Ozone Therapy: What It Is and How It Works

Ozone Therapy: What It Is and How It Works

[tldr]

  • Ozone is the molecule that you can smell in the air after a thunderstorm. It’s a form of oxygen that’s different from what you’re breathing right now.
  • Ozone improves brain function, helps your mitochondria make more energy, kills damaging gut bacteria and toxic mold, speeds up wound healing, decreases inflammation, and makes your teeth and gums stronger.
  •  This article goes over a few different ways to use ozone therapy, both with a doctor and at home. Just be absolutely sure you do ozone therapy safely; while it’s great anywhere outside your lungs, ozone can be lethal if you inhale it.

[/tldr]

You know that fresh, clean smell in the air after it rains? That’s ozone, a powerful molecule that gets pulled from the atmosphere by electricity during a thunderstorm.

Ozone is oxygen, but it’s different to the oxygen molecules you breathe. Its unique structure makes it a potent signaling molecule in your body, and a valuable biohacking tool.

I wrote a lot about using ozone in Head Strong. It’s one of the best ways to upgrade your mitochondria — the power generators in your cells — so they produce more energy, especially in your brain. I used ozone therapy years ago to get rid of damage from toxic mold. I still use it today to make my mitochondria stronger.

Here’s how ozone therapy works, what it’s good for, and how you can use it safely to upgrade your body.

Disclaimer: While ozone therapy can be a powerful tool for improving your health, it’s also potentially fatal if you do it incorrectly and inhale ozone. If you’re going to do ozone therapy at home, do your research so you’re absolutely certain you know what you’re doing, or consult a doctor.

What is ozone therapy?

Ozone therapy floods your body with small amounts of ozone in a controlled way.

In a recent Bulletproof Radio podcast episode [iTunes] I talked to Dr. Frank Shallenberger, one of the leading ozone therapy experts in the world (he’s been doing ozone therapy for 40 years!). Shallenberger describes ozone in this way: 

“Ozone is molecular O3, versus the regular form of oxygen we’re breathing right now, which is molecular O2, meaning that while regular oxygen contains two oxygen atoms, ozone contains three.”

In other words, ozone is a different form of oxygen. When ozone enters your body, the extra oxygen atom reacts with your cell membranes in your body almost immediately and forms lipoperoxides, a type of free radical.

Free radicals aren’t always the bad guy

Normally, you hear about how damaging free radicals are, and how you want to get plenty of antioxidants to prevent them from aging your cells. But in certain cases, free radicals can actually be good for you. 

“We’re led to believe that free radicals are bad,” says Shallenberger. “Nothing in our body that our body makes is ‘bad’ bad. Oxidants and free radicals in the correct dose, in the correct amount, are actually highly beneficial.”

A good example is exercise. Working out creates free radicals in your muscles, and the inflammation they cause makes you build stronger, more efficient muscle with more mitochondria.

Ozone therapy is similar. It introduces lipoperoxides that improve your biology in a bunch of different ways.

Ozone therapy benefits

Ozone therapy affects a lot of different systems in your body, depending on how you get the ozone (more on that later). Here are some of the benefits of ozone therapy: 

  • Energy production. Low doses of ozone lipoperoxides gently stress your mitochondria, making them stronger and more efficient at producing energy.[ref url=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503975/”]
  • Brain function. Lipoperoxides can cross the blood-brain barrier and reach your brain, which has a huge concentration of mitochondria.[ref url=”https://books.google.com/books?id=clTevkIgTVUC”] That could explain why ozone therapy helps people recover brain function after a stroke.[ref url=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146136/”] Ozone therapy also increases blood flow to your brain, which will further boost your mitochondria.[ref url=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC538510/”] I felt a dramatic and almost immediate improvement in my brain function after doing ozone therapy.
  • Decreased inflammation. It seems strange that flooding your body with free radicals decreases inflammation, but it’s true. The key is getting the right dose. Low levels of ozone stress your cells just enough to make them stronger; they produce glutathione and superoxide dismutase, two of the strongest antioxidants in the human body.[ref url=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3298518/”][ref url=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503975/”] Low-level ozone also activates heat shock proteins, the same anti-inflammatory proteins that turn on when you use a sauna.
  • Faster wound healing. Ozone speeds up wound healing, and is especially useful for chronic or treatment-resistant wounds.[ref url=”https://www.ncbi.nlm.nih.gov/pubmed/29536625″]
  • Anti-mold, antibacterial, antimicrobial, and antiparasitic effects. Ozone treatment started out as a way to sterilize drinking water.[ref url=”https://www.ncbi.nlm.nih.gov/pubmed/970023/”] Researchers quickly realized that it also treats bacterial infections, even when bacteria are resistant to antibiotics,[ref url=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783482/”][ref url=”https://www.ncbi.nlm.nih.gov/pubmed/10795372/”] and kills parasites.[ref url=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620192/”] Ozone completely removes toxic mold and mycotoxins as well,[ref url=”https://www.ncbi.nlm.nih.gov/pubmed/22286589/”] which is why I originally got into ozone therapy. At the time, it was the only thing I’d found that helped me recover from toxic black mold exposure.
  • Strong teeth and gums. The combination of antibacterial and anti-inflammatory benefits makes ozone a powerful way to upgrade your teeth and gums.[ref url=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722714/”] A lot of forward-thinking dentists offer ozone therapy. In fact, it was a dentist who introduced me to ozone therapy and taught me how to do it.

What type of ozone therapy is best?

There are a lot of ways to use ozone, but you have to know what you’re doing before you try them. Above all else, you do not want to breathe in ozone. If you do and it reaches your lungs, it can be fatal. If you’re going to do ozone therapy on yourself, make sure you do your research. Shallenberger wrote a step-by-step guide to ozone therapy, specifically for people interested in doing it at home. That’s a great place to start. Or you can just see a doctor.

There are a lot of different ways to get ozone into your body. Which one is best depends on your goals.

  • Ten- pass ozone is the strongest and most effective ozone treatment for most things. It’s also one of the most invasive. A physician pulls some blood out of your body, infuses it with ozone, and then recirculates it, ten times in a row.  I had ten- pass ozone done recently to make my brain mitochondria stronger and felt a profound improvement afterward.
  • Ozonated water/oil is the easiest form of ozone therapy. You put ozone in water or oil and swallow it, delivering ozone to your stomach. This option is good for clearing out pathogenic gut bacteria or parasites. You can also swish ozonated water or oil around your gums for better oral hygiene, or put it on skin wounds and infections.
  • Ozone injections are another option. You can do them at home if you’re trained with needles, or you can get a doctor to do them for you. You can inject ozone pretty much anywhere and it will act locally near the injection site. Ozone injections are good for getting ozone to specific organs and, tumors., etc.
  • Rectal ozonation is exactly what you think it is: you insert a catheter and send about a liter of ozone gas into your colon. This is the option I chose to do to myself for my first ozone treatment. The ozone goes straight to the liver, which makes it good for enhancing detox and liver function, and it will reach parasites and pathogenic bacteria in your gut. You can also have a doctor do this one.

Whichever option you choose, be careful not to inhale ozone. If the room starts to smell like it just rained, turn off your equipment and leave the area. Always biohack responsibly.

 

 

Bigger Brains from Adult Play and Hypnosis: Dr. Mike Dow #525

Dr. Mike Dow is a psychotherapist, a neurotherapist, and a New York Times best-selling author of several books. He is also a well-known expert in relationships, brain health, addiction, and mental illness which is why he is a part of Dr. Oz’s core team of experts.

You may have seen him on TV shows like VH1, TLC, The Today Show, and on top of that, he’s got a second doctorate in clinical sexology and a post-doctorate in psychopharmacology. Dr. Dow is a full time, licensed psychotherapist and sex therapist – plus all sorts of other crazy stuff.

In other words, Mike Dow is a total badass at multiple parts of what it takes to be a high performance, highly functional, happy human being.

Enjoy the show!
Listen on Apple Podcasts or iTunesListen on Google Podcasts

Follow Along with the Transcript

Bigger Brains from Adult Play and Hypnosis: Dr. Mike Dow #525

Links/Resources

Website: Dr.MikeDow.com
Books: Heal Your Drained Brain, Healing the Broken Brain, and The Brain Fog Fix.
Facebook: facebook.com/DrMikeDow
Twitter: @doctormikedow
Instagram: @drmikedow

Show Notes

    • Mike’s brother had a stroke at 15-years-old 00:06:20
    • Why Mike likes meditation but loves hypnosis 00:08:14
    • Do you need to be weak minded to be hypnotized? 00:11:25
    • How humans get stuck in “reality” 00:15:40
    • How you can get started with hypnosis 00:16:50
    • At a fundamental level, what hypnosis does 00:17:15
    • How to know if your hypnosis is safe 00:18:35
    • “We are all seeking love at a fundamental level” 00:21:00
    • Sex is the way that adults play together 00:24:10
    • Play is essential for all human beings 00:24:35
    • How important are “little hits to the head”? 00:36:15
    • Why you should lean into the things that are hard for you to do 00:39:00
    • What to do if you have a brain injury 00:39:55
    • Theta state is where the angels and demons live 00:47:45

Go check out “Headstrong” and “The Bulletproof Diet” on Amazon and leave a review!

If you like today’s episode, check us out on Apple Podcasts at Bulletproof.com/iTunes and leave us a 5-star, positive review.

What Is GMO and Are GMO Foods Safe?

  • Genetically modified organisms (GMOs) are organisms that contain artificially altered genetic material that would not otherwise occur in nature.
  • While the uses of genetic engineering range from chemical production to pharmaceuticals, its most debated use is in GMO food production.
  • The most common GMO foods are corn, cotton, canola, soy, sugar beet, papaya from China or Hawaii, and some varieties of yellow squash.
  • To avoid GMO food, look for the “Non-GMO Project Verified” or “Organic” labels.

These days, it’s hard to find a neutral opinion on genetically modified organisms (GMOs). Some call GMO food frankenfoods while others call them scientific progress. Today’s GMO industry profits big corporations, abuses farmers and the environment, and ignores conflicting research on consumer health.

More and more people are demanding to know what foods are GMO, and current labeling laws are no help. No matter where you fall on the GMO debate, you deserve to know what you put in your body. Read on to discover why GMO foods are not on the Bulletproof list, how to recognize and avoid them, and what they mean for our food system today.

What is GMO?

what is gmoGenetically modified organisms (GMOs) — also labelled as genetically engineered, bioengineered, or recombinant) — are organisms that contain artificially altered genetic material that would not otherwise occur in nature. Scientists can physically edit the DNA of an organism to achieve a desired change, such as improving the yield of a crop, causing bacteria to produce insulin, or making kittens glow (y’know, useful stuff). When people talk about GMO foods, they’re generally referring to genetically modified plant crops.

Genetic modification today is different than selective breeding, the age-old process of breeding plants or animals with the most desired traits. This is how (over thousands of years) your ancestors grew wheat with bigger kernels, or turned wolves into corgis. While this breeding did change the genes of those species, today “genetic engineering” refers instead to the direct editing of DNA to cause changes in an organism.

What foods are usually GMO?

gmo foods When GMOs were first introduced in the ‘70s, the scientific community greeted them as the future of biology. Scientists now had the technology to edit the genetic master code of organisms, the ultimate biohack. While the uses of genetic engineering range from chemical production to pharmaceuticals, its most debated use is in food production.

Today, the most common GMO foods are corn, cotton, canola, soy, sugar beet, papaya from China or Hawaii, and some varieties of yellow squash.

The first GMO food was approved in 1992, and genetically engineered products quickly became staples on grocery shelves.[ref url=”http://sitn.hms.harvard.edu/flash/2015/from-corgis-to-corn-a-brief-look-at-the-long-history-of-gmo-technology/”] While this technology promises crops with bolstered shelf lives, nutrition, and resilience to feed a growing world, the two most common traits engineered into crop plants are herbicide tolerance and insect resistance. Today, 90% of all corn, and 94% of all soy planted in the U.S. are genetically modified to have one or both of these traits, with Monsanto (now Bayer) corporation’s Roundup-Ready and Bt toxin seeds at center stage.[ref url=”https://www.ers.usda.gov/data-products/adoption-of-genetically-engineered-crops-in-the-us/recent-trends-in-ge-adoption.aspx”]

Monsanto’s Roundup-Ready varietals are genetically engineered to resist even high levels of glyphosate, the potent herbicidal ingredient in Monsanto’s popular Roundup weed killer.[ref url=”http://www.monsantoglobal.com/global/au/products/Documents/tech-topic-what-is-roundup-ready-canola.pdf”]This meant farmers could drench their fields in herbicides to kill off weeds without harming their new GMO crops.

Bt toxin crops contain a gene transferred from the bacteria Bacillus thuringiensis, which gives them the ability to produce an insect-killing toxic protein.[ref url=”http://sitn.hms.harvard.edu/flash/2015/insecticidal-plants/”] By nixing pests and weeds, these varieties hugely reduce the amount of labor needed on farms, but their effects on consumer health, the farming industry and the environment are less certain.

Are GMOs safe? GMOs and your health

are gmos safeGMO foods and their derivatives are not included on the Bulletproof Diet, but their health is a hot topic for debate. Studies are contradicting, and few long-term human or animal studies are available, exposing claims on both sides of the fence to criticism.

Animal studies comparing GMO foods (often corn or soy) to their parent (non-GMO) strains often show significant differences, but vary in how they interpret those results.

While some studies simply claim that GMOs are less nutritious (maybe thanks to faster growth and poorer soil), others link them to organ damage, cancer and hormonal shifts.[ref url=”https://www.sciencedirect.com/science/article/pii/S0308814613019201″][ref url=”https://www.ncbi.nlm.nih.gov/pubmed/27752412″]

Other studies suggest that consuming GMO foods may speed liver stress and aging, as well as cause signs of liver and kidney toxicity.[ref url=”https://www.ncbi.nlm.nih.gov/pubmed/18648843″][ref url=”https://www.ncbi.nlm.nih.gov/pubmed/17356802″] Specific changes in the genes and expression of GMO crops may explain these changes.

DNA and protein comparisons of glyphosate-tolerant GMO corn showed increased oxidative stress within the seeds themselves, and weakened metabolic pathways. These seeds also showed large increases of the polyamines putrescine and cadaverine, which can be toxic in high doses, possibly worsening histamine reactions, and helping form carcinogenic nitrosamines.[ref url=”https://www.nature.com/articles/srep37855″]

Unfortunately, most animal studies are too short to investigate what chronic GMO exposure could mean for you. One longer multigenerational study revealed unhealthy differences in kidney weight, cholesterol regulation and protein metabolism in mice fed GMO corn. This study also exposed negative reproductive effects over multiple generations of mice fed GMO corn, another reason why avoiding GMOs is key to detoxing in order to boost fertility. [ref url=”http://www.herbogeminis.com/IMG/pdf/biological_effects_in_mice.pdf”]

One of the earliest concerns with GMOs was their potential to introduce new allergens to our food supply. In an episode of Bulletproof Radio with Jeffrey Smith, founding executive director of The Institute for Responsible Technology, he warned that altering DNA may cause unforeseen changes downstream in the genetic code, such as mutations that change the function or expression of genes.

Monsanto and GMO crops

monsanto and gmoIn the case of our food system, the risks of GMO foods go beyond the genetic modification itself. GMOs such as Monsanto’s Bt toxin crops literally produce pesticides themselves — you can’t rinse that off. The Bt Cry-protein toxins formed by these plants do cause immune (but not allergic) responses in animal tests, as well as damage to intestinal goblet cells, and increased kidney weight in pigs fed Bt corn.[ref url=”https://www.ncbi.nlm.nih.gov/pubmed/21298004″][ref url=”https://www.ncbi.nlm.nih.gov/pubmed/21733303″] While the effects of this toxin may be minute, the long term impact in humans is unknown.

Even more common, Monsanto’s Roundup Ready crops are designed to withstand extreme doses of weedkiller glyphosate, allowing farmers to spray billions of pounds of glyphosate-based Roundup each year to protect their crops from weeds. In 2015, the World Health Organization declared glyphosate a probable human carcinogen.

The same mineral-chelating effects that make roundup so great for killing bugs, also make it an potent antibiotic in your body. “Most of the antibiotics are in fact chelators, and most herbicides are chelators, and it kills selectively the beneficial good bacteria,” explains Jeffrey Smith, founding executive director of The Institute for Responsible Technology, “That can create an overgrowth of negative gut bacteria in the gut that can create harsh gases which can damage the walls of the intestines.”

In addition to wreaking havoc on bacteria in your gut biome, studies also link glyphosate exposure to numerous health risks, such as celiac disease, hormone disruption, fertility issues, and even cancer.[ref url=”https://www.sciencedirect.com/science/article/pii/S027869151530034X?via%3Dihub”] One recent report demonstrated that even very low chronic doses of the Roundup used on crops resulted in non-alcoholic fatty liver disease in rats.[ref url=”https://www.nature.com/articles/srep39328″]

Not only is glyphosate the most widely used herbicide in the world, it’s also an extremely persistent toxin.[ref url=”https://enveurope.springeropen.com/articles/10.1186/s12302-016-0070-0″] Private research companies have even found glyphosate residue in everything from honey to cereal to human breast milk.[ref url=”https://www.reuters.com/article/us-food-agriculture-glyphosate-idUSKBN0N029H20150410″] Once consumed, your body uses glyphosate indistinguishably from the amino acid glycine, storing it away in proteins in your cells.[ref url=”https://people.csail.mit.edu/seneff/2017/SamselSeneff_Glyphosate_VI_final.pdf”] The same glyphosate used to grow GMO corn, soy and alfalfa for animal feed also sticks around in those animals’ bodies: another reason to stick to meat, milk and collagen from organic, grass-fed animals.

Learn more about how glyphosate could be hiding in your food

GMOs, farming and the environment

gmos and environmentHow GMOs impact farmers

It turns out there’s a reason there’s so little available research on GMO food safety. The politics of GMOs took a dark turn in 1980, when a supreme court ruling decided that companies could actually own the rights to a genetically modified organism.[ref url=”http://sitn.hms.harvard.edu/flash/2015/from-corgis-to-corn-a-brief-look-at-the-long-history-of-gmo-technology/”] Because of this, companies like Monsanto can call on intellectual property rights to make it illegal for certain researchers to use their products, making it even harder to find reliable, unbiased data on GMO safety.[ref url=”https://grist.org/food/genetically-modified-seed-research-whats-locked-and-what-isnt/”]

Farmers also find themselves backed into a corner by GMO companies. Thanks to government subsidies and low crop values, more and more farmers turn to GMO crops to pay the bills, speeding the demise of small farms and traditional agriculture.

Monsanto’s copyrighted seeds are designed to be sterile, meaning that these farmers are financially and legally tied to Monsanto year and year again to purchase new seeds, pesticides and herbicides. Unfortunately, these plants aren’t actually entirely sterile, and can quietly contaminate neighboring organic or non-GMO fields, risking those certifications.

You can read more on the slimy politics of GMOs and glyphosate, but the bottom line is: avoiding GMOs means supporting the farmers and companies working to create a safer, more sustainable food system.

GMOs and the environment

Genetically modified crops haven’t been kind to the environment either. Dumping glyphosate on farmland is like over-abusing heavy antibiotics, but on a much larger scale. In an episode of Bulletproof Radio, David Bronner, president of Dr. Bronner’s Magic Soaps and GMO awareness advocate, puts this into perspective: “The plants are sick, the soil is sick, the system’s sick. It doesn’t have the natural beneficial organisms. It doesn’t have the natural pest predators. It’s just a completely broken system and they’re pouring more and more and more chemicals into this to get these things to harvest.”

As more weeds become resistant to Roundup, farmers add even more chemicals into the soil, binding nutrients, wiping out beneficial bacteria, and allowing toxin-forming fungi to grow unchecked. These effects don’t stop at the fence, and can destroy waterways and ecosystems downstream. Worse, the chemical runoff isn’t the only thing escaping: bacteria can actually pick up pieces of genetic information from GMO crops. This process is called horizontal gene transfer, and allows bacteria to share and recombine DNA faster than natural mutations. While it may be rare for these mutations to occur successfully in uncontrolled conditions, it poses an unstudied risk to the environment.[ref url=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3882822/”]

A new risk is on the horizon as well: Genetically modified salmon have recently been introduced as the first GMO animal for food. Their release has faced huge criticism over concerns for wild salmon populations, and the tribal sovereignty of people dependent on salmon in the Pacific Northwest.[ref url=”https://cagj.org/2018/04/salmon-people-a-backgrounder-to-northwest-tribal-opposition-to-ge-salmon/”]

“[The Institute for Responsible Technology] is against the use of GMOs for food and for outdoor release, but we’re not against the use of, say, drug manufacturing when it’s done in a contained manner, because the equation is different,” says Smith. “We do believe that [companies] need to increase their respect for what can go wrong and the current respect is so low that it’s dangerous.”

GMO labeling and how to avoid GMOs

gmo labeling how to avoid gmoHow can you tell if your food is genetically engineered? As awareness of GMO technology increases, more and more consumers demand the right to know. Polls consistently show that around 90% of Americans believe GMO foods should be labeled, yet the U.S. has some of the most lax laws surrounding GMO disclosure.[ref url=”https://www.centerforfoodsafety.org/issues/976/ge-food-labeling/us-polls-on-ge-food-labeling”][ref url=”http://www.loc.gov/law/help/restrictions-on-gmos/”]

The limitations of GMO labeling

The National Bioengineered Food Disclosure Law, signed in 2016, will make it mandatory for producers to label foods containing GMOs, but it won’t exactly make the information any more accessible for consumers. Instead of risking public opinion by printing the word “GMO” or “Bioengineered” on their boxes, producers can opt to hide that information behind a QR code or toll free telephone number. (Because who doesn’t love waiting on hold in the middle of the grocery store?) To make things more confusing, the law will exclude GMO food served at restaurants, animal products made using GMO feed, and GMO processed foods such as oils or sugars, which do not contain DNA.[ref url=”https://cspinet.org/news/abcs-gmo-disclosure-united-states-20170925″]

Myth: PLU labels beginning with “8” indicate GMO produce: while it’s true that the PLU gods did intend this to be true, the indicator never made it to retail. As of 2015, these codes are back in circulation for general produce. Fortunately, you can use PLU codes beginning with “9” to find organic produce, which are always non-GMO.[ref url=”https://www.ifpsglobal.com/Identification/PLU-Codes”]

To keep GMOs out of your food:

Know the most common offenders: The most common GMO crops are corn, cotton, canola, soy, sugar beet, papaya from China or Hawaii, and some varieties of yellow squash.

Eat organic: Both the Certified organic and non-GMO Project Verified labels guarantee that a product is non-GMO. When it comes to produce, avoid common GMOs by looking for either of these labels. And, as mentioned above, PLU codes beginning with a “9” signify organic produce.

Avoid processed foods: Products made with common GMO foods are harder to identify, but carry the same risks. A recent Environmental Working Group (EWG) report found glyphosate in almost all samples of oat-containing processed foods, including breakfast cereal, granola bars and oatmeal.

Read ingredient lists: Many additives are processed forms of GMO foods, under sneaky names like lecithins, syrups, alcohols, aspartame, maltodextrin, citric acid, dextrose, xanthan gum, and certain vitamins, vinegars and yeast. If you eat non-Bulletproof sweeteners, look for sugars with a known source, such as pure cane sugar, maple sugar or coconut sugar, as the general label “sugar” often comes from GMO sugar beets.

Choose grass-fed, organic meat: Opt for grass-fed, organic meats and dairy to avoid toxic residues from GMO feed, and rbST/rbGH/artificial hormones harvested from GMO bacteria.

If you’re following the Bulletproof diet, you’re already steering clear of GMO food like highly processed foods, grain-fed meats and dairy, soy, corn and canola.

Read Next: 5 Ways to Detox From Glyphosate

 

GABA: The Neurotransmitter That Dissolves Anxiety and Improves Sleep

  • GABA is your brain’s main inhibitory neurotransmitter. It keeps your brain from becoming overactive and promotes calm relaxation.
  • GABA is great for anxiety, muscle tension, sleep, stress, and improved mood
  • There are a lot of different ways to increase GABA levels in your brain. This article includes a list of GABA-boosting supplements, as well as lifestyle changes that increase GABA.

If you’re looking to sleep better, ease anxiety, decrease muscle tension, or boost your mood, you may want to try increasing your GABA levels.

GABA is your brain’s main inhibitory neurotransmitter — it calms your neurons (brain cells) and keeps your brain from getting overexcited.

You make GABA naturally and use it across almost all of your brain. You have GABA receptors in your gut, too: your gut bacteria use GABA to talk to your brain and influence your emotions.[ref url=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127831/”] GABA is a powerful tool if you’re looking to gain control over your sleep, stress, or mood. You can boost it with lifestyle hacks, or you can take supplements that increase GABA.

Here’s a complete guide to GABA’s benefits, how it works in your brain, and the best supplements and habits to balance your GABA levels for a happier, calmer life.

What are GABA receptors and what are GABA’s benefits?

gaba benefitsYour brain runs on neurotransmitters, chemicals that let your neurons (brain cells) communicate with one another. Neurotransmitters bind to receptors on your neurons, much like a key fits into a lock. This key-in-the-lock process runs pretty much everything you do. Movement, thoughts, emotions, senses, breathing, heartbeat — they all rely on neurotransmitters binding to receptors.

There are two major types of GABA receptors: GABAA and GABAB

GABAA receptors generally promote relaxation, sedation/sleep, and anti-anxiety effects when something activates them.[ref url=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127831/”] The relaxed, buzzy, social feeling you get when you drink? That happens because alcohol binds very strongly to GABAA receptors.[ref url=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2043151/”] Anti-anxiety drugs like Xanax and Valium are also strong GABAA activators.[ref url=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020178/”] In fact, the reason it’s so dangerous to drink and take anti-anxiety pills together is because they activate GABAA in slightly different ways, so instead of competing with each other (like two keys trying to fit into the same lock), their effects stack, which can be fatal.

Alcohol and Xanax are both strong enough to be addictive, and neither one is Bulletproof-approved. But gentler GABAA activation can help you relax and give you a wonderful sense of calm, without the side effects of more intense activation.

GABAB receptors are the other major GABA receptor type. Activating GABAB promotes mental relaxation and feelings of happiness.[ref url=”https://www.ncbi.nlm.nih.gov/pubmed/15629203″][ref url=”https://www.ncbi.nlm.nih.gov/pubmed/23872369″] GABAB activation also eases muscle tension.[ref url=”https://www.ncbi.nlm.nih.gov/pubmed/23872369″] In general, GABAB receptors have a more subtle effect on your brain than GABAA receptors do.[ref url=”https://www.sciencedirect.com/science/article/pii/S0074774208603049″] Activating both can be useful for improving your performance.

GABA for anxiety and muscle tension

gaba for anxietyStudy after study has found that both GABAA and GABAB activation rapidly and reliably decrease anxiety.[ref url=”https://www.ncbi.nlm.nih.gov/pubmed/15629203″][ref url=”https://www.ncbi.nlm.nih.gov/pubmed/16971751″][ref url=”https://www.ncbi.nlm.nih.gov/pubmed/12662130″][ref url=”https://www.ncbi.nlm.nih.gov/pubmed/17117412″][ref url=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303399/”]  — so much so that benzodiazepines, strong GABA activators, have become the most common drug for treating anxiety.[ref url=”https://books.google.com/books?id=EZlsCgAAQBAJ&pg=PA195″]

But if you’re feeling anxious or tense, you don’t want to rely on a benzodiazepine like Xanax or Valium to relax. Because they’re so strong, benzodiazepines are very addictive, and you build tolerance to them quickly.[ref url=”https://link.springer.com/article/10.2165%2F0023210-200923010-00002″] There are a lot of sustainable options that have similar relaxing effects without the risk of abuse,[ref url=”https://www.ncbi.nlm.nih.gov/pubmed/29168225″] including lifestyle changes that don’t require you to take anything. Keep reading for a full list

Self-care tools, like the Baloo Living Weighted Blankets, are a great combination with GABA to ease your anxiety and sleep better altogether.

Note: this article should not replace medical advice. If you’re currently on benzodiazepines or any other anti-anxiety medication, absolutely talk to your doctor before making any changes.

GABA for sleep

gaba for sleepGABAA activation can help you fall asleep and stay asleep. But, as with anxiety, there’s a sweet spot with GABA and sleep. Too little GABA and you won’t fall asleep at all;[ref url=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353037/”] too much GABA and you’ll go out like a light, but you won’t reach the deeper stages of sleep that are essential for rest and recovery. Benzodiazepines, for example, cause people to fall asleep faster and wake up less, but keep them from reaching deep sleep.[ref url=”https://www.ncbi.nlm.nih.gov/pubmed/11983310″]

Again, the key here is gentle GABA activation. Finding a balance will help you get a good night’s rest.

GABA for depression and mood

gaba for depressionGABA activation also improves mood, although it seems to be indirect and likely comes from easing anxiety and stress.[ref url=”https://www.ncbi.nlm.nih.gov/pubmed/17117412GABA”]  doesn’t seem to affect pure depression.[ref url=”https://www.sciencedirect.com/science/article/pii/0165032790900438″] In other words, if you’re feeling down but you aren’t anxious or stressed, GABA may not help you.

Of course, depression, stress, and anxiety often go hand-in-hand, so GABA indirectly improves mood for a lot of people, and doctors often prescribe GABA-enhancing drugs alongside antidepressants.

If you’re feeling blue and stress or anxiety is a part of it, boosting GABA may help lift your mood and bring a little more relaxed happiness to your life.

The best GABA supplements, dosages, and side effects

Here are a few good ways to increase your GABA with natural remedies and supplements:

Kava

gaba and kavaKava is a root native to the Pacific Islands that contains GABA-activating compounds called kavalactones.[ref url=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917254/”] A Cochrane Review (the gold standard for research reviews) found that kava significantly decreases anxiety with mild-to-no side effects.https://www.ncbi.nlm.nih.gov/pubmed/12535473 Two other studies found that kava is comparable to benzodiazepines at relieving anxiety, without the side effects or risk of addiction.[ref url=”https://www.thieme-connect.de/DOI/DOI?10.1055/s-2007-979474″][ref url=”https://www.ncbi.nlm.nih.gov/pubmed/23635869″]  Kava activates GABAA receptors, which makes it great for sleep,[ref url=”https://www.thieme-connect.com/DOI/DOI?10.1055/s-2001-14334″] and kava tea is a good alternative to alcohol if you want to loosen up without the hangover and damage that drinking incurs.

Kava dose and source: Here’s a guide to kava dosage and the best kava sources.

Magnesium

gaba and magnesiumMagnesium is an amazing supplement for stress and sleep. It’s an essential mineral that regulates GABA activation across most of your brain.[ref url=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452159/”] It’s also involved in hundreds of other biological processes, and more than half of Americans are deficient in it. Magnesium is a good supplement to take every night.[ref url=”https://www.ars.usda.gov/ARSUserFiles/80400530/pdf/0506/usual_nutrient_intake_vitD_ca_phos_mg_2005-06.pdf”]

Magnesium dose: 400 mg, an hour before bed

Magnesium source: Magnesium citrate or magnesium glycinate. Citrate is more bioavailable, but it may upset your stomach; glycinate is slightly less bioavailable and won’t upset your stomach.

Ashwagandha

gaba and ashwagandhaAshwagandha’s name is Sanskrit for “smell of horse,” and if you’ve ever tried this Indian herb, you can likely attest that the name is accurate. You’ll want to get ashwagandha in capsule form to avoid the smell and taste. As long as you do that, ashwagandha is a great way to relieve stress and promote sleep. It’s a gentle GABAA receptor activator.[ref url=”https://www.ncbi.nlm.nih.gov/pubmed/26068424″]

Ashwagandha dose: 500-1000 mg, taken anytime

Ashwagandha source: Zen Mode or pure ashwagandha root

L-theanine

l-theanine and gabaThis amino acid is a natural component of green tea and is also available in supplement form. L-theanine increases your brain’s natural GABA production.[ref url=”https://www.ncbi.nlm.nih.gov/pubmed/17182482″] It’s great for easing stress and boosting mood, and it also becomes a nootropic (aka cognitive enhancer) when you pair it with caffeine.[ref url=”https://www.ncbi.nlm.nih.gov/pubmed/18006208″]

L-theanine dose: 200-400 mg

L-theanine source: Zen Mode, green tea, or L-theanine capsules

Phenibut

phenibut and gabaPhenibut is a strong GABAB activator that Soviet Union scientists developed for their space program, to ease astronauts’ anxiety. Phenibut is a more bioavailable form of pure GABA, which makes it especially powerful. It also improves focus and memory,[ref url=”https://www.ncbi.nlm.nih.gov/pubmed/11830761″] and is a prescription drug in Russia for tension and anxiety. Phenibut is technically legal in the U.S. (it’s in a bit of a gray area), but it has a high risk of dependency and withdrawal if you don’t take it carefully.[ref url=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952553/”][ref url=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3604470/”] Phenibut stays in your system for about 48 hours, and people who assume they can take it daily often experience tolerance and withdrawal within a week or two. If you’re going to try phenibut, take it at most twice a week, with at least 3 days between each dose.

Phenibut dose: 600 mg, at most twice a week

How to raise your GABA naturally

how to increase gaba naturallyYou can also raise GABA without supplements or drugs. Stress-relieving lifestyle habits increase GABA as well. A few good options to boost your GABA:

  • Meditation: Sitting in silent reflection increases brain GABA levels,[ref url=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769029/”] as well as sensitivity to GABA signaling.[ref url=”https://www.ncbi.nlm.nih.gov/pubmed/10859661″] Don’t know where to start? Check out this beginner’s guide to meditation.
  • Yoga: The world’s favorite stretching and mindfulness exercise also increases GABA signaling.[ref url=”https://www.ncbi.nlm.nih.gov/pubmed/10859661″]
  • Exercise: In fact, exercise in general increases GABA signaling and relieves anxiety, stress, and depression.[ref url=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554572/”] Try one of these great workouts to include in your daily life.

Whether you take a supplement or start meditating (or both), your brain will thank you for bringing your GABA levels into balance.

Dr. Ozone: Frank Shallenberger’s 40 years Using Medical Ozone to Fix Everything #524

The guest on this episode of Bulletproof Radio is a doctor who was referenced heavily in Headstrong, my book about cognitive function and mitochondrial hacking. His name is Dr. Frank Shallenberger (or Dr. Ozone) and he has been practicing as a physician for more than four decades in both conventional and alternative medicine.

He started as a western doctor, earlier in his career but then he decided that he wanted to know more about health than what happens in a hospital. He decided this after he realized that the human body is a self-healing mechanism and that it is our lifestyle, belief system, bad exercise, and toxins that cause it to break.

Dr. Shallenberger is one of the guys who has revolutionized the practice of anti-aging and preventative medicine since the very early days of those fields. He has also patented a method to measure mitochondrial function, metabolism, oxygen utilization and in this episode, we talk about that method, his most recent book, Bursting With Energy, and much more.

Enjoy the show!
Listen on Apple Podcasts or iTunesListen on Google Podcasts

Follow Along with the Transcript

Dr. Ozone: Frank Shallenberger’s 40 years Using Medical Ozone to Fix Everything #524

Links/Resources

Website: antiagingmedicine.com
Website: Foundation for Alternative and Integrative Medicine
Book: The Ozone Miracle
Book: Bursting with Energy
Book: The Type 2 Diabetes Breakthrough

Show Notes

    • Ozone is good for almost any medical case you see 00:04:30
    • What is ozone and how does it work? 00:06:35
    • Why Free Radicals aren’t all bad (just some of them) 00:08:45
    • Dave’s experience with Ozone therapy 00:09:30
    • A procedure called Ten Pass Ozone 00:14:30
    • Other ways to use Ozone 00:15:50
    • The real problem with antibiotics 00:21:20
    • How Dave treated a sty in his eye with ozone 00:22:40
    • Can you do Ozone treatments at home? 00:26:15
    • What happens if you breathe ozone gas? (Don’t do it!) 00:27:10
    • NAD to NADH Ratio 00:32:00
    • What poisons the mitochondria? 00:35:15
    • The way you can test your mitochondria 00:38:35
    • How Ketosis effects mitochondria 00:42:05
    • How Coffee and/or Caffeine effect mitochondria 00:45:15
    • How much does the average person need to worry about this? 00:47:00
    • When is the last time you heard of someone dying from nothing? 00:51:40

Go check out “Headstrong” and “The Bulletproof Diet” on Amazon and leave a review!

If you like today’s episode, check us out on Apple Podcasts at Bulletproof.com/iTunes and leave us a 5-star, positive review.

The Bulletproof Exercise Roadmap Free Download

[tldr]

  • One of the biggest mistakes people make when they want to lose weight is thinking that long, exhausting workout sessions torch calories and in turn burns fat.
  • Excessive exercise can actually work against you, putting excessive stress on the body and making you gain weight.
  • Exercise doesn’t burn as many calories as people estimate. And because most people reward themselves for a workout, they end up eating more calories than they burned.
  • You have to exercise for your body, brain, and to prevent disease.
  • So, how much is too much? What kinds of exercise backfire and prevent weight loss?
  • Download the free one-page guide to the best kinds of exercise for optimal physical and mental fitness.

[/tldr]

[Download The Bulletproof Exercise Roadmap]

When I weighed 300lbs, losing weight was my single biggest focus every day in the gym and at meals. I spent at least 20 hours a week trying to lose weight for years. It was a complete waste of time.

Thanks to a lot of self-experimentation and working with world-class experts, I don’t have to spend much time on my physique to stay lean and muscular. All I need is 10 minutes, twice a week to maintain muscle and keep my body fat down.

I wasn’t alone. One of the biggest mistakes people make when they want to lose weight is thinking that long workout sessions burn calories and in turn burns fat. That line of thinking can work against you, actually making you gain weight.

Reason being, exercise stresses your body. In moderate amounts, that’s a good thing. Just enough of the right types of exercise stresses your body enough to wake up your cells, increase brain-derived neurotrophic factor (BDNF),[ref url=”http://www.sciencedirect.com/science/article/pii/S2095254614001161″][ref url=”https://www.ncbi.nlm.nih.gov/pubmed/27385735″] boost your mitochondria (your cells’ battery packs)[ref url=”http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1540458/”] and build muscle, even as you age.[ref url=”https://jamanetwork.com/journals/jama/article-abstract/382128″]

On the other hand, too much exercise over-stresses your body and causes an increase in cortisol (stress hormone) levels in your bloodstream,[ref url=”https://www.psyneuen-journal.com/article/0306-4530(89)90032-2/abstract”][ref url=”https://www.sciencedirect.com/science/article/pii/S030645301100271X”] which over the long-term causes a cascade of reactions in your body. Too much cortisol from any stressor, including exercise, causes you to gain weight[ref url=”https://academic.oup.com/jcem/article/88/10/4924/2845829″] and lose muscle, throws your hormones out of whack, and makes you more likely to quit early in the game.

That’s not to say the only form of exercise you should do is channel surfing. Moving helps pump blood to your brain and nervous system, and it keeps your lymph flowing to help detoxify your body.

So, how much exercise is too much? What kinds of exercise backfire and prevent weight loss? To help you navigate all this, download the free one-page guide to the best kinds of exercise for optimal physical and mental fitness.

What counts as exercise

The Bulletproof Exercise Roadmap_hiking_what counts as exercise

When you use exercise as a means to achieve a lean and more resilient body, keep in mind, exercise must be:

  • Brief
  • Intense
  • Infrequent
  • Safe
  • Purposeful

If your activity does not check off all five of these, you’re not exercising to maximize your physical and mental fitness. Even exercises that challenge your strength and endurance, like ultramarathons, don’t qualify because they don’t improve the way your body works overall — the intensity causes harm over the long run.

For the most part, your workouts should look like play, with a brief rigorous workout once a week to get the muscular benefits people look for when they workout every day. To keep your functional movement abilities in tip-top shape, you want to incorporate strength, cardiovascular, flexibility, and balance exercises into your rotation.

If you want to know what exercises give you the most bang for your buck, which ones aren’t worth your time, and how often you should be active in order to max out your physical and mental performance, download the easy-to-follow Bulletproof Exercise Roadmap.

With so many different types of physical activity you can do, you can get overwhelmed trying to figure out which ones fit into your life, let alone which ones do more harm than good.

If you’ve been around Bulletproof for a while, you know that I love shortcuts. Grab your copy of the Bulletproof Exercise Roadmap to help you lock down your favorite way to move.

Start hacking your way to better than standard performance and results.

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