EP 1254
1254. The New Fasting Protocol to Increase Lifespan by 96% | Chris Rhodes
In this episode of The Human Upgrade, Dave Asprey sits down with biochemist Chris Rhodes to reveal a groundbreaking fasting mimetic that could extend lifespan by 96%—without skipping meals. Mimio, a blend of four key metabolites naturally produced during fasting, replicates the cellular benefits of a 36-hour fast, outperforming traditional longevity drugs like Metformin and Rapamycin. Dave and Chris dive into the science of fasting, metabolism, and aging—unpacking how over-fasting can backfire, why Big Pharma won’t like this discovery, and how you can harness fasting benefits without extreme dietary restrictions.
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In this Episode of The Human Upgrade™...
Can You Mimic Fasting—Without Actually Fasting?
Chris Rhodes, a biochemist and longevity researcher, joins Dave to reveal a groundbreaking fasting mimetic that could revolutionize how we approach aging, metabolism, and health.
Fasting is one of the most powerful tools for longevity, but what if you could achieve the same benefits without hunger, energy crashes, or social sacrifices? Scientists have identified key compounds that mimic fasting at the cellular level—offering a way to extend lifespan, boost metabolism, and enhance cognitive function without giving up food.
Enter Mimio, a blend of four key molecules naturally produced during fasting, is engineered to deliver the life-extending benefits of fasting—without starvation.
For decades, fasting has been the gold standard for longevity, but over-fasting can wreck hormones, metabolism, and muscle mass. So, what if you could get the benefits of a 36-hour fast without the downsides? Chris breaks down the science behind fasting, autophagy, and the game-changing compounds that trick your body into entering a fasted state—even while eating.
What You’ll Learn:
- The optimal fasting window for maximizing lifespan (Hint: It’s not 16 hours)
- The four fasting metabolites that extend life by 96%
- How Mimio mimics fasting benefits—without giving up food
- The real reason over-fasting destroys your metabolism and hormones
- Why traditional longevity drugs (Metformin, Rapamycin) fall short
- Can you build muscle and burn fat at the same time? The science of mTOR & AMPK
- Why Big Pharma doesn’t want you to know about this breakthrough
*** Get 20% off Mimio at mimiohealth.sjv.io/3J9abX with code: DAVE ***
Sponsors:
Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial.
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“We found that there were the synergistic combination of four [metabolites] that we could use to replicate all of these beneficial cellular health effects of fasting. And like we already touched on, we could extend lifespan by 96%.”
Chris Rhodes
- 00:00– Intro
Dave welcomes Chris Rhodes and introduces the topic of fasting, longevity, and biohacking.
- 00:58– Fasting & Longevity
How fasting impacts metabolism, cellular repair, and lifespan extension.
- 01:58– Optimal Fasting Length
What research says about the best fasting duration for maximum health benefits.
- 03:39– Alternate Day Fasting: Pros & Cons
Why alternate-day fasting works—but why it may not be sustainable long-term.
- 05:50– Key Fasting Compounds
Discover the metabolites naturally produced during fasting that drive its benefits.
- 07:34– Spermidine & Longevity Molecules
How spermidine and other fasting byproducts enhance autophagy and longevity.
- 11:41– FDA Roadblocks on Natural Compounds
Why natural molecules like Mimio face restrictions while pharmaceuticals dominate.
- 15:37– AI, Big Data & Longevity Research
How modern bioinformatics is revolutionizing anti-aging and health optimization.
- 31:19– Mimio’s Impact on Testosterone & Aging
Clinical findings on how Mimio raises testosterone and reduces biological age.
- 35:16– Longevity & Death Philosophy
The mindset shift needed to approach aging and death with intention.
- 36:48– Biohacking Origins
How early pioneers shaped the modern movement of biohacking.
- 37:03– Metabolism & Cognitive Function
How fasting and key metabolic pathways affect brain performance.
- 38:35– Unexpected Effects of Fasting
Surprising biological shifts that occur during prolonged fasting.
- 40:43– Fasting & Circadian Rhythms
The best times to fast based on your body’s natural clock.
- 43:09– Mimio Science & Benefits
Breaking down the key metabolites in Mimio and how they mimic fasting.
- 45:14– Mimio in a Daily Routine
How to integrate Mimeo into your lifestyle for maximum effect.
- 55:05– Men vs. Women: Fasting Differences
Why fasting affects men and women differently and what research reveals.
- 01:02:23– Future of Nutrition & Biohacking
What’s next in fasting science, supplements, and longevity research.
- 01:07:21– Conclusion & Discount Code
Final thoughts and an exclusive 20% off code for Mimio.
Resources:
- Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated/
- Mimio Instagram – https://www.instagram.com/mimiohealth/
- Mimio Website: https://mimiohealth.com/
- 2025 Biohacking Conference: https://biohackingconference.com/2025
- Danger Coffee: https://dangercoffee.com
- Dave Asprey’s Website: https://daveasprey.com
- Dave Asprey’s Linktree: https://linktr.ee/daveasprey
- Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com
- Own an Upgrade Labs: https://ownanupgradelabs.com
- Upgrade Labs: https://upgradelabs.com
- 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com
Enjoy the show!
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