Hey, it’s Dave.
The calendar says I’m in my 50s. My lab tests say otherwise. I’ve reversed my biological age by over 20 years, and people constantly ask me how I did it.
The honest answer is I don’t share my full stack because what works for my biology won’t necessarily work for yours. But there are core interventions that work for human biology in general, and those I’ll talk about all day. I’ve spent over two decades and more than $2 million figuring out which ones actually work (and which don’t). Here’s where I’d start.
In order to address aging, you have to understand the underlying mechanisms.
Mimio’s formulation is built around the biology of a 36-hour fast. It replicates the metabolic state your body enters during extended fasting, activating autophagy, AMPK, and sirtuin pathways without requiring you to actually fast.
Stem cell mobilization: STEMREGEN
Stem cell scientist Christian Drapeau spent 20 years developing this formula, and two capsules put an average of 10 million of your own stem cells into circulation, roughly doubling what a typical 50-year-old has in their bloodstream.
Mitochondrial renewal: Timeline / Mitopure
Mitopure delivers Urolithin A, a postbiotic compound that triggers mitophagy, the selective clearance of damaged mitochondria. Your cells replace dysfunctional mitochondria with healthy ones, and the effects show up as more energy, better muscle function, and improved recovery.
NAD+ restoration: Qualia NAD+
Qualia NAD+ uses three NAD+ precursors simultaneously: NIAGEN, a clinically studied form of nicotinamide riboside, niacinamide, and nicotinic acid. It also features resveratrol for sirtuin activation, Coffeeberry to support cellular pathways involved in NAD+ metabolism, and a full B-complex plus magnesium to provide the cofactors NAD+ synthesis depends on. In two randomized double-blind placebo-controlled trials, it raised blood NAD+ levels by roughly 70% on average. Most NAD+ products pick one precursor and stop there. This formula targets multiple steps in the production and recycling pathway at once.
Inflammation: LYMA Laser
The LYMA Laser delivers coherent near-infrared laser light deep into skin tissue, triggering mitochondrial stimulation and reducing inflammation at the cellular level. Peer-reviewed research published in the Aesthetic Surgery Journal showed it activated 45 longevity genes in the skin. It’s one of the only clinic-grade laser devices you can use at home.
Nitric oxide and vascular health: N101
N101 is a nitric oxide lozenge developed by Dr. Nathan Bryan, one of the leading researchers in nitric oxide biology. It dissolves in your mouth to support nitric oxide production directly in your blood vessel walls, improving circulation, oxygen delivery to cells, and vascular flexibility.
Biological age testing: Generation Lab
Nothing on this list matters if you don’t know your baseline. Generation Lab runs comprehensive biological age testing that looks at DNA methylation patterns, immune aging markers, and organ-level function. This tells you where you actually are, not where you assume you are, and gives you a real way to measure whether what you’re doing is working.
You don’t have to do all of this at once. Start with testing so you know where you are right now, pick the mechanism that feels most relevant to what you’re experiencing, and build from there.
The goal is to be measurably younger next year than you are today.
Stay upgraded,
Dave
The calendar says I’m in my 50s. My lab tests say otherwise. I’ve reversed my biological age by over 20 years, and people constantly ask me how I did it.
The honest answer is I don’t share my full stack because what works for my biology won’t necessarily work for yours. But there are core interventions that work for human biology in general, and those I’ll talk about all day. I’ve spent over two decades and more than $2 million figuring out which ones actually work (and which don’t). Here’s where I’d start.
In order to address aging, you have to understand the underlying mechanisms.
Here are 7 core processes that contribute to aging:
- You accumulate senescent cells. As your cells accumulate damage, some of them stop functioning but refuse to die. These zombie cells release inflammatory signals that speed up damage in the surrounding tissue. The more you accumulate, the faster everything downstream degrades.
- Autophagy slows down. Your body has a built-in cellular cleanup system that breaks down damaged proteins and organelles and recycles them. As you age, this slows down.
- Your mitochondria decline. Your mitochondria produce the energy your cells run on. As you age, damaged mitochondria accumulate and a process called mitophagy, which clears out the dysfunctional ones to make room for new ones, slows significantly. This shows up as lower energy, slower recovery, and accelerated cellular aging.
- NAD+ levels drop. NAD+ is the coenzyme your cells need for energy production, DNA repair, and sirtuin activation. Sirtuins are the proteins that regulate cellular health and longevity. NAD+ levels drop by roughly 50% between your 20s and 50s, and the cellular processes that depend on it slow down accordingly.
- Stem cells become exhausted. Your body repairs itself through stem cells that circulate in your bloodstream, detect damage signals, and migrate into tissue that needs repair. With age, both the number of circulating stem cells and their ability to reach damaged tissue decline significantly, so damage accumulates faster than your body can address it.
- You start inflammaging. Chronic low-grade inflammation is one of the main drivers of accelerated aging. It disrupts immune function, damages tissue, and creates a feedback loop that compounds over time. A lot of people are walking around with significant systemic inflammation and have no idea.
- Your nitric oxide levels decline. Nitric oxide is a signaling molecule that keeps blood vessels flexible and blood flowing so that oxygen and nutrients can reach every cell. Production declines by roughly 10% per decade starting in your 20s, and by the time most people hit their 50s, their vascular function is meaningfully compromised.
My Longevity Stack:
Cellular cleanup and autophagy: Mimio HealthMimio’s formulation is built around the biology of a 36-hour fast. It replicates the metabolic state your body enters during extended fasting, activating autophagy, AMPK, and sirtuin pathways without requiring you to actually fast.
Stem cell mobilization: STEMREGEN
Stem cell scientist Christian Drapeau spent 20 years developing this formula, and two capsules put an average of 10 million of your own stem cells into circulation, roughly doubling what a typical 50-year-old has in their bloodstream.
Mitochondrial renewal: Timeline / Mitopure
Mitopure delivers Urolithin A, a postbiotic compound that triggers mitophagy, the selective clearance of damaged mitochondria. Your cells replace dysfunctional mitochondria with healthy ones, and the effects show up as more energy, better muscle function, and improved recovery.
NAD+ restoration: Qualia NAD+
Qualia NAD+ uses three NAD+ precursors simultaneously: NIAGEN, a clinically studied form of nicotinamide riboside, niacinamide, and nicotinic acid. It also features resveratrol for sirtuin activation, Coffeeberry to support cellular pathways involved in NAD+ metabolism, and a full B-complex plus magnesium to provide the cofactors NAD+ synthesis depends on. In two randomized double-blind placebo-controlled trials, it raised blood NAD+ levels by roughly 70% on average. Most NAD+ products pick one precursor and stop there. This formula targets multiple steps in the production and recycling pathway at once.
Inflammation: LYMA Laser
The LYMA Laser delivers coherent near-infrared laser light deep into skin tissue, triggering mitochondrial stimulation and reducing inflammation at the cellular level. Peer-reviewed research published in the Aesthetic Surgery Journal showed it activated 45 longevity genes in the skin. It’s one of the only clinic-grade laser devices you can use at home.
Nitric oxide and vascular health: N101
N101 is a nitric oxide lozenge developed by Dr. Nathan Bryan, one of the leading researchers in nitric oxide biology. It dissolves in your mouth to support nitric oxide production directly in your blood vessel walls, improving circulation, oxygen delivery to cells, and vascular flexibility.
Biological age testing: Generation Lab
Nothing on this list matters if you don’t know your baseline. Generation Lab runs comprehensive biological age testing that looks at DNA methylation patterns, immune aging markers, and organ-level function. This tells you where you actually are, not where you assume you are, and gives you a real way to measure whether what you’re doing is working.
You don’t have to do all of this at once. Start with testing so you know where you are right now, pick the mechanism that feels most relevant to what you’re experiencing, and build from there.
The goal is to be measurably younger next year than you are today.
Stay upgraded,
Dave
