In this episode of The Human Upgrade, Host Dave Asprey sits down with functional medicine pioneer Dr. Josh Axe to expose why some of today’s most popular “healthy” foods are quietly destroying your gut and hormones. They unpack the hidden dangers of depleted soil, industrial farming, and synthetic supplements—and reveal how regenerative agriculture can rebuild your body from the ground up. You’ll learn why testosterone is collapsing in both men and women, how birth control impacts thyroid and mitochondrial health, and why biblical farming principles could hold the key to modern longevity. This conversation blends science, spirituality, and high-performance biohacking for a deeply personal look at what it really means to nourish the body, mind, and soil.
You’ve been told to eat clean, but what if your “healthy” foods are wrecking your gut, crushing your hormones, and aging you faster? This episode exposes the nutrient-depleted truth behind modern diets, soil erosion, and why regenerative farming might be the key to reversing chronic disease, boosting mitochondria, and rebuilding your biology from the ground up.
Host Dave Asprey sits down with Dr. Josh Axe, a trusted pioneer in functional medicine, bestselling author, and co-founder of Ancient Nutrition. Dr. Axe bridges the gap between biblical farming, ancestral nutrition, and modern science to explain how your food and even your supplements may be harming your human performance, digestion, and brain health. With clinical insights, personal stories, and science-backed tools, he shares what to eat instead if you want real longevity, energy, and healing.
They dig into the collapse of soil nutrients, how monocropping damages the microbiome, and why organic food standards may be outdated. You’ll learn how regenerative agriculture rebuilds the earth and your gut, and why biohacking starts with dirt, not pills. Plus, they explore the hormonal chaos caused by seed oils, plastics, blue light, sleep disruption, and even birth control, especially in relation to testosterone loss in men and women.
This episode also touches on biblical nutrition, fasting cycles, natural nootropics, testosterone-supporting peptides, the dangers of synthetic vitamins, and the future of real-time self-quantification. From poop-powered farming to smarter sourcing, it’s a wild ride into how food, faith, and farming affect every part of your biology.
This is essential listening for anyone serious about biohacking, neurohacking, longevity, Upgrade Labs, Danger Coffee, Smarter Not Harder, and understanding the real root of disease and dysfunction.
You’ll Learn:
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.
Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing.
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Quick hook on testosterone, food, and why ‘eating dirt’ might not be crazy.
Dave introduces the episode’s central question about “healthy” food and gut health.
Josh shares his journey from chiropractic care to regenerative agriculture.
How depleted soil affects nutrient density and long-term human health.
Solutions to topsoil loss, monocropping, and industrial food damage.
Blending ancient wisdom with soil science and animal grazing.
Why “organic” might be outdated and what standards are better.
The top reasons men and women are losing testosterone fast.
The overlooked risks of long-term birth control on thyroid and fertility.
Breakthroughs in testosterone therapy that avoid harmful side effects.
Coming tech for real-time data on hormones, nutrients, and microbiome.
Josh defines the foundational principles found in scripture-based farming.
Foods prioritized in the Bible and their biological impact.
Olives, figs, pomegranates, meat, and the deeper meaning behind them.
Why pork is controversial in both religious and health contexts.
What ancient Eastern medicine says about pork and health conditions.
A look at lifespan decline in scripture and potential environmental triggers.
Exploring whether biodynamic agriculture is spiritual, evil, or misunderstood.
How parenting and affirmations shape resilience and emotional health.
The real foods his family eats and how they handle oxalates and grains.
The powerful link between emotional well-being, belief, and physical health.
Dave and Josh wrap with practical takeaways and spiritual reflections.
Resources:
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