EP 1145

1145. How Dogs Are Going to Make You Live Longer: Rapamycin & Longevity

Dr. Matt Kaeberlein, CEO of Optispan and aging expert, discusses aging measurement accuracy, diet’s role in human/canine longevity, rapamycin’s potential for reducing age-related inflammation, and how AI is reshaping our understanding of longevity.

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In this Episode of The Human Upgrade™...

How can we make our furry best friends live longer, healthier lives?

A true pioneer in this field, Dr. Matt Kaeberlein, is here to unpack this important subject while highlighting the crossover between human and canine longevity. You read that right; this episode isn’t just for dog lovers—it’s a deep dive into longevity for humans, too.

Dr. Matt Kaeberlein, who’s the CEO of Optispan and a key figure in the Dog Aging Project, brings a wealth of knowledge from his distinguished career in aging and healthspan research. He’s an Affiliate Professor at the University of Washington and a notable figure in gerontology, recognized by organizations like the American Association for the Advancement of Science and the Gerontological Society of America.

Matt’s work is groundbreaking, demonstrated in over 250 scientific papers on aging, numerous prestigious awards, and he’s even a Fellow of several aging associations. He’s on a mission to unlock the secrets of aging, not just in humans, but in our four-legged companions as well.
We explore the accuracy of measuring age with telomeres versus epigenetics and get into the nitty-gritty of diet’s impact on longevity for both dogs and humans, reminding us it’s not just about living longer, but living well.

Matt explains the impressive trial results on rapamycin for reducing age-related inflammation, a breakthrough that’s not just exciting for us but also for our pets. Finally, we touch on how AI is revolutionizing our approach to understanding and extending our healthspan.

For those who want to get more involved, check out dogagingproject.org. It’s not every day you meet someone who’s made such significant strides in understanding aging across species. So whether you’re a pet parent or just passionate about extending your own health span, this episode is for you.


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“There's a lot of probability in life. But you can change the probabilities in your favor by taking steps to reduce your likelihood of dying.”



Dogs Are the Bridge Between Lab Studies & Human Longevity

  • Matt’s panel at SXSW: could dogs be the key to unraveling human longevity?
  • Discussing aging clocks in the consumer space 
  • Measuring age through telomeres vs. epigenetics
  • Studying aspects of aging biology shared across broad evolutionary distance 


Exploring the Impact of Diet on Longevity

  • Parallels between what humans eat and the diet given to pets 
  • How food impacts longevity vs. healthspan 
  • What’s worse: not exercising or eating a fast food diet?
  • Multiple types of high quality diets and what’s optimal for most people
  • The most important food groups to avoid in your diet 


How Our Unique Biology Impacts Aging

  • How our own autoimmune response drives the biology of aging 
  • Prime age to begin longevity interventions to be effective
  • How advances in AI can contribute to disentangling the complexities of longevity
  • The results of Dave’s gene therapy
  • How Optispan is aiming to make longevity more accessible 


Exploring How Size & Diet Impact Health Across Species

  • Parallels between size and longevity between species 
  • What drives chronic pain and inflammatory diseases in dogs?
  • The Dog Aging Project: dogagingproject.org
  • Why dogs eat poop 
  • Why people who own dogs live longer 
  • Should you feed your pets vegan or human food? 
  • Addressing the intentional engineering of the food industry that drives obesity


Fighting Age-Related Inflammation with Rapamycin


AI Interventions for Longevity Testing


Dave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books 

Learn More: http://dogagingproject.org

Website: https://www.optispan.life/

X: https://twitter.com/mkaeberlein

The Optispan Podcast with Matt Kaeberlein: https://podcasts.apple.com/us/podcast/the-optispan-podcast-with-matt-kaeberlein/id1728587274

Enjoy the show!


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