In this episode of The Human Upgrade, Host Dave Asprey dives into what may be the most advanced longevity technology of our time: mitochondrial transfusion. Joined by tech entrepreneur and Mitrix founder Tom Benson, Dave explores how restoring your own youthful mitochondria could radically extend healthspan, reverse biological aging, and transform human performance. They unpack the science behind mitochondrial bioreactors, stem cell-derived energy repair, and why mitochondria may function as AI-like processors that regulate everything from metabolism to brain optimization. You’ll learn how mitochondrial hacking could unlock new frontiers in functional medicine, neuroplasticity, and disease prevention—and why this cellular upgrade may soon rival stem cells, nootropics, and NAD+ as the future of biohacking.
This may be the most cutting-edge life extension technology you’ll hear about for decades. You’ll discover how mitochondrial transfusion, rejuvenation, and repair could reverse biological aging, supercharge your metabolism, and radically extend healthspan—all by upgrading the cellular energy systems that power every function in your body.
Host Dave Asprey sits down with inventor and tech entrepreneur Tom Benson, founder of Mitrix. After launching three successful Silicon Valley companies, Benson shifted focus to one of the most promising frontiers in science: mitochondrial bioreactors designed to regrow your own autologous mitochondria. This isn’t theory—it’s a near-future anti-aging technology poised to transform functional medicine, personalized medicine, and the global conversation around aging reversal.
They explore how mitochondrial DNA mismatches affect aging, why mitochondria act like cellular AI cores, and how dysfunction in these ancient organelles contributes to neurodegenerative disease, metabolic decline, and cognitive disorders. You’ll learn how restoring mitochondria could enhance everything from stem cell therapy and nootropics to ketosis, fasting, cold therapy, and even sleep optimization.
You’ll Learn:
This episode is essential listening for anyone passionate about biohacking longevity, functional aging, mitochondrial testing, and next-gen human optimization.
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.
Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing.
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A powerful opening teaser highlighting the promise of mitochondria for human performance and longevity.
Dave sets the stage for a deep dive into mitochondrial science and why it matters more than ever.
Exploring how mitochondrial DNA directly affects energy, resilience, and cellular optimization.
A look at the scientific roadblocks and unknowns surrounding mitochondrial enhancement.
How cutting-edge research could unlock treatments for aging, disease, and performance enhancement.
Linking mitochondrial function to lifespan extension and age-related decline.
Ancient approaches and Eastern perspectives on supporting mitochondrial health.
Why mitochondria are a central concern in space travel and human survival beyond Earth.
Reflections on how mitochondrial weakness reveals the limits of human biology.
A deeper look into how mitochondrial dysfunction drives visible and invisible aging.
Emerging studies and unconventional trials pushing the boundaries of mitochondrial science.
What happens when we start editing energy systems at the core of human life?
Connecting mitochondrial function to depression, anxiety, and brain energy.
Promising therapies and tools already showing results in mitochondrial restoration.
Dave shares his own daily practices and protocols to support mitochondrial power.
Final thoughts and resources for diving deeper into the mitochondrial upgrade.
Resources:
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