Spirulina, Chlorella & the Truth About Superfoods: The Mitochondrial Advantage

Spirulina, Chlorella & the Truth About Superfoods: The Mitochondrial Advantage

Superfoods are one of the most overhyped (and annoying) categories in nutrition. Why? Because every year some “new miracle berry” shows up from the Amazon that supposedly cures everything. Then you find out it’s loaded with plant toxins like oxalates or lectins, and the hype train moves on to the next thing.

Spinach, kale, quinoa, almonds—yeah, those have some nutrients. But they also come with compounds that mess with your gut, your minerals, and your mitochondria.

Coffee, on the other hand, is a superfood. It has mountains of evidence behind it, and I’ve built an entire company around making coffee even better (hi, Danger Coffee).

But there’s another category of true superfoods I’ve been talking about since the beginning of the biohacking movement: algae. Specifically, spirulina and chlorella.

The Most Nutrient-Dense Food on Earth

The United Nations has endorsed algae as a solution to world hunger because it’s the highest-protein food on the planet. NASA has called spirulina one of the most nutrient-dense foods available, with an extraordinary concentration of protein, vitamins, and minerals .

Spirulina and chlorella aren’t just trendy powders. They’re multi-billion-dollar agricultural crops in Asia, used safely for over 60 years. And unlike most “superfoods,” they don’t come with a long list of side effects. They simply work.

Why Algae Works: It’s All About Mitochondria

Your mitochondria are the engines of your cells. They determine how much energy you have, how fast you age, and whether chronic disease takes root. Protecting mitochondria = protecting longevity.

Algae provides unique compounds that directly impact mitochondrial health:

  • Superoxide Dismutase (SOD): A powerful antioxidant enzyme that neutralizes superoxide, the most damaging free radical mitochondria produce. Your body makes SOD until about age 30—then production falls off a cliff. Spirulina polysaccharide complex has been shown in vitro to upregulate SOD2, restore mitochondrial membrane potential, and boost ATP production in aging fibroblasts .
  • Phycocyanin: A blue pigment in spirulina found almost nowhere else in nature. Lab studies show it supports healthy energy production and may promote apoptosis (natural cell death) in damaged cells . More research is needed in humans, but it’s a promising bioactive.
  • Chlorophyll & Glutathione Support: Chlorella is rich in chlorophyll and can bind to heavy metals. A human trial found that chlorella-based supplementation reduced hair levels of mercury, silver, tin, and lead in people with dental amalgams . This supports its detox role, alongside animal and environmental studies confirming its heavy-metal binding capacity .

Clinical Data: Better Mitochondria in Just 7 Days

Katherine Arnston, founder of EnergyBits, recently sponsored a small pilot trial with UC San Diego. The results?

  • Mitochondrial respiration increased by ~20%
  • ATP production vs. glycolysis improved ~15%
  • Reactive oxygen species (ROS) decreased significantly

And it happened in just 7 days of daily spirulina supplementation. By comparison, the same lab found intermittent fasting took three months to deliver similar mitochondrial benefits. While this pilot study is small and unpublished, it aligns with peer-reviewed data showing algae’s role in mitochondrial support .

Spirulina vs. Chlorella

  • Spirulina: “Nutritional insurance.” Brain, energy, mitochondria, ATP. Think performance fuel.
  • Chlorella: “Health insurance.” Detox, immune support, heavy-metal removal. Think recovery and cleanup.

Professional athletes use this one-two punch all the time: spirulina pre-game for focus and energy, chlorella post-game for recovery and detox.

The Bigger Picture

Nearly 50% of people under age 40 already show signs of mitochondrial dysfunction . By the time you’re over 40, we just call it “aging.”

Spirulina and chlorella are powerful, evidence-based tools to slow that process down. They’re not fads. They’re part of a longevity strategy built on mitochondrial resilience, clean inputs, and the right nutrients that bypass the usual pitfalls of plants.

Biohacking is mitochondria-hacking. When you take care of your ancient cellular engines, you get more energy today—and more years tomorrow.

How to Try It

If you want to experience the difference for yourself, here’s the good news: spirulina and chlorella are affordable. A therapeutic dose costs about a dollar a day.

Go to EnergyBits.com and use code UPGRADE for 20% off. Try it for a week. See if your brain, energy, and performance feel different. You might not notice the change immediately—but stop taking it for a few days, and you’ll notice what you’re missing.

This isn’t about hype. It’s about a food that’s been around for billions of years, with 25,000+ studies behind it, and a track record of improving energy and longevity for decades.

Bottom line: Spirulina and chlorella are the rare “superfoods” that deserve the title. No fads, no plant-toxin baggage—just pure mitochondrial fuel.

 

? References

  1. NASA. Spirulina: One of the world’s most nutrient-dense foods. (NASA Technical Reports)
  2. Machihara K, et al. Restoration of mitochondrial function by Spirulina polysaccharide complex (SPC) in aging fibroblasts. Biogerontology. 2023. PubMed PMID: 37416477
  3. Romay C, et al. Phycocyanin: A biliprotein with antioxidant, anti-inflammatory, and neuroprotective effects. Curr Protein Pept Sci. 2003.
  4. Merino JJ, et al. The Long-Term Algae Extract (Chlorella and Fucus sp) on Hair Heavy Metal Levels in Patients with Dental Amalgams and Implants. Biol Trace Elem Res. 2019. PMC6523211
  5. Kyratzopoulou E, et al. The Efficiency of Chlorella vulgaris in Heavy Metal Removal. Environments. 2025. MDPI
  6. Nawrocka D, et al. Spirulina platensis improves mitochondrial function impaired by oxidative stress in metabolic syndrome models. Cell Stress Chaperones. 2017.
  7. Wallace DC. Mitochondrial dysfunction in disease and aging. Nature. 2005; 435: 356-362.

Long-COVID & Vaccine Recovery: Dave Asprey’s 5-Step Protocol + 2 Extras 

If you’re dealing with lingering symptoms after a virus or a vaccine, you’re not alone. Many people report fatigue, brain fog, inflammation, and strange, hard-to-explain issues that don’t go away. This guide lays out a practical, step-by-step protocol to support recovery. 

These are the tools I personally use, combining published research with personal experience. The protocol targets key problem areas like histamine overload, spike protein debris, nutrient depletion, and mitochondrial dysfunction. It also includes two optional additions that may enhance recovery further. 

You can use this protocol to explore options with your doctor or practitioner—and adjust based on your unique needs. 

1. Use H1 and H2 Antihistamines for Mast? Cell Support 

Studies show that many long-covid and vaccine-related inflammatory symptoms are due to overactive mast cells [1]. Mast cells are a type of white blood cell that release histamine and other substances during inflammatory and allergic reactions (2). When your mast cells are overactive, they release way too much histamine, causing a variety of symptoms including rashes, rapid heartbeat, flushing, gastrointestinal issues, low blood pressure, fainting, nasal stuffiness, and more [3]. 

To address this, I recommend taking antihistamines that work on two types of histamine receptors – H1 and H2. Claritin (loratadine) is an H1 blocker and Pepcid (famotidine) is an H2 blocker. Take both twice a day – once in the morning and once in the evening. Continue this regimen for six months, the typical time it takes your body to regenerate mast cells. 

Pepcid blocks stomach acid production but you need stomach acid to digest your food. Always take Betaine HCl with your meals when you’re doing this protocol.  

2. Take Enzymes to Tackle Spike? Protein Fragments 

Enzyme blends like nattokinase, serrapeptase and lumbrokinase help break down leftover spike?protein fragments and prevent excess blood clotting [4] [5]. Enzymes will also help with brain fog because better blood flow means getting more oxygen and nutrients to your brain. Take systemic enzymes on an empty stomach, away from food, so your body directs them toward circulation and repair instead of digestion.
 

3. Take Fat-Soluble Vitamins 

Stress depletes your vitamin and mineral levels [6]. Diet alone won’t give you everything you need.  The fat-soluble vitamins (vitamins D,A,K, and E) are especially important for immunity and post-viral recovery [7].  Studies show many people who have long COVID have low vitamin D levels [8]. The best strategy is to take a combined fat-soluble vitamin (DAKE) supplement since they work best together. Everyone responds differently to vitamin D supplements, so if you need to, you can take extra D3 until your blood levels reach 70-90 ng/mL which is the level most anti-aging doctors recommend. I take Vitamin DAKE from my company, Suppgrade Labs.  

4. Don’t Forget Your Minerals 

Minerals power every reaction that goes on in your body. They’ll support your recovery from long-COVID. I take Minerals 101 from Suppgrade Labs since it has all of the right minerals in the right forms that your body needs. 

5. Take Mitochondrial Stimulators 

People with long COVID have mitochondrial dysfunction [9]. Some of the best mitochondrial stimulators are urolithin A [10], L-carnitine, MitoQ, and alpha-lipoic acid [11]. Follow dosing from the supplement manufacturers.  

6. Extras: 

Look into Low-Dose Nicotine Therapy 

First of all, this is not smoking. Smoking is bad for you. We are talking about pure, low-dose pharmaceutical-grade nicotine. Here’s how it works: Studies show COVID proteins bind to specific receptors in your body and impair the cholinergic system [12]. This is a system that helps control things like thinking, memory and bodily functions. Nicotine binds to the same receptors within this system that viral proteins bind to. Scientists believe that nicotine can displace the viral proteins at this site which then restores normal function of the cholinergic system [13]. Start slowly. Between 1-6 mg per day is the sweet spot for most people. More is not better. You can use a nicotine patch, gum, or lozenges. If you choose gum or lozenges, make sure they’re from a reputable brand and don’t have any artificial ingredients or microplastics.   

Quercetin  

Quercetin is a mast cell stabilizer meaning it prevents mast cells from releasing histamine and other inflammatory compounds [14]. It also helps clear senescent cells aka “zombie cells” which accumulate in long-COVID [15]. Take 500-1000 mg per day. 

 

TL;DR 

1. Antihistamines 

  • Claritin (H1 blocker): AM + PM for 6 months 
  • Pepcid (H2 blocker) AM + PM for 6 months (take Betaine HCl with meals) 

2. Enzymes 

  • Nattokinase, serrapeptase, lumbrokinase daily on an empty stomach 

3. Vitamins 

  • Vitamin DAKE (fat-soluble blend) – daily 
  • Vitamin D3 until blood levels reach 70-90 ng/mL 

4. Minerals 

  • Minerals 101 – daily 

5. Mitochondrial Support 

  • Urolithin A, l-carnitine, MitoQ, alpha lipoic acid daily  

6. Extras: 

  • Nicotine: 1-6 mg daily (patch, additive-free gum or lozenge) 
  • Quercetin: 500-1000 mg per day 

 

References: 

  1. Weinstock LB, Brook JB, Walters AS, Goris A, Afrin LB, Molderings GJ. Mast cell activation symptoms are prevalent in Long-COVID. Int J Infect Dis. 2021 Nov;112:217-226. doi: 10.1016/j.ijid.2021.09.043. Epub 2021 Sep 23. PMID: 34563706; PMCID: PMC8459548. 
  2. Christ P, Sowa AS, Froy O, Lorentz A. The Circadian Clock Drives Mast Cell Functions in Allergic Reactions. Front Immunol. 2018 Jul 6;9:1526. doi: 10.3389/fimmu.2018.01526. PMID: 30034393; PMCID: PMC6043637. 
  3. Frieri M. Mast Cell Activation Syndrome. Clin Rev Allergy Immunol. 2018 Jun;54(3):353-365. doi: 10.1007/s12016-015-8487-6. PMID: 25944644. 
  4. Tanikawa T, Kiba Y, Yu J, Hsu K, Chen S, Ishii A, Yokogawa T, Suzuki R, Inoue Y, Kitamura M. Degradative Effect of Nattokinase on Spike Protein of SARS-CoV-2. Molecules. 2022 Aug 24;27(17):5405. doi: 10.3390/molecules27175405. PMID: 36080170; PMCID: PMC9458005. 
  5. Wang KY, Tull L, Cooper E, Wang N, Liu D. Recombinant protein production of earthworm lumbrokinase for potential antithrombotic application. Evid Based Complement Alternat Med. 2013;2013:783971. doi: 10.1155/2013/783971. Epub 2013 Dec 12. PMID: 24416067; PMCID: PMC3876685. 
  6. Lopresti AL. The Effects of Psychological and Environmental Stress on Micronutrient Concentrations in the Body: A Review of the Evidence. Adv Nutr. 2020 Jan 1;11(1):103-112. doi: 10.1093/advances/nmz082. PMID: 31504084; PMCID: PMC7442351. 
  7. Samad N, Dutta S, Sodunke TE, Fairuz A, Sapkota A, Miftah ZF, Jahan I, Sharma P, Abubakar AR, Rowaiye AB, Oli AN, Charan J, Islam S, Haque M. Fat-Soluble Vitamins and the Current Global Pandemic of COVID-19: Evidence-Based Efficacy from Literature Review. J Inflamm Res. 2021 May 21;14:2091-2110. doi: 10.2147/JIR.S307333. PMID: 34045883; PMCID: PMC8149275. 
  8. di Filippo L, Frara S, Nannipieri F, Cotellessa A, Locatelli M, Rovere Querini P, Giustina A. Low Vitamin D Levels Are Associated With Long COVID Syndrome in COVID-19 Survivors. J Clin Endocrinol Metab. 2023 Sep 18;108(10):e1106-e1116. doi: 10.1210/clinem/dgad207. PMID: 37051747; PMCID: PMC10505553. 
  9. Molnar T, Lehoczki A, Fekete M, Varnai R, Zavori L, Erdo-Bonyar S, Simon D, Berki T, Csecsei P, Ezer E. Mitochondrial dysfunction in long COVID: mechanisms, consequences, and potential therapeutic approaches. Geroscience. 2024 Oct;46(5):5267-5286. doi: 10.1007/s11357-024-01165-5. Epub 2024 Apr 26. PMID: 38668888; PMCID: PMC11336094. 
  10. Andreux PA, Blanco-Bose W, Ryu D, Burdet F, Ibberson M, Aebischer P, Auwerx J, Singh A, Rinsch C. The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans. Nat Metab. 2019 Jun;1(6):595-603. doi: 10.1038/s42255-019-0073-4. Epub 2019 Jun 14. PMID: 32694802. 
  11. Molnar T, Lehoczki A, Fekete M, Varnai R, Zavori L, Erdo-Bonyar S, Simon D, Berki T, Csecsei P, Ezer E. Mitochondrial dysfunction in long COVID: mechanisms, consequences, and potential therapeutic approaches. Geroscience. 2024 Oct;46(5):5267-5286. doi: 10.1007/s11357-024-01165-5. Epub 2024 Apr 26. PMID: 38668888; PMCID: PMC11336094. 
  12. Leitzke M, Roach DT, Hesse S, Schönknecht P, Becker GA, Rullmann M, Sattler B, Sabri O. Long COVID – a critical disruption of cholinergic neurotransmission? Bioelectron Med. 2025 Feb 27;11(1):5. doi: 10.1186/s42234-025-00167-8. PMID: 40011942; PMCID: PMC11866872. 
  13. Kopa?ska M, Batoryna M, Bartman P, Szczygielski J, Bana?-Z?bczyk A. Disorders of the Cholinergic System in COVID-19 Era-A Review of the Latest Research. Int J Mol Sci. 2022 Jan 8;23(2):672. doi: 10.3390/ijms23020672. PMID: 35054856; PMCID: PMC8775685. 
  14. Weng Z, Zhang B, Asadi S, Sismanopoulos N, Butcher A, Fu X, Katsarou-Katsari A, Antoniou C, Theoharides TC. Quercetin is more effective than cromolyn in blocking human mast cell cytokine release and inhibits contact dermatitis and photosensitivity in humans. PLoS One. 2012;7(3):e33805. doi: 10.1371/journal.pone.0033805. Epub 2012 Mar 28. PMID: 22470478; PMCID: PMC3314669. 
  15. Wissler Gerdes EO, Vanichkachorn G, Verdoorn BP, Hanson GJ, Joshi AY, Murad MH, Rizza SA, Hurt RT, Tchkonia T, Kirkland JL. Role of senescence in the chronic health consequences of COVID-19. Transl Res. 2022 Mar;241:96-108. doi: 10.1016/j.trsl.2021.10.003. Epub 2021 Oct 22. PMID: 34695606; PMCID: PMC8532377. 

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