493. It’s Not Dementia, It’s Distraction: Dr. Peter Attia

(00:00:09) Introduction to the Guest and Episode  

• Dave Asprey introduces Dr. Peter Attia  
• Cool fact of the day about music mind meld  

(00:01:00) The Phenomenon of Brain Synchronization with Live Music 

• Study on delta brainwaves and audience experience 
• Implications for social interactions and collective experiences  

(00:01:44) Dr. Peter Attia’s Background and Multi-Disciplinary Approach to Health 

• Journey from mechanical engineering to medicine 
• Peter’s unique perspective on health as an integration of various fields  

(00:03:01) Dr. Attia’s Thoughts on Longevity and the 180-Year Life Goal 

• The probability of significant advances in longevity science 
• Importance of managing metabolic health and atherosclerosis for long-term health.  

(00:05:22) Discussing the Next Breakthroughs in Longevity 

• Potential of manipulating the TOR pathway 
• Challenges in reprogramming senescent cells and targeting atherosclerosis.  

(00:10:42) Preventative Strategies for Prolonged Healthspan 

• Managing inflammation and avoiding chronic diseases 
• The importance of cardiovascular and metabolic health in aging. 

(00:16:52) The Role of Lipoproteins and Inflammation in Longevity 

• Dr. Attia’s approach to evaluating and treating cardiovascular risk factors. 
• The delicate balance between lowering LDL and maintaining cognitive health. 

(00:22:19) The Complexity of Biological Systems in Health Optimization 

• The limitations of our current understanding in biology 
• Applying engineering principles to biological problems 

(00:25:16) Risk Stratification for Longevity 

• The role of family history and blood tests in assessing long-term health risks 
• Strategies for mitigating the most probable health threats. 

(00:27:54) The Intricacies of Cholesterol and Heart Disease 

• Discussion on the nuances of cholesterol types and their role in health 
• Peter’s stance on the relationship between cholesterol and diet 

(00:34:16) The Interplay of Neurodegenerative Diseases and Cholesterol 

• Challenges in optimizing cholesterol levels without increasing other health risks 
• How metabolic health impacts cognitive function. 

(00:40:47) The Effects of Dietary Changes on Health and Cognition 

• Peter’s experience with veganism and its impact on health 
• The importance of dietary flexibility and genetic predispositions 

(00:43:10) Insights on Gut Biome Sequencing and Health Interventions 

• Limitations and potential of gut biome sequencing for health improvements 
• Dr. Attia’s skepticism and hope for future advancements 

(00:47:39) Enhancing Cognitive Function and Protecting Against Decline 

• The correlation between optimizing metabolism and vascular health and cognitive function 
• Strategies for delaying cognitive impairment and enhancing brain performance. 

(00:50:18) The Benefits and Risks of Exogenous Ketones for Brain Health 

• Dave and Peter discuss their experiences with ketone supplementation 
• The potential for exogenous ketones to support cognitive function 

Resources: 

Dave Asprey’s Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books

Follow Dave on Instagram: @Dave.Asprey

Follow The Human Upgrade: @TheHumanUpgradePodcast

Peter Attia Website
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