EP 1362
1362. The Secret Federal Plan to Feed Us Legal Poison
In this episode of The Human Upgrade, Host Dave Asprey sits down with Dr. Will Cole to reveal how government approved food policies, regulatory loopholes, and corporate influence have normalized ingredients that quietly damage human biology. They break down how biotoxins from food, mold, and viral exposure drive immune dysregulation, mast cell activation, low blood pressure, and mitochondrial shutdown, creating the overlapping patterns seen in long COVID, POTS, dysautonomia, chronic fatigue, and mold illness. Dave and Will explain how histamine overload, cortisol imbalance, genetics, and electrolyte depletion impair brain energy and nervous system stability, then share practical functional medicine strategies involving sodium, electrolytes, creatine, cortisol support, and targeted supplementation. The conversation also covers methylene blue, nicotine as a nootropic, folinic acid, and why removing the underlying trigger matters more than chasing symptoms, offering a clearer framework for recovery, longevity, and human performance with a smarter not harder approach led by Dave Asprey.
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In this Episode of The Human Upgrade™...
You’re about to learn how government approved food policies, regulatory loopholes, and corporate lobbying have quietly reshaped what’s allowed in the food supply and why these decisions are driving chronic inflammation, immune dysfunction, and neurological breakdown at scale. This episode exposes how biotoxins, ultra processed ingredients, and systemic regulatory failures contribute to long COVID, POTS, mold illness, chronic fatigue, and dysautonomia and why so many people feel sick despite following official health guidance.
Host Dave Asprey sits down with Dr. Will Cole, a functional medicine expert who works extensively with autoimmune disease, mold illness, hormonal dysfunction, digestive disorders, and complex brain related symptoms. Dr. Cole brings years of clinical experience analyzing lab data and treating patients with biotoxin exposure, neuro immune dysregulation, and chronic fatigue patterns.
Together, they connect the dots between mold exposure, post viral illness, mast cell activation, low blood pressure, and why many people with long COVID or POTS feel dizzy, inflamed, and cognitively impaired. They explain how histamine overload, electrolyte depletion, cortisol imbalance, and genetics combine to disrupt blood flow to the brain and shut down human performance. The conversation focuses on practical functional medicine and biohacking tools that help rebuild resilience at the mitochondrial and nervous system level.
You’ll Learn:
- Why long COVID, mold illness, POTS, and chronic fatigue often share the same biological drivers
- How biotoxins like mold and viral exposure dysregulate the neuro immune endocrine axis
- Why low blood pressure reduces blood flow to the brain and causes brain fog and fatigue
- What mast cell activation syndrome is and how histamine overload affects the body and brain
- Why electrolytes, especially sodium, potassium, and magnesium, are foundational for recovery
- How creatine supports brain energy, hydration, and mitochondrial function
- The role of cortisol in inflammation, stress tolerance, and nervous system stability
- When antihistamines and mast cell stabilizers can improve quality of life
- How nicotine acts as a low dose neuroprotective compound when used carefully
- The benefits and risks of methylene blue for mitochondrial and cognitive support
- Why removing the trigger matters more than chasing symptoms
- How a functional medicine approach rebuilds resilience instead of masking dysfunction
- Why creatine absorption improves when added to hot coffee
- How Danger Coffee fits into performance, hydration, and brain energy
Keywords: long COVID, POTS syndrome, dysautonomia, mold illness, biotoxin illness, mast cell activation, histamine intolerance, low blood pressure brain fog, chronic fatigue syndrome, mitochondrial dysfunction, cortisol imbalance, electrolytes sodium potassium, creatine brain energy, functional medicine long COVID, nicotine neuroprotection, methylene blue mitochondria, brain fog causes, neuro immune dysfunction, will cole dave asprey, will cole biohacking
Thank you to our sponsors!
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Resources:
- Dr. Will Cole’s Website: https://drwillcole.com/
- Dave Asprey’s Latest News | Go to https://daveasprey.com/tojoin Inside Track today.
- Danger Coffee: https://dangercoffee.com/discount/dave15
- My Daily Supplements: SuppGrade Labs(15% Off)
- Favorite Blue Light Blocking Glasses: TrueDark(15% Off)
- Dave Asprey’s BEYOND Conference: https://beyondconference.com
- Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
- Upgrade Collective: https://www.ourupgradecollective.com
- Upgrade Labs: https://upgradelabs.com
- 40 Years of Zen: https://40yearsofzen.com
“We would all support anybody that was actually progressing human health. To me, this isn’t political. Health is a human issue.”
Will Cole
0:00 – Trailer
A fast paced preview highlighting the core themes around health freedom, chronic illness, and biohacking recovery.
1:25 – Introduction
Dave sets the stage for the conversation and explains why these topics matter right now.
2:20 – Conspiracy and misinformation
A breakdown of how the term misinformation is used to control narratives and shut down debate.
9:07 – Vaccine safety and fertility
A discussion on fertility concerns, pregnancy risk, and why informed consent matters in medicine.
12:48 – Big Food front groups
How major food companies use front groups to influence labeling laws and public perception.
19:38 – POTS, dysautonomia, biotoxins
The shared biological roots linking POTS, dysautonomia, mold exposure, and post viral illness.
20:51 – HLA genetics and immunity
Why certain genetic haplotypes struggle to clear biotoxins and regulate inflammation.
25:11 – Mast cells and histamine
How mast cell activation and histamine overload drive brain fog, fatigue, and pain.
28:41 – Electrolytes and sodium
Why sodium, potassium, and magnesium are critical for blood pressure and brain function.
33:37 – Cortisol and inflammation
The misunderstood role of cortisol in immune regulation, stress tolerance, and resilience.
35:01 – HPA axis burnout
How chronic stress and illness dysregulate the HPA axis and drain energy reserves.
39:22 – Bioidentical cortisol support
When bioidentical cortisol and licorice root can restore function in depleted systems.
40:27 – Methylene blue and mitochondria
How methylene blue affects mitochondrial energy and why dosing and context matter.
46:51 – Methylation and MTHFR
Why methylation problems are common in chronic illness and how genetics influence recovery.
49:57 – Folinic acid and homocysteine
How folinic acid supports methylation and lowers inflammatory homocysteine levels.
52:52 – Creatine in coffee hack
A simple creatine absorption trick that boosts brain energy and performance.
Enjoy the show!
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