EP 1280
1280. The New Science Behind Psychedelics, Shrooms, & Daily Flow-States | Matt Zemon
In this episode of The Human Upgrade, Dave Asprey sits down with Matt Zemon, author and psychedelic wellness expert, to explore how psychedelic shrooms are unlocking daily flow states, mental clarity, and emotional resilience. They dive into the latest neuroscience on psilocybin, how it rewires the brain for performance and healing, and what actually works when it comes to microdosing. You’ll learn the difference between casual use and intentional optimization, the truth about stacking shrooms with nootropics, and how ancient compounds are being used to spark modern transformation.
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In this Episode of The Human Upgrade™...
Your brain has a gear you’ve never touched. Psychedelics can shift you into it.
In this episode of The Human Upgrade, Dave Asprey uncovers how high-performance psychedelic mushrooms help you access flow states, rewire your brain, and enhance clarity, energy, and emotional resilience. This is next-level biohacking rooted in real science.
You will learn how to use psychedelics with intention. When to microdose. When to go deep. How to stack them with nootropics for even stronger results. Dave breaks down the latest research on psilocybin, brain plasticity, trauma release, and how to turn ancient compounds into modern performance tools.
What You Will Learn in This Episode:
- How psychedelic shrooms unlock flow, focus, and creative power
- Why psilocybin boosts neuroplasticity, mood, and emotional healing
- Microdosing vs. full-dose: what works, when, and how
- How to stack psychedelics with nootropics and other biohacks
- The newest research on brain optimization and long-term benefits
- How to use psychedelics safely, strategically, and for real results
- Why shrooms may be the strongest mental upgrade in your toolkit
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“Psychedelics are not cures. They are catalysts. They put us in a state where we remember who we are, and the practice is everything that happens afterwards.”
Matt Zemon
- 00:00 – Trailer
A glimpse into the psychedelic tools and brain upgrades discussed in this episode.
- 01:00 – Intro
Dave Asprey introduces guest Matt Zemon and the promise of daily flow states through psychedelics.
- 06:01 – Personal Psychedelic Journeys
Matt shares how his first experiences with psychedelics reshaped his worldview and purpose.
- 07:39 – Psychedelics and Self-Discovery
Exploring how altered states help uncover deeper layers of identity and consciousness.
- 11:59 – Safe Use and Smart Navigation
How to approach psychedelics with intention, safety, and structure.
- 29:09 – Psychedelics and Society
The growing cultural, therapeutic, and economic impact of psychedelics worldwide.
- 36:40 – Building Trust in the Process
Why safety, trust, and environment are essential to healing outcomes.
- 37:14 – Facing Inner Fear
Using psychedelics to confront suppressed emotions and trauma.
- 37:38 – Choice and Healing
The role of agency and mindset in achieving transformational results.
- 37:51 – Diet and Conscious Decisions
How food choices reflect and influence personal growth.
- 38:55 – Judgment and Relationships
Psychedelics as a tool for reducing judgment and deepening connection.
- 39:29 – Spirituality and Psychedelics
The spiritual dimensions of psilocybin and mushroom therapy.
- 40:07 – The Entheogenic Reformation
Matt explains the shift from dogma to direct spiritual experience.
- 41:29 – Past Lives and Expanded States
Stories of transcendence, past-life recall, and altered perception.
- 43:44 – Where Science Meets Spirituality
A look at how psychedelic science and spiritual practice intersect.
- 49:59 – Gratitude and Compassion in Healing
Why do these emotional states accelerate recovery and rewire the brain.
- 01:01:47 – The Power of Apologies
How authenticity and ownership play into personal and relational healing.
- 01:04:56 – Psychedelics in Therapy
The evolving role of psychedelics and ketamine in clinical mental health treatment.
- 01:08:57 – Final Thoughts on Psychedelics and Culture
Matt and Dave reflect on where psychedelic healing is headed next.
Resources:
- Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated/
- Matt’s Website – https://mattzemon.com/
- Matt’s Instagram – https://www.instagram.com/matt.zemon/
- 2025 Biohacking Conference: https://biohackingconference.com/2025
- Danger Coffee: https://dangercoffee.com
- Dave Asprey’s Website: https://daveasprey.com
- Dave Asprey’s Linktree: https://linktr.ee/daveasprey
- Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com
- Own an Upgrade Labs: https://ownanupgradelabs.com
- Upgrade Labs: https://upgradelabs.com
- 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com
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