Trigger Autophagy Without Fasting – Dr. Elizabeth Yurth Talks Spermidine with Dave Asprey – #773

Spermidine promotes cellular renewal to slow down aging through autophagy and anti-inflammatory effects.

In this episode of Bulletproof Radio, my guest Dr. Elizabeth Yurth explains how spermidine, a substance found in the human body and almost all plants and animals, can slow down the cellular aging process and influence your overall health.

“Where we see spermidine work is at a very, very base level to correct the autophagy to get rid of those bad mitochondria so that now we’re not being overwhelmed by reactive oxygen species,” Dr. Yurth says. “We actually will start to recycle the bad parts of the cell and start with a new cell at that point.”

 Dr. Yurth is medical director/chief medical officer at Boulder Longevity Institute, and a partner with Longevity Labs+, the company that’s been pioneering spermidine research for the last decade and focuses their research on the improvement of aging.

So what does spermidine do? Most importantly, it regulates a cell renewal process called autophagy, one of the most touted benefits of fasting.

Spermidine helps you take control of the aging process.

SpermidineLIFE® is the first naturally extracted and clinically tested dietary supplement to promote cellular renewal after multiple studies, trials and 10 years of research.

People in clinical trials reported better memory, better sleep, more energy, reduced brain fog, improved skin and hair, and more.

“Spermidine’s working on so many pathways to reduce reactive oxygen species, to improve the immune health, and to reduce the inflammatory cytokines that we know are initiated in these disease processes,” Dr. Yurth says.

Spermidine is an important part of the body’s cellular processes that:

  • Support healthy cell aging
  • Have preventive effects on age-related diseases
  • Increase life expectancy and liver protection
  • Promote healthy weight
  • Normalize bone density
  • Reduce age-dependent muscular atrophy
  • Enhance growth of hair, skin, and nails

“Every single species, every one-cell organism. Everybody has this, so we know it’s critical to life,” Dr. Yurth says. “We absolutely know it’s critical to life.”

Enjoy! And get more resources at Dave.Asprey/podcasts

BULLETPROOF RADIO LISTENER SPECIAL OFFER: Go to https://spermidinelife.us/dave; use code DAVE25 for 25% off your first purchase

WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!
Light Therapy: https://joovv.com/pages/dave-asprey; use code DAVE
Fitness Tech: https://www.fitbit.com/global/us/home; six FREE months of Fitbit Premium with the purchase of a Fitbit Sense
Nature’s Nootropic
https://gettrukava.com; use code DAVE15 for 15% off

Listen on Apple Podcasts or iTunesListen on Google Podcasts

Follow Along with the Transcript

Trigger Autophagy Without Fasting – Dr. Elizabeth Yurth Talks Spermidine with Dave Asprey – #773

Links/Resources

Website: spermidinelife.us
Facebook: facebook.com/spermidineLIFE.us/
Instagram: instagram.com/spermidinelife.us/
Dr. Elizabeth Yurth: instagram.com/dryurth/
Boulder Longevity Institute: boulderlongevity.com
For scientific research and studies on spermidine, visit:  longevitybioresearch.org

Key Notes

  • How did you discover spermidine, or how did this become an area of focus for you? – 3:06
  • “Oh my gosh, this is the answer to a whole bunch of problems,” because it worked at very, very base level in fixing the cell. – 4:43
  • What does spermidine do in cells that makes it such a broad spectrum thing?  – 6:27
  • It’s changing the oxidative phosphorylation pathway.  – 9:38
  • Where we see the spermidine work is at a very, very base level to correct the autophagy to get rid of those bad mitochondria so that now we don’t have, we’re not being overwhelmed by reactive oxygen species.  – 10:15
  • In the heart, it actually increases the number of mitochondria. – 10:30
  • We know that it actually decreases some of the inflammatory cytokines like tumor necrosis factor-alpha. That links to things like osteoarthritis. It’s doing a whole host of things probably because it’s working at that very, very bottom level to restore those normal mitochondrial oxidative phosphorylation pathways to stop producing so many reactive oxygen species. – 11:32
  • If it’s a fasting memetic, can you take spermidine instead of fasting? – 12:43
  • Spermidine is in our diet. It’s in soy. It’s in mushrooms. It’s in those aged smelly cheeses like Roquefort. It’s in soybean pea, one of the theories is that one of the reasons the Mediterranean diet is so good for us is because it has a high polyamine content. – 15:15
  • Do you see patients who have gluten problems having any issues with it because it does come from a wheat-based substance. – 16:58
  • Just like if you look at just taking CBDs or just taking THC and not having a full spectrum hemp, there’s probably differences in the way it’s going to react in your body, right? The same thing is true with spermidine. It’s one of the reasons that we’ve really appreciated spermidine LIFE product. – 22:31
  • Putrescine basically converts into spermidine, and then spermidine into spermine. – 23:13
  • If you eat bad meat, you’ll get putrescine. You can overwhelm that pathway and then it will go into much more toxic metabolite doing a whole lot of damage. That’s why you really wouldn’t want to just eat putrescine even though it will channel into spermidine. – 24:03
  • If you have higher level of spermidine, it will improve the gut bacteria that make more spermidine, so actually it becomes sort of a cycle. – 28:29
  • We saw that in the osteoarthritis mouse study is that it markedly reduce a lot of the inflammatory cytokines that we see elevated, like tumor necrosis factor-alpha and interleukin-6. – 31:45
  • Do you think it’s as important as Glutathione? – 34:57
  • It really appears to work on fat loss is by actually increasing some of the transaminases that are converting fat. It works specifically on visceral fat. – 38:35
  • Because of its stem cell activities, it’s epithelial stem cell activity, so you’re increasing basically the number of hair follicles, so you’re actually not just … Hair grew faster. It grew longer, and it increased density. – 41:11
  • There’s a study, it’s still ongoing called the Smartest Study that’s actually looking at blood pressure, so actually hypertension, treat it with spermidine. The early results from that are looking pretty promising that it actually is really helpful there, but again, for lowering … LP (a), which is one of the hard things to treat. – 46:26
  • Loss of stem cells in bone is one of things that is now causing that demise as we age. That’s probably its big effect is on stem cell production, but again, if I’m going to increase improvement in mitochondria, again loss of mitochondria muscle cells, improving the mitochondria is going to make the muscles more functional. – 49:50
  • Betsy:
    bodybuilders who work out together seem to get better results than working out independently. It’s that socialization that increases Oxytocin. – 52:11
  • You’ve got to learn that you’ve got to understand it, and then you’ve got to take control. If you follow me on Instagram @dryurth@boulderlongevity, and then go to Human Optimization site, which in on boulderlongevity.com. – 58:20

If you like today’s episode, check us out on Apple Podcasts at Bulletproof.com/apple and leave us a (hopefully) 5-star rating and a creative review.

Go check out my new book Super Human: The Bulletproof Plan to Age Backward and Maybe Even Live Forever and also “Game Changers“, “Headstrong” and “The Bulletproof Diet” on Amazon and consider leaving a review!

Want to help others reach their full potential? Check out the incredible Human Potential Coach Training program I set up with Dr. Mark Atkinson.

You may also like

Share on facebook
Share on twitter
Share on linkedin
Share on pinterest
Share on facebook
Share on twitter
Share on linkedin
Share on pinterest
Dave Asprey

Statements made on this website have not been evaluated by the U.S. Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. Information provided by this website or this company is not a substitute for individual medical advice. Articles and information on this website may only be copied, reprinted, or redistributed with written permission (but please ask, we like to give written permission!) The purpose of this Blog is to encourage the free exchange of ideas. The entire contents of this website is based upon the opinions of Dave Asprey, unless otherwise noted. Individual articles are based upon the opinions of the respective authors, who may retain copyright as marked. The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the personal research and experience of Dave Asprey and the community. We will attempt to keep all objectionable messages off this site; however, it is impossible to review all messages immediately. All messages expressed on the Blog, including comments posted to Blog entries, represent the views of the author exclusively and we are not responsible for the content of any message.