Dr. Jonathan Wisor, Ph.D.: Hack Your Sleep – #31

Dr. Wisor is one of the foremost researchers on sleep and nervous system function.  His laboratory is funded by both the Department of Defense and the National Institute of Neurological Disorders and Stroke to apply molecular genetic and biochemical techniques to study sleep.

Dr. Wisor comes on the show today to talk about how you can use biochemistry and the latest research to improve sleep and your quality of life.


Click here to read the free transcript of this episode (coming soon).

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What We Cover

  1. What does sleep deprivation do to the body?
  2. What would you say is the most common cause of sleep deprivation?
  3. What are some of the best ways people can improve their sleep?
  4. Is it important to sync your sleep with your circadian rhythm?  If so, what happens when you don’t?
  5. Assuming you get enough sleep, does it matter when it occurs?  Is there any benefit from waking with the sun and going to be at dusk versus being a night owl?
  6. How can medications or drugs interfere with sleep?
  7. How does chronic or acute stress affect sleep?
  8. What do you think of the Zeo sleep monitor?  Have you tried one?
  9. Why is sleep important for athletes or active people?  If someone was working out a lot, and restricting sleep (partly to workout), is the exercise doing more harm than good?
  10. What role do genetics play in sleep needs?
  11. How does sleep (and sleep loss) effect growth and development in kids?
  12. Have you done any research or looked at how sleep might be improved with cranial electrostimulation?
  13. How can nutrient deficiencies (like magnesium) impair sleep?
  14. Are there any supplements that help sleep?
  15. How does sleep affect memory and intelligence.
  16. What is dreaming, and why do we do it?
  17. You did a study on the effects of methamphetamine and Modafinil on the sleep/wake cycles of mice.  How did these drugs affect the mice, and how might these results be relevant for humans?
  18. Can sleep deprivation cause inflammation in the brain?  If so, can this turn into a perpetual cycle where sleep loss = inflammation, and inflammation = sleep loss?
  19. What are your top three recommendations for someone who wants to be as powerful and high performance in all aspects of life?
  20. Where can people learn more about you and your work?

Links From The Show


Click here for more information on Dr. Wisor

Online Psychomotor Vigilance Test (this takes less than 2 minutes).


Food & Supplements




Upgraded™ Glutathione

Vitamin C



Better Baby Book



Earthing Mat

Bulletproof Vibe




Podcast #26: Body by Science with Dr. Doug McGuff

Protein Fasting – Josh Whiton‘s thoughts on hacking autophagy

Bulletproof Diet

A Bad Combination for Women: Intermittent Fasting and Paleo


Biohacker Report

A review of the latest research to help you achieve the Bulletproof state of high performance.

“Short-term sprint interval versus traditional endurance training: similar initial adaptations in human skeletal muscle and exercise performance.”



Upgraded Chef, the cookbook for the Bulletproof Diet, is almost ready.  We’ve compiled a fantastic list of recipes that are 100% Bulletproof, so you don’t have to keep cobbling together ingredients from different paleo recipes that aren’t quite up to par.  Stay tuned for more information.

The Bulletproof Biohacking Conference mentioned for September has been postponed until after the New Year.

Listener Q & A Summary

  1. Is doing [the rapid fat loss protocol] for 75 days going to decrease muscle or cause other adverse effects?
  2. Is it ok to do the Bulletproof Rapid Fat loss Protocols and high intensity exercise?
  3. How and why it’s a good idea to cycle fasting and eating Bulletproof.
  4. Once I stop fasting, will eating make me gain weight/lose muscle/have adverse health issues, even if I eat Paleo/Organic?
  5. Will there be days that suck? What can I expect?  I need to drop 100, though 120 would be better.
  6. Would taking an appetite suppressant, such as Hoodia or HCG assist in the process?
  7. Are things going to sag?

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