Meakin with Dave Asprey – #801

• What made you get into medicine in the first place?  – 2:12
• There’s always one of the paradoxes in life where what looks like it might be an obstruction ends up being the path  – 4:23
• What did you find when you started doing things like exercise bands and oxygen therapy and these other things? What did you find in your patients and in yourself when you added these in? – 6:13
• If you go natural, monitor the crap out of it, and work with an oncologist anyway. – 8:20
• Metabolic theory and therapy has reemerged. In fact, there’s a famous set of authors, Weinberg and Hanahan. They wrote the Six Hallmarks of Cancer. Then in 2011, they added two. They added that seventh and eighth  – 11:16
• There are small improvements and iterations that have been championed by somatic mutation theory, but in general, we’re failing in my mind on the war on cancer.  – 12:55
• Tell me about what is drug repurposing, and then tell me about these four drugs and how they caught your interest? – 14:48
• John McCain and Ted Kennedy. They didn’t agree on much politically, but they would agree that the diagnosis of glioblastoma was a difficult one, and they had the best access to care. I have four patients, three that have never had a recurrence, and they’re all out. One of the longest is 33 months. – 17:50
• These four drugs were picked because they had non-overlapping mechanisms of action. They were well vetted and safe and been out in the literature, and used for more than 30 years  – 20:21
• Literature would say that about a third of the time when you have a cancer diagnosis, there is some chronic bacterial, fungal, viral, parasitical infection brewing in the background, this churning inflammation that makes it harder for your own body to identify those tumor cells through your T-cell mediated immunity  – 23:15
• If you go to clinicaltrials.gov, there’s six trials. One is ours with mebendazole, our Metrics Trial from England. Then for the statins, there’s over 30 of them. There’s 36 trials in place. For metformin, there’s over 200. For doxy, there’s 26 trials going on. – 24:48
• Our ultimate goal is a paradigm shift to not just let cancer develop, and then try to jump on it in our current ways once it’s done, but to work in a better way with prevention and earlier identification. – 27:31
• When a person has a chronic infection, it’s almost impossible to eradicate that cancer in the patient, and you need to spend time trying to fix the infection. – 34:47
• What percentage of cancer do you think is purely genetic and not epigenetic? – 35:05
• The common cancers in women are different than those in men  – 36″32
• I use the acronym the big six, because people could remember that  – 37:40
• I remind them that exercise is almost like a little intermittent, a small fast. It does everything good for the body, and what it does for the brain is remarkable. – 40:10
• There’s a book by Kelly Turner. It’s called Radical Remission. She brilliantly in a novel way looked at not the standard outcome. She looked at the outliers that really broke the code and survived a long time with impossible cancers  – 43:03
• I encourage this with patients, to come to a reckoning with the possibility or the probability, 100% probability of death at some point. Your goal is to come to terms with liking yourself. When you get those two issues resolved, it liberates you to do what’s really important, and live in the moment and not worry about it  – 45:26
• That’s such a nuanced and wise view on death. Thank you for sharing that. It’s always a rough conversation to have, because no one wants to think about that on a regular basis. – 50:56
• Do you believe that living a better, happier, more fulfilling life reduces your odds of getting cancer? – 53:37

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