Mushroom Upgrade: Big Benefits for Human Biomes and Natural Ecosystems

Paul Stamets & Julian Mitchell

Learn how mushrooms can feed you, kill you, heal you, or send you on a spiritual journey.

Paul Staments, above left. Julian Mitchell, above right.

In this Episode of The Human Upgrade™...

… you’ll learn how your cells, mitochondria, immune system, sleep patterns, inflammation, nerve growth pattern, and energy levels all benefit from mushrooms. These fungi are full of compounds and nutrients that your body will love. There’s a whole lot of science behind this now.

In this special podcast edition, you’ll hear how two mushroom experts are studying and harnessing the amazing powers of mushrooms for the deepest parts of human biology and the natural environment.

Paul Stamets is a speaker, author, mycologist, medical researcher and entrepreneur. He’s considered an intellectual and industry leader in habitat, medicinal use and production of fungi, and he considers himself a “mycological warrior.”

He’s spent over four decades in the Pacific Northwest studying and researching the world of mushrooms. Listening to him describe, decode and illuminate the workings of the mushroom world is an enthralling experience, indeed.

He says we’re intertwined with mushrooms at a cellular level. He believes that habitats have immune systems—just like people—and mushrooms are cellular bridges between the two. Our close evolutionary relationship to fungi can be the basis for novel pairings in the microbiome that lead to greater sustainability and immune enhancement. And from neurogenesis to our microbiome to our mitochondria, fungi are linked to us.

He’s also making some amazing discoveries having to do with bears, bees, butterflies and biodefense.

Julian Mitchell —co-founder and CEO of the Australian-based company Life Cykel—and his team work with mushrooms as innovative food sources and medicinals in Australia. “Mushrooms and mushroom-based foods are going to play a huge role in the future of food,” Julian explains. “They grow quickly requiring very little resources in terms of water, power, and land. They have an amazing nutritional profile, and of course, they are 100% natural.”

“Mushrooms are almost an uncharted continent, with infinite applications not just in food but in biotechnology.”

For day-to-day use, you’ll want to go with cooked, not raw, mushrooms. For those of you who aren’t fans of eating mushrooms, there’s an option for you, too: “Having it as a tincture makes it very easy to add to a coffee, add to a tea, add to a smoothie,” Julian says. “It’s quite tasteless and at the same time micro-dosing it in small amounts straight into your mouth is a great way to have it as well and absorb it straight into your blood system.”

“I authenticated that the diluted extracts of mycelium, the water and ethanol, had extremely potent antiviral activities far exceeding that of pharmaceuticals.”

Paul Stamets, Mycological warrior

If you liked this special episode with Paul and Julian, you’ll learn even more from listening to their full podcasts, directly below.

Mycelium Just Might Save the Bees, And Us – Paul Stamets – #624

  •  “You and I are actually mycelial beings, and we are descendant of fungi,” Paul Stamets says. “Fungi are our ancestors.” Visit

Mushrooms Are Your New Anti-Aging Strategy – Life Cykel #603

  • “The more we look to the natural world for solutions, the better off we’re going to be and so, mushrooms and the fungi kingdom are hugely important to our evolution,” Julian Mitchell says. Visit

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  • Transitioned from sports in the UK to mushrooms, how the heck does that happen?  – 1:34
  • Over 500 million years ago, fungi were the first organisms to come to land.  – 2:15
  • I see that science and spirituality are now merging into a greater state of awareness.  – 4:18
  • Mushrooms and mushroom-based foods are going to play a huge role in the future of food.  – 6:06
  • Really, we’re still Neanderthals with nuclear weapons. We really have not waken up to the enormity of our presence and the miracle of our existence. – 9:27
  • At Life Cykel, our process for deciding what mushrooms we grow and put into our product starts firstly with a detailed scientific literature review, toxicology evaluations and laboratory tests. – 10:23
  • Is there such a thing as too much psilocybin?  – 13:20
  • The key nutrients for functional mushrooms, such as your lion’s mane, your reishi, cordyceps, turkey tail are the amino acids, the beta-glucans, the dried terpenoids and the antioxidants.  – 15:06
  • 5% of the population, they don’t like mushrooms. It makes them feel queasy. They don’t like them. I realize now that’s actually a scientific observation. It may be their microbiome is incompatible with the mushrooms that’s a prebiotic. – 17:52
  • What does the research show about what happens when people eat oyster mushrooms?  – 19:00
  • If you’re listening to this, you go, “Oh, tincture, that sounds hard.” No, you make a tincture every morning. It’s called coffee.  – 22:15
  • A natural product offers a stronger effects than a pure pharmaceutical, in this case, compared to ribavirin and cidofovir. These are two well-known antiviral drugs.  – 23:26
  • Once a beehive has 7% mite infestation, that is terminal. That beehives won’t survive. Now, we tested about 10 species. Five of these polypores have demonstratively positive effects in reducing these viruses. There seems to be species specificity factors. Very interesting. Certain species of these polypore mushrooms are more active against certain species of virus.  – 25:19
  • These play a major role in an adaptive immune system by secreting antibodies. Secondary to this, it also secretes metabolites, which have potent antioxidant properties, such as polysaccharide and triterpenoids.  – 27:30

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