1338. Why Women’s Joints Are Failing 10x Faster

Salt Re-Examined: Why Your Cells Actually Need It for Hydration, Energy & Performance

We’ve heard for decades: “Cut the salt.” But what if the real story isn’t simply “less salt,” but which salt, how much, and when? I dig into the true role of salt—how your body uses sodium and chloride, why athletes and biohackers often need more than the average person, and how choosing the right type of salt can improve hydration, focus, and performance.


What Salt Actually Does

Salt (primarily sodium chloride) does far more than season food. It plays a pivotal role in fluid balance, nerve signaling, muscle contraction, and maintaining the electrical voltage across your cells.
When you allow sodium levels to drop—either through excessive sweating, low-carb diets, frequent sauna sessions, or over-hydration—you reduce your cells’ voltage and impair performance.
In one study, exercise in heat coupled with low sodium intake led to significantly increased risk of low blood-sodium states. (PMC)
In another large analysis, small changes in dietary salt intake altered plasma sodium and extracellular fluid volume, which affects cellular function. (American Heart Association Journals)

This means: drinking water helps—but if you’re not supporting sodium and chloride, your hydration may stay superficial. Your body might be hydrated externally, but your cells remain under-charged.


Why “Low Salt” Settings Can Hurt Performance

If you train intensely, fast, expose yourself to heat or sauna, or follow a low?carbohydrate diet, you’re likely flushing a lot of sodium. Without replacing it:

  • Blood volume may decline ? less oxygen and nutrient delivery.
  • Nervous system signaling slows ? muscle performance drops.
  • You may crave salt or feel sluggish and light-headed.

For example, a hydration study found that fluids with added sodium improved hydration and plasma volume recovery better than plain water after heavy exercise. (Cadence™)
Also, a recent intervention found replacing part of salt with a potassium salt had direct effects on cardiovascular outcomes—showing that the type and balance of salt matter too. (American Heart Association Journals)

So if you’re living a performance or fasting lifestyle, seeing your salt intake as a variable—not just a fixed background number—is smart.


Real Salt vs. Table Salt

Not all salts deliver equal benefit. Here’s what to look for:

  • Refined table salt often contains mostly sodium chloride, with anti-caking agents, and lacks trace minerals. Over-reliance on it might disturb the electrolyte balance.
  • Unrefined or mineral-rich salts, like those harvested from ancient seas or deserts, provide sodium with supporting trace minerals (magnesium, potassium, etc.) that assist cellular hydration and signaling.
  • That’s why I prefer the Oryx Desert Salt—as part of my stack I use when performance, travel or recovery demand premium support.
    Try Oryx Desert Salt here (affiliate link).

When you upgrade which salt you use—not just the amount—you upgrade the downstream effect on your hydration, energy and cellular voltage.


How to Use Salt Smartly

Here’s how I integrate salt into my routine (active lifestyle, travel, training) and how you can too:

  • On training or sauna days: Add ½ to 1 teaspoon of high-quality salt (like Oryx) into your water or beverage after heavy sweat.
  • During fasting or low?carb days: When insulin falls, kidneys excrete more sodium—so proactively add salt to prevent drop in energy and focus.
  • With travel and time-zone shifts: Salt helps maintain fluid volume, prevent dehydration and support focus when your rhythm is off.
  • Avoid over-doing it: If you have hypertension, kidney disease or are on sodium?restricted diets, you must consult your physician.

Myths & Reality

Myth: “All salt is bad for you.”
Reality: For many healthy, active adults, the right salt in the right context supports hydration and performance—not just cardiovascular risk.

Myth: “You don’t need salt if you drink enough water.”
Reality: Water without sodium can fail to properly hydrate at the cellular level. When plasma sodium drops, your cells lose voltage even though you’re “hydrated.”

Myth: “Salt automatically raises blood pressure.”
Reality: The relationship is more complex—diet quality, activity level, genetics and mineral balance all matter. Some trials show modest sodium changes impact blood pressure; others show context is key. (Harvard Health)


Watch: Salt & Your Family

In this YouTube episode, I walk through:

  • Why salt matters for cellular voltage and hydration
  • The difference between types of salt
  • My actual protocol: how much, when, and how I use it

Watch now: Should You Give Babies Salt?


Bottom Line

Salt isn’t the villain—it’s how and which salt you use that determines the outcome.
Use high-quality salt, pay attention to your context (training, fasting, sweating, travel), and you’ll unlock hydration, performance, and cellular health you didn’t even know was missing.
It’s time to look at salt not just as seasoning—but as foundational to your biology and performance.

 

Nicotine: Smart-Drug Potential for Focus, Brain, and Longevity

Most people hear “nicotine” and think “cigarettes.” But nicotine itself isn’t the villain—it’s the delivery system that causes harm. In my most recent episode of The Human Upgrade, I explain why low-dose nicotine, used occasionally and correctly, can enhance focus, improve brain function, and possibly support longevity.

Let’s separate science from smoke.


What Nicotine Actually Does

Nicotine activates nicotinic acetylcholine receptors (nAChRs)—the same pathways that regulate alertness, learning, and attention. When stimulated in moderation, these receptors can improve cognitive performance.

Studies show that nicotine:

  • Increases attention and working memory in healthy adults (PMID: 29110618)
  • Improves synaptic signaling and neurotransmitter efficiency (PMC6018192)
  • Enhances motor control and reaction time during cognitive tasks

When used intentionally, nicotine acts as a short-term nootropic—a tool that can fine-tune your brain’s performance rather than overstimulate it.


Nicotine and the Brain

Your brain consumes roughly 20 percent of your body’s energy even when you’re at rest. When fatigue, aging, or stress hit, your neurons demand more efficient signaling to stay sharp.

Low-dose nicotine supports neuronal efficiency and neuroplasticity in controlled studies. One 2023 review found nicotine helps attenuate age-related cognitive decline and may boost neurotrophic factors that protect neurons (Frontiers in Neuroscience, 2023).

Another study of adults aged 60–75 found that nicotine enhanced performance in those with lower baseline scores, suggesting it restores cognitive efficiency rather than artificially overstimulating high performers (Frontiers in Aging Neuroscience, 2021).

The takeaway: nicotine doesn’t “boost” everyone equally—it helps fill energy gaps where your brain needs it most.


Nicotine and Longevity

Longevity is about preserving function and maintaining resilience. Emerging data suggests nicotine can influence mitochondrial signaling and neuronal protection when used carefully.

A 2023 Frontiers in Neuroscience paper identified nicotine as a potential modulator of mitochondrial function and neuroinflammation (Frontiers in Neuroscience, 2023).

However, a systematic review from 2020 found inconsistent results and warned that nicotine’s benefits depend on dose, frequency, and user baseline—and that industry-funded studies sometimes overstate results (PMC7271274).

In short: nicotine can play a protective role in theory, but overuse flips that switch. Biohackers should view it as a precision molecule, not a habit.


How I Use Nicotine (and When I Don’t)

This is my personal protocol—not a recommendation for everyone.

When I use it:

  • During long writing or recording sessions that demand deep focus
  • When crossing time zones and needing alertness without caffeine crashes
  • Occasionally, to extend fasting focus

How I dose it:

  • Start at 1–2 mg, delivered as a clean lozenge (not smoking or vaping)
  • Use for 30–60 minutes max, no more than a few times a week
  • Always stay hydrated and avoid stacking with other stimulants

When I skip it:

  • On high cardiovascular load days (training, sauna, etc.)
  • If I feel jittery or notice any craving
  • If I’m using other stimulants or under high stress

The biohacker’s rule applies: use it as a tool, not a crutch.


Myths and Reality Checks

Myth 1: “Nicotine kills brain cells.”
Fact: Smoking does. Pure nicotine, in moderate doses, can enhance cognitive performance and neural signaling (Scientific American, 2017).

Myth 2: “Nicotine is automatically addictive.”
Fact: Addiction risk increases with fast delivery systems like smoking or vaping. Slow, low-dose forms such as lozenges or gum carry lower potential for dependency when used occasionally.

Myth 3: “It’s the same as cigarettes.”
Fact: Nicotine ? tobacco smoke. Cigarettes deliver over 7,000 chemicals. Pure nicotine, used in isolation, has a dramatically different safety profile.

Myth 4: “It gives a caffeine-like jolt.”
Fact: Nicotine provides a focused clarity, not a stimulant surge. Think “tightening the signal,” not “hitting the gas pedal.”


Watch: Nicotine, the Misunderstood Smart Drug

In this YouTube episode, I explain how nicotine works in the brain, why dose and delivery determine safety, and how I use it strategically for cognitive performance and longevity—not addiction.

Watch the full episode: Nicotine: Smart-Drug Potential for Focus, Brain, and Longevity


Bottom Line

Nicotine, stripped of smoke and used in microdoses, has legitimate nootropic and neuroprotective potential. It improves attention, supports brain metabolism, and may even slow certain aspects of cognitive aging.

But like any powerful compound, context and restraint matter. Used occasionally and intentionally, it’s a tool for focus. Used daily or carelessly, it’s a liability.

The difference between biohacking and self-sabotage is precision.

Watch My Nicotine Masterclass Part 1:


References

  1. Mansvelder HD. Cognitive Effects of Nicotine: Recent Progress. 2018. PMC6018192
  2. Posner MI. Nicotine and Brain Activation During Working Memory Tasks. PNAS, 2006.
  3. Echeverria V et al. Nicotine and Its Derivatives in Disorders of Cognition. Frontiers in Neuroscience, 2023.
  4. Pasetes SV et al. Cognitive Performance Effects of Nicotine and Industry Affiliation: A Systematic Review.Substance Abuse, 2020.
  5. Min et al. Nicotine and Cognition in Cognitively Normal Older Adults. Frontiers in Aging Neuroscience, 2021.
  6. Scientific American. “Will a Nicotine Patch Make You Smarter?” 2017.

 

Creatine: The Science-Backed Supplement for Energy, Brain Power & Longevity

Creatine isn’t just for athletes—it’s for anyone who wants better energy, sharper focus, and longer-lasting mitochondria.


What Creatine Actually Does

Creatine acts as your cellular power reserve.
It stores high-energy phosphate groups as phosphocreatine, which your cells use to rapidly regenerate ATP—your main energy molecule.

A 2021 review found that creatine supplementation increases intramuscular phosphocreatine and accelerates ATP resynthesis, improving both muscular and cognitive output [PMID 33912199].
Another study described the creatine phosphate shuttle as a key regulator of energy transfer inside cells [PMID 33527080].

When you have more phosphocreatine, you don’t just move faster—your cells think faster.

(Related: Mitochondria 101: How to Supercharge Your Cells for Energy and Longevity)


How Creatine Boosts Brain Function

Your brain consumes about 20 % of your total ATP—even when you’re doing nothing. When ATP drops, focus, memory, and mood drop too.

MRI studies show creatine supplementation raises brain creatine levels and improves working memory and reaction time, especially under sleep deprivation [PMID 12836166; PMID 36641239].
A 2023 Nutrition Reviews meta-analysis confirmed creatine enhances memory and attention in older adults [PMID 36990355].

Translation: creatine keeps your neurons charged when life drains your batteries.

(Also read: Top 10 Supplements That Everyone Should Be Taking)


Creatine and Longevity

Mitochondrial decline is one of aging’s earliest warning signs. As ATP production falls, recovery and repair slow.
Creatine buffers that drop by stabilizing cellular voltage and reducing oxidative stress.

A 2022 Journal of Cachexia, Sarcopenia & Muscle paper showed creatine supplementation in older adults preserved muscle, strength, and cognition [PMID 35862069].
Other research demonstrates creatine enhances mitochondrial membrane potential and shields cells from metabolic stress [PMID 8838971].

You don’t just take creatine to lift heavier—you take it to age better.

(Explore: How I Reversed My Age With These 10 Simple Supplements)


Proven Benefits

  • Increases ATP regeneration and cellular voltage
  • Boosts focus, working memory, and mental stamina
  • Enhances strength, recovery, and performance
  • Supports mitochondrial health and longevity
  • Safe for long-term use in healthy adults

The Journal of the International Society of Sports Nutrition calls creatine “one of the most effective, evidence-based ergogenic aids available” [PMID 28615996].


How to Take Creatine for Maximum Results

Forget “loading phases.”
Take 3–5 grams per day of creatine monohydrate—consistently.

Timing Tips:

  • Morning: with coffee or your first meal to support daytime mitochondria.

  • Pre-workout: to enhance energy and recovery.

  • During fasting: doesn’t break fast or raise insulin.

For better uptake, pair creatine with electrolytes.
I use LMNT—a clean sodium-potassium-magnesium mix that supports osmotic balance.

Try LMNT here (affiliate link; free sample pack with purchase).


Myths You Should Ignore

“Creatine damages kidneys.” Studies show no kidney harm in healthy adults at standard doses [PMID 28615996].
“It causes bloating.” That’s just intracellular hydration—it means it’s working.
“It’s only for gym rats.” Wrong. Creatine benefits your brain, heart, and mitochondria.


Watch: The Real Science of Creatine – Energy, Focus & Longevity

In this video, I explain:

  • How creatine charges your mitochondria

  • Why it enhances brain performance

  • The best form, timing, and stack for longevity

Watch now: Why I Add Creatine To My Coffee Every Morning


Bottom Line

Creatine is one of the simplest, safest, and most powerful tools in your biohacking arsenal.
It powers your muscles, sharpens your brain, and strengthens your mitochondria—all for less than the price of a coffee.

Take 3–5 g daily, hydrate well, and watch your energy, focus, and recovery transform.

The Hidden Link Between Electrolytes, Energy, and Mitochondria

You can drink all the water you want – but if you’re low on electrolytes, you’re still dehydrated. Not “thirsty dehydrated.” Cellularly dehydrated.

That’s the kind of dehydration that tanks your energy, focus, and performance – even when you think you’re doing everything right.
Let’s fix that.


What Electrolytes Really Do

Electrolytes – sodium, potassium, magnesium, and calcium – aren’t just minerals. They’re the electrical wiring of your biology.
They power the charge across your cell membranes, control muscle contraction, keep your heart rhythm steady, and help your mitochondria make energy.

In other words: without electrolytes, your cells can’t fire properly. You’re a biohacker running on airplane mode.


The Mitochondrial Connection

Mitochondria – the tiny power plants inside your cells – depend on voltage gradients to generate ATP (cellular energy).
Electrolytes maintain that gradient. When levels drop, your mitochondrial function and energy output drop with them.

A 2023 review in Free Radical Biology and Medicine found that mineral cofactors are essential for mitochondrial function and redox balance, noting that electrolyte deficiencies directly impair energy production and oxidative resilience?PMID: 35131590?.

Another study published in Frontiers in Physiology (2024) confirmed that imbalances in sodium, potassium, and magnesium alter mitochondrial membrane potential and lead to increased oxidative stress?PMID: 38261509?.

The takeaway?
When you skimp on electrolytes, your mitochondria literally lose their charge.


Why Hydration Without Electrolytes Doesn’t Work

Water follows electrolytes – not the other way around. Without minerals to guide it, water passes through your body instead of entering your cells.
That’s why you can chug a liter of water and still feel tired or dizzy 30 minutes later.

A study in The Journal of Applied Physiology found that plasma sodium concentration is the single best predictor of hydration status after exercise – not water volume?PMID: 28402954?.

Translation: You need minerals for hydration that matters.


How Keto, Fasting, and Saunas Deplete Electrolytes

If you’re fasting, eating low-carb, sweating in the sauna, or using Bulletproof Coffee to extend your intermittent fast, you’re losing electrolytes faster than average.

Low insulin levels make your kidneys excrete sodium and water – taking magnesium and potassium with them.
That’s one reason why “keto flu” or “fasting fatigue” hits so hard: your electrolyte stores drop, your voltage drops, and your brain feels like it’s running through mud.

A 2022 clinical review in Nutrients showed that electrolyte depletion during low-carb or fasting states impairs neuromuscular efficiency and increases perceived fatigue?PMID: 35956347?.


Signs You’re Low on Electrolytes

You don’t need a lab test to know when your electrolytes are low. Your body tells you:

  • Brain fog or mid-day energy crashes
  • Salt cravings or dizziness
  • Muscle cramps or twitching
  • Headaches that improve after salt
  • Fatigue even after sleeping well
  • Dry mouth or thirst that won’t quit

If that sounds familiar, your problem isn’t hydration – it’s charge.


Why “Just Salt” Isn’t Enough

Regular table salt gives you sodium (and chloride), but no magnesium or potassium.
Those other electrolytes keep sodium balanced and prevent fluid retention or cramping.

The goal isn’t “more salt.” It’s the right ratios:

  • Sodium: 1000–2000 mg
  • Potassium: 200–400 mg
  • Magnesium: 60–100 mg

That’s what your mitochondria need for voltage stability, nerve signaling, and hydration efficiency.


What I Personally Use

I use LMNTa clean, science-backed electrolyte mix with zero sugar, no artificial junk, and optimal mineral ratios.
I use it during fasting, travel, and sauna sessions to keep my voltage high and prevent energy crashes.

Try LMNT here  – use my affiliate link to get a free sample pack with any purchase.

(Affiliate disclosure: I may receive a commission if you use this link, at no additional cost to you.)


Watch: “The Real Reason You Feel Dehydrated”

In this episode on my YouTube channel, I break down how electrolytes regulate mitochondrial voltage, what happens when you’re chronically low, and why smart hydration is one of the easiest performance upgrades you can make.

Watch now: You Need More Electrolytes On a Keto Diet


The Bottom Line

You don’t need more water. You need better water—water charged with the minerals that make life electric.

Optimize your electrolytes. Power up your mitochondria.
And watch your energy, focus, and recovery shift from “meh” to upgraded.

Start hacking your way to better than standard performance and results.

Receive weekly biohacking tips and tech by becoming a Dave Asprey insider.

By sharing your email, you agree to our Terms of Service and Privacy Policy