EP 1265
1265. The Dirty Secret Behind Ozempic: How It Wrecks Your Gut (Here’s How to Fix It) | Hannah Kleinfeld
In this episode of The Human Upgrade, Dave Asprey sits down with gut health innovator Hannah Kleinfeld to uncover how antibiotic use, GLP-1 drugs, glyphosate exposure, and even stress can disrupt your gut microbiome—silently driving brain fog, inflammation, and metabolic dysfunction. From her personal battle with Lyme disease to pioneering targeted probiotics that survive stomach acid and actually work, Hannah shares cutting-edge insights on healing leaky gut, reversing dysbiosis, and how AI is reshaping the future of microbiome optimization.
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In this Episode of The Human Upgrade™...
For decades, gut health was reduced to yogurt commercials and vague promises from probiotics that barely worked. But what if we’ve been targeting the wrong bugs, using the wrong delivery, and ignoring the true source of chronic inflammation and accelerated aging?
In this thought-provoking episode, Dave sits down with Hannah Kleinfeld, a leader in microbiome innovation, to expose why most probiotics fail—and how one company’s scientifically validated approach could redefine your gut, brain, immune system, and even your metabolism.
You’ll learn how dysbiosis may be wrecking your brain without you knowing it, why your probiotic likely died in your stomach acid, and the secret to rebooting your microbiome after antibiotics, GLP-1 drugs, or years of toxic exposure. This isn’t just about digestion—your gut controls your cravings, energy, sleep, mood, and aging trajectory.
So what’s the one upgrade that can actually reset your gut… for good?
What You’ll Learn in This Episode:
- Why your gut—not your brain—is making most of your decisions
- How 93% of probiotics on the market fail before they reach your intestines
- The “AB 10” protocol that rebuilds your gut after antibiotics or SIBO
- What GLP-1 weight-loss drugs are doing to your microbiome (and how to stop it)
- The shocking gut–brain–heart axis connection you’ve never heard of
- Why inflammation, brain fog, and mood swings may start with leaky gut
- Which probiotic strains are clinically proven to improve cognition and mood
- What to do if you want to eat gluten again—or survive American wheat
- How a fermented papaya concentrate could replace your acid reflux meds
- Why optimizing your gut could extend your lifespan by 40%
***Get 20% off your next purchase by going to https://omnibioticlife.com/pages/dave-asprey/ or omnibioticlife.com/dave***
SPONSORS
Timeline | Head to https://www.timeline.com/dave to get 10% off your first order.
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“Your gut microbiome is tied to everything—your immune system, your brain, your liver. Mice without a gut microbiome live a fraction of normal. A healthy microbiome is directly linked to longevity and disease prevention.”
Hannah Kleinfeld
- 00:00 – Trailer
- 03:15 – Intro
Henna Kleinfeld and Dave Asprey share personal health journeys that led them to the cutting edge of gut health biohacking.
- 05:05 – Probiotics, Prebiotics, and Postbiotics Explained
Breakdown of how each component functions in the microbiome—and why most supplements get it wrong.
- 08:21 – The Importance of Delivery Mechanisms
Why probiotic survival matters, and how Omni-Biotic’s rehydration method beats traditional capsules by 12x.
- 17:36 – Addressing SIBO and Gut Health Protocols
Practical advice for tackling bacterial overgrowth and restoring microbial balance after chronic gut issues.
- 31:55 – The Impact of GLP-1 Drugs on Gut Health
How popular weight-loss drugs like Ozempic may be silently destroying your gut microbiome—and how to protect it.
- 39:26 – The Role of Gut Bacteria in Hunger and Fasting
Revealing how bacteria influence cravings, satiety, and fat storage via secret biochemical signals.
- 40:01 – Painkillers and Gut Health: A Personal Experience
Dave shares post-surgery lessons on NSAIDs, stomach acid blockers, and their impact on the microbiome.
- 40:51 – The Dangers of Proton Pump Inhibitors
How long-term PPI use compromises gut defense, increases dysbiosis, and accelerates aging.
- 42:00 – The Importance of Stomach Acid
Stomach acid isn’t the enemy—it’s essential. Learn how low acid levels can cause heartburn and gut dysfunction.
- 44:55 – Probiotics for Chronic Conditions
Targeted strains for stress, brain fog, immune issues, and post-antibiotic recovery—with clinical results to back them.
- 48:38 – The Impact of Glyphosate on Gut Health
Why the herbicide found in most U.S. wheat may be shredding your gut lining—and what to do about it.
- 57:04 – Alcohol and Gut Bacteria
How even moderate drinking alters gut flora, increases inflammation, and leads to systemic imbalances.
- 01:02:01 – New Solutions for Acid Reflux
A powerful fermented papaya formula that coats the stomach, reduces heartburn, and supports gut lining repair.
- 01:07:57 – The Future of Gut Health and Longevity
What science is revealing about the microbiome’s role in lifespan—and how optimizing your gut could extend your life by decades.
- 01:11:33 – Conclusion and Special Offer
Dave recaps the biggest takeaways and gives listeners 20% off Omni-Biotic formulations that actually work.
Resources:
- Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated/
- OMNi-BiOTiC’s Instagram – https://www.instagram.com/fatty15/
- OMNi-BiOTiC’sWebsite: https://omnibioticlife.com/
- 2025 Biohacking Conference: https://biohackingconference.com/2025
- Danger Coffee: https://dangercoffee.com
- Dave Asprey’s Website: https://daveasprey.com
- Dave Asprey’s Linktree: https://linktr.ee/daveasprey
- Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com
- Own an Upgrade Labs: https://ownanupgradelabs.com
- Upgrade Labs: https://upgradelabs.com
- 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com
Enjoy the show!
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