Inflammation is Aging Your Brain – Dr. Andrew Miller – #643

Photo of Andrew Miller
The brain-immune system connection indicates that inflammation is a driving force in physical and psychological ailments.

In this episode of Bulletproof Radio, my guest, Dr. Andrew Miller, is an internationally recognized expert in the interactions between the brain and immune system as they relate to stress and depression.

“Inflammaging is one of the hottest topics in immunology right now because we recognize that much of what drives the process of aging in the brain and much of what drives many of the illnesses that eventually do people in, are driven by inflammation,” he says.  “So, we’re talking cardiovascular disease, we’re talking about diabetes, we’re talking about cancer, we’re talking about neurodegenerative disorders.” … “All the modern ills that we as a society are grappling with right now.”

Dr. Miller is the vice-chair of Research in the Department of Psychiatry and Behavioral Sciences and director of the Behavioral Immunology Program at Emory School of Medicine. His research focuses on the underlying mechanisms by which inflammation can cause depression in humans and non-human primates. Additionally, Dr. Miller and his group conducted the first clinical trial examining the efficacy of an immunotherapy for the treatment of depression.

Enjoy the show!

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Follow Along with the Transcript

Inflammation is Aging Your Brain – Dr. Andrew Miller – #643


Faculty Bio:

Key Notes

  • Why Dr. Miller chose to go against the grain 00:04:10
  • A story of a patient on immunotherapy 00:07:50
  • Inflammation and disease 00:10:05
  • The relationship between inflammation and depression 00:12:00
  • What is Inflammageing? 00:13:05
  • We are not designed to live in the world as it is now 00:14:00
  • The gene that makes you more prone to inflammation 00:16:20
  • The decision-making process is influenced by inflammation 00:22:30
  • Why Dave takes a “stack of herbs” 00:25:40
  • The influence of sub-bacterial infections and the microbiome 00:26:05
  • Are specific regions of the brain more susceptible? 00:31:00
  • The three tests you need to get 00:33:15
  • What is the best anti-inflammatory compound? 00:34:10
  • The role of dopamine 00:38:05
  • Nicotine and inflammation 00:39:40
  • The problem with testing substances for future supplements 00:42:00
  • The role of glutamate/glutamine and depression 00:47:45
  • Electroceuticals 00:52:15
  • NSAIDs and Aspirin for depression? 00:54:00
  • Low vitamin D, stress levels and social-economic situations 01:00:00
  • Metformin and ageing 01:03:00

Go check out my new book Super Human: The Bulletproof Plan to Age Backward and Maybe Even Live Forever and also “Game Changers“, “Headstrong” and “The Bulletproof Diet” on Amazon and consider leaving a review!

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Dave Asprey

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