EP 1277
1277. Biohacking Your Heart Health: The Life-Saving Molecule You Need to Know | Dr. Anurag Singh
In this episode of The Human Upgrade, Dave Asprey sits down with Dr. Anurag Singh, Chief Medical Officer of Timeline, to reveal the groundbreaking science behind reversing mitochondrial aging and boosting heart, brain, and whole-body health. You’ll discover how mitochondrial decline accelerates aging—and how cutting-edge molecules, supplements, and lifestyle strategies can not only slow the process but turn it back. From improving cardiovascular performance and cognitive function to supporting fertility and skin health, this conversation unpacks the latest clinical insights and practical biohacks for optimizing your mitochondrial energy and unlocking long-term vitality.
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In this Episode of The Human Upgrade™...
What if you could reverse the age of your heart…without leaving home?
In this episode of The Human Upgrade, Dave Asprey sits down with Dr. Anurag Singh, Chief Medical Officer of Timeline, to reveal groundbreaking science that targets cardiovascular aging at the cellular level. You’ll discover how mitochondrial decline drives heart failure, why postmenopausal women face skyrocketing cardiac risks, and how one powerful molecule, Urolithin A, can rejuvenate your heart’s energy systems.
Dr. Singh shares clinical research showing how Urolithin A improves mitochondrial function, boosts endurance, and may even reverse biological aging markers in the heart. You’ll also learn how simple lifestyle biohacks, combined with cellular nutrition, can protect your cardiovascular health and extend your healthspan.
What You’ll Learn in This Episode:
- The link between mitochondrial decline and heart failure
- Why women’s cardiac risk skyrockets after menopause
- How Urolithin A stimulates mitophagy and energy renewal
- New human clinical data on reversing cardiac aging markers
- Biohacking strategies to fortify your cardiovascular health
- How to optimize endurance, recovery, and heart resilience
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“No one was thinking about reversing heart aging—until we saw VO? improving.”
Dr. Anurag Singh
- 00:00 — Trailer
Dave sets up the episode’s big promise: reversing mitochondrial aging for better heart and brain health.
- 02:11 — Supplements that help
Dr. Singh shares key compounds shown to support mitochondrial energy and repair.
- 03:05 — Long-term benefits
Studies reveal how consistent use of mitochondrial support leads to better aging outcomes.
- 04:38 — Stacking with lifestyle
Why combining supplements with exercise and diet multiplies the effects.
- 22:19 — Heart health connection
How mitochondrial function directly impacts cardiovascular performance and resilience.
- 29:39 — Mitochondria & brain function
The surprising role mitochondria play in memory, mood, and cognition.
- 33:04 — Glymphatic system & Alzheimer’s
New research linking mitochondrial decline, glymphatic dysfunction, and dementia.
- 33:53 — Bed height & brain health
Simple biohacks—like elevating your bed—can improve glymphatic flow at night.
- 34:18 — Why mitochondria matter
Dr. Singh explains why mitochondria are the true regulators of aging and vitality.
- 35:43 — Inflammation & dysfunction
How chronic inflammation damages mitochondria and accelerates biological aging.
- 38:12 — Transplants & consciousness
Exploring cutting-edge research into mitochondrial transplantation and its effects on brain health.
- 39:19 — Meditation’s effects
The link between mindfulness practices and improved mitochondrial function.
- 40:33 — The ultimate biohacking stack
Dave and Dr. Singh reveal their ideal mitochondrial support protocol.
- 43:06 — Creatine for sleep & focus
Why creatine isn’t just for muscles—it also supports brain energy and better sleep.
- 50:00 — Fertility insights
Mitochondrial health’s surprising impact on reproductive function.
- 57:23 — Skin health
How mitochondria influence collagen, elasticity, and youthful skin.
- 01:00:28 — Final thoughts
Dave and Dr. Singh summarize key takeaways for upgrading mitochondrial and overall health.
Resources:
- Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated/
- Timeline Website – https://www.timeline.com/partners/dave-asprey
- Timeline Instagram – https://www.instagram.com/timeline_longevity/
- 2025 Biohacking Conference: https://biohackingconference.com/2025
- Danger Coffee: https://dangercoffee.com
- Dave Asprey’s Website: https://daveasprey.com
- Dave Asprey’s Linktree: https://linktr.ee/daveasprey
- Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com
- Own an Upgrade Labs: https://ownanupgradelabs.com
- Upgrade Labs: https://upgradelabs.com
- 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com
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