EP 1281
1281. The Anti-Aging Chamber That Rewinds Your Biological Clock | Dr. Jason Sonners
In this episode of The Human Upgrade, Dave Asprey sits down with Dr. Jason Sonners to explore how hyperbaric oxygen therapy is becoming a breakthrough tool for reversing biological age, activating stem cells, and enhancing cellular repair. They dive into the latest research on oxygen under pressure, why it boosts recovery and reduces inflammation, and how to stack it with fasting, red light, or methylene blue for even greater results.
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In this Episode of The Human Upgrade™...
Your cells are starving. Not for food—but for oxygen.
In this episode of The Human Upgrade, Dave Asprey sits down with Dr. Jason Sonners, world-renowned hyperbaric expert and regenerative medicine pioneer, to reveal how controlled oxygen under pressure is becoming one of the most powerful tools in anti-aging and performance science.
You’ll learn how hyperbaric oxygen therapy (HBOT) triggers stem cell activation, rewires your epigenome, boosts mitochondrial energy, and reverses biological aging—if you use it the right way. Jason shares breakthrough findings from his latest PhD research comparing low- and high-pressure chambers, with surprising results on inflammation, telomeres, cognitive performance, and recovery speed.
This is next-gen longevity—measurable, stackable, and customizable. From sleep upgrades and HRV boosts to stacking HBOT with fasting, methylene blue, or red light, this episode dives into what it takes to oxygenate your biology at the deepest level.
You’ll Learn:
- How hyperbaric oxygen therapy (HBOT) triggers stem cell regeneration and cellular repair
- Why mild-pressure chambers may be more powerful than you think
- What HBOT does to inflammation, brain fog, and biological aging markers
- How to stack HBOT with fasting, red light, and methylene blue for amplified results
- What Dr. Sonners’ PhD research reveals about oxygen pressure and genetic expression
- The truth about oxygen toxicity—and how to avoid the common mistakes
- How elite performers use HBOT for brain optimization, recovery, and resilience
** Get 30% of yourr tickets to the Biohacking conference by going to https://biohackingconference.com/2025 and use code ‘OXYHEALTH’ **
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“There’s short term and long term effects of hyperbaric, and one of the most significant short-term effects is as you drive more oxygen into a cell, you start making more energy. Almost immediately.”
Jason Sonners
- 00:00 – Trailer
Get a quick preview of how oxygen therapy might reverse biological aging.
- 01:59 – Intro
Dave welcomes Dr. Jason Sonners and tees up the real science behind hyperbarics.
- 03:14 – New research on aging and oxygen
How pressurized oxygen impacts inflammation, gene expression, and longevity markers.
- 05:39 – Mild vs. hard-shell chambers
Breaking down pressure levels, accessibility, and which type might work best for you.
- 13:05 – HBOT for longevity and stem cells
Why oxygen is a trigger for regeneration—and how it’s being used to slow aging.
- 16:43 – How to optimize your sessions
Dr. Sonners shares best practices for frequency, duration, and recovery timing.
- 22:35 – Best therapies to stack with HBOT
How to pair oxygen therapy with red light, ozone, methylene blue, or fasting.
- 25:40 – Oxygen delivery and safety
What actually happens when oxygen is delivered under pressure—and how to do it right.
- 26:43 – Altitude and chamber effects
Why where you live matters: how elevation influences oxygen saturation and outcomes.
- 30:01 – Key benefits of hyperbaric therapy
From brain fog and injury recovery to mitochondrial energy and clarity.
- 34:22 – Supplement synergy and timing
When to use supplements with HBOT—and which ones can make it more effective.
- 37:25 – Pressure and oxygenation findings
Surprising results from Dr. Sonners’ PhD research comparing different chamber protocols.
- 39:27 – Medical vs. welding oxygen
Clearing up one of the most misunderstood aspects of home-use hyperbarics.
- 44:57 – Safety myths and toxicity risks
How to avoid common mistakes and oxygen misuse in pressurized settings.
- 47:39 – Future of biohacking with oxygen
Where HBOT is heading next—and how to get the most from it now.
Resources:
- Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated/
- Jason’s Website – www.hbotusa.com
- OxyHealth Website: https://www.oxyhealth.com/
- 2025 Biohacking Conference: https://biohackingconference.com/2025
- Danger Coffee: https://dangercoffee.com
- Dave Asprey’s Website: https://daveasprey.com
- Dave Asprey’s Linktree: https://linktr.ee/daveasprey
- Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com
- Own an Upgrade Labs: https://ownanupgradelabs.com
- Upgrade Labs: https://upgradelabs.com
- 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com
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