Groundbreaking Research Shows Strong Mitochondria Protect Your DNA

Are Statin Side Effects Worth the Risk_Statins interfere with your mitochondria


  • New research shows that damaged mitochondria, the parts of your cells that produce energy, steal parts from healthy DNA to fix itself.
  • This study confirms what I’ve been saying for years: strong mitochondria are the foundation for aging the way everyone wants to age.
  • You can use this research to possibly take advantage of a few known pathways that support mitochondria and give your DNA what it needs.
  • Read on to find out what I do to support my mitochondria and protect my DNA.


A new study shows that damaged mitochondria, the parts of your cells that make energy, steal parts from healthy DNA to fix itself. Researchers observed imperfect mitochondria snatching away nucleotides, which are the building blocks of DNA, from healthy cells.[ref url=”″]

This is groundbreaking research that confirms what I’ve been saying for years. Strong mitochondria are the foundation for aging the way everyone wants to age. It’s one of the Seven Pillars of Aging — the cellular-level changes that drive all forms of aging, head to toe. You can dive deep into the Seven Pillars in my new book, Super Human.

If you want your brain to work the way it does now (or better), if you want to fight the diseases that typically come with old age, if you want to be able to move around and live your best life for your entire lifespan … there’s no way around it — your mitochondria have work well.

The link between mitochondria and cell function

The Bulletproof Exercise Roadmap_hiking_what counts as exerciseWhen your mitochondria are strong, your cells are able to do what they need to do. During the times when your cells are performing their specific function, they will do it to their fullest because your mitochondria make plenty of energy to do it.

When it’s time for repair and healing, strong mitochondria give your cells the energy to carry out complex maintenance. Having enough energy for autophagy, the time when your cells essentially take out the trash, and for all of the healing and repair work they do — that’s what keeps you young and makes you perform well.

What happens when mitochondria get damaged and weak

Everyone over age 40 and 48% of people under age 40 have some level of impaired mitochondria. When your mitochondria don’t work well, autophagy isn’t as efficient. So, used up cell parts that don’t belong will stay put, and get in the way of healthy cell function. Repair doesn’t happen as efficiently.

What’s worse, it’s a self-perpetuating problem. Sluggish and damaged mitochondria lead to cells that can’t repair themselves, and your body prioritizes mitochondria so highly that it scraps healthy DNA for parts to repair them. Then, there’s more to repair, which requires mitochondrial energy … rinse and repeat.

Mitochondrial dysfunction leads to dismantling parts of nuclear DNA, which leads to cancer — one of the four killers that I talk about in Super Human (cancer, diabetes, Altzheimer’s, and cardiovascular disease). This research came out after Super Human was published, but it provides yet another link from one of the seven pillars to one of the four killers.

Now more than ever in the history of biohacking, we know that strong mitochondria protect nuclear DNA. This new study confirms it.

Ever since my twenties, when I made the decision to take control of my biology, I’ve focused on my mitochondria. At first, I wanted to feel better in the moment. I found that when I stopped doing the things my mitochondria don’t like, then added practices and supplements that support mitochondria, I felt incredible.

Once I started feeling human again, I shifted to focusing on my mitochondria for the long-term benefits.

What I do to support mitochondria protect DNA

You can use this research to possibly take advantage of a few known pathways that support mitochondria and give your DNA what it needs. Here’s what I do.

  • Supplement ribose. Nucleotides are made of nitrogen, phosphorous, and ribose. You’ll get nitrogen and phosphorous through food, but ribose is a little harder to come by. I mix two scoops of MitoSweet into my coffee once or twice a day, which is a sweetener made with ribose. Ribose is a special kind of carbohydrate that lowers blood sugar, presumably because it increases mitochondrial function.
  • Take oxaloacetate. Oxaloacetate supports mitochondrial function by acting on glutamate,[ref url=”″] which is a brain chemical that can make you feel tweaky or foggy. Bulletproof KetoPrime contains oxaloacetate plus other ingredients that your mitochondria love.
  • Use Brain Octane Oil. Brain Octane Oil converts to ketones within minutes, which go straight to your mitochondria for energy production.
  • Keep your inflammation down. Start by following a ketogenic diet and eating polyphenol-rich foods. You can listen to this episode of Bulletproof Radio to learn more about what foods are making you weak.
  • Do resistance training. Incorporating weight-bearing exercise one or two days a week increases your mitochondria, and more mitochondria mean that each individual mitochondrion is less likely to get burnt out.

Your mitochondria determine how you feel and age, but ultimately you’re in the driver’s seat. If you know what slows them down and speeds them up, you’ll stay in control of them.





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Smarter Not Harder: The Biohacker’s Guide to Getting the Body and Mind You Want is about helping you to become the best version of yourself by embracing laziness while increasing your energy and optimizing your biology.

If you want to lose weight, increase your energy, or sharpen your mind, there are shelves of books offering myriad styles of advice. If you want to build up your strength and cardio fitness, there are plenty of gyms and trainers ready to offer you their guidance. What all of these resources have in common is they offer you a bad deal: a lot of effort for a little payoff. Dave Asprey has found a better way.

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