Trigger Autophagy Without Fasting – Dr. Elizabeth Yurth Talks Spermidine with Dave Asprey – #773

• How did you discover spermidine, or how did this become an area of focus for you? – 3:06
• “Oh my gosh, this is the answer to a whole bunch of problems,” because it worked at very, very base level in fixing the cell. – 4:43
• What does spermidine do in cells that makes it such a broad spectrum thing?  – 6:27
• It’s changing the oxidative phosphorylation pathway.  – 9:38
• Where we see the spermidine work is at a very, very base level to correct the autophagy to get rid of those bad mitochondria so that now we don’t have, we’re not being overwhelmed by reactive oxygen species.  – 10:15
• In the heart, it actually increases the number of mitochondria. – 10:30
  
• We know that it actually decreases some of the inflammatory cytokines like tumor necrosis factor-alpha. That links to things like osteoarthritis. It’s doing a whole host of things probably because it’s working at that very, very bottom level to restore those normal mitochondrial oxidative phosphorylation pathways to stop producing so many reactive oxygen species. – 11:32
  
• If it’s a fasting memetic, can you take spermidine instead of fasting? – 12:43
  
• Spermidine is in our diet. It’s in soy. It’s in mushrooms. It’s in those aged smelly cheeses like Roquefort. It’s in soybean pea, one of the theories is that one of the reasons the Mediterranean diet is so good for us is because it has a high polyamine content. – 15:15
  
• Do you see patients who have gluten problems having any issues with it because it does come from a wheat-based substance. – 16:58
  
• Just like if you look at just taking CBDs or just taking THC and not having a full spectrum hemp, there’s probably differences in the way it’s going to react in your body, right? The same thing is true with spermidine. It’s one of the reasons that we’ve really appreciated spermidine LIFE product. – 22:31
  
• Putrescine basically converts into spermidine, and then spermidine into spermine. – 23:13
  
• If you eat bad meat, you’ll get putrescine. You can overwhelm that pathway and then it will go into much more toxic metabolite doing a whole lot of damage. That’s why you really wouldn’t want to just eat putrescine even though it will channel into spermidine. – 24:03
  
• If you have higher level of spermidine, it will improve the gut bacteria that make more spermidine, so actually it becomes sort of a cycle. – 28:29
  
• We saw that in the osteoarthritis mouse study is that it markedly reduce a lot of the inflammatory cytokines that we see elevated, like tumor necrosis factor-alpha and interleukin-6. – 31:45
  
• Do you think it’s as important as Glutathione? – 34:57
  
• It really appears to work on fat loss is by actually increasing some of the transaminases that are converting fat. It works specifically on visceral fat. – 38:35
  
• Because of its stem cell activities, it’s epithelial stem cell activity, so you’re increasing basically the number of hair follicles, so you’re actually not just … Hair grew faster. It grew longer, and it increased density. – 41:11
  
• There’s a study, it’s still ongoing called the Smartest Study that’s actually looking at blood pressure, so actually hypertension, treat it with spermidine. The early results from that are looking pretty promising that it actually is really helpful there, but again, for lowering … LP (a), which is one of the hard things to treat. – 46:26
  
• Loss of stem cells in bone is one of things that is now causing that demise as we age. That’s probably its big effect is on stem cell production, but again, if I’m going to increase improvement in mitochondria, again loss of mitochondria muscle cells, improving the mitochondria is going to make the muscles more functional. – 49:50
  
• Betsy:
  bodybuilders who work out together seem to get better results than working out independently. It’s that socialization that increases Oxytocin. – 52:11
  
• You’ve got to learn that you’ve got to understand it, and then you’ve got to take control. If you follow me on Instagram @dryurth@boulderlongevity, and then go to Human Optimization site, which in on boulderlongevity.com. – 58:20

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