In this episode of The Human Upgrade, Host Dave Asprey explores how facing death directly can unlock resilience, forgiveness, and peace while improving longevity, human performance, and brain optimization. Joined by hospice nurse and Doulagivers founder Suzanne O’Brien, RN—who has guided over 1,000 people through the end of life—Dave uncovers what the dying can teach us about gratitude, neuroplasticity, metabolism, and living without regret. You’ll learn how unresolved trauma fuels disease, why forgiveness and gratitude change mitochondrial health, and how smarter not harder biohacks like fasting, ketosis, cold therapy, supplements, and functional medicine can transform fear into freedom and create a life—and death—worth celebrating.
Most people spend their lives trying to outrun death instead of learning from it. This episode shows you why facing mortality directly can unlock resilience, forgiveness, gratitude, and peace while upgrading longevity, human performance, and even brain optimization.
Host Dave Asprey sits down with Suzanne O’Brien, RN—an end-of-life expert, hospice nurse, and founder of Doulagivers who has guided over 1,000 people through their final moments. She shares what the dying can teach the living about biohacking fear, letting go of unresolved trauma, and finding clarity before it’s too late.
Together they explore how hacking your mindset around death transforms not only emotional well-being but also physical health, neuroplasticity, and metabolism. You’ll hear stories of people who discovered forgiveness and gratitude at the end of life, and how those practices directly influence mitochondria, sleep optimization, and longevity. They dive into the link between fear, stress chemistry, and chronic illness—and why tools like fasting, ketosis, cold therapy, supplements, nootropics, and functional medicine create the inner and outer resilience needed to face life fully.
You’ll Learn:
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners,?The Human Upgrade?is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.
Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing.
Keywords: fear of death, hospice nurse, doulagivers, end of life planning, good death, forgiveness practice, gratitude science, near death experience, hospice care stories, emotional trauma release, spiritual awakening, conscious dying, home funeral, palliative care, death doula training, legacy planning, end of life rituals, soul agreements, dying process stages, compassionate care
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00:00 — Trailer
Quick preview of the conversation’s core themes: death, forgiveness, and what makes life meaningful.
01:05 — Introduction
Dave sets the scene, introduces the guest, and frames the importance of end-of-life conversations.
03:13 — End-of-Life Choices
Exploring how defining quality of life and making conscious decisions changes the dying process.
09:50 — Forgiveness & Suffering
How unprocessed emotional pain surfaces at the end of life and the transformative power of forgiveness.
15:46 — Advice to Younger Self
Lessons learned from the dying that reshape how to live fully without regret.
20:00 — What Makes a Good Death
The essential elements of a peaceful passing and why regret is often the greatest fear.
23:00 — Hospice Stories & Mystical Experiences
Firsthand accounts of patients seeing loved ones, transitions, and spiritual visions at death’s edge.
33:05 — The Good Death Defined
Describing what a “good death” looks like and how it brings meaning to both the dying and their families.
41:01 — Meaning & Purpose
How people reflect on their lives at the end, and the importance of knowing you made a difference.
Resources:
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