EP 1156

1156. Muscle Preservation with GLP-1 Drugs

Discover insights into how to maintain muscle mass during weight loss, improve mitochondrial function, and what’s on the horizon in terms of medical treatments for weight management.

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In this Episode of The Human Upgrade™...

Today on The Human Upgrade, Dr. Anurag Singh, a renowned expert in muscle biology and aging, shares his expertise on the impact of GLP-1 agonists like Ozempic and Wegovy on weight loss, muscle health, and aging. In this episode, you’ll learn about the science behind these popular drugs, their potential benefits, and the risks involved. Discover how you can maintain muscle mass while losing weight, enhance your mitochondrial function for better health, and what the future holds for medical treatments in weight management. Gain expert insights into making smart choices for your long-term health and wellness, whether you’re considering these treatments or just curious about new health technologies.


"Focusing on mitochondrial health is key because you're losing muscle at rates seen only in starvation or severe medical conditions."


Introduction to GLP-1 Agonists: 

  • Background on their rise to popularity. 
  • Basic mechanism of action in weight loss and diabetes control. 

Muscle Health Concerns: 

  • The challenge of muscle loss with GLP-1 treatments. 
  • Strategies to preserve muscle mass and strength. 

Mitochondrial Function and Longevity: 

  • The impact of these drugs on cellular energy production. 
  • Potential benefits for longevity under proper usage conditions. 

Future of Weight Loss Treatments: 

  • Predictions for advancements in drug development and combined treatments. 

Navigating Side Effects: 

  • Common side effects of GLP-1 agonists and how to manage them. 
  • Strategies for dealing with nausea, one of the most frequent side effects. 

Nutritional Considerations: 

  • Importance of diet in complementing the effects of GLP-1 drugs. 
  • Recommendations for protein intake and nutrient-rich diets to support muscle and overall health. 

Lifestyle Modifications: 

  • The role of exercise and physical activity in enhancing the effectiveness of GLP-1 treatment. 
  • How lifestyle changes can mitigate potential negative effects on muscle and metabolism. 

Psychological Impacts of Rapid Weight Loss: 

  • Discussing the emotional and psychological aspects of significant weight loss. 
  • Strategies for maintaining mental health and body image positivity during and after treatment. 

Emerging Research and Clinical Trials: 

  • Overview of ongoing research into the long-term effects of GLP-1 agonists. 
  • Future prospects for integrating these treatments with other longevity strategies. 



Enjoy the show!


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