EP 1310

1310. Top 5 Secret Dopamine Boosters for Superhuman Energy

In this episode of The Human Upgrade, Host Dave Asprey dives deep into the world of underground dopamine hacks with Australia’s top biohacker, Lucas Aoun. Together, they unpack the cutting-edge science behind Russian compounds like Bromantane and ITPP—powerful tools for enhancing motivation, neuroplasticity, and energy without the crash. You’ll learn how elite performers are stacking nootropics, amino acids, and targeted supplements to build unstoppable drive, optimize mitochondria, and reclaim hormonal balance. Lucas reveals how dopamine connects to testosterone, libido, and confidence—and why most “calming” supplements might be killing your ambition. Whether you’re interested in brain optimization, functional medicine, or hacking your metabolism, this episode gives you the tools to boost motivation, enhance cognitive control, and enter superhuman states of performance. 

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In this Episode of The Human Upgrade™...

Ready to learn about the secret compounds, molecules, nootropics, and stacks that Big Pharma doesn’t want you to know about? This episode is packed with the exact dopamine-boosting compounds, stacks, and biohacking protocols that top performers are using to supercharge human performance, brain optimization, and long-term resilience. 

 

Host Dave Asprey sits down with Lucas Aoun, Australia’s leading biohacker and founder of Ergogenic Health. Known for his fearless, data-driven experimentation, Lucas specializes in nootropics, dopamine modulation, mitochondria, and functional medicine. He’s spent over a decade testing underground nootropics, hormone-based strategies, and metabolic stacks to achieve elite-level brain and body performance. 

 

Together, they explore Russian-developed compounds like Bromantane and ITPP, revealing how these rare substances impact dopamine regulationneuroplasticity, and mental drive. You’ll learn how to upregulate tyrosine hydroxylase (your brain’s dopamine switch), build a personalized dopamine stack to boost confidence and focus, and avoid the misleading supplements that quietly kill your ambition. 

 

They also break down the relationship between dopamine and testosterone, and why optimizing both is essential for masculine identity, libido, and high-agency living. The episode dives into DHT scienceprolactin suppressionGABA balance, and how to design your own dopamine protocol using proven brain optimization techniques and biohacking supplements. 

 

Other key topics include why ashwagandha may harm motivation, how cold therapy can influence neurotransmitters, and how to enhance sleep with strategic nootropics and amino acids. You’ll also hear about fastingketosissleep optimizationcabergolineciproheptadine, and why your metabolism and mitochondrial health are core to sustainable motivation. 

 

You’ll Learn: 

  • The #1 Russian compound for explosive dopamine and drive
  • Why most “calming” supplements destroy your ambition
  • How dopamine and DHT shape masculinity and performance
  • Advanced biohacks for sleep, motivation, libido, and mood
  • The truth about serotonin dominance and how to escape it
  • Which functional medicine tools enhance brain energy and metabolism
  • How to build your own dopamine protocol using proven nootropics
  • Why mitochondrial health is the hidden key to motivation and mood

 

This is essential listening for anyone serious about biohackingbrain optimizationhormone hackingfunctional medicine, emotional resilience, and building a state of unstoppable energy. Whether you’re into ketosiscarnivore, or simply looking for the most effective dopamine boosters to feel like your most powerful self, this episode delivers. 

 

Extended Keywords: 

dopamine boosters, russian nootropics, bromantane benefits, biohacking dopamine, boost motivation naturally, dopamine stack, lucas aoun podcast, dave asprey dopamine, nootropics for energy, secret russian compounds, brain optimization, biohacking supplements, increase dopamine levels, functional medicine hacks, hormone optimization, dopamine and testosterone, neuroplasticity hacks, superhuman energy, underground nootropics, dopamine protocols 

 

Thank you to our sponsors!  

“The ultimate state is high dopamine, high GABA, moderately high acetylcholine, and low serotonin. That’s when I build empires, and here’s how I do it.”

Lucas Aoun

0:00 – Trailer 

Highlights from the episode, including dopamine insights, hormonal hacks, and supplement strategies. 

0:49 – Intro 

Dave welcomes Lucas Aoun and sets the stage for a deep dive into neurohormonal optimization. 

1:35 – Dopamine Hacking & Bromantane 

Exploring how to modulate dopamine safely and effectively using compounds like Bromantane. 

4:25 – Modafinil, Adamantane, and More 

A comparison of smart drugs and exotic compounds for focus, motivation, and cognition. 

9:11 – Risks and Balancing Neurotransmitters 

The dangers of overstimulating dopamine and the importance of GABA for neurological balance. 

11:11 – Masculinity, DHT, and Hormones 

How DHT and testosterone influence male performance, mood, and confidence. 

14:12 – Natural Aphrodisiacs and Dopamine Stacks 

Lucas shares libido-boosting herbal stacks that double as motivation and performance enhancers. 

17:26 – Ashwagandha, Cortisol, and Stress 

The nuanced effects of ashwagandha and how to manage cortisol for optimal stress resilience. 

21:09 – Supplements for Sleep and Neurochemistry 

Sleep stacks, histamine, and the delicate neurochemical balance for restorative rest. 

39:10 – Oxalates, Collagen, and Mitochondrial Health 

Discussion on oxalate toxicity, collagen bioavailability, and mitochondrial optimization. 

47:39 – Biohacking for Women & Hormone Balance 

Targeted protocols for thyroid, perimenopause, and female neurohormonal support. 

51:26 – Supplements to Avoid 

Personal experiences with ineffective or counterproductive compounds, including ashwagandha and reishi. 

54:45 – Mitochondrial Supplements & Endurance 

PQQ, CoQ10, and ITPP for energy, longevity, and enhanced physical output. 

1:02:43 – Closing & Where to Find Lucas 

Final thoughts and where to follow Lucas Aoun and his work online. 

 

Resources:  

Enjoy the show!

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