EP 1243
1243. Biohacking 2025 State of the Union: Master Supplementation Guide with Dr. Sandra Kaufmann
In this episode of The Human Upgrade, Dave Asprey sits down with Dr. Sandra Kaufmann, longevity expert and author of the Kaufmann Protocol, to unpack the 2025 Biohacking State of the Union. Together, they explore groundbreaking supplementation strategies, the science of aging, and practical tools for optimizing health and performance. From mastering circadian rhythms to hacking your mitochondria, Dr. Kaufmann reveals how you can extend your lifespan, boost vitality, and thrive—without giving up life’s indulgences.
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In this Episode of The Human Upgrade™...
What if you could cheat aging, indulge in life’s guilty pleasures, and still thrive?
Dr. Sandra Kaufmann, a pioneering longevity expert and fearless explorer of the biochemical frontier, joins Dave to reveal how you can bend the rules of biology to live longer, smarter, and stronger. Forget perfection—Dr. Kaufmann’s radically practical approach embraces the human side of longevity, showing you how to optimize your body while enjoying the ride.
From downing Diet Cokes to defying traditional medical dogma, she’s rewritten the playbook on anti-aging with her Seven Tenets of Aging. Together, she and Dave dive into everything from molecular hacks for outsmarting junk food to unlocking the secret power of your mitochondria, DNA, and circadian rhythms. This episode goes beyond the surface with mind-blowing insights, hilarious moments, and actionable steps to take your health (and your fun) to the next level.
What You’ll Learn:
- The Seven Tenets of Aging and how they’ll change your approach to health
- Why indulging in “bad” habits doesn’t have to sabotage your longevity
- Biochemical secrets to combat oxidative stress, glycation, and cellular junk
- The real story behind NAD, circadian rhythms, and the tools for better sleep
- How to create a personalized health plan that’s sustainable, effective—and fun
SPONSORS:
Leela Quantum | Head to https://leelaq.com/DAVE for 10% off
Timeline | Head to https://www.timeline.com/dave to get 10% off your first order.
“The idea of longevity is you don’t have to be perfect. Accept what you can do, accept what you can’t, and optimize from there.”
Dr. Sandra Kaufmann
- 00:00
Get a sneak peek of the bold ideas and hacks discussed in this episode.
- 00:45 Guest Introduction
Meet Dr. Sandra Kaufman, a longevity expert redefining anti-aging science.
- 02:30 Longevity Insights
Explore the biochemical hacks to slow aging and improve overall health.
- 04:22 Personal Stories
Hilarious and relatable anecdotes from Dr. Kaufman’s longevity journey.
- 08:00 Pharmaceuticals
Learn about the role of pharmaceuticals in optimizing health and longevity.
- 12:26 Diet and Lifestyle
How indulgent habits can coexist with a biohacking lifestyle.
- 18:19 Seven Tenets
A breakdown of the Kaufmann Protocol’s Seven Tenets of Aging.
- 22:04 Sleep and Circadian Rhythms
Discover how circadian rhythm hacks can improve sleep and longevity.
- 26:41 NAD and Supplements
Unpacking NAD supplementation and its impact on cellular health.
- 37:46 Blood Sugar and AGEs
Tools to manage blood sugar and reduce harmful glycation effects.
- 47:09 Microcirculation
Pharmaceuticals and methods to enhance blood flow and microcirculation.
- 49:08 NRS and Imports
Discussion on sourcing longevity medications like NRS.
- 49:18 Celebrex Medication
The surprising benefits of Celebrex in combating aging.
- 50:03 Celebrex Benefits
Why Celebrex is a game-changer for longevity enthusiasts.
- 50:41 Alzheimer’s and Celebrex
How Celebrex may help combat Alzheimer’s and cognitive decline.
- 51:28 Antioxidants
The role of free radical scavengers in preserving cellular health.
- 54:26 Stem Cells and Exosomes
Insights into stem cells and exosomes as safer, cutting-edge therapies.
- 58:03 Laser Skin Treatments
Exploring laser technologies to enhance skin health and rejuvenation.
- 01:07:34 Hormones and Longevity
How hormone therapies can extend healthspan and vitality.
- 01:20:03 Lithium for Mood
The connection between lithium, mood regulation, and longevity.
- 01:27:45 Gender and Longevity
Key differences in aging and longevity between men and women.
- 01:32:39 Final Thoughts
Wrap-up and resources to dive deeper into Dr. Kaufmann’s work.
Resources:
- 2025 Biohacking Conference: https://biohackingconference.com/2025
- Supplement Protocol One-Sheet: https://www.instagram.com/dave.asprey/?hl=en
- Kaufmann Protocol Website: https://kaufmannprotocol.com
- Sandra Kaufmann’s Book – Why We Age and How to Stop It: https://www.amazon.com/Kaufmann-Protocol-Why-Age-Stop/dp/0692089047
- Sandra Kaufmann’s Instagram: https://www.instagram.com/kaufmannantiaging/?hl=en
- Danger Coffee: https://dangercoffee.com
- Dave Asprey’s Website: https://daveasprey.com
- Dave Asprey’s Book – Smarter Not Harder: https://daveasprey.com/books
- Dave Asprey’s Linktree: https://linktr.ee/daveasprey
- Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com
- Own an Upgrade Labs: https://ownanupgradelabs.com
- Upgrade Labs: https://upgradelabs.com
- 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com
Enjoy the show!
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