EP 1279
1279. Why Oral Testosterone Is the Ultimate Upgrade for Energy, Mood and Longevity (Men AND Women) | Shalin Shah
In this episode of The Human Upgrade, Dave Asprey dives deep into the truth about testosterone with Shalin Shah, CEO of Marius Pharmaceuticals. They uncover why testosterone levels are plummeting in both men and women—and why diet, sleep, and exercise alone won’t fix it. You’ll learn how oral testosterone is revolutionizing hormone health, how it impacts energy, brain function, motivation, sex drive, and longevity, and why it matters just as much for women as for men. Shah reveals breakthrough research, common myths, and how this next-gen delivery system mimics natural circadian rhythm—without the needles, creams, or pellets.
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In this Episode of The Human Upgrade™...
Low testosterone is sabotaging your health, motivation, and longevity. Diet alone will not fix it.
In this episode of The Human Upgrade, Dave Asprey sits down with Shalin Shah, CEO of Marius Pharmaceuticals, to expose the truth about testosterone decline in both men and women. They break down why testosterone is crashing worldwide, why natural fixes almost always fail, and how the latest science finally makes testosterone therapy safer, simpler, and more effective than ever before.
You will discover why testosterone is essential for dopamine, brain function, sleep, muscle, libido, and mitochondrial health. Fixing your levels can reverse fatigue, brain fog, poor motivation, and slow aging itself.
Shalin reveals how new oral testosterone technology (Kyzatrex®) overcomes the dangers of old therapies and restores natural hormone rhythms without needles, creams, or dangerous side effects.
What You Will Learn in This Episode:
- Why testosterone matters for men and women at every age
- The real causes of the global testosterone crash
- Why diet, sleep, and exercise cannot fully fix low testosterone
- How testosterone drives dopamine, motivation, and longevity
- The breakthrough that makes oral testosterone safe and effective
- How Kyzatrex® lowers SHBG and boosts free testosterone naturally
- Why maintaining youthful testosterone levels protects brain, muscle, libido, and lifespan
- How to safely use testosterone therapy without suppressing fertility or causing side effects
** Visit livethrive.com/asprey to get a discount on your first month’s supply! **
“If you’re alive today, you’re probably low T—and everything else you do for your health won’t work until you fix that.”
Shalin Shah
00:00 Trailer
A powerful glimpse into why oral testosterone is changing everything for health, energy, and aging.
00:52 Introduction
Dave Asprey opens the episode with Shalin Shah to expose the testosterone crisis affecting men and women.
01:29 Global Decline in Testosterone Levels
They discuss the environmental and lifestyle factors driving a worldwide collapse in testosterone.
02:27 Symptoms of Low Testosterone
Fatigue, brain fog, low libido, poor sleep, and mood crashes — how low T shows up in real life.
03:48 Personal Journey with Testosterone Therapy
Dave shares how testosterone therapy changed his life and why diet alone wasn’t enough.
05:06 The Role of Testosterone in Overall Health
Testosterone influences every major system — brain, muscle, sleep, mitochondria, and more.
06:18 Testosterone Levels in Men and Women
Shalin breaks down why women have more testosterone than estrogen and why it matters.
08:48 Challenges and Innovations in Testosterone Delivery
From dangerous creams to painful injections — and how oral testosterone solves it.
16:25 The Importance of Circadian Rhythm in Testosterone Therapy
Daily hormone timing is crucial for sleep, fertility, and healthy endocrine feedback loops.
19:19 The Future of Testosterone Therapy
Oral testosterone offers a safer, more natural option that restores hormonal rhythm.
32:00 Investment and Development in Testosterone Therapy
Shalin shares how Marius Pharmaceuticals built the first effective oral testosterone solution.
34:57 Introduction to FDA and Hormone Replacement
The episode dives into how regulatory mistakes stalled hormonal health for decades.
35:31 FDA’s Impact on Women’s Health
How misinformation about hormone replacement harmed millions of women.
36:10 Testosterone and Cardiovascular Risk
New studies show testosterone protects the heart — not harms it.
39:05 Testosterone and Depression
Low testosterone means low dopamine — and that means low motivation and mood.
40:30 Testosterone Testing and Misconceptions
Why it’s still shockingly difficult to get tested, and what your levels actually mean.
44:58 The Testosterone Project and Female Hormone Therapy
Shalin’s initiative to expand hormone access for women and fix outdated standards.
47:51 Testosterone’s Role in Longevity and Health
Why healthy testosterone levels slow aging and enhance long-term vitality.
55:37 Cost and Accessibility of Testosterone Therapy
How much Kyzatrex® costs, how it compares to injections, and how to get it.
01:04:03 Conclusion and Final Thoughts
Dave and Shalin wrap up with a call to action for reclaiming your hormonal health.
Resources:
- Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated/
- Purchase Kyzatrex®– https://thesmarthuman.com/
- Shalin’s Instagram – https://www.instagram.com/themetabolicceo/
- 2025 Biohacking Conference: https://biohackingconference.com/2025
- Danger Coffee: https://dangercoffee.com
- Dave Asprey’s Website: https://daveasprey.com
- Dave Asprey’s Linktree: https://linktr.ee/daveasprey
- Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com
- Own an Upgrade Labs: https://ownanupgradelabs.com
- Upgrade Labs: https://upgradelabs.com
- 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com
Enjoy the show!
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