In this episode of The Human Upgrade, Host Dave Asprey talks with Jon Hacker, a biomedical engineer and the CEO of NeurGear, the company behind ZenBud. Jon explains how focused ultrasound can directly stimulate the auricular branch of the vagus nerve to regulate stress, improve heart rate variability, and shift the nervous system out of sympathetic overdrive. You will learn why electrical vagus nerve devices often fail, how early trauma wires the autonomic system, and how daily ultrasound training strengthens vagal tone through Hebbian learning. Dave and Jon break down real clinical findings, including anxiety remission results, and explore how this technology supports recovery, emotional balance, and long term resilience. They also discuss the future of non invasive brain interfaces, the risks of algorithm driven stress, and why autonomic control is becoming essential in a high tech world.
Most people stay locked in a constant sympathetic state without realizing it, which drains focus, sleep quality, emotional balance, and long-term resilience. This episode gives you a science backed path to retrain your nervous system, improve heart rate variability, and shift out of stress on command using focused ultrasound technology that targets the vagus nerve.
**Go to http://www.zenbud.health/dave and use code ‘Dave15’ for a discount! **
Host Dave Asprey talks with Jon Hacker, CEO of NeurGear and creator of ZenBud. Jon is a biomedical engineer who has dedicated his career to bridging neuroscience and daily wellness. His work includes peer reviewed clinical research on anxiety, PTSD, autonomic regulation, and non invasive vagus nerve stimulation. He is one of the first innovators to bring focused ultrasound out of the lab and into a practical wearable designed to help people regulate state, build resilience, and create more conscious control over their biology.
In this conversation, Dave and Jon break down how ultrasound activates the auricular branch of the vagus nerve, why most electrical vagus nerve devices fail, and what actually happens in the first three to five minutes when the system begins shifting out of sympathetic activation. Jon explains how early trauma wires the autonomic system, why chronic stress is often physiological rather than psychological, and how daily stimulation strengthens vagal tone through Hebbian learning. They also explore how HRV reflects hidden state changes, how nervous system training supports clearer thinking and better emotional regulation, and why this type of tech matters as AI, algorithms, and modern stressors continue to push people into dysregulated states.
You’ll Learn:
This episode is essential for anyone interested in biohacking, stress physiology, nervous system training, emotional regulation, HRV, meditation, trauma recovery, longevity, and building a more adaptable brain and body. It gives you a practical look at how the autonomic system really works and how focused ultrasound may change the future of human performance.
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.
New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.
Keywords: focused ultrasound vagus nerve stimulation, autonomic nervous system regulation, sympathetic dominance recovery, auricular vagus nerve activation, heart rate variability training, anxiety remission ultrasound, PTSD autonomic modulation, Hebbian learning vagal tone, parasympathetic state shift, ultrasound neuromodulation research, trauma induced nervous system wiring, panic attack recovery tools, non invasive brain interface, emotional regulation biohacking, stress physiology retraining, early adverse events autonomic impact, vagus nerve inflammation pathway, TBI secondary injury prevention, ultrasound neural action potentials, HRV resilience protocols
Resources:
• Go to http://www.zenbud.health/dave and use code ‘Dave15’ for a discount! You’ll also receive:
• Dave Asprey’s Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/dave15
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Upgrade Collective: https://www.ourupgradecollective.com
• Upgrade Labs: https://upgradelabs.com
• 40 Years of Zen: https://40yearsofzen.com
0:00 – Trailer
A fast preview of the core ideas in this episode, including how modern stress hijacks the nervous system and how ultrasound-based vagus nerve stimulation can help people regain control.
2:00 – Intro
Host Dave Asprey introduces the problem of sympathetic overload, explains how social media algorithms manipulate the nervous system, and sets up the conversation about vagus nerve stimulation and consciousness.
8:04 – Understanding Stress and the Vagus Nerve
Dave and Jon break down the autonomic nervous system, why most people stay stuck in fight or flight, how stress becomes physiological instead of psychological, and the specific role of the vagus nerve in shifting state.
14:14 – Jon’s Story and Why He Built ZenBud
Jon shares his history with severe OCD, how it shaped his understanding of the nervous system, and why he committed his engineering and neuroscience work to helping people regulate stress.
16:17 – How Vagus Nerve Stimulation Works
Jon explains the history of invasive and non invasive vagus nerve stimulators, why electrical devices fail to target the nerve precisely, and how focused ultrasound can activate the auricular branch with far greater accuracy.
21:07 – Using ZenBud and Clinical Results
They discuss how the device works in real time, the three to five minute onset window, Jon’s experience using ZenBud during panic attacks, and clinical data showing strong anxiety and PTSD outcomes.
24:23 – Why We’re All So Anxious
Jon outlines how constant dopamine stimulation, algorithmic content, early trauma, and lack of physiological training create dysregulated vagal tone, especially in Gen Z and Gen Alpha.
30:54 – Longevity, TBI and Recovery
Dave and Jon dive into how vagus nerve activation influences inflammation, recovery, brain protection, and why ultrasound based stimulation may help prevent secondary damage in traumatic brain injury.
44:01 – The Future of Brain Computer Interfaces
A deep discussion about AI, consciousness, and the risks of invasive BCIs, and why non invasive ultrasound may be a safer path for enhancing cognition without losing autonomy.
50:54 – Closing
Dave summarizes the value of ZenBud, offers final thoughts on nervous system control, and reminds listeners how this technology fits into a practical biohacking and longevity toolkit.
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