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1304. The Biohacking Tool That Will Change the World (Mitochondrial Transfusions)

Unlocking Cellular Health: The Power of Mitopure

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In the quest for optimal health and longevity, understanding how to nourish our cells has never been more crucial. Dave Asprey, renowned biohacker and author, has partnered with Timeline to bring us Mitopure, a groundbreaking supplement that focuses on cellular energy and rejuvenation.

What is Mitopure?

Mitopure is a unique product derived from Urolithin A, a compound that has shown promising benefits for mitochondrial health. With over 15 years of research and multiple clinical trials involving over 900 participants, Mitopure stands out as a doctor-recommended brand that is reshaping how we think about aging and energy production.

The Benefits of Urolithin A

Research has demonstrated that Urolithin A can significantly enhance mitochondrial function, leading to:

  • Increased Energy: Users can experience improved cellular energy levels.
  • Enhanced Muscle Strength: Clinical studies have shown muscle strength increases of up to 12% after 16 weeks of consistent use.
  • Improved Endurance: Users may see a 17% boost in muscle endurance after just 8 weeks.
  • Optimal Urolithin A Levels: Mitopure unlocks six times more Urolithin A than diet alone, making it a powerful addition to any health routine.

Products to Explore

Mitopure Gummies

These strawberry-flavored gummies provide a delicious and convenient way to boost your cellular energy.

Mitopure Softgels

For those looking for simplicity, the softgels deliver a precise dose of Urolithin A (500mg) to support your health goals.

Skincare Line

Timeline also offers a skincare line infused with Mitopure, including eye cream, day cream, and night cream, designed to combat signs of aging while nourishing the skin.

Testimonials from Experts

Dave Asprey himself has emphasized the importance of incorporating Mitopure into his daily routine. He states, “This is something I’m permanently adding, based on evidence, to my personal stack.” Esteemed doctors and researchers, including Dr. Mark Hyman and Dr. Johan Auwerx, have also endorsed Mitopure for its transformative effects on health.

Join the Movement

As we continue to explore innovative ways to enhance our health, Mitopure offers a powerful solution backed by science. With a 30-day money-back guarantee and free shipping within the U.S., trying Mitopure is a risk-free investment in your health.

For more information and to discover the full range of products, visit the Timeline website.

Embrace the future of health with Mitopure and experience the difference for yourself!

Your Testosterone is Probably Low. Here’s How to Hack It.

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Most guys think low testosterone is just part of aging. It’s not. It’s a side effect of modern life—and it’s 100% hackable. 

In my 20s, I was inflamed, tired, and stuck. Doctors told me to accept it. 

But I wasn’t going to accept it. I decided to do some tests. It turns out my testosterone levels were lower than my mother’s. 

So I hacked my biology. 

Now, in my 50s, my T levels are higher than they were in my 30s. Here’s how you can hack yours too (with the same supplements I personally use): 

1. Eat Like Your Hormones Matter

Your testicles contain tiny factories (Leydig cells) that build testosterone. But they need raw materials to function. 

Here’s what to do: 

  • Eat more saturated fat: grass-fed beef, pasture-raised eggs, butter, raw A2 cheese 
  • Cut seed oils: ditch canola, sunflower, soybean, corn oil, etc. 

Forget calorie-counting. It makes you weak. Fuel your biology with high quality raw materials. 

2. Prioritize Deep, High-Quality Sleep

One bad night of sleep can cause a 15% drop in testosterone levels. Don’t treat sleep like it’s optional. 

Here are some sleep hacks to support testosterone levels: 

  • Avoid large meals and workouts 2-3 hours before bed 
  • Black out your room 
  • Cool down your room (aim for ~68°F) 

Sleep is free hormone therapy. Use it. 

3. Fix Your Light Exposure

Light controls your circadian rhythm—and your hormones. 

Get outside in the sun within 30 minutes of waking up. Don’t wear sunglasses. You only need about 10-15 minutes to get the benefits. 

At night, avoid junk light from LEDs and compact fluorescent lights (CFLs). Use warm lighting and block artificial light after sunset. 

Your hormones respond to light. Get it right, and you flip the testosterone switch. 

4. Track Your Progress: 

It’s also important to track your testosterone levels to see if your interventions are working. 

  • Get labs (Total testosterone, free testosterone, SHBG, estradiol). If you can’t get them from your doctor, check out AXO by Upgrade Labs. It’s a platform that provides personalized health insights through advanced lab testing, wearable data integration, and tailored recommendations. And the best part is you don’t have to go to a doctor or deal with your insurance company 
  • Track morning wood (yes, really). If it’s not there, you have a problem 
  • Monitor your energy and drive—testosterone fuels motivation 

A Quick Word for Women 

Believe it or not, women need testosterone too. If you’re a woman and you’re low in testosterone you might experience a low sex drive, mood changes, and fatigue. Make sure you get your levels tested and if they’re low, work with a functional doctor to find an intervention that works for you.  

The Shortcut: Safe Testosterone Replacement Therapy 

It’s possible to raise your testosterone levels naturally. But sometimes your body needs some extra help. When I found out my testosterone levels were low, I found a new doctor who helped me get onto testosterone replacement therapy. When I went on testosterone my brain changed. I’ve been on it the vast majority of the time since then. It’s made me healthier, stronger, and more motivated.  

I’m a huge fan of KYZATREX® from Thrive, which is an FDA-approved, twice-daily oral capsule for testosterone replacement therapy in adult men who have low testosterone. They designed it for peak absorption—and it bypasses your liver to prevent damage. This means you can experience the benefits of TRT without the potential liver strain associated with other forms of TRT. And you don’t have to take any injections.  

Want to get the oral testosterone that I use?

Go to LiveThrive.co/asprey to get your motivation back — with a discount on your first month. 

Don’t settle for low energy and low drive. Take control of your testosterone levels now.  Learn more about how to hack your testosterone levels in this YouTube video:

EWOT – How Exercising with Oxygen Can Change Your Life

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Whether you’re a biohacker, an athlete, or you have a chronic autoimmune disease, oxygen is your ally.
The problem is, as you age your body gets less efficient at delivering oxygen to your tissues. These low oxygen conditions lead to brain fog, fatigue, reduced performance, and a weak immune system. Low oxygen also increases your risk of getting a chronic disease like Alzheimer’s 11.

So how can you get more oxygen into your tissues?
Enter EWOT.

What is EWOT?

EWOT stands for Exercise With Oxygen Therapy. You inhale air with a higher oxygen concentration (often 93–95%, compared to 21% in ambient air) through a mask while you exercise—such as cycling, walking on a treadmill, or strength training. The goal is to increase oxygen delivery to tissues, potentially improving exercise tolerance, reducing fatigue, and enhancing cellular function.

EWOT vs. HBOT

EWOT is different from Hyperbaric Oxygen Therapy (HBOT), where you get into a pressurized chamber.

I’m a huge fan of both.

  • EWOT is more affordable and accessible than HBOT.

  • It’s also more time-efficient—an HBOT session typically takes 90 minutes, while an EWOT session takes 15.

If your goal is longevity, you might want to include both in your regimen (just spread them out—too much oxygen can be toxic). Many people try both and pick what works best. If you have specific medical conditions, consult a functional doctor to guide your choice.

Benefits of EWOT

1. Exercise Performance

As exercise intensity increases, your muscles demand more oxygen. If your body can’t keep up, you fatigue faster.
EWOT increases circulation and oxygen delivery to your muscles, which improves performance.
One study found EWOT improved endurance in healthy people by 17–45% after two weeks 22.

2. Brain Performance

Your brain requires a constant, high supply of oxygen to function at its best.
Studies show that EWOT improves reaction time and short-term memory 33.

3. Inflammation Reduction

Hypoxia (low oxygen) contributes to inflammation 44.
EWOT improves oxygenation and circulation, which helps reduce inflammation in tissues.

4. Longevity

As you age, oxygen transport becomes less efficient—contributing to many aging-related diseases 55.
EWOT restores oxygen delivery and is a strong addition to any longevity regimen.

How to Do It

You may be able to find a clinic or biohacking center offering EWOT, or you can invest in a home system. Entry-level options start around $1,700, and you’ll also need a stationary bike or treadmill.

Many people feel results after just one session. With consistent use, benefits can last weeks, months—even years 66.

Want to Learn More?

  • EWOT: Stay tuned for The Human Upgrade Podcast episode coming soon

  • HBOT: Check out Episode 1281

References

  1. Liu G, Yang C, Wang X, Chen X, Wang Y, Le W. Oxygen metabolism abnormality and Alzheimer’s disease: An update. Redox Biol. 2023 Dec;68:102955.

  2. von Ardenne M, Klemm W, Klinger J. Double-blind study on the long-lasting improvement of physical endurance following oxygen-multistep-therapy. Z Alternsforsch. 1984 Jan-Feb;39(1):17-30.

  3. von Ardenne M, Klemm W. Increasing mental performance by multistep oxygen therapy. Z Alternsforsch. 1989 Jan-Feb;44(1):37-48.

  4. Bartels K, Grenz A, Eltzschig HK. Hypoxia and inflammation are two sides of the same coin. Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):18351-2.

  5. Valli A, Harris AL, Kessler BM. Hypoxia metabolism in ageing. Aging (Albany NY). 2015 Jul;7(7):465-6.

  6. von Ardenne M. Age-dependence of oxygen transport into body tissues and the favorable modification of this transport by multistep oxygen therapy. Z Alternsforsch. 1984 Jul-Aug;39(4):187-210.

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