Les Dethlefsen: Fecal Transplant Pills, The Microbiota & How to Restore Gut Health – #240

fecal transplant

Why you should listen – 

Les Dethlefsen comes on Bulletproof Radio today to discuss recent discoveries about the microbiota, when you should take pre and probiotics, hacking the harmful effects that antibiotics have on our gut flora, and how a fecal transplant can save your life. Enjoy the show!

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Les Dethlefsen, Ph.D., is a staff scientist at the Relman labs at Stanford.  Since joining the lab in 2004, his work has been focused on the temporal dynamics of the gut microbiota.  Les has an undergraduate double major in physics and molecular biology.  He earned his Ph.D. in both Microbiology and Ecology/Evolutionary Biology from Michigan State.  His current study, ‘Dynamics of the Human Microbiota,’ is looking for participants.

What You Will Hear

  •      0:14 – Cool fact of the day
  •      1:03 – Welcome Les Dethlefsen
  •      2:42 – You and your microbes
  •    11:30 – Dave’s weird biohacking experiment
  •    18:27 – Antibiotics and its effects on bacteria
  •    25:00 – Rebuilding the gut microbiome
  •    36:52 – Gut bacteria and obesity
  •    44:44 – Thoughts on industrial meat
  •    53:00 – Fecal transplants?
  • 1:03:08 – Top three recommendations for kicking more ass and being Bulletproof!



Sign up for Les Dethlefsen’s experiment


Pseudomonas aeruginosa


Trichuris trichiura (pig whipworm eggs)


DD-transpeptidase (Bacterial DD)


Fasting-induced adipose factor (FIAF)


Quantified Self


Hadza, Tanzania


Caprylic acid

Chronic low-grade inflammation

Glyphosate (Roundup)

Fecal Transplant

Clostridium difficile (pseudomembranous colitis)

Ulcerative colitis



Brain Octane Oil


Bulletproof Coffee Shop

Bulletproof Conference

Moldy Movie

Bulletproof Diet Book

Free Bulletproof Diet Roadmap

Questions for the podcast?

Leave your questions and responses in the comments section below. If you want your question to be featured on the next Q&A episode, submit it in the Podcast Question form! You can also ask your questions and engage with other listeners through The Bulletproof Forum, Twitter, and Facebook!


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Dave Asprey

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