EP 1187

1187. Memory, Psychedelics, and Biohacking

Dr. Manoj Doss discusses the intriguing effects of psychedelics on memory and cognitive function, offering insights into how these substances can influence both episodic and semantic memory.

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In this Episode of The Human Upgrade™...

In this episode of The Human Upgrade, Dr. Manoj Doss, a neuroscientist at the University of Texas at Austin Dell Medical School, explores the fascinating intersection of psychedelics, memory, and cognitive enhancement. Drawing from his extensive research, Dr. Doss dives into how psychoactive substances like THC, ketamine, and psychedelics can alter memory formation, consolidation, and retrieval. He challenges the conventional understanding of memory by revealing how these substances might disrupt traditional memory processes while potentially opening new pathways for learning and cognition. 

You’ll discover how different drugs impact your brain’s ability to encode and recall information, the surprising effects of psychedelics on semantic and episodic memory, and the role of the hippocampus in shaping our personal narratives. Dr. Doss also delves into the potential benefits and risks of cognitive enhancers like nicotine and modafinil, offering insights into their effects on memory and brain function. 

Dr. Doss provides a nuanced perspective on the malleability of memory, the ethical implications of memory manipulation, and the complex relationship between trauma, memory, and psychedelics. This episode is essential for anyone interested in the cutting-edge science of memory, the therapeutic potential of psychedelics, and the quest to enhance cognitive performance. 

Sponsors: 

  • ARMRA | Go to TryARMRA.com and use the code DAVE to get 15% off your first order. 

"Memory is not just a record of the past; it's a tool for predicting the future."

Dr. Manoj Doss

00:00:01 — Opening 

  • Introduction to the episode’s focus on memory and cognitive function. 

00:01:39 — Introduction to Dr. Manoj Doss 

  • Dr. Doss shares his background and research on psychoactive drugs and memory. 

00:03:20 — The Impact of Psychedelics on Memory 

  • Discussion on how different doses of psychedelics affect cognitive performance and longevity. 

00:13:22 — Alcohol and Retrograde Facilitation: Enhancing Memory Post-Study 

  • Exploring the paradoxical effect of alcohol on memory when consumed immediately after studying. 

00:19:00 — Differences Between Episodic and Semantic Memory 

  • Dr. Doss explains the differences between these two types of memory and their implications for cognitive health. 

00:32:35 — Exercise, BDNF, and Memory Enhancement 

  • How exercise and Brain-Derived Neurotrophic Factor (BDNF) play a role in maintaining cognitive function. 

00:52:16 — The Fallibility of Memory and False Memory Formation 

  • Insights into how memory can be distorted and the potential consequences of false memories. 

01:09:04 — The Influence of Nicotine, Modafinil, and Other Cognitive Enhancers 

  • A discussion on the effects of popular cognitive enhancers on memory and brain health. 

01:30:34 — Closing Remarks 

  • Final thoughts on the episode and where to find more information about Dr. Doss’s work. 

Resources: 

  • Follow Dr. Manoj Doss on Twitter 

Enjoy the show!

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