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Best of 2022

UpgradeYour Energy

Ari Whitten

Learn why you’re tired, how to fix it, and what you can do to increase your energy currency.

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In this "Best of" Episode of The Human Upgrade™...

Ari Whitten, Ph.D. (Cand.), CES, PES, explains how to double your energy through improved resilience, cell defense, nutrition and supplementation.  

In his newest book, “EAT FOR ENERGY: How to Beat Fatigue, Supercharge Your Mitochondria, and Unlock All-Day Energy,” Ari explains that 5.4 million adults in the U.S. have been diagnosed with chronic fatigue syndrome (the most severe case of fatigue). However, the true fatigue epidemic affects 50 to 100 times more people with many experiencing some level of being flat-out tired as hell.

This conversation gets right into the role of mitochondria in human energy. The cause of fatigue is mitochondrial dysfunction, Ari says. The biggest factors that affect your mitochondria include:

  • Circadian rhythm dysregulation and poor sleep 
  • Carrying too much body fat and too little muscle mass 
  • Poor gut and microbiome health 
  • Blood sugar dysregulation 
  • Nutritional toxicities and deficiencies 
  • Neurotransmitter and hormone imbalances

Ari recommends science-backed ways that you can get your mitochondria moving, dial in your nutrition and upgrade your brain, gut and hormones.

“Mitochondria are the most upstream thing that regulates human energy levels. It’s the actual thing deciding whether we should be producing lots of energy at the cellular level or not very much energy.”

Ari Whitten

More about Ari Whitten: He created The Energy Blueprint science-based lifestyle programs that target brain energy and mitochondria. He also hosts The Energy Blueprint podcast. He’s the author of several books, including: “The Ultimate Guide To Red Light Therapy: How to Use Red and Near-Infrared Light Therapy for Anti-Aging, Fat Loss, Muscle Gain, Performance Enhancement, and Brain Optimization.” He earned a Bachelor of Science in Kinesiology and two advanced certifications from the National Academy of Sports Medicine as a Corrective Exercise Specialist and Performance Enhancement Specialist. He’s completed three years of coursework for his Ph.D. in Clinical Psychology, an education which rounds out his approach to optimal health, a trifecta of nutrition, fitness, and psychology.

Enjoy the show!

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  • You’ve talked about low carb diet traps in other books and even the low carb myth, because turns out you make energy from carbs. But let’s just get right into it. Tell me about human energy, where it comes from.  – 2:53
  • And what they find is, in general, between the ages of 20 to 40, most people lose about half of their mitochondrial capacity, between the ages of 40 to 70, it gets cut in half again.  – 8:42
  • There are certain supplements that have been shown in people with stress related fatigue and exhaustion to cut their levels of fatigue, to cut their levels of depression and anxiety and brain fog in half in a week or a month.  – 12:33
  • Rhodiola is a powerful one. I look at PQQ as a really powerful one as well, even coenzyme Q10 for a lot of people is a big deal, so is acetyl-acetate, which is a mitochondrial metabolite that actually primes the pump.  – 13:11
  • I think we need to be cautious around making sure we understand physiology accurately and making sure that we’re working with the intelligence of our body and not against it.  – 20:14
  • The idea you that your mental state is one of the many variables that affects mitochondria is really important. But do people get chronic fatigue because they had a bad breakup?  – 24:53
  • So, I mean, these are six nutritional causes specifically. So, circadian rhythm disruption, blood sugar dysregulation, poor body composition, poor gut health and poor brain health.  – 29:46
  • There’s many layers to this, but melatonin is actually, turns out, is basically the most important mitochondrial antioxidant and is vital for protecting our mitochondria and our neurons, and has profound anti-cancer effects as well, super important for preventing the development of cancer.  – 34:35
  • But too much antioxidants all the time, no. No antioxidants ever, no. How would we know how much to take? What do you do to look at that?  – 41:49
  • Red and near-infrared light also have another mechanism of action that’s very important, which is retrograde signaling.  – 48:53
  • There’s advantages to building up that natural, innate sunscreen that we’re all born with the capacity to produce. Well, almost all, unless you’re extreme Fitzpatrick type 1, or you have albinism or something like that.  – 56:24

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