EP 1383
1384. Your Penis Is a Longevity Organ (Here’s How to Hack It)
In this episode of The Human Upgrade, Host Dave Asprey sits down with Dr. Justin Houman, Assistant Professor of Urology at Cedars-Sinai Medical Center and one of the leading experts in male fertility, sexual medicine, and testosterone optimization, to deliver the most comprehensive masterclass on men’s health ever recorded on the show. They cover why testosterone levels have dropped 30 percent in a single generation, what that collapse is doing to men’s mood, metabolism, cardiovascular health, and sexual performance, and exactly what to do about it. From shockwave therapy and red light protocols to daily Cialis, peptides, and the fertility-safe TRT stack, this conversation leaves nothing on the table. Dave also shares his own personal protocols including cabergoline for prolactin management, creatine dissolved in Danger Coffee for four times the bioavailability, and the full pre-performance optimization stack he uses himself. Whether you are dealing with low energy, erectile dysfunction, fertility concerns, or just want to know how to keep your testosterone optimized for the next several decades, this episode gives you the tools to take control of your biology starting today.
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In this Episode of The Human Upgrade™...
Testosterone levels in 40-year-old men are 30 percent lower than their fathers, and most doctors still have no idea what to do about it.
Host Dave Asprey sits down with Dr. Justin Houman, a nationally recognized urologist and Assistant Professor of Urology at Cedars-Sinai Medical Center. Fellowship-trained and specializing in men’s health, male fertility, and sexual medicine, Dr. Houman combines cutting-edge medical advancements with holistic lifestyle strategies to help men optimize testosterone, sexual health, and reproductive performance at every age.
Together, Dave and Dr. Houman tear through the myths, the bad science, and the outdated medical dogma around testosterone, erectile function, fertility, and male sexual health. They cover everything from why testosterone levels have collapsed in a single generation, to the real story behind the FDA black box warning, to practical protocols for men who want to optimize without sacrificing fertility. This is the masterclass on men’s health that no one else is having on record.
This is essential listening for anyone serious about biohacking, longevity, human performance, hormone optimization, brain optimization, anti-aging, functional medicine, mitochondria, and Smarter Not Harder approaches to male health.
You’ll Learn:
- Why testosterone levels in 40-year-old men are 30 percent lower than their fathers and what is driving the collapse
- How low testosterone connects to anxiety, depression, high cholesterol, blood sugar dysregulation, and all-cause mortality risk
- The truth about the original testosterone and heart attack study and why it still has not been retracted
- How to preserve fertility while on TRT using Clomid, enclomiphene, and HCG
- Why daily low-dose Cialis is one of the cheapest and most effective longevity drugs available
- What shockwave therapy, PRP, exosomes, and Botox injections actually do for erectile function
- How red light therapy at 660 and 850 nanometers supports testosterone production and nocturnal erections
- The supplement stack including ashwagandha, tongkat ali, fadogia agrestis, and creatine that supports healthy hormone levels
- Why porn-induced ED is epidemic in young men and how to reverse it
- How PT-141 and peptides fit into a complete male optimization protocol
Keywords: testosterone, low testosterone, TRT, testosterone replacement therapy, male fertility, erectile dysfunction, ED, men’s health, sexual health, hormone optimization, Dave Asprey, biohacking, longevity, anti-aging, human performance, Dr. Justin Houman, Cedars-Sinai, urologist, shockwave therapy, PRP, exosomes, Botox penis
, red light therapy, nitric oxide, Cialis, tadalafil, Viagra, sildenafil, PT-141, Melanotan, peptides, ashwagandha, tongkat ali, fadogiaagrestis, creatine, Danger Coffee, Smarter Not Harder, Kyzatrex, clomid, enclomiphene, HCG, prolactin, cabergoline, porn-induced ED, refractory period, fertility, sperm health, spermatogenesis, FSH, LH, estrogen, aromatization, functional medicine, supplements, mitochondria, circadian rhythm, sleep optimization, cortisol, microplastics, inflammation, cardiovascular health, dementia, all-cause mortality, nocturnal erections, penile health, male optimization
Resources:
- Learn More About Dr. Houman’s Work At: https://houmanmd.com/
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"Men with adequate testosterone have a much lower risk of all cause mortality."
Justin Houman
00:00 – Introduction
Dave Asprey sets up the episode with a focus on what makes men into men and why testosterone is one of the most important and misunderstood hormones in the body.
02:04 – Low Testosterone Epidemic
Dr. Houman explains why testosterone levels in 40-year-old men today are 30 percent lower than their fathers, pointing to processed food, obesity, stress, blue light, and microplastics as the driving forces.
04:23 – Ejaculation & Testosterone
Dave and Dr. Houman discuss how ejaculation affects testosterone and prolactin levels, why frequency matters for fertility, and what ancient Taoist practices say about optimizing ejaculation for longevity.
07:30 – Refractory Period & Aging
Dr. Houman breaks down why the refractory period lengthens with age, how nerve sensitivity, prolactin clearance, and declining testosterone all play a role, and what men can do to slow that process.
09:58 – Porn-Induced ED
Dr. Houman explains why porn-induced erectile dysfunction is increasingly common in young men, how it rewires the brain’s reward system, and why eliminating porn is often the most effective treatment.
11:09 – Cabergoline & Prolactin Management
Dave shares his personal protocol of using low-dose cabergoline to blunt the post-ejaculation prolactin spike, and Dr. Houman weighs in on who might benefit most from this approach.
12:42 – Oral Testosterone (Kyzatrex)
Dave discusses his experience switching from injections to Kyzatrex, the first FDA-approved oral testosterone, and why it has changed how he manages his hormone levels day to day.
13:24 – Testosterone Target Levels
Dr. Houman explains why chasing symptoms matters more than chasing a number, and why the right testosterone level varies dramatically from one man to the next.
16:46 – Supplements for Testosterone
Dr. Houman walks through his top supplement recommendations for natural testosterone support including ashwagandha, tongkat ali, and fadogia agrestis, with Dave adding his own stack and a warning about ashwagandha overuse.
18:46 – Anxiety-Based ED
Dr. Houman reveals that up to 98 percent of erectile dysfunction in men under 35 is anxiety-based, and explains the psychological and social pressures driving the epidemic in younger men.
26:23 – Penis Enhancement Options
Dave and Dr. Houman run through the full landscape of penile enhancement options including stretching devices, vacuum therapy, fat transfer, hyaluronic acid, and surgical implants.
27:37 – Shockwave Therapy
Dr. Houman explains how high-energy shockwave therapy creates new blood vessel growth in erectile tissue, and Dave shares his personal results including a dramatic change in size he did not expect.
28:57 – Cialis for Longevity
Dave and Dr. Houman make the case for daily low-dose Cialis as one of the most underrated longevity drugs available, with benefits extending to cardiovascular health, dementia risk reduction, and systemic blood flow.
29:56 – Fat & Filler Injections
Dr. Houman breaks down the pros and cons of fat transfer, hyaluronic acid, and silicone implants for penile enhancement, including why fat distribution can be unpredictable and how hyaluronic acid can be reversed.
34:50 – Pre-Sex Optimization
Dave and Dr. Houman build out a practical game-time protocol including Cialis, nitric oxide support, apomorphine lozenges, and why doing a trial run at home before date night is always a good idea.
40:13 – Red Light Therapy
Dr. Houman explains how red and near-infrared light at 660 and 850 nanometers supports erectile function, strengthens nocturnal erections, boosts testosterone production, and improves sperm health.
42:18 – Heat & Cold for Testosterone
Dave shares his protocol of cooling the testicles during sauna sessions, and Dr. Houman confirms why heat from hot tubs, saunas, and laptops is one of the most overlooked threats to testosterone and fertility.
43:35 – Underwear & Microplastics
Dr. Houman discusses the emerging data on how synthetic underwear and microplastic exposure may negatively impact testosterone levels and sperm motility, and why breathable natural fabrics matter.
44:58 – Testosterone & Fertility
Dave and Dr. Houman tackle the biggest fear men have about TRT, explaining exactly how exogenous testosterone shuts down sperm production and what to do about it if you still want to have children.
49:15 – HCG & Preserving Fertility
Dr. Houman explains how HCG, Clomid, and enclomiphene can preserve or restore fertility in men on TRT, and Dave shares his unexpected and uncomfortable personal experience with HCG-driven estrogen conversion.
52:00 – Testosterone Dosing Timing
Dave and Dr. Houman discuss the circadian nature of testosterone and why timing your doses in the morning and at midday produces better hormonal alignment than taking it at night.
53:22 – Creatine & Mitochondrial Health
Dave explains why dissolving creatine in hot liquid like Danger Coffee makes it four times more bioavailable, and how mitochondrial energy production in the testes makes creatine directly relevant to testosterone and sexual performance.
56:24 – Peptides (PT-141)
Dave and Dr. Houman discuss PT-141 and Melanotan as libido-enhancing peptides, who responds best to them, and why peptides should only be layered on top of an already optimized hormone foundation.
59:08 – Optimal Diet for Fertility
Dr. Houman lays out his ideal daily meal plan for male hormonal health including eggs, walnuts, salmon, sweet potato, and red meat, with Dave pushing for higher protein targets and grass-fed sourcing.
1:03:46 – Closing
Dave wraps up the masterclass and points listeners to AXO Health for at-home testosterone testing and Dr. Houman’s practice for anyone ready to take their men’s health seriously.
Thank you to our sponsors!
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