5 Anti-aging Secrets for Your Mitochondria

5 Anti-aging Secrets for Your Mitochondria

While wrinkles and a sagging belly might be among the wince-inducing initial signs, aging actually begins in your cells. Mitochondria are the power plants within your cells that are ground zero for energy production.

Often called the “powerhouse of the cell,” mitochondria produce energy as adenosine triphosphate (ATP) that your body then uses to fuel your day-to-day activities. Mitochondria dictate how you feel all the time. They’re the bedrock of a strong body and a powerful mind.

 

Get the two-week plan on how to strengthen your mitochondria and boost brain performance in your copy of Head Strong.

 

Some cells have more mitochondria than others. Your brain cells are teeming with these little guys. Ditto your heart. Muscle cells have a pretty massive mitochondrial crew.

You want tons of these guys working at full capacity and cranking out constant energy. Stronger mitochondria make for stronger brains and stronger bodies. So does consistency: mitochondrial biogenesis, or creating new mitochondria, becomes crucial for vibrant aging, optimal energy production, and protection against oxidative stress.

The opposite – mitochondrial dysfunction – spells disaster for your energy levels, contributing to numerous problems including cardiovascular disease and obesity. [1]

Unfortunately, the enormous amount of energy your mitochondria produce makes them susceptible to free radical damage and decay as you age. This means that your mitochondria become weaker and decline in number as you age. Ultimately, all the things we associate with aging – fatigue, excess fat, and a decrease in muscle mass and cognitive ability – are all symptoms of weakening mitochondria.

[Tweet “Strong body and powerful mind? It starts with your cells. #mitochondria #Bulletproof”]

But if you’re familiar with Bulletproof, you know that we don’t stand for weight gain or low energy. Mitochondrial glitches are not inevitable. Here are five ways you can support your mitochondria (even grow new ones!) for greater vitality and a more vigorous life. 

 

5 Ways to Upgrade Your Mitochondria

In the past, researchers and doctors have relied on things like chronic calorie restriction (CR) to convince your body to create more mitochondria. [2] That works, but it takes a great deal of willpower. These five hacks are much easier than starving yourself.

  1) Curb inflammation

Inflammation plays a key role in aging, damaging mitochondria and increasing mitochondrial dysfunction. [3] Ways to dial down inflammation include Bulletproof Protein fasting, exercising, taking a quality krill oil supplement, and following the Bulletproof Diet, where you replace inflammatory foods like grains, dairy, and omega-6 oils with anti-inflammatory , nutrient-rich fats, meats, and vegetables.

  2) Get good sleep

Studies show crappy sleep and sleep disorders play a key role in mitochondrial dysfunction. [4] In 2012, researchers identified the glymphatic system, which uses the cells’ mitochondria to remove cellular waste from the brain, particularly while you sleep. [5] In other words, as you sleep, the cells in your brain use their mitochondria to remove cellular waste. Join our 14-Day Free Sleep Challenge to hack your sleep

3) Boost your brain fuel

Brain Octane turns into ketones within minutes, providing abundant fuel for your mitochondria. Ketones boost your metabolism, increase fat burning, curb hunger, and sharpen your focus. They make your mitochondria more efficient at producing energy. 

4) HIIT it

Among its gazillion benefits, moving your body improves mitochondrial function and helps your brain perform better. [6] Walking has its merits, but the real advantages come from stepping it up a notch. Try high-intensity interval training (HIIT) to work out your mitochondria. One study found just two weeks of HIIT “significantly increased mitochondrial function in skeletal muscle.” [7]

5) Try Unfair Advantage

The best supplement to crank up your mitochondria is a unique active form of pyrroloquinoline quinone (PQQ), the cousin of the popular supplement CoQ10. Adding ActivePQQ, the activated form of PQQ, can make you feel like you’re flipping on a switch of clean-burning energy. Bulletproof takes it a step further by packaging ActivePQQ in a colloidal delivery system along with CoQ10, to enhance bioavailability and absorption. The result is Unfair Advantage, a powerful way to support your mitochondria.  

Have you hacked your mitochondria to increase your energy? Any tips or tricks? Share them below. Thanks for reading and have a great week. 

 

[expand title=”Click to read the complete list of references.” swaptitle=”Click to hide references.”]

[1]  http://www.ncbi.nlm.nih.gov/pubmed/18662766

[2] http://www.ncbi.nlm.nih.gov/pubmed/18662766

[3] http://www.ncbi.nlm.nih.gov/pubmed/25684584

[4] http://www.ncbi.nlm.nih.gov/pubmed/25325607

[5]http://www.alzforum.org/news/research-news/brain-drain-glymphatic-pathway-clears-av-requires-water-channel

[7] http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1540458/

[8] http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338748/

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Mind, Buddha, Spirit with Dan Harris – #343

Why you should listen –

Dan Harris is the author of the #1 New York Times Bestseller 10% Happier: How I Tamed the Voice in My Head, Reduced Stress Without Losing My Edge, and Found Self-Help That Actually Works—A True Story. He’s is the co-creator of the 10% Happier: Meditation for Fidgety Skeptics app and the host of the podcast 10% Happier with Dan Harris. Dan is also a co-anchor for ABC News’ Nightline and for the weekend edition of Good Morning America. On this episode of Bulletproof Radio, Dan and Dave talk about meditation and mindfulness, Buddhism, spirituality and religion, breathing exercises, podcasting and more. Enjoy the show!

Bulletproof Executive Radio at the iTunes, App Store, iBookstore, and Mac App Store

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Dave Asprey: A quick question for all you hard working entrepreneurs putting in the hours while summer beckons. Has dealing with your day-to-day paperwork ever brought about feelings that resemble anything close to joy, satisfaction, or ease? I didn’t think so. If you are ready for that to change my friends at Fresh Books are inviting you to try the ridiculously easy cloud accounting software that’s a total joy to use. Yes. I just used the words easy, joy, and accounting in the same sentence.

 

Using FreshBooks it takes literally about 30 seconds to create and send a polished, professional looking invoice. You can link your Fresh Books account to your credit and debit card, so next time you expense that business lunch or tank of gas, it will show up automatically in your Fresh Books account. With 2 clicks Fresh Books can set you up to receive payments online which can seriously improve how quickly you get paid. To see all the ways Fresh Books can bring the joy by changing the way you feel about your paperwork, they’re offering all Bulletproof Radio listeners an unrestricted 30 day free trial. To claim it just go to FreshBooks.com/Bulletproof and enter Bulletproof Radio in the, ‘How did you hear about us?’ Section. That’s FreshBooks.com/Bulletproof and enter Bulletproof Radio.

 

Female Voiceove:       Bulletproof Radio. A state of high performance.

 

Dave Asprey: You’re listening to Bulletproof Radio with Dave Asprey. Today’s cool fact of the day is that meditation has amazing psychological benefits. Things like stress reduction and brain wave coherence. But you probably knew that. But what you probably didn’t know is that studies also show that one of the physiological benefits is meditation can improve your sex life because it increases your libido, and it does it by boosting the sex hormone called DHEA, which is a precursor to things like testosterone that increase libido. Also that means you’ll get better sex if you sit there and meditate. You wouldn’t expect this, but it’s true. I am living evidence of this. At least I like to think I am. Before we get into the show today …

 

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Dave Asprey: I am wearing one of the many Bulletproof t-shirts today. Check out the t-shirt shop on Bulletproof.com. Whether it’s coffee or butter that makes you happy, you can tell the world what it is. The shirt I’m wearing is actually a picture of the caffeine molecule and it says, “Caffeine: My drug of choice”. This is a replica, but better designed, than the very first t-shirt ever sold over the internet. In fact, it was the very first anything sold over the internet because way back in the early 90s, the first e-commerce on the planet was apparently out of my dorm room selling a t-shirt that said exactly these words. “I designed it in Corel Draw. If you remember that, you’re at least 40.

 

All right. Today’s guest is Dan Harris. Dan is an Emmy award winning co-anchor of Night Line and the weekend edition of Good Morning America. He is regularly on 20/20, World News Tonight with David Mirror, Good Morning America ABC Digital News and Radio, pretty much all over the place if you watch TV. Which most of us do. He’s also had an amazing story where he goes and he covers some of the most incredible things. Things like natural disasters in Haiti, New Orleans; combat in Afghanistan, Israel, Gaza, the West Bank. He’s been to Iraq 6 times, and he’s on the show because he just wrote The New York Times best selling book, ‘Ten Percent Happier: How I Tamed the Voice in My Head, Reduced Stress Without Losing my Edge, and Found Self Help That Actually Works’. He’s even got an app designed to teach meditation to skeptics which Dan, makes me laugh like crazy. Welcome to the show.

 

Dan Harris:    Thanks for having me. I don’t know if you remember, but I did a story about you.

 

Dave Asprey: That is true. You did.

 

Dan Harris:    I did a story about you, and I think it was pro vigil.

 

Dave Asprey: That was actually one of the very, very first national news things about Modafinil that I’ve ever seen. In fact I remember sitting in my backyard with you. We were meditating while they were filming, and my dog came up and sat on your feet if memory serves.

 

Dan Harris:    I remember all of that except for the dog, but I like the dog part.

 

Dave Asprey: It was, I’m pretty sure he did. He likes to come and sit on your feet while you meditate. It’s a strange thing, but it’s a Dachshund thing. It’s kind of funny. That was about 4 or 5 years ago I’d say. You’ve tamed the voice in your head since then. I think you were already working on it back then. At least you seemed like you knew how to meditate. Why did you decide to write the book?

 

Dan Harris:    There’s the long story, the medium story, the short story. I’ll try to pack it in to the medium. I think the inciting event for me really was that I had a panic attack on national television back in 2004 on Good Morning America. I was reading the news headlines. I was the guy who comes on at the top of the hour and reads the headlines. I just, my heart started racing, my lungs seized up, my mouth dried up, my palms were sweating. I couldn’t deal, and I couldn’t breathe. I had to quit in the middle of my little news cast and toss it back to the main anchors of the show, Diane Sawyer and Charlie Gibson. That was embarrassing, but even more embarrassing was the back story.

 

I had, as you mentioned, I spent a lot of time in Iraq and other war zones as an ambitious young reporter. After 9/11 I was in Afghanistan, and Israel, and The West Bank, and Gaza. I got depressed after doing that, and did a very stupid thing which is I started to self medicate with recreational drugs like cocaine and ecstasy. After I had the panic attack I went to a doctor who was trying to get to the bottom of the problem and he asked me whether I did drugs, and I said, “Yeah.” He pointed out that that was what caused the panic attack. It artificially raised the level of adrenaline in my brain and primed me to freak out. That kind of set me off on this long journey of trying to be less of an idiot. This is where I’m going to shorten, truncate things very dramatically.

 

It ultimately led me to meditation which I always thought was very, was totally ridiculous. Meant only for hippies, and freaks, and people who live in Yurts and wear little finger symbols, and are really into Cat Stevens, and crystals, and things like that. I wasn’t entirely wrong about that, but I was wrong enough as I learned. I started discovering the science around meditation. That really changed my mind.

 

Why I decided to write the book was that I realized that there was at that time, this was around 2008, 2009, there was a lot of really interesting science, and there were a lot of really interesting people who were starting to get into meditation, but there weren’t a lot of books that were designed for skeptics. A lot of the books had a background of pan flute music, or it felt like they did. Or it felt like you were being addressed as grasshopper. I wanted to write a book that had irony, and I share a lot of really embarrassing things about myself. I swear a lot, and I thought that would be maybe, I had an entrepreneurial itch, so that’s why I did it.

 

Dave Asprey: It’s funny because I come from Silicon Valley. My grandmother met my grandfather on The Manhattan Project and she still subscribes to this day, she’s 94, to The Skeptical Enquirer, which is like the original troll magazine like from the 1960s. If I mention meditation to her, she’s kind of like, “Meh. Why would you do such a thing?” But there is some science behind it so kudos to figuring out how to talk to a group of people who can probably benefit from it.

 

I look at this, there’s a group of people who think the glass is half full, and they’ve probably got pan flutes going. There’s a group of people who think it’s half empty, and they’re the angry skeptics. Then there’s well there’s a glass and it’s got stuff in it. You could think about it. There just isn’t a big perspective on it. It’s okay. Whatever. It seems like walking that middle is the most functional place to be. Would you agree with that given your path? Or are you one of those that’s you should be in one direction versus the other?

 

Dan Harris:    No, I think I agree with that. I was really trying to find a way to speak to everybody, including the people. The glass half empty people. Or your grandmother. Or frankly, my mom. My mom is a scientist, who when I was like 8, sat me down and explained that not only is there no Santa Claus, but there is also no God. This is the type of house that I grew up in. I too, am a diet in the wall skeptic, but there’s a difference between being skeptical and being cynical. Blinded by cynicism. I think that’s where I was. Especially as it pertained to meditation.

 

Once you see the science, let me just say a few words about it, it’s really in its early stages, and in danger at times of being hyped. But what I think we can say with real certainty is that the explosion of scientific research into meditation strongly suggests a long list of tantalizing health benefits, like lowering your blood pressure, boosting your immune system. Literally rewiring key parts of your brain that have to do with focus, and stress, and emotional activity, and compassion. I don’t care how skeptical you are, once you hear this, it starts to, you start to get intrigued. I think there’s a pretty good analogy to be made to physical exercise. Even if you’re a skeptic, I think most people embrace physical exercise, know that physical exercise is good for you, whether you do it or not. That’s where I think we’re heading with meditation.

 

Dave Asprey: Great analogy. It seems like there’s been a shift. I’ve been interested in meditation for the performance benefits for a very long time. I put it on my Linked In profile, at least 15 years ago. I put meditation and yoga at the end of the interests. In Silicon Valley that was kind of like people would look at you weird if they noticed it. It was like maybe 1 in 10 were like, “Yeah. I actually do something like that too,” but most people, it was sort of like an admission of weakness. Has that changed? Do you think public perception has shifted?

 

Dan Harris:    Yeah. I think it is shifting, but I can see how it would be seen as an admission of weakness. Just the way saying you go to a therapist would be seen as an admission of weakness.

 

Dave Asprey: Yeah.

 

Dan Harris:    Or probably was 15 years ago. Less so now. But we’re in an era where Kobe Bryant, Michael Jordan, The New York Knicks, Novak Djokovic, 50 Cent, the lead singer of Weezer, Lina Dunham, Google, Twitter, Etna, George Stephanopoulos, Robin Roberts, Katie Perry, all of these founders of Twitter, you, all of these people that are aspirational figures who are, and are tough people, the US Marines, and the US Army, are all meditating, so I think it’s hard to see it as a sign of weakness when you look at the crew of people who are now doing this. I think perceptions are shifting. I think that’s really great because I think this is the next big public health revolution.

 

I’m excited about it not only because I think it will improve health overall, but also unlike past health revolutions like oral hygiene, which really happened after World War 2 as far as I understand, you know when the troops were told that they need to brush their teeth, oral hygiene or physical exercise which really started to happen in the last century too, those had health benefits, but they didn’t really result in widespread behavioral change. I think meditation, I think if the current percentage of the population that currently engages in physical exercise starts to engage in mental exercise, think about the impact on bullying, on education, on parenting, on marriage, on politics, on journalism, on road rage. All of these aspects of our life. I think that’s very exciting.

 

Dave Asprey: It’s one of those things where people could be nicer to each other, 10% nicer comes from being 10% happier. Right? It’s one of the reasons I talk about it really openly is that I was also very skeptical. Also, I was, I think the technical word is, I was pretty much an asshole a lot of the time. It wasn’t on purpose though, it was just like a lack of understanding, and probably a lack of training of the brain. I spent extensive amounts of time and money, 10 weeks with electrodes on my head to let me meditate better with feedback, and things like that. That’s one of the things behind Bulletproof is like look. If you’re not hungry all the time. If you don’t have blood sugar crashes. If your brain is a little bit better organized you’re less likely to flip off the guy in front of you in traffic. That triples when you do things like that.

 

Dan Harris:    That is exactly right. Especially for beginning meditator and I would count myself sort of in the beginning. The benefit is that you are less yanked around by your emotions. Most guys don’t like talking about emotions, and I don’t either, but you have them. Or as my friend Chris Cuomo, who is a news anchor on CNN says that he shifts gears between his 2 primary emotions which are rage and self pity. When you are unaware of these emotions, when you are unaware of the non stop conversation you are having with yourself it yanks you around, and that is why you do stupid shit, like lose your temper when it’s strategically unwise in a professional context, or say the thing that ruins the next 48 hours of your marriage, or eat the 18th cookie, or whatever it is.

 

All the stuff that you don’t want to be doing is because you are unaware of the voice in your head and are therefore yanked around by it. Meditation is just the building of an internal telescope that allows you to see what the activity of your mind so that it doesn’t yank you around. Now there are a lot of other things that meditation can do, but I think for beginners that’s the right way to think about it. It’s not complicated. It’s not mystical. It does not involve believing in anything, joining a group, wearing special outfits, sitting in a funny position. It’s actually very simple. My sort of raison d’etre, my function on the planet now is to say this as clearly as possible, as loudly as possible, in as many places as possible, so that people start to see this as an option that is viable for them.

 

Dave Asprey: If you could have told me 20 years ago that I could turn off the voice in my head, I would have given anything to do it because it was kind of a mean son of a bitch, right. I have done that. Like I don’t actually have a voice in my head anymore. After a lot of meditation, and breathing, and also some of the computer driven stuff that I do. People have a hard time believing it, but it’s possible. There isn’t something, like the harsh critic, all that stuff that was really a core part of the anxiety that I used to have. It just goes away. But I think the vast majority of people, when you say that, even that the voice in their head can go away, they also experience some fear from that. Did you go through that as your, okay I want to get in charge of this voice in my head, but if I’m in charge then I’m responsible. Did you have like a reflexive, what if it’s not safe kind of moment?

 

Dan Harris:    Well I have a bunch of things to say about that. I think it’s totally intriguing that you feel like the voice in your head has gone away. That is definitely not the case for me. I retain the capacity to be a schmuck, so that’s why I like the whole 10% thing because it is my way of counter programming against the reckless over promising that you see in the self help industry generally. By which I’m not referring to you, I’m just referring to the sort of, the power of positive thinking people.

 

Dave Asprey: You haven’t levitated yet either?

 

Dan Harris:    No. I have not. But I did have concerns about meditation because I thought it would make me lose my edge. I thought that this internal son of a bitch was the reason for any success I had enjoyed in my life. I think a lot of people have these feelings, and this is one of the main things I am working on over the course of the book. The thing I am kind of struggling with, and what I’ve come to is that it’s okay to have stress. It’s okay to worry. It’s okay to criticize yourself. It’s that we tend to make our suffering worse than it needs to be.

 

What meditation or mindfulness allows you to do is to draw the line between useful constructive anguish, and useless rumination. If you are going to try to be great at anything yeah, there is going to be some mental churn and anguish at times. Some worries. Some plotting. Some planning. Some strategizing. Some stress, but you know, on the 17th time that you’re pulling out all of the awful ramifications of some business problem that has arisen, maybe ask yourself, this is something my meditation teacher counsels, maybe ask yourself a very simple question. Is this useful? That is mindfulness in action. Your ability to do that is vastly improved through learning the simple exercise of meditation.

 

Dave Asprey: In your book you write about how Peter Jennings told you to cover faith in America. You just said you don’t have to wear clothes. You don’t have to belong to an organization. Those are usually aspects of faith. How did covering the evangelical movement in America effect your perspective on meditation?

 

Dan Harris:    That happened. Peter pulled me aside and said that he wanted me to start covering faith and spirituality for ABC News. That happened way before I started meditating or even thought it was an option. I didn’t want to do it. I was like, “Dude, don’t make me do this.” I was raised in the People’s Republic of Massachusetts. As I said, both of my parents are scientists. I don’t know. I said my mother is a scientist, but both of my parents are scientists. My wife is a scientist. I did have a Bar Mitzvah, but only for the money. I was not at all spiritually inclined, but it was very useful for me covering religion for a couple of reasons.

 

1 is I realized how sort of reflexively, how ignorant I was about what faith actually is and the role it plays in people’s lives. I was kind of reflexively judgmental. 2, is I saw the value of having a world view that transcends your own narrow interests. There is an expression that we are always, when you’re never looking up, you’re always looking around. While I don’t believe, per se, or I am respectfully agnostic about the Jesus story for example.

 

Was he the son of God who rose from the dead? I haven’t seen any evidence of that, but none the less, people who are active believers have a time every Sunday morning at 11, they’re going to church and they’re thinking about things from a broader perspective. They’re thinking outside of their own narrow interests. That is really useful. That is what I took away from covering faith and spirituality even though I didn’t join a church or anything like that. But I just will say because the kind of meditation that I practice, and I believe this is true for you, but you can correct me if I’m wrong, is Buddhist meditation. Now I believe you spent some time in Tibet.

 

Dave Asprey: Yeah. Nepal and Tibet. I learned at a monastery there.

 

Dan Harris:    Yeah. I think actually in some ways the kind of the root of your whole coffee, part of the Tibet and coffee mixture.

 

Dave Asprey: The Tibetan yak butter tea. That’s right. That’s how Bulletproof Coffee came about.

 

Dan Harris:    Yes. I’m remembering some of my time with you. I think that Buddhism can be practiced as a religion with lots of deities, and prostration, and belief in metaphysical claims. It’s one of the only religions that I know of where the more fundamentalist you get, the less metaphysical you get. If you look at what the Buddha actually said, he was not talking that much. He was not making that many metaphysical claims. He did not claim to be a god. He had no explanation for the origins of the universe. He did talk about reincarnation and sort of minor deities and things like that, but he specifically said, “You can take or leave that stuff.” Really what he was doing was giving you an exercise regime for the mind. As has often been said, “Buddhism is not something to believe in. It’s something to do.” In that spirit I have become a Buddhist, although I would also call myself an atheist.

 

Dave Asprey: That is actually a really powerful way of expressing it. I use the Buddhist attempts to explain feelings in the body all the time when I’m meditating, or doing the things that I do. I think that it’s very hard for me to say, “Well, okay. In order to let go of whatever that emotion is that would make me act like a total jerk, step 1 is open the heart, and step 2 is envision a purple field.” There aren’t words to express a physical manifestation of an emotion in the body, so I think a lot of the Buddhist writings are, “Envision the Buddha sitting on a 42 petal lotus.”

 

It’s their idea of trying to create the feeling in your mind of it because it’s very hard to communicate between 2 people. Even 2 people who meditate. “You know that one thing you do when you do that one thing?” There’s just no language for it. Thousands of years of trying and writing all sorts of rolled up manuscripts, they still are struggling with that as far as I could tell, but there is something about paying attention to those feelings, and then learning to take them from one place to another. I found that I was okay with breathing exercises that were more Hindu based, like Art of Living stuff.

 

Which I did with a lot of entrepreneurs in Silicon Valley for 5 years, but then I really connected when I was doing the Buddhist thing with computers telling me when my brain was doing it right. It was like rubber bumpers for meditation for me was when I found like, oh. Now that one feeling that I was trying to get to that I didn’t know I was trying to get to. I got there. It was the number 7 on the screen kind of thing. That I believe is the future of meditation. Have you done any of that kind of stuff? Heart rate variability and any of the feedback based meditations?

 

Dan Harris:    I have a friend named Judd Brewer who is a really interesting guy. You might want to take a look at him. He’s got a book coming out in the next couple of months. I don’t remember the title, but Dr. Juddson Brewer. Formerly of Yale. Now the head of research at the University of Massachusetts Center for Mindfulness.

 

Dave Asprey: Oh cool. I would love to meet him.

 

Dan Harris:    He is a great guy. He is a friend and he is a neuroscientist, one of the top neuroscientists. There’s this whole cadre of neuroscientists who have been looking at the effect that meditation has on the brain. What Judd has been working on is, first he did it in FMRIs, but those are hard. Those are very expensive. Those are the big tubes you get into, and they look at blood flow in the brain. Then he moved to something less expensive involving EEG, so sort of electrodes on your head, which you had referenced before, which and that gives you, the meditator, real time feedback on what you are doing.

 

I had a rather embarrassing experience where I went and did it and it was saying that I was meditating incorrectly. It was basically saying that I was a shitty meditator. It was really embarrassing, and frustrating, and demoralizing. That night, the day I had that experience with Judd in his rig, his EEG rig, I went to dinner with both Judd and a guy named Joseph Goldstein who is my meditation teacher, and Judd’s meditation teacher. We’re at dinner and I say to Joseph Mann, “Look I did this thing. I was in Judd’s EEG machine. It told me I was meditating incorrectly.” Joseph said, “It said the same thing to me.”

 

What I have taken that to mean is that meditation is so, we know so little about the mind, and the brain, and the interconnection between the 2, and what’s happening when you meditate. What kind of meditation does what. That I am really intrigued with neuro-feedback, and getting people to meditate correctly, and stop wasting their time. I just have some fundamental questions about how doable it is. But I suspect you have more fully formed opinions than I do.

 

Dave Asprey: I have been doing it, well 10 weeks of my life I’ve had electrodes on. I opened a neuro-feedback institute earlier this year. I’ve been before that working with a variety of partners on making it happen, but it’s very different than most of the like, “Let’s look at this.” It’s all directed by you. Brock will you hand me my spider hat thing? In fact, I’m so convinced on this, and we won’t spend the rest of the show talking about this. I’ll just mention it. This is like a clinical grade, 24 channel thing. Let me see if I can hold it up so you can see it better.

 

Dan Harris:    Yeah. I can see it.

 

Dave Asprey: Every one of the people who works at Bulletproof gets access to neuro-feedback as part of our employee performance management because it makes them happier. All of my direct reports get the 5 day intensive, it’s basically 10 hours a day of focused work with neuro-feedback like this and a couple of other systems in order to give your brain the 2 aspects of Buddhist meditation that we know about, which is higher alpha and higher level of synchrony. It’s completely, that’s why the voice in my head behaves itself in the best possible way.

 

It’s one of those things where there’s so much that you read about, and there’s so much opportunity right now in neuro-feedback. There’s $300 devices and all these things. I am not convinced that we know enough to say, “This is the perfect optimal state,” but I think there are clusters of people who have been studying, mostly meditators, or people who just naturally are profoundly happy, or just have other unusual skills. Or they have pockets of information, but we haven’t shared it all with all the neuroscientists.

 

Partly that’s because there has been a lot of look at pathology, and not a lot of look at why does this person have superpowers? Right. They can be in the middle of a tornado, and they’re like, “Isn’t that a beautiful tornado? Yeah I might die, but it’s a beautiful tornado.” There’s some kind of a thing that they’re doing in their brain that I want to learn. I don’t know that I’ve learned it all the way, but for me to have my own progress I thought it was important to have neuroscientists working directly with me who are very focused on that, so it’s been a big focus in the last year.

 

Dan Harris:    I agree. I think there is an enormous amount of potential. I am incredibly intrigued by the idea of neuro-feedback. I’d love to learn more about what you’re doing.

 

Dave Asprey: We can do that after the show. Yeah.

 

Dan Harris:    Sure. It’s just to my mind it seems tricky, but I think it will be done, and it will be huge. The other thing I was going to say about the, you were talking before about pathology.

 

Dave Asprey: Yeah.

 

Dan Harris:    The history of our understanding of the mind, a scientific understanding of the mind, the history of neuroscience, and psychology, and psychiatry has really been looking at disorder, dysfunction. We’re now moving into an ear where science is looking at well being. Positive mental states and how to cultivate those. The lesson here, whether you’re interested in neuroscience or not, the lesson for you as a human being, is that your mind is trainable. That is a huge headline and available to anybody. Things you don’t like about yourself, you can’t magically make them go away, but over time you can reduce the likelihood that you will be an asshole, or that you will be impatient, or that you will be cruel to yourself. All of these things you can work on through meditation. That is just enormous. I think the role for neuro-feedback in that is just Earth shatteringly interesting. I look forward to whatever comes.

 

Dave Asprey: I would love to have the opportunity to interview your neuroscientist friend as well as your meditation teacher if they would be up for that. Anyone who is exploring the mind, whether they are doing it by sitting in a cave looking at a wall for 20 years and looking at what happens. Will they look at the wall or are they doing it with every kind of medical sensor known to man? It’s all, the most important area of exploration that we have right now, there’s Mars, and then there’s inside our own heads. Otherwise we have done a lot of stuff. Do you see a role for meditation or any of the sort of self help side of things that you have investigated for kids in high school or younger? What is your take on that?

 

Dan Harris:    Yes. Yes. Yes. For sure. I think this is an incredibly promising area. We’re already starting to see a lot of work being done in schools. We’re seeing some studies of these students and the preliminary results from what I can tell are really promising. Both as it pertains to behavior in the classroom, and performance in the classroom. Academic performance, so focus, grades, and behavior. I don’t have all of my data at my fingertips, and I think it’s definitely in its germinal stages, but very, very promising. The tricky part is, and this is very tricky.

 

We are already seeing some push back because some parents, especially in areas where you have high levels of religiosity don’t like the idea of meditation being brought in because they believe correctly that it’s derived from eastern religions. It’s derived, depending on what kind of meditation you’re teaching, either from Hinduism or from Buddhism. They are correct about that, except for they are incorrect, in my view that the way that it’s currently being taught has some religious overtones.

 

I don’t think it does. I think it’s been stripped almost entirely of almost in every case of metaphysical claims in religious lingo, and is really just about these exercises for your brain. It is no more, meditation is no more mindfulness, which is the fruit of Buddhist meditation, is no more Buddhist than algebra which is an Arabic word, is a Muslim thing. It is a fundamental. It’s a law of the universe. It’s just something that happens to be described well by the Buddhist.

 

Dave Asprey: I was looking for that example and I came up with tobacco, which is a Native American sacrament or you smoke it everyday. It’s not a religious act anymore, but it once was.

 

Dan Harris:    Yes. Absolutely.

 

Dave Asprey: Were you bullied in high school?

 

Dan Harris:    A little bit. Yeah. Both directions. I was a little bit of a bully in elementary school. I remember my friend Larry and I got in trouble because we thought it was very funny in the winter to, all the little kids wore hats with pom poms on the top. We would grab the pom and throw it as far as we could in the air. We got in trouble for that. Then in junior high I got pretty badly bullied by this guy. This was like straight out of a movie. Mugsy Malone. His name was Mugsy Malone. I remember I was a bit of a wise as still. A bit of a wise ass. I remember telling, he was sort of making fun of me for being Jewish, although I’m only half Jewish. I explained to him that Jesus was a Jew. He Charlie-horsed me and I had to crawl to class crying. Mugsy Malone went on to be the secretary of education in Massachusetts.

 

Dave Asprey: Wow. Even with that name, that’s impressive.

 

Dan Harris:    His nickname was Mugsy. His name is Matthew. He grew up to be a really smart, nice man. Yes. I definitely was. I captured some bullying on both sides of the spectrum. Why do you ask?

 

Dave Asprey: I’m asking because I’ve experienced, a lot of people when they do meditation, a lot of the anxiety actually comes up from that. We were just talking about high school. It made me think of it. Because we get that programming early in life. If you just feel threatened by whatever bullying environment, you find years later that you’re replicating that, and then when you start a practice of mindfulness, you start realizing that I’m still defending myself against these absolutely stupid threats, because they aren’t threats anymore. Did that come up with you in your meditation practice? Or the sources of your anxiety? Or was it more kind of Iraq kind of stuff?

 

Dan Harris:    You know, so it is very common, and I think probably quite healthy as long it’s not too much, for your anxieties and maybe even some traumas to come up when you quiet the mind. When you stop, when you get off the hamster wheel, and you are just right there with whatever is happening in your mind, I think some of these things are going to surface. Interestingly for me, not a lot of that has happened. That could mean 1 of 2 things.

 

Either I am a terrible meditator. Which is entirely possible. Or that I have had a really charmed life. I was raised by 2 loving parents who are still together. I have a very happy marriage. A beautiful kid. An amazing career. I was born on third base. I’m aware of that and very grateful for it. I certainly get a lot of self criticism that comes up. A lot of self judgement, so some unpleasant stuff, but not a lot of Mahler music playing in the backdrop of my particular psyche. But I think it is ery, very common.

 

For the average meditator I would argue if that happens, as long as it’s not in the realm of psychopathology, like where you’re hearing voices that are telling you to do bad things. That’s okay. In fact, it can be a sign of progress. However I think you should, if this is happening and becoming worrisome to you, I think you should work with an experienced meditation teacher and/or a psychiatrist, or psychologist.

 

Dave Asprey: Very well put. I believe that if we teach meditation to younger kids, just for people listening, there is a large audience, I don’t mean a religious attempt at all. No candles. No white robes. None of that stuff. Just like hey, pay attention. The way I teach my kids. Take a deep breath in. Where is the emotion in your body? Just breathe out now. Are you feeling some emotions? Tell me about them. Draw me a picture of the emotions. Just paying attention to what they are instead of reacting to them shifts the framing.

 

I think if we teach kids that we would see less bullying, and less of the high school violence, and even middle school violence that we’re seeing now. When you get into that situation as a kid, your brain isn’t done. It’s a very young brain. It’s like training a puppy. Puppies, they still pee on the rug and they do whatever. Eventually they become either service dogs or they become like the dog that tears up the furniture, or the dog that bites all the other dogs.

 

My brain was probably closer to the dog that bites all the other dogs. Now it’s relatively service dog like. You nailed it exactly. The brain can be trained. I kind of do look at it like a dog. It’s an animal thing. It is an animal. It’s part of our meat. When you look at all of the things you have done, what has been the single most effective meditation for you Dan?

 

Dan Harris:    Let me just say first of all that I totally agree with you. Everything you said, I do think that it is, it could be very fruitful to teach to young people, and they obviously have it appears, the malleability although what modern neuroscience is showing is that the brain can change and is changing all the time. The question is are you going to be in control of those changes or are you going to let them happen willy nilly?

 

I wouldn’t say there’s one kind. People ask me all the time, “What meditation do you do?” It’s a little bit of a tricky answer. I guess the answer would me mindfulness meditation. What does that actually mean? Mindfulness meditation is derived from Buddhism. That’s what we teach on this Ten Percent Happier app that I’ve just started. Actually we share a venture capitalist. Gus Ty. Who invested in your company, is an investor in my company.

 

Dave Asprey: How did I not know that? I’ve known Gus for many years. Oh my gosh.

 

Dan Harris:    Well he’s a new person in my life. He’s been a phenomenally helpful individual. I am new to business. We just raised our capital 6, 8 months ago. Gus was really, he wrote one of the biggest checks. He’s been incredibly helpful. Really. He’s a special guy. Let’s just say that. He loves you.

 

Dave Asprey: Thanks for connecting those dots because I know Ten Percent Happier is one of their companies, but I just connected the title of your book with the company. Oh my goodness. Okay. Basically this is a Sandhill Road venture capital company. The first guys to invest in Starbucks and Jamba juice. They invested in you, you said 6 months ago?

 

Dan Harris:    6 to 8 months ago.

 

Dave Asprey: 6 to 8 months. Okay. It’s been probably a year and a half for Bulletproof. I’ve known Gus for definitely more than 10 years. He sits on my board of directors. What a small world. I did not make that connection. My bad.

 

Dan Harris:    He is really bullish on your business. He really likes you personally. You’ve come up a bunch of times in our conversations. Just to answer your question, on the app we teach mindfulness meditation. Secular mindfulness meditation. Mindfulness. What is mindfulness? Mindfulness is the ability to know what is happening in your head right now without getting carried away by it. That is really the fruit. Mindfulness and focus which are related. That’s really the fruit of secular meditation. That’s what we’re teaching on the app.

 

I guess in my own personal practice though, I as I said before, I am a little bit more interested in Buddhist meditation. Mindfulness is derived from Buddhist meditation. Some people get a little hinky about Buddhism because they think it’s a religion. And as I said before in some, in many places it is practiced as a religion, but I think you can practice it without it being religious. Depending on what you mean by religious.

 

Mindfulness meditation has been hugely useful for me. Why? For the reasons that we’ve just discussed. It’s that we all have this voice in our head. It’s constantly yammering at us. Has us wanting stuff. Not wanting stuff. Thinking about the past or thinking about the future to the detriment of whatever is happening right now. Comparing ourselves to people. Judging other people. Judging ourselves. When you’re unaware of this chaos of your own mind, my friend Sam Harris says that when he thinks about the voice in his head, he feels like he had been hijacked by the most boring person alive who says the same shit over and over. Sam is right.

 

When you are unaware of this, it yanks you around. It’s why you find yourself with your hand in the fridge when you’re not hungry, or you’re saying something stupid that you later regret. Or you’re checking your e-mail in the middle of a conversation with your kids. That really has been what has changed my life. I jokingly use the term ten percent happier, again just as kind of a joke, but what I now have come to believe is that the ten percent compounds annually. That you get better and better at this skill. There really is no ceiling. It’s not like physical exercise where you are limited by your body. The mind has, is limitless in many ways. You can get better, and better, and better at this. It only gets more interesting.

 

Dave Asprey: As you’ve been doing this secular practice, have you ever had a spiritual experience during meditation?

 

Dan Harris:    Well it depends how you define spiritual right?

 

Dave Asprey: It does.

 

Dan Harris:    Spiritual has a lot of connotations that I am not personally comfortable with, like metaphysical connotation. By which, by metaphysical I mean stuff you can’t prove. But if you think about spiritual as dropping the borders of the ego. Where you’re not so tightly confined by this Stalinist in your head, then yes. All the time. There’s one simple little exercise. I don’t know if you’re friends with Sam Harris. He’s a neuroscientist and leading atheist, but also an acting meditator and he is the one who connected me with my teacher Joseph Goldstein.

 

Dave Asprey: Oh wow.

 

Dan Harris:    Sam talks. He has a book called ‘Waking Up’. It’s a really great book. He talks about this exercise. He recommends this exercise in his book, which is actually based on an exercise in another book. I’m referencing a lot of books here before I actually tell you what the exercise is. The other book is called ‘On Having No Head’. ‘On Having No Head’ is the name of the book. Okay. The exercise sounded to me, a little silly at first. Over time it has become incredibly meaningful to me. This is the silly part.

 

From your perspective everybody in the world has a head. But you do not. You can’t see your own head. You see everybody else’s head, but you don’t see your own head. If you just imagine yourself in a state of headlessness all that is left is the world. There is no you. This you that is like the center point of your life. That is always wanting, and not wanting, and not caring, needs all of this care, and feeding, and is worrying all the time. But if you just drop that for a second and realize that actually if you look around it’s just the world.

 

What is looking out? This yawning chasm of pure knowing to get a little heavy with you. It’s just this knowing faculty of the mind. That is a spiritual experience. Right there. Easily and perennially available, and spiritual in that it shaves down the ego. The ego is, one could argue, the source of all of your unhappiness.

 

Dave Asprey: Changing your frame of reference here. Perception is really profound. I’ve been looking for ways to make that happen quickly, and to be able to share it with other people. At the Bulletproof Conference this year on September 23 in Pasadena, yes that was a blatant plug.

 

Dan Harris:    Can I just say that I have no problem with blatant plugs? Just for the record.

 

Dave Asprey: Well I appreciate that. Plus it’s my show. I can plug whatever I want. You know what I mean.

 

Dan Harris:    Yes. Amen.

 

Dave Asprey: Here is what we are doing though that is totally in line with this. This is something that actually we are putting together in the lab where I am interviewing at right now. It’s an experience for people who come to the conference. They put on virtual reality goggles. They are fed a real time video feed from a camera, but the camera is mounted up behind their head. All of a sudden instead of looking out through your eyes, you are looking out through the camera at the back of yourself. Then you go through a little obstacle course. You play yourself like a video game.

 

Instantly your sense of self moves from oh no I’m trapped in this head, to I am outside of this body looking down, and your level of awareness goes up. Your skin tingles. You have all these interesting feelings. The only problem is that if you’re prone to dis-associative states you’re not allowed to do it because it might be bad for you, so we have a waiver and a little warning there. But it’s exactly what you just described there.

 

Dan Harris:    I love that.

 

Dave Asprey: Taking the eyes out of the head and putting them behind the head so that you’re not in your head anymore. The veil comes down. It’s so cool.

 

Dan Harris:    Absolutely. I think that’s a brilliant thing that you’re describing. It just really points to the fact that this expression of, “I’m in my head so much.” Being in your head. Being self conscious is what makes it impossible to access the zone in sports, or to focus on your work because you’re so worried about whatever shit you are worried about. Or so focused on feeding whatever addiction you have, like cigarettes, or food, or whatever. Or it makes it impossible to get up and dance at your daughter’s wedding. Exercises like the one you just described are incredibly useful. Meditation which requires a little bit more time, but not that much more time, is just a way to get you there.

 

Dave Asprey: Very well said. Do you do breathing exercises in conjunction with your meditation?

 

Dan Harris:    I don’t, but I’m very open to them. I’ve heard very powerful arguments. You talked about the Art of Living. Is that Sri Sri Ravi Shankar?

 

Dave Asprey: Yeah.

 

Dan Harris:    I think so. I know the scientist who is another person you should think about having on your podcast. I’m embarrassingly spacing on her name. It will come to be in a second, but she is a big devotee of, she’s at Stanford University. She’s a head of research at the center for compassion at, Emma Seppala is her name. Emma Seppala.

 

Dave Asprey: We’ll get her on the show too. This is awesome.

 

Dan Harris:    She is great. I can help you book this podcast in her pertuity if you would like.

 

Dave Asprey: Thank you. I would like.

 

Dan Harris:    She is a big believer in breathing exercises. There appear to be a number of studies that show it really works. I’m very open minded and intrigued about it. Before, you may have some things to say about that, but before it leaves my mind let me just extend an invitation because I would, and this is a sincere one and I will follow up with your folks on this. I just started a few months ago a little Ten Percent Happier podcast. I’m new to the game. I’m nowhere near at your level, but I would love to have you on because you’ve been asking me great questions and letting me yammer on about my own crap, but I would love to reverse it and have you on, and ask you a bunch of questions. Think about it.

 

Dave Asprey: I would be honored to be a guest, and that was a great plug. Ten Percent Happier podcast. Dan’s new podcast. You say you’re new to the game, but let’s face it, you’ve been on national news more times than just about 99, actually I don’t know how many 9s to do, but almost any human being ever.

 

Dan Harris:    Yeah.

 

Dave Asprey: I’m pretty sure you know how to interview and how to roll a pretty nice podcast. I’d be honored to be on. I think for people listening to the show, here is what they don’t tell you about podcasting. Interviewing is a skill and an art. I would give myself maybe a 5 out of a 10. Dan has spent his life doing it, so he knows how to interview people and how to get the story in a way that I have yet to even experience. You’re going to have a good listening experience. I can say that not having listened to your show, but just knowing your skills in your craft. I’m actually excited to be on.

 

Dan Harris:    Well thank you because I am going to bug you about that. The thing about podcasting that’s interesting though, is actually the amateurs have an advantage because, and I may be wrong about this, but let me just advance the theory and then you can swat it away. I was born and raised for more than 20 years in network news. I have this very formal way about me.

 

Often professional interviewers aren’t even listening to the answers because they’re so wrapped up in thinking about what the next question they are going to ask is. A guy like you is just like literally having a conversation. It’s maybe not, it’s pretty polished, but it’s maybe not as polished as Charlie Rose. That’s not what podcast listeners want. They want authenticity. They want a real conversation and a real exchange between 2 minds, or however many minds are on the podcast. I would say you’re well above a 5, and that’s because maybe you’re not measuring it in the right way.

 

Dave Asprey: I am grateful for the compliment. I don’t listen to very many podcasts. Partly because my commute is through the garden that raises the roof of my family. My morning commute has nothing to do, but there is at least a quarter of a million podcasts right now. When you listen to a lot of them, you take apart the ones that just don’t have production quality where the sound quality is good enough to be respectful of the listeners.

 

People have no idea. There is studio lighting. There is 3 cameras focused on me. There are 2 audio things. We do audio engineering and all that so it sounds good. Because it is painful to listen to people with bad audio. But even then, there are so many of these where people don’t have anything to say, but they feel obligated to talk. I think this is the ego that you’re talking about there. If you are doing a podcast that has a point, that is there to deliver something, it has more in common with the news. You are there to deliver something. You are doing what you are trained to do.

 

Your style of interview will be different, but I find the signal to noise ratio in the world podcasting is very, it’s not very good. There is a lot of noise out there and not a lot of signal. You have been pretty well trained to deliver a signal, and it sounds like now you’re training is going to be less in your head when you’re doing it, and to be a little bit more flowing then you normally would if you had a teleprompter telling you the next question, the next question.

 

Brother I’m totally just guessing all that. I’ve been interviewed by you. You didn’t have teleprompters. You were at my house when you interviewed me. You did a cool segment. I don’t know how you do your craft, but the questions you asked me there were probing. They were intelligent. You listened to the answers. You asked the right following questions. That ability to be linear seems to be lacking in some podcasts. It’s one that I’m working on, but I don’t want to be too linear because like you said, then it comes off as programmatic, and it wouldn’t be fun to listen to. Then what’s the point, right?

 

Dan Harris:    You actually, you totally nailed what the challenges are for somebody like me in getting into podcasting. It’s really about dropping some of the artifice and pretense that comes with sitting at a desk with all these lights. Talking into a camera with a million unseen viewers on the other side of it which is a very surreal thing to do, and to be more like the Dan that chit chats with his wife or with his friends. That has been a bit of a process. I really think that there is a connection between good interviewing and meditation.

 

Dave Asprey: Oh heck yeah.

 

Dan Harris:    That meditation just allows you, it trains you over time to be right there with whatever is happening, so not so caught up in planning the next question or whatever point you want to make so that I’m listening to you talk. I am able to recall the 3 or 4 things that you said that I want to respond to. Or when I’m doing a podcast, I can have a plan. When I’m the interviewer. I’m the interviewer on my own podcast. I can have a plan for the way I want things to go, but I am totally willing to throw that plan out based on what the interviewee says and just go down whatever tributary that person wants to lead me down.

 

Dave Asprey: It’s pretty amazing. I hadn’t thought of it like that, but yeah. In order to do well on stage as a public speaker, I used to come into that when I started doing this, I was in a complete state of panic. I would go into a flow state which was really helpful. In my early days of public speaking. After I did the meditation and all this other stuff I got to the point where I have the low level awareness to okay maybe there’s a hostile question in the audience. Maybe there is not. Maybe the slides are working right, or maybe there is a technical error, or maybe they just gave me half the time I had.

 

None of it makes me feel like I’m going to die anymore. It’s that fear thing. Because my fear response is trained. It’s like the police dog. You can hear a gun fire and it doesn’t jump up and cower. To be able to sit there and hear whatever the next question is. Maybe I decided not to go that route. There isn’t the visceral response that I would have had before. Oh no. What if I don’t go there? Maybe I will die. Or maybe no one will like me. You go down these incredible spirals. It will be the end of Bulletproof radio. People will make fun of me. No one will like me.

 

All that stuff that would have been there in my head is just like oh. I’m going to do this and either one of these is okay. That frees up so much mitochondrial capacity to then listen, and to be present. Very well put. I hadn’t thought of it that way. Thank you for that.

 

Dan Harris:    You know there is a Buddhist term for what you just described. It’s like these little movies we make. It’s called Prapanca. P-R-A-P-A-N-C-A. Which means, and this is an amazing, it’s amazing that the Buddhists came up with a phrase like this. It literally means the imperialistic tendency of mind, which is that we, a data point arises. Like you have a moment of fear. Then you automatically, it colonizes the whole future. You’re like okay. I asked a question that I’m not sure is the right question. The guest is going to hate me. The audience is going to hate me. It’s going to be the end of Bulletproof Radio. I’m going to be living on the street somewhere. That happens in a second.

 

Dave Asprey: Exactly.

 

Dan Harris:    I have a 1 and a half year old. He won’t brush his teeth. It’s like he won’t brush his teeth. He’s never going to brush his teeth. He’s going to have meth mouth. He’s never going to have a job. It’s like that happens immediately. We live our whole lives with this going on. We don’t even know what’s happening. Now I’m sure your listeners are sort of nodding their head because this happens to everybody, but the beauty and the value of meditation, of having this self awareness, mindfulness, is that you can catch that and get off the train earlier before you go kick the dog or whatever it is that you do when you get frustrated.

 

Dave Asprey: We talked about being in your head. That whole thing happens almost outside of your head. It’s unconscious. You feel the emotion, but the steps that led up to it, unless you’re watching them, you’re not going to see them. Then you’re just like okay I feel this way. There must be a reason. Then you make up a story about the reason which is clearly the dog’s fault, so you should kick the dog. It doesn’t make you feel better.

 

I had an experience when I first got into the personal development side of things. I had been through a rough divorce. I lost the $6 million I made when I was 26. Which okay, those are a couple of the big WHO stressors. I was at a personal growth retreat. The people leading it were saying, “Well Dave, there’s got to be some feelings in there.” Yeah. There’s a feeling. I’m angry. They’re like, “No, there’s other feelings in there.” I’m like, “No, there’s not.” I spent 2 days going through this argument all in my head. Nope. Angry. Nothing. Anger. Finally they did some things that just made me feel uncomfortable. I’ve got to leave now. No. There’s something. Finally this lady looks at me and she goes, “Okay do you feel anything in your body?” I go, “Yeah. There’s something in my stomach.” She looks me right in the eyes and she goes, “Do you know what that is? That’s called fear.” I looked at her and I go, “Really?”

 

It was because I was so in my head that I had this story that’s like there’s no reason for me to be afraid right now. Therefore that feeling is not fear. Therefore you should ignore it because it’s noise. For me, the biggest part of learning to be a good podcaster or to just be a good CEO, or a good husband, has been to learn there’s great value in paying attention to all the weird stuff that’s happening and then figuring out why it’s happening. Not making up a story about why it’s happening. But actually watching it to see why it’s happening. Then going back and figuring where did that, in my view of the world, where did that bad programming come from that’s causing that for no good reason? And then, and this has been my biggest challenge, how do you reset the programming so it doesn’t happen anymore?

 

Rather training the dog to sit still, it’s like another level beyond that, so there isn’t the impulse in the first place. That’s a powerful thing, and that’s where very advanced meditation from many different paths can lead you, and where some psychologists can lead you too. It’s been the most fun thing to explore I’ve ever thought of because I was such an asshole because I was always acting on that, and I just didn’t know it. Right.

 

Dan Harris:    Yeah. I mean I think what you’re talking about is enlightenment. What meditation in the shallow end of the pool, the my level. I’ve only been doing it for like 7 years is really about being self aware enough so that you’re not triggered by blindly by your patterns or by external stimuli. But enlightenment in the Buddhist conception is that you uproot all negative tendencies, and that it’s a step wise progression. There are these very detailed maps in the various Buddhist schools from how you get from what they call an uninstructed world-ling, so basically me.

 

To step, to having a set of experiences that have been mapped out for millennia that ultimately culminate allegedly. I say that. I want to put emphasis on that because I have not seen any evidence for it, but allegedly culminate in the complete uprooting of greed, hatred, and confusion. Or to use your expression you deprogram and the bug is gone.

 

Dave Asprey: I believe there is something to that. The definition of enlightenment that I work with is when you have full control and awareness of all aspects of your biology, which sounds kind of small, but if you have knowledge of what every cell in your body is doing. Every mitochondria, all these sensors for the world around you, you realize that the world is nothing like what you thought it was. Because you have actually grown that level of awareness. That’s where I’m working. Just growing awareness.

 

When you grow awareness it automatically makes you less of an asshole. You’re nicer to people around you and you’re more in a position, and you have more desire to serve other people. I could be entirely wrong on all of this, but I am happier along the way. I would like to think I am more than 10 percent happier than I used to be. It seems to be working, but I’ll tell you when I’m 180.

 

Dan Harris:    Nice. Excellent.

 

Dave Asprey: Now Dan we are coming up on the end of the show, and there is a question I have asked everyone. You have a very unique set of experiences having visited all of these churches and all of these war zones. Having been on TV for so long. If someone came to you tomorrow, given everything that you know, and said, “Look I want to perform better at everything I do. I want to kick more ass in life. What are the 3 most important things I need to know?” What would you tell them?

 

Dan Harris:    Look none of this is going to be surprising, but the 3, I would say 4 things that are like the basic recipe for human flourishing are the basic bodily, I’ll keep it the 3, the basic bodily maintenance like exercise, and diet, and sleep. Because without that you can’t function. And I know you are interested in lots of hacks around those areas. I’m open to that too. But you’ve got to figure that out. 2 is great relationships in your life.

 

We are social animals. Without good relationships we go crazy. The quickest, you listen to John McCain he says, “The worst part about being a POW was not the beatings, it was solitary confinement.” We need to have good relationships in our life. I think the third which for far too long has been ignored is mental training. All of the meditation that we’ve talked about for these last few minutes. Those are the 3 things I would recommend as sort of a path to excellence and happiness in your life.

 

Dave Asprey: Beautiful answers. Where can people find out more about your book, about your app, about your company, and any other place you want to send them?

 

Dan Harris:    Thank you for letting me shamelessly plug. I really do appreciate that, although this has been fun on every conceivable level, but I also appreciate the plug.

 

Dave Asprey: Of course.

 

Dan Harris:    The book you can get it anywhere. Amazon. Whatever. It’s called ‘Ten Percent Happier’. The app is right now it’s in the Apple app store. We’re working on an Android version. If you don’t have an Apple device you can get it at TenPercentHappier.com. I would love to hear from you or your users about the app because we’re really sort of at the beginning stages. We’re a start up. I love hearing from people if you hit me on Twitter @DanBHarris. Tell me what you think of the thing.

 

It’s free to start with. You can check it out, and download it, and try it for a couple of days. What we do that we think is interesting is that we everyday, everyday you get video and audio. Every time you use the thing. And you can skip the video if you don’t want to do it. Everyday either you get me for a couple of minutes chit chatting with a meditation teacher and asking all of the obnoxious questions you might have. Then it goes right into a guided meditation. The other thing we do that is different is we give you a coach. Like a real human being that you can text with through the app and ask any question you have. That person is a real human being and an experienced meditator who can help you out.

 

Then if you want to listen to the podcast it’s available everywhere that podcasts are available. Like I said, I love hearing from people who use this stuff. Read the book, or listen to the podcast, or use the app. In particular I like hearing where I am going wrong and what I should fix. If you hit me on Twitter that’s the one social medium where I actually do read the comments.

 

Dave Asprey: Thank you Dan.

 

Dan Harris:    Huge pleasure being on here, and I’m going to hold you to letting me turn the tables on you. Thank you and it won’t be the end.

 

Dave Asprey: You’re very welcome. If you enjoyed today’s episode you know what to do. Go pick up a copy of ‘Ten Percent Happier’. Dan is an interesting guy. If you saw that original piece on Modafinal or Providual and me that I am sure we have linked to on the website, that was actually Dan at my house. Years ago he flew out from New York with a camera crew to film. What a small world. What a fascinating world that here we are about 5 years later talking on a podcast, and I get to interview you. Never would have imagined. Super cool. I look forward to hanging out again.

 

Dan Harris:    Thank you sir.

 

Male Voiceover:         Thanks for watching. Don’t miss out. To keep getting great videos like this that help you kick more ass at life, subscribe to the Bulletproof YouTube channel at BulletproofExec.com/YouTube. Stay Bulletproof.

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Say GeNOme to Cancer with David Haussler – #342

Why you should listen –

David Haussler is a human genome expert and developer of new statistical and algorithmic methods to explore molecular function, evolution and disease process in the genome. David and his team posted the first publicly available computational assembly of the human genome sequence as collaborators on the international Human Genome Project. On today’s episode of Bulletproof Radio, David and Dave give advice on avoiding cancer, immunotherapy and other new treatment, hormonal Vitamin D, genome sequencing and more. Enjoy the show!
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Dave: Do you feel like you’re stuck in life? Like your creativity’s blocked? You need to check out the Unmistakable Creative Podcast. Think Ted Talks and Oprah put together on a podcast show. They recently talked about the art of strategic gifting and how you can make someone feel appreciated with a simple gift. To listen and be creatively inspired, go to podcastone.com or download the free mobile app now.

 

Speaker 2:  Bulletproof Radio, a state of high performance.

 

Dave: You’re listening to Bulletproof Radio with Dave Asprey. Today’s cool fact of the day is that there are about 37 trillion cells in the human body and if you unwound all of the DNA encased in each cell and put it end to end, you would have enough DNA to stretch from the sun to Pluto and back seventeen times. That is actually kind of profound. It’s also totally, totally not true because the orbit of Pluto is not circular, in case you’re into astronomy, but anyway, it’s a good analogy. That’s about right, if you look at the average orbit of Pluto, so let’s just be precise here.

 

Before I get into the show today, which I might have just hinted has something to do with DNA, if you’re a regular listener of Bulletproof Radio, you’ve heard me share the top ten list of biohacks. Let’s talk about number nine, Fun Hacks for the Bulletproof Mind. It may sound weird but hanging upside down is a great way to hack your brain. Regularly inverting trains your brain capillaries, making them stronger and more capable of bringing oxygen to your brain. It’s a pretty straightforward thing. More oxygen to the brain means better performance for you.

 

I get my daily stretch and a good dose of brain oxygen with my Teeter Inversion Table, which is essential for optimum focus, concentration, and mental energy. It also just feels good and it’s an effective way to keep your back in good shape. That full body stretch elongates your spine and takes the pressure off the discs so they can plump back up. Less pressure means more flexibility and less pain. If you have back pain, even if you’ve been lucky enough to avoid it, you need a Teeter to invert every day to keep your back and your joints and your brain feeling great.

 

For over 35 years, Teeter has set the standard for quality inversion equipment you can trust, and there’s an amazing offer just for Bulletproof listeners. For a limited time you can get the Teeter Inversion Table, the same one that I use with bonus accessories and a free pair of gravity boots so you can invert at home or take the boots with you to the gym. To get the deal, which is a savings of over $138, you have to go to getteeter.com/bulletproof. You also get free shipping and a 60 day money back guarantee and free returns so there’s absolutely no risk to try it out. Remember, you can only get the Teeter with bonus accessories and a free pair of gravity boots by going to getteeter.com/bulletproof. That’s G-E-T-T-E-E-T-E-R.com/bulletproof. Check it out.

 

If you don’t know about the Bulletproof Performance Kits, that’s probably because you haven’t been to the Bulletproof Store in a little while. If you’re new to Bulletproof or you’re just looking to figure out what works for other people, we’ve got a bunch of new performance kits. More than a dozen of them to choose from like the coffee kit, the brain kit, the detox kits and these are based on what the Bulletproof ambassadors do that helps them perform better. Head on over to bulletproof.com and check out how you can pair these products up to get more performance out of your brain every single day.

 

Today’s guy is a guy I’m really looking forward to having on the show and you may not have heard of him before but he’s done some pretty amazing work. He’s also a little bit diverse. He actually studied psychotherapy for a little while back in the day and today he’s a distinguished professor of biomolecular engineering at University of California, Santa Cruz. He’s also a bioinformatician combining math, computer science and molecular biology to develop new algorithms to understand the human genome. He’s pretty well-known if you’re a genetics focused person, for his work on the human genome project where it was his team that made the first publicly available computational assembly of a human genome sequence on the internet. His name is Professor, Doctor, it’s not right. Anyways, his name is Dr. David Haussler.

 

David:         Yes the professors and the doctors. It’s wonderful to be here. It’s great to have a chance to talk with you about the exciting potential for DNA. We can probably use it for other things than reaching to Pluto and back. I think the analogy though is out. There is an enormous amount of information in our genome and we’re just now beginning to understand it.

 

Dave: I was intrigued at your very early work with the human genome. Back in my career in Silicon Valley I ran the web and internet engineering program for UC Santa Cruz, the extension of Silicon Valley. I used to teach working engineers how the internet work instead of how computers pre-internet work. It’s the first wave of eCommerce companies. Google’s first server is on our data centers. We also had a company called Double Twist. I did work on their infrastructure. You know who these guys are, right?

 

David:         Double Twist, yeah.

 

Dave: Literally I’ve been in the data center Double Twist for people listening was the company that held the data as I understand it for the work you were doing, computational analysis and they were doing the storage for the human genome. It was a whole floor of a data center in Alameda, if I remember right. I did architecture for them.

 

David:         Double Twist was one of the early bioinformatics companies in the upsurge leading up to the combination of the human genome project in the year 2000. They were built by the venture capital community in view that here’s an opportunity and it surely to work out but I think being conceived and created by the venture capitalist rather than an independent genius who really had a passion for it, they were doomed, I thought they were doomed to failure from the beginning. You can’t create these companies out of whole cloth. You got to have individuals that are passionate about …

 

Dave: You need your Craig Venter.

 

David:         Yeah, you need somebody like Craig or one of the other great thinkers.

 

Dave: Who are the other maybe less famous but other great thinkers in the field that you would name the other two or three people worth following?

 

David:         George Church, Eric Lander, there are a number of really fascinating people in this area. I’ll get into trouble if I make a long list and leave somebody out.

 

Dave: I understand, that’s why I asked for two.

 

David:         There are dozens and dozens and I’m just giving the very big names that are probably household, somebody that’s been on [Cobear 00:07:00], that level. For instance, Collins, George have been on so it’s a great area. We do exciting things and we’re thrilled to be able to …

 

Dave: One of the things that you do that’s particularly interesting is you focus a lot on human genome and cancer. Talk a little bit more about what you’re doing to map our genetic predisposition for cancer. People listening may not know a lot about genetics so give me the entry level view but a little deeper.

 

David:         Absolutely. The quest to map the human genome started out early on we had actually a meeting here at Santa Cruz, the chancellor Sinsheimer called it in 1985 and had some of the great experts come and say, “Is it possible to map the three billion different bases of As, Cs, Ts and Gs in the human genome?” Figure out what a typical person’s genome looks like by hardcore biochemistry to sequence this and it was initially thought that that would be impossible but it turned out that by 2000 as you said we’ve had the first draft and we were very proud to do the computational analysis.

 

There were a bunch of little snippets of DNA that were produced by the genome sequencing machines and we did the key assembly to put them together into a coherent first draft of our human genome. Posted that on the internet on July 7th 2000. This was simultaneous with the production of the genome by Celera so Craig Venter’s company and my good friend and colleague Gene Myers. We went to school together. Led the assembly of that version of the human genome. By 2000, suddenly there were two versions of the human genome and that set the stage for a subsequent development in thinking about, “Okay, now if this is the overall map for the human genome and we’re all 99.9% identical at the DNA level then what about the differences and how did those differences affect our health?”

 

The primary differences that people were thinking about in the initial stages were the differences that we have in our genomes that we inherited from our mom and dad. You get one copy of a gene from mom and one copy of the gene from dad and little variations in those genes in the DNA can make a difference in your health and in your propensity to get various diseases. Actually, there is a disease, cancer, in which new changes happen as you grow older. Not in those trillions of cells that you were just mentioning in this intro, they all start essentially with the same genome that you got from mom and dad but as you grow old they accumulate changes and so when cells divide they naturally don’t make a perfect copy of their genome for the daughter cells.

 

That’s a main source of differences but also you can have various chemicals that are carcinogenic and increase the amount of mutation that occurs in particular, smoking creates these compounds and they can cause mutations in the cells in your lungs. Some light can cause mutations in the cells of your skin and those are then significant events rarely do they do anything bad, most of them make no difference whatsoever but with trillions of cells the odds are that if you keep going on long enough, if you live long enough then you’re going to have a bad combination of mutations that causes that cell to grow into a cancer tumor.

 

We now have confirmed through careful investigation over the last few decades that cancer is actually very much a genetic disease. The cause of cancer is mutations that happen in some of the cells in your body that cause them to go rouge. Treating cancer is all about killing the cells that have those dangerous mutations and it is an enormous effort and we are learning so much more about it now that we can read the DNA of the tumor cells.

 

Dave: I’m working on a book about mitochondria right now. I’m going pretty deep on krebs cycle. It’s a book meant for lay people and frankly I’m not a university grade researcher on mitochondrial benchtop chemistry but I’m pretty good at what I do. I’ve interviewed guys like Dominic D’Agostino looking at the mitochondrial angle on cancer and the mitochondrial DNA mutations which happen more quickly than the human genome DNA.

 

David:         Nuclear genome. The human genome has a nuclear component in the mitochondrial genome.

 

Dave: Thank you. That is exactly what I was thinking. You have the nuclear DNA which is where we focus all of this and we’re developing this view, I am looking at Wallace’s research on mitochondrial epigenetics and what gets expressed from the nuclear side of things. I’m wondering, your take on this, you are one of the top people in the world looking at the nuclear side of genetics and cancer and I’m talking to other people who are looking at the mitochondrial dysfunction side of cancer. How do you line those two perspectives up? I don’t know.

 

David:         I think mitochondria have now been shown to be involved in a number of diseases including cancer. They are of course the energy factories of the cell and such. That among the other key roles they play in telling a cell whether it’s over, basically, you should commit suicide or whether you should keep going. All of these information and energy processes that are rooted through the mitochondria are important to the cell and important to disease so we certainly appreciate the value of the mitochondria even though it has a tiny genome 16,000 bases of DNA compared to the three billion bases of DNA in the nuclear genome.

 

The nuclear genome contains more of what we are just more bits of information about what we are but the mitochondria, tiny as it is it’s very important also to our health. There are number of new studies that show mitochondrial effects in cancer and how that can alter the course of the disease but again, there’s more going on in the nuclear part of the genome in cancer than there is in the mitochondria and that’s not surprising just because there’s so much more complexity in the nuclear part.

 

Dave: Just given the size there.

 

David:         Yes, just given the size.

 

Dave: How far are we from being able to look at someone’s nuclear DNA and saying, “Based on this we have a very reasonable likelihood of what kind of cancer you’re going to get if you get cancer”?

 

David:         We’ll never get to that point where we can be highly predictive because the progression of cancer depends on random and inherently unpredictable events. It could be a cosmic ray that comes down and hits the right place in the genome of the right cell at the right time or wrong place wrong time if you want.

 

Dave: You could start smoking, right?

 

David:         Yeah, you can start smoking so we won’t be able to predict it in that sense but I think the largest hope for the future is that we would be able to catch it earlier than we are now. The most difficult problem with cancer today is that patients are coming in after the cancer has progressed to a point where it’s very difficult to unwind and get rid of all the cancer cells. The hardest thing about treating cancer is that you need to get rid of all the cells. If you leave some behind and they grow back and that’s the problem.

 

On the other hand, the good thing about cancer is that you only have to kill the cells, you don’t have to fix them. If you have cells that you need, your neurons or something and you’re trying to alter them to work right, that’s very much harder than killing cells. The good part of cancer is we only have to kill, the bad part is we have to kill them all. There are challenges.

 

Dave: There’s a whole bunch of things I want to ask you based on that. I’ve looked a lot at the respiration of cells. It seems like there are pre-cancer cells that can be fixed where you haven’t kicked off that cell death process called Apoptosis. Do you ascribe to that? I’m not a cancer expert. You are, so I’m asking questions without meaning to question what you’re saying there or to challenge what you’re saying there but just to get an understanding. I know a lot of people who’ve listened to the show have had heard several guests talking about increasing electrons in mitochondria and reversing hypoxic states in cells and turning anaerobic cells back into aerobic cells thereby preventing them from further progressing to become cancerous. Is there meat on the bone for that theory in your experience or was this more of a nuclear DNA problem?

 

David:         There definitely is a metabolic shift that occurs in cancer and it does towards anaerobic from aerobic. That is part of the cancer switching into a metabolism that is optimized for tumor growth. Cancer of course is an evolutionary struggle within your own body. The cancer cells are competing for real estate against your normal cells. Growing faster and being more vigorous in stealing resources like blood vessels are characteristics of cancer because that’s characteristic of who wins this battle for real estate in your body. Part of that is shifting metabolism and that brings again in the mitochondrial aspect because mitochondria are so fundamental in this metabolic process.

 

Again, that’s just part of the story. The overall cell cycle is critical and that’s been the most extensively investigated in cancer. You have to start dividing and you’d have to divide a lot and rapidly to be a bad and dangerous cancer. What happens is that when you’re an embryo, your cells are dividing a lot and then that process slows down and so when you’re adult, most of your cells are senescent. Basically they finish, they are dividing and they are occupying their place in your body and they shouldn’t start dividing again. When they revert to this, “Wow, I think I’m like a stem cell like thing, I’m going to divide again.” That’s a symptom of cancer that is more central and profound than the energy shift but it’s all part of the story. There are many hallmarks of cancer that we look at.

 

Dave: What do you do in your life to minimize your chances of getting cancer?

 

David:         I try to use sunscreen. I don’t smoke. I watch some of the foods that I eat so you don’t want to eat moldy peanuts for example. Aflatoxin is one of the most potent carcinogens known. There are number of chemical carcinogens that aren’t necessarily just from industrial processes. They are so called organic, natural carcinogens the aflatoxin grows peanut mold grows if you’re an organic farmer or not. You can’t just say I eat organic and so I’m safe. You have to be very, very cognizant of the molecules that you’re exposed to, make sure that they are not cancer-causing.

 

As I said before, really the most important thing is detection and early prevention because no matter how careful you are, there’s still this increasing probability that you will have that unlucky event that will cause mutations in your cells as you grow older. There are really no amount of diet and lifestyle can prevent that risk because it’s an intrinsic fact of the way cells divide and how they age that will force us to be exposed to cancer. In fact, many have said that there’s a dual relationship between cancer and longevity. We may alter our mitochondrial if you’re an NAD+ person and so forth.

 

Dave: I am.

 

David:         A lot of us are so we may alter our lifestyle and even our chemistry to live longer but that will have the effect of increasing the amount of time that our cells are waiting to mutate. Ultimately, your chances for cancer will just accumulate. If we are going to be successful in very high longevity situation then we will have to do better with cancer. It won’t be diet that will save us from cancer. It’s going to have to be detection and prevention and rapid treatment. We’ll need that more and more as we age.

 

Dave: No doubt, if you live longer you have a greater incidents of cancer.

 

David:         That’s it, yup. Nothing that can change that completely.

 

Dave: When we talk about NAD+ there for listeners, when your mitochondria are making energy, you add electrons NAD+ and they could end up NADH and what’s going on there is if you can change the ratio of those two molecules you can change the efficiency of your mitochondria and thereby have more energy right now which is one of the big topics of my upcoming book. Also potentially change your risk of the mitochondrial side of cancer at least that’s what some of the research I’ve seen says. By improving the efficiency of the Krebs Cycle reducing oxidative species in the cells, it appears to have a cancer-reducing risk. For some compounds it even appears to make chemotherapy work better.

 

David:         Chemotherapy is a hell of a toxic thing. All the organic fruit and so forth that you’re eating has a little effect compared to the dramatic effects of the chemotherapy compounds that are commonly used to treat cancer and radiation of course again which is still commonly used to treat cancer. One of the goals of cancer research based on our knowledge of the DNA and the DNA mutations is to try to get beyond some of these more toxic methods for treating cancer. If you’re faced with cancer that is so much more important than the healthy diet or the NAD+. It really is important that we get to the point where we can have therapies that are precision targeted towards the cells that have cancer and have little collateral damage on the other cells.

 

That’s been a major goal and it’s a major hope. The Vice President has announced the moonshot and there’s optimism. A lot of this optimism is based on the idea that maybe we can coax or induce your own immune system to fight off the cancer cells and this is an idea that’s been around for decades but only become really operational within the last few years and has resulted in some spectacular results for certain types of cancers. We’re still trying to understand why it works for those cancers and doesn’t seem to work for other cancers at least in the incarnation we know about this immune approach we sometimes call immunotherapy.

 

That would obviously be a terrific approach to cancer if you can just get your own body to eliminate the cancer by targeting your immune system to it. That’s terrific. Part of that in combination, a lot of people are talking about doing that in combination with crippling or killing many of the cancer cells. The immune system is drawn into a fight sometimes that is started by either chemotherapy or some other kind of targeted therapy and if the immune system can lock on and finish the job, that is terrific in cancer.

 

Dave: The immunotherapy you’re talking about there actually saved my cousin’s life. I wish I knew exactly what kind of cancer it was. I believe it was a brain thing, some kind of pretty aggressive thing. This is not a cousin I’m close to. It’s wife’s family in Europe but he flew to Israel and did a very advanced form of immunotherapy where they essentially in layman’s term made a vaccine to some cancer cells, injected it and he’s perfectly healthy with no signs of cancer today. This wouldn’t have happened five years ago. It’s just shocking.

 

David:         No, it couldn’t. It’s spectacular. That form of treatment where you’re actually using an inactivated virus or something like that to draw attention of the immune system to the tumor. You can do this with bacterial molecules that bacteria create or viruses. They do this in bladder cancer for example. They’ll use these kind of molecules that activate strongly activate the immune system to then recognize the tumor. We’re very interested in the actual molecules that the tumor displays that allow the immune system to distinguish the tumor cells from the normal cells. We know a lot about this from immunology. We know in fact that all of the proteins that are made inside the cell and make the cell work and do all its stuff are essentially ground up into pieces.

 

Some of those pieces are representative set of those pieces of protein are actually displayed on the surface of the cell as if to say to the rest of the body, “This is what’s going on in me right now. Here’s a sampling of pieces of my proteins.” In a sense, the cell in your body is telling the rest of your body, “Here’s what I’m about right now.” Your immune system is acclimated to recognize those signals and it’s constantly surveying your cells and saying, “Looks like this one is okay. Yeah, this one is okay.” When a cancer cell comes along it gets DNA mutations and some of those DNA mutations then cause the proteins to be mutated and so you get little snippets of mutated proteins on the surface of a cell and that’s what the immune system uses to recognize that something wonky is going on on that cell.

 

A vaccine essentially functions to alert the immune system that this is the kind of thing you should be looking for in attacking the cell. This whole system evolved over millions and millions of years of evolution. For example if a cell gets infected by a virus, the virus will make its own viral proteins and those will show up as foreign proteins and then be recognized by the immune system and the cell will know to attack. It’s a regional phenomenon so you want to get a hot zone around the tumor where the immune system is highly active. It turns out that in the last few years we’ve learned that tumors have these tricks for shutting down the immune system.

 

Everything in biology is about balance and so over these years of evolution actually human cells have evolved a way to say, “Hey, I’m in trouble. Hey, I’m really in trouble, you should attack me. Hey I’m only kind of in trouble, shut down the attack.” That ladder message is used by cancer, the cancer will actually distort this natural biological process and make the cancer cells such that they are saying, “Yeah, I’m kind of in trouble but not so bad so don’t really attack me.” New drugs that shut off that signal are the most exciting thing in immunotherapy. They are trying to make so the cancer can’t hide from the immune system anymore but it requires two things.

 

It requires the inhibition of these, “Don’t kill me, I’m really okay,” signals but it also requires that there will be at least something, some different protein on the surface that the cancer is displaying that the immune system can latch on to to distinguish it. Actually, that is from… I made this long story so we could get back to why we care about DNA sequencing cancer because we have programs about a dozen other labs now have computer programs where we can take a sample of your cancer tissue, sequence it in a DNA sequencing machine and then use computer analysis to infer what kinds of abnormal proteins are in the cancer.

 

What kinds of pieces of them might be on the surface and hence, what the cancer cell might be telling your immune system. We also look at whether it’s sending out these special signals about, “Don’t really harm me.” If we can tell whether a cell is actually displaying that it’s different and also maybe shutting down the immune response then we know that by reversing the shut down of the immune response, the immune system should be able to recognize it because it is displaying something different. If it doesn’t recognize it, we could actually in principle customize a vaccine because we know how, what kind of different signal we need to train the immune system to recognize that cancer.

 

It’s a very, very exciting potential coming up here. We’re still years off from actual routine use of vaccine related cancer. Your cousin was in a very, very special program that’s not routine in all hospitals. The new drugs, the so-called PD1 checkpoint inhibitor drugs, checkpoint blockade drugs which shut down this PD1 signal that the cancer is using to hide from the immune system are now in almost routine use for many different cancers in particular, melanomas. They were proved recently for non-small cell lung cancer and so forth. We are getting to the point where this is not exotic anymore but becoming part of regular clinical practice but before the vaccine stuff is regular, it’s going to require more work.

 

Dave: There’s a set of genes that have been identified that make people more prone to auto-immune conditions. They are on the HLA-DR. I’m one in four people who has a tendency towards auto-immunity. I’m sensitive to toxic mold in the environment. I actually did a documentary about that because it absolutely just causes inflammation neurologically and throughout my physiology which also increases my risk of cancer and all. At least according to some of the stuff I’ve read it does. Now, that’s irritating because my plan is to live to 180-years-old.

 

I said it was my plan. I’m doing everything I can to get there. I don’t know if I will or not but I’m sure I’m going to do everything possible that normal people would never think about. How quickly am I going to be able to use CRISPR or some other technology to just go in there and get rid of those few annoying genes and some meaningful substantial subset of my cells? Over the course of seven years as I replace my cells, I can just be done with that.

 

David:         Very interesting that you bring up the HLA genes because they are the scaffolds that actually hold the proteins to show the immune system. The HLA genes are amazing in the sense that they are generic proteins that will load on a small piece of random protein from some protein that’s being made in the cell and then carry it to the surface and display it to the immune system. The immune system comes along and recognizes it by these cells called T cells. They are part of your white blood cells. The T cells have these receptors and they are constantly looking to see whether the peptide that’s being displayed by your HLA molecule is of the normal kind or whether it’s something weird that they haven’t seen before. That is the key event in immunity. It’s the key event in deciding whether it’s okay or whether something is wrong.

 

Now, if something is wrong, genuinely wrong like a virus has invaded the cell or is a cancer cell then you want the T cells to respond. You want the T cells to go into emergency mode send out the cytokine signals and all of these other signals that say, “Something is wrong, we’ve got to start killing.” This ultimately the killers so called literally killer T cells are very powerful in terms of attacking cells. It’s a very powerful system but it also has to be carefully controlled and so the auto immunity problems that you refer to come in when there’s a mis-adjustment of the immune systems so that you have propensity now for the immune system to make a mistake and think normal cells need to be attacked. Then, once your immune system starts attacking certain of your normal cells then you have problems. You may have arthritis if it’s attacking the cells in your joints.

 

Dave: I had arthritis when I was 14 in my knees. I don’t have it anymore but I did.

 

David:         Yup, you may have multiple sclerosis if it attacks the sheets on your particular axons and your neurons and so forth.

 

Dave: I’ve never said this on the air but I am reasonably certain that I would have ended up with MS had I not radically changed my biology using the lifestyle and all the other things I’ve done. I’ve never been diagnosed with it but I could see what was going on in my nervous system with neurological inflammation. I’m friends with Terry Wahls, Minding my mitochondria and I am stronger now at 43 than I was at 23 because I’m aware of the problems and able to take action to turn that off. Most people aren’t but I suspect I would have by the time I’m 50 I probably would have had MS. I don’t think there’s a chance in hell that’s going to happen to me now.

 

David:         Good. That’s the most important thing is the health thing. I could say actually I’m stronger now at 62 than I was at 43.

 

Dave: Good. Wow.

 

David:         It’s possible to keep it up.

 

Dave: That’s powerful.

 

David:         Mainly because I’ve started working out in the last five years. You get to a certain age and you think, “Oh my God, if I don’t do something,” I’m not really paying any attention and not really doing anything for regular health. Now I am but back to the immune system, I think it’s not so much that you want to actually go in and try to genetically change your HLA molecules. I mean, every cell in your body has the aversion of HLA genes that you got from mom and dad and my suggestion is that you got to live with that. It’s not going to be easy to change all those cells, they make up your whole body. You don’t want to start changing your fundamental genetics.

 

Dave: Sure I do, why not?

 

David:         Okay. Let’s not go there right now, you may want to do that but that’s not going to be the easy route.

 

Dave: Agreed. Okay, I’m with you there.

 

David:         What happens is then there’s got to be some particular peptides that these HLAs are expressing to your immune system in particular cells that where the problem is arising, right? There’s some particular mis-recognition phenomenon that’s happening, it’s not all over your body. It’s only under certain circumstances that these certain HLAs will produce an inappropriate immune response that causes autoimmunity. If we could target just that, just like we do cancer, if we can target that inappropriate immune response specifically without messing with any other part of your body or your immune system, that would be in my mind a more appropriate approach to autoimmunity.

 

The beautiful thing about this is now we have billions of dollars being poured into immunotherapy because cancer is a huge, huge topic. We are learning about the molecular details of the immune response at an outstanding rate because it’s driving billions and billions and billions of dollars of investment in new immunotherapy drugs. Part of that we’ll have and I’ll make a prediction here that might be a little comforting, part of that will have the side effect of greater understanding and greater technology that will allow us to manipulate the immune system. We can imagine a world in a decade where we can measure exactly what your immune system is doing at anytime and we can say, “Okay, this looks great. All right, you had a cold two weeks ago and your immune system reacted to it.

 

It looks it’s appropriately calming down, right, then so we’re not having T cells that are reacting to that rhinovirus anymore, we don’t need them,” and it’s great. What we want to be able to say is but if this is indeed the case we’re starting to see an autoimmune reaction in certain tissues where you have these particular T cells with this receptor that’s recognizing this displayed peptide and that is an inappropriate interaction between the T cell and the normal cell. We need to stop that interaction. On the other hand you may also have a tiny, tiny cancer that’s starting somewhere in your body and your immune system is not recognizing the abnormal protein.

 

These events are two sides of the same coin, in the one case you want the T cell to recognize the protein and the other case you wanted to stop recognizing or stop reacting to the protein. That’s the autoimmunity case. Because cancer and autoimmunity are two sides of the same coin, the more we understand the system of how the immune system recognizes the peptides that are being displayed and the more we have technology to manipulate it, the better we’ll get on both sides. I think the enormous investment is going to payoff within a decade where we’ll be able to have more precise manipulation, more precise surveillance and then more precise manipulation of the immune system which could save you a whole world of pain in the future if you have an autoimmune disease and it’s well worth the investment. I mean international investment in research.

 

Dave: It is one of the most important things you can do because this stuff affects at least one in four people and probably more than that if you look at just subsets like Hashimoto’s and things like that that are almost rampant at this point. Now, I’m debating, I want to talk about the Global Alliance for Genomics and Health, the computer hacker side of me. I’m really intrigued at sharing this volume of data securely. Before we go there I’ve said I want to see if I can either freak you out or offend you given what you just said about immune presentation. One of the things that reduced my autoimmunity and I haven’t talked about this on air either before but I just want to pick your brain.

 

Tell me if I’m crazy. When you’re having autoimmune reaction you release a lot of antigens in your urine and there’s discussing Ayurvedic practices of drinking urine and things like that that don’t work but are meant to work via this pathway. However, when you take those antigens, collect them from urine when you’re having an immune reaction. These are the inappropriate immune molecules. They are immune molecules created by an inappropriate response. If you present them to the immune system as foreign molecules you can make antibodies to your own antibodies and cancel them out.

 

When I have a big autoimmune attack I actually, now this is going to sound crazy, I didn’t invent this, I will take the urine, I’ll mix it with Lidocaine and I’ll inject it through a 50 micropore filter into my muscle tissue. It presents those antigens. I can eat foods I couldn’t eat before and I have a lot less reactivity even to the things I’m most reactive to. It seems to be working and it’s like completely caveman level immunotherapy but I’m kind of liking my life. Am I nuts?

 

David:         You’re nuts. I’ll tell you a story. Before I went back to graduate school I work at a ranch. It’s an old family ranch. We’ve had it in near Paso Robles we had in the family since my 1920. My great uncle started it and he got ill and died and there was nobody really there to take care of the property. In between undergraduate school and graduate school I spent a couple of years managing the property, the farm, where we grew almonds and walnuts and dozens of different varieties of fruit. It’s a little organic farm.

 

Dave: Gorgeous.

 

David:         I had a hell of a time with poison oak, very reactive to it and being out in the field I was always seeming … It was seeming an annoyance and you couldn’t get away from it. I was downtown one time when Paso Robles was a little town and not the wine mecca that it is today. I was talking with an old farmer there, Charlie Yearwood was his name. He did a lot of tractor work around the area. I had noticed him on a job burning poison oak and then actually driving his tractor into it to compact it and breathing this poison oak smoke. I just couldn’t believe. That’s the worst exposure that you can have.

 

Dave: You could die from that.

 

David:         You could die from that. You could definitely die from that. The oils of the poison oak coming in and I said, “Charlie, how is it that you’re not allergic to poison oak?” and he said, “I was when I was young. I had a horrible reaction to poison oak but I found this woman down in Paso Robles. Some people call her a witch but she said all you have to do is go out there in the springtime when the leaves are just about the size of a squirrel’s ear and you just eat one of them. Come back the next day and eat another one of them, you do that for seven days, you never have a problem with poison oak again.”

 

Somewhat the same principle, right, you’re kind of overloading your system at some point and trying to get your immune system to switch. I don’t know. I was stupid enough at this point. To think that this should might work and I was living there with my best friend Don and I went out one morning in the spring, picked the leaf, chewed it up. What the hell? Here we go, right. Got back home, spent the night worrying about it. Nothing happened. Got up in the morning, told Don what I had done and I said, “Look this is proof, I feel great.

 

This is great. Day one I’m tip top.” I went down, ate another leaf. Second day I came back and so forth, went to bed. I woke up in the morning my whole system was swelled, my whole mouth was swelled up, my whole internal digestive system was on fire, I was a total mess. I got very little sympathy from Don, the only thing he said as I recall is, “I guess you don’t know how big a squirrel’s ear is, do you?”

 

Dave: This was all a joke to see if he could get you to do it.

 

David:         Right. Charlie, yeah. Charlie’s good joke. I don’t know. I think you’re crazy.

 

Dave: I have been called that before and I might sustained one or two biohacking injuries. I appreciate you both sharing the story and rendering your opinion there. I figured I was unlikely to do a lot of harm and I’m always curious. I think if it’s not going to really, really cause permanent negative effects in my work, someone’s got to be the guinea pig it might as well be me.

 

David:         Right.

 

Dave: Let’s talk about sharing the human genome because now that we’ve got this data and the data is relatively affordable. I just had my entire genome sequenced at HLI. I didn’t have the results yet but the full thing which is pretty cool that a mere mortal can get it done. It’s still reasonably expensive.

 

David:         Price is still coming down.

 

Dave: It is.

 

David:         My genome sequencing.

 

Dave: How much is the current price?

 

David:         The cheapest price is a couple of thousand bucks if you just get the machine to do it and without the interpretation and so forth. That’s getting to be within range of larger and larger number of people and then of course if you just want to snip it. You want to look at the tiny fraction say one out of a thousand different positions that are the most informative positions in your genome, you can just go to 23andMe and 95 bucks I think you can get a glimpse I would say, a snapshot of some of the important parts of your genome. Whether you want the whole thing done or just a little bit, it beats the price, it can range from a hundred to several thousand dollars but these are not undoable numbers.

 

Dave: What are the big barriers of sharing this data? We have a world let’s say where now thousands of people have their full genome sequenced then soon hundreds of thousands or millions of people. What are the barriers to doing this and what are you doing at Global Alliance for Genomics and Health to solve this?

 

David:         When we did the first genome as part of the public human genome sequencing project we were very proud to be a public effort that was going to share all of our data. Really the day July 7th that we posted that, July 7th 2000 was the best day of my life, I mean it’s the day I’m most proud of. We shared that first glimpse of our genetic heritage free and unrestricted as open source, open data on the web. That was part of the whole structure of the public effort that it was scientist all over the world just trying to help humanity making this information fully open and available so that we could most rapidly advance our medical research and our basic biology.

 

Let’s face it the understanding of who we are. Evolution is the process that created our genome over billions of years from our distant, distant ancestors and the results of that are really the product of untold numbers of stumbles and triumphs by our ancestors through the eons. This is a fundamental script for humanity that has been sculpted by so much pain and triumph that you have to make it in our opinion public and something that we can now cherish and understand. What happens as we got now into medical sequencing, clinical sequencing is that the tendency is just the opposite, the tendency is to lock data up immediately and not to share. Part of that is just HIPA and the whole tradition of medical privacy.

 

Dave: HIPA, for people listening define HIPA?

 

David:         Yeah, this is the Health Information Protection Act that make sure that when somebody asks about your medical information they don’t tell that person unless it’s you or a designated relative so that people cannot go spying or snooping around on your hospital records. Now, there are very good reasons why we don’t want to let arbitrary people have access to our medical records and the DNA is increasingly part of the medical records. We’re not arguing that the DNA and all of the rest of the medical record should just be named public. The problem is that when you start to not even make this information available for research then you’re losing an enormous opportunity and cancer is a great example.

 

We know that there have been mutations in cancer tumors from the very beginning and we know that there are untold millions of different combinations of mutations in those tumors. We will not be able to figure out the important ones that we need to develop therapies for versus the unimportant ones sometimes called passenger mutations that don’t do anything. Unless we have a large number of cases to study. I often say that if you just have one genome you can’t learn anything. It’s only by comparing genomes to each other that the patterns emerge. Anybody who knows statistics also can understand that there’s a signal to noise ratio problem when you have only very little data and a lot of variables, a lot of things to look at.

 

The genome is a classic example of that, there’s three billion bases that can change. There are a lot of variables to deal with and in order to do that we need to look at a lot of genomes. The focus of the Global Alliance for Genomics and Health which I co-founded three years ago is to create a mechanism so the world can share these genomic data. There are certain types of genomic data that can be shared openly and publicly. For example it’s reasonable that even if you don’t share your genome that you got from mom and dad, your so called germline genome technically. You may still want to share the changes that happened in your cancer tumor because you’re not going to pass those onto your kids, they are not private to you, they are like any other medical symptom.

 

We need to account for the frequency of all of these medical symptoms including the genetic variance as well as the other measured variance. We have a program right now that we’re trying to push called the Cancer Gene Trust where we’re trying to get people to share the genetic variance that occur only in their cancer and just publish them openly so everybody can research those. If we do this right there’s no privacy problem there, the problem is that the general public doesn’t understand the distinction. It’s a scientific distinction, right, between DNA that’s changed in the tumor versus DNA that’s part of your cells that you’re going to pass on to your kids. That gets complicated to explain that but if we can get that kind of thing to be shared that would be great.

 

Now, there are also are cases though where we want to share information from your germline DNA, information that you will pass on to your kids. Another project we have is a the BRCA challenge. You may know the gene BRCA. Many people know it because Angelina Jolie made the famous announcement that because she had a genetic variant in her BRCA gene that made her highly prone to breast cancer she was going to have a double radical mastectomy. That certainly was a wake up call all over the world to be the importance of this particular gene and the importance of genetic testing when it comes to thinking about and planning for your future.

 

The problem is that right now when women go in to get tested for BRCA, a very significant percentage of those women are told, “Yes, you have an unusual variant in the gene BRCA but it’s a variant of uncertain significance. Go away and worry about it but we can’t tell you anything about it.” What a horrible, what a horrible report for a woman to get and there’s one and only one reason for that is that we haven’t shared the data, we haven’t accumulated enough observations of that variant to be able to decide whether it is associated with breast cancer or not. If we only been sharing the data we probably could be able to tell. The BRCA exchange is about getting the world to share that data.

 

Now, in this case we’re sharing it with experts, we’re not publishing it openly on the web. We’re not asking women to publish their BRCA, full BRCA gene sequence that the same one they will pass on to their kids. We‘re not asking them to publish this, we’re asking them to share it with the experts and let the experts help classify the variants so that everyone gets a better diagnosis. Those are two projects, one where you’re publicly open, one that we’re trying to at least share the genomic information with the experts.

 

Dave: In 2011 at the big data conference called the Gigaom Conference in New York I proposed a system like the one that you’re talking about, a policy basis to expose some of your genetic or lifestyle information for instance your fitness tracker information so that you could share it with your community, you can share with your doctor, you sell it to a drug company, you can sell it without your name on it, you could associate different things, do it all by policy. Essentially create a marketplace for your data because a lot of people also react, “I don’t want big pharma doing research on my genes.” Basically most people that I know now kind of look at big pharma as not necessarily honest like one step away from big tobacco and frankly if they’re going to patent one of my genes I get a cut or you guys don’t get my genes.

 

David:         That attitude has got to change. The solution to that is to prevent patenting and this is very relevant in the breast cancer area because there was one company Myriad Genetics that had the exclusive patent on BRCA gene testing and that was thrown out by the Supreme Court two years ago.

 

Dave: What a win.

 

David:         Hallelujah. There’s a step forward. I think the goal is not to keep information from the pharmaceutical industry but to make sure that they’re not misusing it in the sense of exclusively patenting genes because we do need people to develop drugs. You’re really going to cut yourself short if you completely cripple the pharmaceutical industry. I intend to take a less radical view of that but go ahead.

 

Dave: I’m speaking for a lot of people listening to the show and I have no fundamental problem with drugs. Drugs who save lots of people’s lives probably including mine when I had a really bad infection or something.

 

David:         That’s right.

 

Dave: No problem there. Some of the business models and behaviors associated with these companies are ethically challenged. For instance we make drugs that reverse the effects of the pesticides that we sell from the other arm of the company. That kind of crap has to stop, Monsanto I’m talking to you, all right. There’s other disturbing things like that that I think people have woken up to and they’re not willing to contribute to that system. If you put them in a hospital and say, “There’s a tumor this big inside your head,” they’re going to gladly consume whatever cocktail of things is going to get rid of that. Assuming that it is a cocktail of drugs that are going to do it. We haven’t talked about vitamin D in cancer, we haven’t talked about ketosis and cancer, some of the other things that we probably won’t get to in the time we got.

 

David:         You have to talk to my brother about vitamin D, Mark Haussler. He is one of the major discoverers of the hormonal form of vitamin D and really, really is an expert on how it increases longevity and may help with cancer and so forth. He’s devoted his life to the study of vitamin D, brilliant.

 

Dave: What’s his name?

 

David:         Mark Haussler, my brother, my older brother.

 

Dave: Would you facilitate an introduction?

 

David:         Sure, I’ll have him on. Yeah, he’s great.

 

Dave: I would love to. I’ve been using vitamin D and looking at that in the various interactions with light for a long time. That would be fantastic. What a neat family. It must be amazing. Let’s talk about what you’re doing with the block chain which for people listening this is what Bitcoin uses and this is the idea that you can take data that you want control over who sees it and who does what with it. You can encrypt the data with the data that came before, the data that came after so you can sort of track whether anyone has accessed it or if anyone has messed with it. Do you have this rolled out for genetic data? Could I share my stuff today on block chain?

 

David:         We don’t have this rolled out. We’re just working with the system, for the cancer gene trust we have one version that uses block chain and one version that doesn’t use block chain that’s even simpler but just as a start. What we want to do is make sure that we get people starting to share right away with a little overhead and just get it going and then add more bells and whistles as we go on. The block chain would be important for transparency, we’re using it as a public ledger which you can record all of the transactions that have taken place. Simplest transaction is Sue decided to share this genetic information and Billy used that genetic information and then Bob shared this information and so forth.

 

All of these things being transparent and being available in a public record that can’t forged or cheated or something like that is very, very important. In sense when you say share the data this is the other part of this, most people are thinking share the data with who and who has control of the data. What to share the data? We give it all to Google and they distribute it or we give it all to the US government they build a big database that the world can use and so forth? Most people are unhappy with those solutions, they really want something that’s organic like the internet itself so that we are essentially posting that data onto a shared database that is essentially a globally shared database.

 

In that the block chain maybe one mechanism for keeping track of who does what in terms of submitting data and using the data. If it’s transactional then you can actually use that to create an economy of the type you are talking about, right. You can keep track of who’s using your data, you can get various types of feedback or even value back from the data. I’m highly discouraging of the idea of selling your genomic data at this point, I think that will hold research back.

 

Dave: Agree.

 

David:         I would like people to first consider contributing data to science for the purposes of knowing that you did something good for the world.

 

Dave: I fully agree. I support that.

 

David:         We run a pediatric cancer program and I’ll tell you briefly about it. The Governor of California announced the precision medicine initiative. In California there was a serious competition for that about a year ago and of all the applications we were thrilled that ours was one of two that were picked. The program is called The California Kids Cancer Comparison, it is idea of introducing DNA comparison into the treatment of kids with cancer. A kid comes into one of the hospitals that treats kids with cancer and they’re only about a dozen in California, less than a dozen in California. They would be referred from a smaller clinic up into one of these larger hospitals.

 

Even the case as the kind that there is a standard therapy that’s very likely to work, in which case the kid gets this therapy or the child has a type of cancer that we really don’t know how to treat or the child, the worst case is the child is coming back with a recurrent cancer that was treated before and now has emerged resistance or is re-surging again. Those are particularly hard to treat. The proposal to the governor and the state of California is every kid either the latter to the categories if their cancer is hard to treat from the get go or they’re coming back with a second cancer. They should have their genome sequenced.

 

We should look at all the mutations in the tumor and try to come up with a precision medicine treatment for this child. This was accepted, we are well into it, we have three clinical trials which is a mechanism for trying to do creative, more creative things with treatment. One is in the Pediatric Cancer Group at Stanford with Alejandro Sweet-Cordero, fabulous pediatrician who works in the area of pediatric cancer. He’s now invited us to participate in the weekly tumor boards that they have where we discuss the individual hard to treat cases. We present all of our genetic analysis along with regular cancer analysis and all of the best minds at Stanford think about, “Okay, what can we do for this kid who’s failed the original therapy and now we’re looking for an alternative?”

 

This is just an enormous opportunity to have an impact at this stage. What we’re mainly suffering from into this and a similar program at UCSF and a similar program at UC Irvine, Children’s Hospital of Orange County. We’re all involved in these things and we’re finding that the biggest frustration is that these kids have different combinations of mutations and there isn’t a database out there that we can look up to find similar kids. I’m getting back to this, this is why the Global Alliance is so important that you know there are other kids that have had mutations like this.

 

God damn it why can’t we find them and understand what happen to them and allow it to treat the next kid. If we talk to parents do they want to share this information, yes they want to share this information and purely for the satisfaction of knowing that their child’s struggle helps some other child.

 

Dave: Absolutely.

 

David:         That’s enough. They don’t want to get paid.

 

Dave: Not at all.

 

David:         They don’t care whether a pharmaceutical company is going to make a drug out of it. They would like to just help other kids and they want to share this information. We are trying to help them share this information so every kid has a fighting chance, every kid can learn from every other kid who’s ever had cancer. Obviously I get a little agitated about this but that’s really important.

 

Dave: That’s what this is about is helping people. A friend of mine Alexander Carmichael started a company called Patients Like Me.

 

David:         Yes, I think it’s great.

 

Dave: Okay, and I love Alexander, she’s unique and she has autoimmunity, right. In fact I would argue she probably had mold exposure given all of her symptoms but she and I have talked about all kinds of stuff and I have no idea if mold is it or not. She’s been very open about this, I wouldn’t talk about it. Anyway, she said, “Okay, there’s tens of thousands of people who deal with all these stuff everyday, why don’t we get together and run our own trials because things are too slow.” They did exactly the same thing but they didn’t have the genetic data because this was five years ago.

 

David:         Exactly.

 

Dave: What we’re talking about now is patients like 2.0 with genetic data and you’re putting the structures in place in a profit to facilitate, actually control for parents who have sick kids. Find the other three sick kids like this, find the genome therapy that work for one of them and maybe it’ll help me. We owe that to each other as human beings, I support that all the way.

 

David:         I love that line. Can we use that line?

 

Dave: It’s yours to do it.

 

David:         “We owe this to each other as human beings,” that’s exactly why we need to share this data.

 

Dave: That’s the motivating factor for why I share all the biohacks I do too. No one gave me an instruction manual and I weighed 300 pounds and I had arthritis and all these other things. I’m irritated that I spent 20 years and almost a million dollars hacking it but hey I’m happy I’m here. It’s been a fascinating interview and I’ve got one question for you, David.

 

David:         Okay.

 

Dave: If someone came to you tomorrow and they said, “Based on everything you’ve learned in your life not just in your academics but in everything, I want three pieces of advice. I want to perform better at everything like I want to kick ass at everything I do. What are the three most important things I need to know?”

 

David:         This goes back to the classic kind of response to the genome skeptics, right. The classic story is you get your genome sequenced and you get the total quantified self and you know everything about it and you ask the biggest guru in the world and he says, “Yeah, there’s three things you need to do. Exercise, eat right and get plenty of sleep,” “Thank you. I pay $30,000.”

 

Dave: Those come up remarkably often as answers to that question.

 

David:         Yeah, and this parable is actually had some essence to it that’s important to understand is that the human body and or physiology and our health is a very, very complex process. We are only gradually starting to understand it and part of it is because we were working with it as a black box for so long. That those the previous medicine just simply was in this hopeless state, I’m not being able to open the box and see what’s going on and we’re only now starting to make that transition to where we can start to understand the complexity of what’s going on.

 

In there it’s still incredibly daunting and there’s still lots of things we can’t measure and there are a lots of modalities that we can’t model. Until we get a lot more data and a lot smarter, it’s still going to be difficult to give a very precise plan for maximum health. All I can say is the only way we’ll get there is massive sharing of data, massive data of analysis and engagement of everybody. I welcome citizen scientist for getting involved and they’ve been shut out completely up until now. There was no way they can get access to any data that they needed. We need to bring the best minds to bear on this.

 

Dave: Some of those best minds are probably biohackers who are dealing with these conditions and are unwilling to keep dealing with it and I’m one of them.

 

David:         Yeah, that’s great. You have the strong motivation and brilliance and so we need to make an avenue through a global sharing and internet based infrastructure where we can share these data. Still protect the privacy of the individuals information but nevertheless share with individuals who can help.

 

Dave: David, where can people find out more about the initiatives that you’re working and how can they support them?

 

David:         Go to Global Alliance and Health, globalallianceforgenomicsandhealth.org, you can ga4gh.org is the kind of the geek site. If you just Google Global Alliance for Genomics and Health, just Google that phrase you will get the main web pages. It’s all about our projects and our leadership. We have an enormous participation more than 400 different institutes from 40 different countries are members and are participating. Our scientific advisory board is very illustrious, Francis Collins the director of the NIH here for example is on our scientific advisory board, just to drop one name there. We do have a substantial investment in data sharing at this point and if you’re a geek you can go directly to the github site where you can see all of our open source code.

 

Anyone can participate, it’s a classic open source culture, if you start actually making creative enhancements to the code all you do is … You can come out of anywhere. We don’t require membership or anything like that but if your code change or pull request as they say gets thumbs up from three different other existing engineers on the project then it will be incorporated into the code base and you’ve now become a developer for the Global Alliance. This is the Apache voting rules of open source, right, three plus ones and no minus ones and your pull request is accepted. It’s an open embracing, welcoming community of geeks that are trying to make a difference and we want everybody to join.

 

Dave: David, thank you so much for being on Bulletproof Radio today. It’s been a very illuminating. I appreciate you taking a really complex topic and making it something that all of us can understand.

 

David:         Thank you. All right, all the best with your health quest. We’ll celebrate when you’re 180 and I’m 200.

 

Dave: It’s a deal.

 

David:         Okay, thanks.

 

Dave: Thanks for watching. Don’t miss out. To keep getting great videos like this to help you kick more ass at life, subscribe to the Bulletproof YouTube channel at bulletproofexec.com/youtube and stay Bulletproof.
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50 Shades of Dave with Mistress Natalie – #341

Why you should listen –

Mistress Natalie is a professional dominatrix and life coach to entrepreneurs. Before becoming a full-time dominatrix, she was an entrepreneur with several successful businesses under her belt. Over the course of several sessions with her clients, she began to see the therapeutic value of BDSM and decided to go back to school to get accredited as a life coach. Her “Kinky Coaching” uses BDSM along with several biohacking principles as tools to elevate a person’s mental and physical state, increase neurofeedback and run a successful business. Enjoy the show!

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Dave:  If you’re a regular listener of Bulletproof Radio, you’ve heard me share the top ten list of biohacks. Let’s talk about number 9. Fun hacks for the Bulletproof mind. It may sound weird but hanging up side down is a great way to hack your brain. Regularly inverting trains your brain capillaries making them stronger and more capable of bringing oxygen to your brain. It’s a pretty straight-forward thing. More oxygen to the brain means better performance for you. I get my daily stretch and a good dose of brain oxygen with my Teeter inversion table which is essential for optimum focus, concentration and energy. It also just feels good and it’s an effective way to keep your back in good shape. That full body stretch elongates your spine and takes the pressure off the discs so they can plump back up. Less pressure means more flexibility and less pain. If you have back pain, even if you’ve been lucky enough to avoid, you need a Teeter to invert everyday to keep your back and your joints and your brain feeling great.

 

For over 35 years Teeter has set the standard for quality inversion equipment you can trust and there’s an amazing offer just for Bulletproof listeners. For a limited time you can get the Teeter inversion table, the same one that I use, with bonus accessories and a free pair of gravity boots so you can invert at home or take the boots with you to the gym. To get the deal, which is a savings of over $130 you have to go to getteeter.com/bulletproof. You’ll also get free shipping and a 60 day money back guarantee and free returns so there’s absolutely no risk to try it out. Remember you can only get the Teeter with bonus accessories and a free pair of gravity boots by going to getteeter.com/bulletproof. That’s getteeter.com/bulletproof. Check it out.

 

Speaker 2:      Bulletproof Radio, a state of high performance.

 

Dave:  You’re listening to Bulletproof radio with Dave Asprey. Today’s cool fact of the day is that recent Canadian study has shown that BDSM, that’s like bondage and fantasies are really common in both men and women. About 51% of women, fantasize about being tied up while 46% want to be in charge. On the other hand, I have no idea of the other small percentage who’s left over, about 3% apparently are asexual. On the other hand the 53% of men fantasize about being dominated and 46% think about spanking for sexual pleasure. Contrary to the characters in 50 Shades of Grey, our studies also show that BDSM participants are just as healthy psychologically about sex as people who do it the old fashion way.

 

Today’s episode is going to delve into some of those things. I don’t think we’re going to get too … What’s the word for it? Too graphic here, however, I have no idea exactly how graphic it’ll get. If you are listening with people in the car who are impressionable and need to know nothing about what we’re going to talk about, you can skip this episode and that’s all right. Before we get into today’s guest and by now you’re going, who is this woman who’s going to be on this show? You’ll know in a minute.

 

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Dave:  Let’s talk about what you can do to your Bulletproof Coffee to upgrade your sex drive a little bit. There’s something called Bulletproof Cacao Butter and of course you can get a high quality chocolate powder. You can mix these into your Bulletproof coffee and you get more like a mocha flavor without the sweetness. You can put a bit of Xylitol from birch trees and if you want the sweet but cacao both the oil and the powder contains something called PEA or phenyle … I can never say this word right. Phenylethylamine, which is a mood enhancing compound that simulates endorphines and this is a neurochemicals of pleasure.

 

Those chemicals are also known to improve your libido. The Journal of Sexual Medicine says that women who enjoy chocolate everyday have a more active sex life than those who don’t. It’s summer, you can’t even get the Bulletproof Chocolate Bars right now but we have lab tested chocolate bars that are laced with brain octane and zero sugar. What I do during the cold months is I’ll ship those to you and during the hot months I stop shipping them, but I stock up. I still have about 50 of these Bulletproof Chocolate Bars at home so I’m never without my chocolate. Sorry you missed out but you can check out the Cacao Powder and Cacao Butter on Bulletproof.com.

 

All right, today’s guest is Mistress Natalie. She is a professional dominatrix, a certified life coach and an entrepreneur. She’s got about 20 years of doing something called BDSM and we’re going to have a scientific conversation about why and how and what happens there. She’s done pretty much everything that I can think of there, bondage, corporal punishment, humiliation, something called slut training, you can tell us what that is, medical torment, financial domination. That is an impressive one. Getting people to fetishize giving you money, that has to be the ultimate hack. Hypnosis and other techniques and things like that. That’s impressive and totally unusual and it’s a form of biohacking for sure and we’ll get into why I believe that’s the case. The other reason that you’re on the show and I’m saying you, because hey Mistress Natalie say hello.

 

Natalie:           Hi.

 

Dave:  The other reason I wanted you on the show today is that you hit 240 pounds when you were a teenager. You were a vegan on a very restrictive calorie diet, you broke your health. We actually have very similar health journeys where being heavy as a teenager doesn’t work out very well. For people who are watching the video on YouTube, go to bulletproofexec.com/youtube in order to find the YouTube channel. You’ll see that Mistress Natalie is I think technically very attractive would be the right way of putting it. Is that accurate? What do you think.

 

Natalie:           Thank you. I hope so.

 

Dave:  See I was trying to make you toot your own horn there and good you can do it.

 

Natalie:           No I’m sorry. Only when I’m in my professional mode will I toot my own horn ad nauseam.

 

Dave:  Exactly, and as it should be. The reason that I wanted to have you on the show here is that this is actually really a common thing. 50 Shades of Grey was an incredible best seller and just overwhelming in terms of the amount of interest in it and it’s hard to go Safeway without seeing 50 Shades of Grey on the shelf.

 

Natalie:           The book are everywhere.

 

Dave:  I get it’s entered the national consciousness and there’s a lot of interesting psychology that comes out with this kind of stuff from what I’ve heard. I’m from Silicon Valley, it’s Bay Area. They do this stuff all over the place.

 

Natalie:           All the time yes.

 

Dave:  Some of the things like inversion therapy, this is just from our conversations ahead of time. I hang upside down. You hang people upside down, maybe slightly differently.

 

Natalie:           I do.

 

Dave:  [Sensory deprivation can produce profound changes in your brain. I have a sensory deprivation tank. One of the techniques that you use is actually like blindfolding and plugging people’s ears and stuff like that. They’ve got no where to go but inside the mind even though maybe they’ve lost control there. You do a lot of electrical stem it sounds like?

 

Natalie:           Yes. Definitely.

 

Dave:  I do a lot of electrical stem.

 

Natalie:           I know, so many similarities.

 

Dave:  It’s seems like a bit of a stretch but there’s probably some physiology going here that we can dig in on. Finally, you talk about chastity play which I’m very intrigued to hear about because long time listeners know that I gave a talk, jeez, it’s going back about 4 or 5 years about how ejaculating too frequently actually sucks your energy and makes you … At least for men. I don’t think it’s particularly healthy based on Tantra and based on a year of experimenting with going up to 30 days without ejaculating, just not without sex, just without ejaculation. I believe that there’s probably some cool stuff going here and I just wanted want to talk to one of the world’s experts on this. Welcome to the show and this is going to be fun and interesting and we’ll see if it’s titillating or not.

 

Natalie:           I think it should be and yes, I mean all of the things that you mentioned. Definitely the parallels that I can see as someone who started biohacking about 4 years ago now and doing what I have been doing for about 22, I’m drawing all these connections in my mind being like oh my God, I didn’t realize what I had been doing for the past 22 years have a lot of similarities with the things people do and biohacking and self improvements and other parts of life. It was very interesting for me when the brain started to make these connections. I was like, “Hey wait a minute.” Hopefully we can bring some of those to light.

 

Dave:  Now let’s talk about your definition of BDSM. There are people listening and there’s all kinds of preconceived notions about this. I’ve had a few friends who are super into BDSM and they all like different things and it seems like a very broad definition. Tell the audience how you define it and let’s just go through your story and then talk about what it does for people. First, what is it?

 

Natalie:           Well, the acronym is bondage, discipline, dominance, submission and sadomasochism but again those words mean a lot of different things to different people especially when you put them all together. It definitely excludes another part of BDSM which is fetishism. The actual acronym doesn’t really represent the whole picture and it is hugely hugely just wide open to people’s perception of what they consider BDSM. For me because I’ve been practicing for so long and I have a lot of interest, it can be a range of things but I can tell you instead of maybe what exactly it is, it’s what it’s not at least for me in my professional and personal life. It’s not about really, truly hurting somebody, it’s not about being completely selfish and it’s not about being this demanding over-arching stereotypical woman who’s just using and debasing another human being. It’s really about using kinky things, counter culture things, fetish and some of the things we would associate with BDSM, bondage and leather and restraints and restriction and punishment to sort of get a person to where they need to be.

 

That’s why what I do is so broad because it’s completely individualized. I’m there as a sort of facilitator more than anything else. It all is in this context of a power exchange. I’m the one in charge, you’re the one not in charge but in reality all of the boundaries and interests have been set up ahead of time so nothing would ever go on that wasn’t already approved from both ends. For me its really more about getting somebody to go some place that they need to go through, fetish and kinky outside of the box avenues.

 

Dave:  What is really happening there is that you’re setting up something ahead of time with someone where they’re saying these are the things that I want to experience.

 

Natalie:           Mm-hmm (affirmative).

 

Dave:  Then you are helping them experience this. Okay what do you get out of it other than, paid.

 

Natalie:           Actually it’s really interesting. I fell into this one, I was very, very young and I always had an interest one in things that were medical and two, anything that was counter culture, punk rock music, leather chains. When I was young Motley Crue had a video and we saw the girls in these outfits and so that’s why I was originally attracted to it and sort of fell into it but then as I started developing my own interest I realized what I got out of it above everything else was knowing that the person left me feeling better than when they walked through the door. Having your job be where you can make somebody feel better is the best job that there possibly is so I get emails and letters and things that have literally brought me to tears with gratitude and thanking me and seeing how essential our play and what we do is in their life making them better parents, better colleagues, just better people themselves. I mean, what more could you ask for?

 

Dave:  There are people I know who practice BDSM. Several of them have told me it’s therapeutic. They feel somehow just different when they’re done and that it’s not necessarily sexual. Do you have sex with your clients?

 

Natalie:           Not at all. Actually I would say that there is only a fraction of my clients who actually orgasm during our time together and it’s never anything that I sort of facilitate. If anything it’s kind of the opposite of that. It takes sex or what we think of this traditional sex and it really brings it to a mental level. There’s a lot of physical things going on but it’s not sex in the traditional way especially the way men think of it which is a very physical act that can only really be exemplified by completion with an orgasm. For many of my subs and slaves that’s not even broached and for the ones that it is it’s an interplay often times like you had mentioned chastity have a large percentage of my subs who during our play time are actually in chastity the whole time because when that’s not the focus then all of these other things can be realized and all these other experiences can be brought to light and on many levels.

 

Dave:  What does in chastity mean?

 

Natalie:           There’s various devices that you can actually wear that sort of keep your genitals from getting an erection and that you can’t stimulate it at all. It’s just sort of being locked away.

 

Dave:  You actually padlock the equipment there. All right.

 

Natalie:           Yes.

 

Dave:  You kind of take that off the table at the beginning.

 

Natalie:           Just take … This has nothing to do with what we’re about to do. You’re locked up, I have the key, maybe you’ll get it back, we’ll see.

 

Dave:  Okay.

 

Natalie:           Sometimes I’ll keep the key, give them a key in a lock box with a combination and then they have to wait X number of days for hopefully the email that comes with the code.

 

Dave:  You send them home and they’re still padlocked, wow. I guess the TSA…

 

Natalie:           Wives, they love it.

 

Dave:  The wives love it?

 

Natalie:           Well if they’re a couple and a couple is okay with this kind of play a lot of times there are assignments. They’ll have assignments to really give their partner a lot of attention and all of a sudden the focus just goes on pleasing somebody else.

 

Dave:  You have wives who send their husbands to you?

 

Natalie:           I have a few but it’s more like they’re couples and the wives are okay with the play but really just don’t have an interest in participating. Some will participate a little bit to the level of they know and will be incorporated that way and some are just like, “Do what you want to do that’s totally fine. I understand this is part of you but I don’t get it. It’s not in me and I don’t want to be that person.”

 

Dave:  Okay. Do you have women who are clients as well?

 

Natalie:           I do. A smaller percentage. I think for a couple of different reasons. One, in our society, I still don’t think it’s okay to pay for what’s considered sexual services whereas with men it’s totally acceptable. I think that plays a lot into it. Also I just don’t think a lot of dominate females gear their audience towards submissive females so I just don’t think from a general marketing perspective that a lot of women really know about it unless they search out.

 

Dave:  You mentioned that you just felt attracted to this as a young person. How did you become a professional though? I’m sure there’s lots of people who experiment when they’re young, who are attracted to all sorts of things but then you took it one step further. When did you decide that you were going to charge for this?

 

Natalie:           It was a total accident to be honest. This was back in 1993. There’s no internet, there’s nothing, I had no idea that this existed as a career. While I had interest in it, I still didn’t understand it to almost sort of real level. It was like imagery that was attractive to me. It was just a friend of mine who I hadn’t seen for a couple of years was working in this role play domination house and I bumped into her on a weekend home from college and she’s, “Hey come to work with me.” You’re 19, not even 19, 18. You’re like, “Sure, whatever.” I go to hang out with her. You don’t think, oh what do you do? Where are you working? Things started to develop as the day went on. I was like, “What is this place?” She explained it to me and I was fascinated. I just thought it was wonderful but I didn’t think it would be anything I’d do. One, I had lost a significant amount of weight but was still very overweight. I was probably about 170 or 180 pounds and just getting over being …

 

Dave:  What are you now just for comparison?

 

Natalie:           About 140.

 

Dave:  Okay, so you’re much lighter now and you’re at a healthy weight?

 

Natalie:           Yes and I was 240 so I was still … I was overweight since kindergarten. I saw these attractive women and these little outfits and I was like, “Oh that could never be me. I’m the fat girl that never had a boyfriend.” I just started hanging out there and watching and just being the eyes until one day my friend just had literally dragged me into the session room. I don’t remember the session, I just remember afterwards she was like, “Oh my God, how did you know how to say that and do that? I’ve been doing this for a year and I didn’t know how to do that.” I was just like, “I don’t know.” The woman who owned the place was like, “Work for me,” and I was in college. I was, “God, I could pay for school.” I started coming home every weekends and practicing and playing and paying for school and after about a year when I started to get a little confidence, I was like, “I really think this is something for me.”

 

Probably also because it changed my perspective about myself completely. Here I was ingrained in me that there was something really wrong with me. My whole life it was always the you’d be pretty if you lost weight or you’d be much more attractive if, if, if, and boys didn’t talk to me and all of a sudden these men who were 30 years my senior were just like, “Oh.” I was like, “What the hell is this?” It started to slowly help transform the perception of myself which I think was very cathartic and something could take people decades to do that I was able to really have done in this kinky, crazy, underground city environment. It’s always really positive to me. It was never anything negative.

 

Dave:  It helped you, it brought you catharsis and what does it bring for your clients? How much does it cost?

 

Natalie:           It really depends. I am definitely the upper end of the spectrum and I have my own private studio with no other employees in my town Manhattan.

 

Dave:  It’s going to be very expensive up here in New York city.

 

Natalie:           Yes my session range depending on how long I’ve known you and how long you’re playing between 250 and 400 hourly if I don’t drop.

 

Dave:  Okay and this is without sex? That’s not what you do.

 

Natalie:           Oh no, no. Absolutely no sex at all. It’s all just BDSM and fetish and role play to various degrees.

 

Dave:  That’s about in New York what you spend on a good massage.

 

Natalie:           A therapist.

 

Dave:  It’s 250 bucks is a massage right?

 

Natalie:           Yes and if you go to a shrink you’re easily paying a 400 an hour.

 

Dave:  You’re some …

 

Natalie:           Somewhere right in the middle.

 

Dave:  You’re a life coach too. How much do you consider what you do psychological versus physical?

 

Natalie:           At this point I would say it’s a good 85% psychological but I have 22 years of getting a group of subs that are probably more interested in the psychological benefits and the deeper connection that this can give. I don’t take on a lot of new people at this point in my career and if I do, they really have to be interested in sort of the over-arching sense of what BDSM can give and not just the physical aspect of it because I feel that’s leading. If you can tap into the mental aspects of it, that’ll just keep giving and giving and giving. I have some subs now that are in their mid to late 70s.

 

Dave:  Wow.

 

Natalie:           When other things start to not work so well and the body can’t handle as much because I’ve been seeing them for 10 up to 16 years consistently. The brain is still very active and you can continue getting such joy out of things and that sense of total relief and stress relieving from their mental aspect. Me personally, my style is way more mental than physical.

 

Dave:  Do you get turned on when you’re doing it?

 

Natalie:           I get turned on between my ears but not between my thighs.

 

Dave:  Okay.

 

Natalie:           That’s something people ask. I’m also constantly thinking the entire time. Even if I was doing say a very simple foot fetish session where somebody’s rubbing my feet, which yes, I can say, “Oh yes, that feels good.” That is a wonderful sensation but my brain is more concentrating on where is this going? Where are they at in this particular part of the scene? When is it time to do something else? It’s never something where I’m just going to be sitting back and enjoying sexual pleasure. Doesn’t really do it for me.

 

Dave:  You’re spending your energy basically being in charge and figuring stuff out so the other person lets go but you’re not going to be letting go.

 

Natalie:           Exactly it’s constantly reading body language, audible sounds, checking on things especially during heavier scenes where there’s very restrictive bondage or other intense activities going on. I’m looking at it not just from the mental perspective but then also the physical perspective of I’m the one completely in charge in the situation. They are trusting me 1000% to make sure that everything goes well. It’s a huge responsibility and so the brain is always going and thinking.

 

Dave:  What’s the riskiest part of what you do?

 

Natalie:           I guess there’s a couple of things that are risky. One is when you’re pushing heavy play just making sure the person’s going to physically be okay.

 

Dave:  Heavy play, this is like spanking really hard or whipping or something?

 

Natalie:           Well, spanking really hard and whipping unless you are doing something you shouldn’t like whipping over the kidney area or doing some wrap arounds, probably going to be okay. There’s not a lot of damage that can happen from that but I’ve heard some pretty nasty horror stories where people who were doing some nipple play and they had clamps on that were pretty, what they call alligator clamps and the woman didn’t understand and tugged on them and literally ripped off the nipple.

 

Dave:  That would hurt.

 

Natalie:           That sort of stuff but for me personally, I’ve love medical and I do a lot of heavy medical scenes with catheters and sounds and colonics and …

 

Dave:  Wow, that’s pretty …

 

Natalie:           Scrotal inflation and piercing and … Yes. I’m always looking, making sure things are sterile and clean and the person’s reacting okay to whatever it is that I’m doing just on a health standpoint. Also breath play. If you do restrictive breathing, hypoxic breathing, you really have to be in tune with person that you’re doing this with to make sure that they’re going to be okay. I’ve had people have panic attacks or get nauseous so you just really need to watch their physical aspect. The risky thing on other levels is, in New York, technically BDSM is iegal but there’s always this sort of grey area. If you look at the letter of the law, there’s no well, oh yes, this is legal.

 

You really have to watch and worry and wonder who’s coming through the door before you see them from that standpoint and also their mental soundness before you see them on even if it’s not from a legal standpoint just like, is this a safe person? I am alone with a stranger if you’re seeing them for the first time in the room doing all of these things that are supposed to push somebody’s boundaries, are they stable, are they going to flip out on you? There’s a couple of risky things there.

 

Dave:  That could definitely be scary. I hadn’t quite thought about that. That leads to another question here. Stereotypically people would say … People who like this stuff clearly there’s something deviant about them that there’s something wrong with them, like they’re sick. There’s something abnormal. They said the same thing about gay people and about people of other minorities. There’s always this, that’s a group of other people but what we’re finding from this study I talked about at the beginning I was like, half of people are these fantasizing about this stuff so there’s probably something to it. What do you say to people who are like, “Okay, you need psychological help essentially”?

 

Natalie:           Unfortunately society doesn’t approve of BDSM and fetish but if you were to look at some things that I believe have very masochistic tendencies. A lot of other people may question and never want to do in their life but never cast aside as them being off in some way. You look at people who want to sky dive or jump out of planes or the people who do marathons or ultra marathons or triathlons or these obstacle course races punishing their bodies again and again and again and doing some what I would consider extra ordinarily masochistic games but they are applauded for this. It’s masculine, it’s the thing to do, it’s like yes and who says that that is any more sick or disturbed or twisted than what they decide to do to sort of get the same effect, feeling of accomplishment and you made it through a challenge and you’re putting your body through these rigors and you’re getting out of your head space.

 

To me it’s just society says X, Y and Z is wrong and some doctors long time ago said, “Well this isn’t the way that it should be and we live in a very puritanical culture and our roots come from that. I think if you look at BDSM and fetish in other cultures, even in Germany, Europe in general, Canada it’s really not frowned upon like it is here in the US. You just look at the activities and look at some of the other activities we do that we give a thumbs up to and you might want to question.

 

Dave:  A lot of the activities you just mentioned there are things that put people on a flow state and I’ve interviewed the flow state Genome guys. I’m their first investor in the flow genome project. Is BDSM something that puts people in the state of flow?

 

Natalie:           Oh definitely, without a doubt. In the community generally people call it sub space but yes, it can if done properly. Really put the person who’s participating in it in a serious state of flow. The after effects can last days where there’s focus, there’s relaxation, there’s clarity, so I would see a huge parallel between the two.

 

Dave:  People are coming to you. They’re pushing their boundaries and we know from the research on flow that pushing your boundaries puts you in the state of flow and what you’ve got going on is you’re pushing different boundaries than your ability to run even further in a marathon or something you’re pushing your boundaries. What is the boundary they’re pushing? It seems like …

 

Natalie:           For everybody’s different. I think for some people running a half marathon would get them into that state if they weren’t trained and for other people they’d have to run 3 marathons. Everybody’s sort of trail path to get to that state is different. That’s why it’s really important to sort of communicate with them. For some people it’s physical, it’s like corporal punishment, one specific thing, spanking, flogging, whipping. Slowly gradually building up taking more and more intensity, more and more severe pieces of equipment over a period of time until they get there. Some people can get there really quickly and again some people takes them quite a bit of time, a lot more pushing. Same for bondage, restriction, for some people it’s simple. It’s a blind fold or a gag and for others it literally has to be head and neck immobilization, blind fold gags, straight jacket, body bag, toe bondage but it can be any of these activities to really push that person.

 

Dave:  It sounds kind of like an addiction? Because you started out with just one and then you need two and then you need three. Is it like smoking? Or is this like utopia, an endorphin addiction?

 

Natalie:           Well I don’t know if it’s so much of an addiction. For some people I think just like with marathon. It’s like one marathon will always be enough. That will always be more than enough but for other people they do want marathon and it’s like, no I want to try ultra marathoning. I have people I’ve being seeing for literally 15 years and they’re … What would get them into flow is still the same as it was about 15 years ago. Then there are the more, more, more people and that’s a lot more challenging because sometimes I need to ring it in and be like, no there isn’t more, more, more. This has to … You have to learn to sort of adjust your expectations to what we have right here because it’s not really healthy to keep expecting and always wanting bigger and better and more.

 

It’s not possible but then there are those self experimenters who do like to try a little bit of everything. That’s always fun so for a couple of years maybe it’s one thing and then they need to try something else, go down a different path and being really self aware helps them sort of see okay, this isn’t giving me what I really needed to give me anymore. I would like to try X, Y and Z.

 

Dave:  Do you ever have clients who tried all of the things that they wanted to try and they’re like, “Oh I got that out of my system. I’m done. I don’t like BDSM anymore.”

 

Natalie:           Usually it’s not, “I don’t like BDSM anymore.” It’s usually like instead of coming for a session or practicing BDSM every week or every month for a couple of years, it may be a once a year thing or twice a year thing. Whereas it’s no longer necessary to do it on a consistent basis.

 

Dave:  Are they really just working through old traumas they have? Just kind of re experiencing them in a safe place?

 

Natalie:           Some, yes. Of course. I really do believe that that is … Some in a very positive way. Something traumatic happens to you X, Y and Z. You’re taking it, you’re owning it yourself and then you’re sexualizing it and making it this positive thing. It is definitely a form of therapy if you’re working through something like that but for other people … One of my subs is always like, “I don’t know. I would just way rather get spanked than get a massage.” It just hits certain parts in the brain that are more satisfying and pleasurable than things that people with traditionally see as positively affecting their mental state and physical well being.

 

Dave:  I’ve done this, as 40 Years of Zen. is in very advanced, intensive neurofeedback training program with clients. Some of whom have BDSM inclinations and people get very personal during these kind of things. It’s kind of therapeutic but we have a process that goes through and removes traumas. It’s very interesting because I’m hearing analogues to what you do. What we do is we put all the electrodes on your head, we show you how to go into a very deep alpha state which is one of the most reliable ways to put yourself in an alpha state is to have a sexual fantasy.

 

Natalie:           Interesting. I did not know that.

 

Dave:  Yes, if you’re stuck in the neurofeedback pod and we have this … this looks like Xavier’s School for the Gifted, the facility where we do this. You’re in this mansion and you’re in a fiber glass pod and you’ve got all these speakers and headphones and the things and they’re like, “I can’t make my brain do what I want it to do.” You’re like, think about whatever turns you own the most and for your set of clients it would be probably getting tied up or whatever, for someone else it may be, this is my wife or my husband. But then you can see the brainwaves are like, dun dun dun dun, lead her back in the zone.

 

It’s a way of getting unstuck. What we do in that program is we show you what your inhibitions and negative thoughts actually are because there’s a lie detector. You can’t hide from your internal dialogue with a lie detector telling you, no, no, no, but then in order to undo that, in order to release yourself from that, we actually have you go back and re experience the psychological pain, the physical sensation of the pain that caused your trauma and often times I always believed in fifth grade and I remember what it felt like when they pushed me down the stairs and it creates physical things in the body. The emotions are stuck somewhere.

 

What you do is you re experience whatever you felt at that time in life but then you re experience it as you are now then you raise your alpha brainwaves which has the effect of basically un-writing the rule your nervous system so you can let go. What I’m hearing you say here is that someone comes in, if they did have some trauma and it sounds like a lot of the stuff you’re doing is birth related. Like you’re squished and it’s sticky and you can’t move and you’re coming out. By the way I was born with a cord wrapped around my neck so I had lots of birth trauma. I have processed all that stuff so I don’t carry that with me the way I used to.

 

What I could see here happening is just someone goes in, you put them in a place via physical sensation that triggers whatever is stalking them and then now they’re experiencing from a place where they know they’re safe because they could always call a safe word or do whatever. To say, I need to stop here. Now we experience a sense of control whereas the first time the felt like they didn’t have control and then they feel better for a while afterwards. Is that … ?

 

Natalie:           Yes, I know that’s very, very similar to what I do. I didn’t understand exactly what happened with the neurofeedback but it’s strikingly similar scarily so actually.

 

Dave:  Yes, if you want to feel what a very high ultra brainwave say, it looks like have an orgasm. When they look at your brain, an orgasm that’s what happens. You don’t actually have to have an orgasm you see be turned on and your alpha brainwaves go up. You are absolutely putting people in an alpha brain state when you do that and probably a fate of brain state too if they’re hallucinating and sensor deprivation like the flow tank.

 

Natalie:           Oh yes, definitely. They will remember things that didn’t actually happen when we review the session.

 

Dave:  Wow.

 

Natalie:           Because their brain is literally seeing things that aren’t there or hearing things that aren’t there. It’s really interesting. To sort of review afterwards.

 

Dave:  Okay. They’re re-seeing the danger instead which is a same thing that you get from proof floating in a century tank. The people experience stuff that didn’t happen because the brain’s like, what do I do? I didn’t have enough input. In your case because you’ve gotten blind folded or whatever. There are some really weird deep parallels to biohacking. By the way if somebody gets there in an alpha state or a theta state, an alpha state is usually a good state and a theta state is if it’s in a controlled theta state where you’re day dreaming and you’re experiencing good things when you want to do it, it’s also a very powerful thing. You’re helping people get into altered states that then lets them process stuff.

 

Natalie:           On the other side there’s also the opposite of just being very present which I think people today are hardly ever truly present. When you walk through the door, the cellphones get shut off, there is no texting, there’s no emailing, there’s none of that. Just the break from all of that in an environment where you must focus 100% of your energy on what’s going on directly in front of you with zero distraction and I’m there to really make sure that that focus is kept for the entire time, an hour, two hours is very powerful. To really just know that you really can’t be distracted by anything else that’s going on in your brain or in life. Once you walk through that door it’s …

 

Dave:  It’s a focus exercise for people then.

 

Natalie:           Yes.

 

Dave:  It reminds me of my buddy Maneesh Sethi. Maneesh runs Pavlok a company that has a wristband that’ll shock you if you misbehave. You can either have your friends on Facebook shock you. By the way you’d probably like this. I don’t know where you put this little sock and bracelet but I’m actually an investor in Pavlok

 

Natalie:           Oh I have to look into this.

 

Dave:  Yes, I’ll introduce you if you want but Maneesh got sort of famous. He’s very ADHD and he hired a woman on Craig’s list to come and slap him in the face every time he use Facebook so he can get work done. It helped him focus and that ended up becoming the genesis for his wristband and the idea there is when he does something that he doesn’t like, he literally shocks himself so his nervous system will behave. He’s had people quit smoking and done all these other things. The name even Pavlok is Pavlov and Lok. He wanted the bracelet to lock on so you couldn’t take it off and so other people could shock you if you didn’t go to the gym when you said you would. I think he’s more of the business model of it from there but it kind of has a few shades of what you’re talking about.

 

Natalie:           Oh definitely. It really does. I have a lot of my subs who have, it’s sort of they’re under contract to get to the gym and eat certain way or have their weigh ins and there’s definitely repercussions if those guidelines aren’t followed.

 

Dave:  What does under contract mean? As a way of losing weight who knows? Explain it.

 

Natalie:           Again this is particular to people who thrive under that sort of hard rule. Some people they can do a boot camp style workout and having somebody yell on their face and be really aggressive and sort of debase them gets them motivated whereas other people will turn around and walk out the door. You need to know who you’re dealing with when you do something like this and who needs what sort of interaction which would be beneficial. For a few of my subs who are very serious about improving their life and health, especially since if I had known somebody 5 years, 7 years, 10 years, I tell them this is long term. This relationship isn’t going anywhere.

 

You need to be the best you that you can be in order to please me. They’re really working very hard to better themselves because it’ll make me happy. To facilitate this if they need to lose weight, they’re on high blood pressure medication they’re on. The traditional American diet and they sit behind a desk for work, God knows how many hours a day and don’t really get any activity. They sort of are, okay, you want to continue this relationship, you’re going to sign the contract. I come up with the parameters of weekly weigh ins and they’re going to stay between this 5 pound range and make sure they do XYZ to exercise and take a vacation and whatever it is. Literally I have weekly check ins to make sure that they are doing what they’re supposed to do.

 

Dave:  What would happen if someone didn’t make a weigh in or ate something they weren’t supposed to eat? What do you do?

 

Natalie:           It’s interesting. Again everybody is different. You would think that okay, you’re going to get punished but wait, you like to be punished. That doesn’t really work so often times their punishment is they don’t get to come in and see me.

 

Dave:  Oh wow you banish them?

 

Natalie:           It’s like, okay, you didn’t do what you were supposed to do. You don’t get to come in and see me and so you have another chance to prove to me that you’re going to fall through what you’re supposed to do. It’s sort of like the worst punishment. There are other lesser ones. Somebody’s like, “I really hate my nipples to be touched or played with,” so it’s sort of mild and fraction will be like, “All right, you didn’t do what you were supposed to do. I’m going to spend an hour just completely torturing your nipples because we both know that you really truly don’t like it.”

 

Dave:  You find something they don’t like. If you compare what you do with a normal life coach which is, yes you should really try to hold yourself accountable. You’re like, if you dont’ do it, I’m basically going to make your nipples hurt for a week.

 

Natalie:           Yes, I’m holding them accountable.

 

Dave:  That’s sounds like kind of a scary coach but I can see how that would be motivating.

 

Natalie:           Again, everybody is different and the ramifications are different for everybody but it is somebody that you have to check in with. By the point I’m making a contract with someone, we already have a very established relationship. More than anything the idea of disappointing somebody that they trust and look up to is probably they’re the biggest accountability. Because I’ll be like, “Well why? Why do you have beer and pizza? It’s like you know you’re not supposed to have gluten. What are you doing?” They’re like, “I knew I was at, I was this, I was that.” They know that they shouldn’t have done it. They don’t have to tell you, they could lie but they literally say, “I made a poor choice. I just want to let you know.” Then I sort of go through the whole your better choices, et cetera, et cetera, but yes, accountability.

 

Dave:  I run the Bulletproof Coach Training Program which is a certification program all right. I actually can’t say I’ve run it, Dr Mark runs it but I helped to design it and I’m part of the training curriculum and it’s based on my work and we co-designed it. A big part of that for coaches is holding someone accountable. They are weekly check ins but they’re like, “Did you do it?” If not well I guess there isn’t any consequence of not doing it except you just have to tell your coach yes, I was busy this week so I didn’t do what I said I was going to do. Nutritionally, business wise or anything else, you just I guess carry a bigger stick than the average executive coach or life coach?

 

Natalie:           I do. I’m able to definitely push their accountability a little bit further by giving them some really nasty punishments if they don’t follow through. Yes, so it’s a lot more fun.

 

Dave:  I can imagine. What I’ve learned through doing neurofeedback in this 4 years is anything, 10 weeks of my life just like with a lie detector, there’s ego. There’s a process that runs inside of you that something is making the decision to eat the gluten or to not do what you said you were going to do. Either it’s you or it’s another process inside of you. I don’t know how many times when I was obese, I’m like, “I’m not going to eat the cookie.” Then by the end of the meeting where there’s a plate of cookies I eat the cookie. I’m like, “Damn it. I’m so weak,” but at the end of the day, my own understanding of my own consciousness now is that actually there’s just another consciousness inside my body that’s working in my body’s best interest not what I want. It’s the animal side of things. It sounds like, what you’re doing there, if you tell someone you’re in charge and you’re deciding, you’re taking that part of them.

 

Natalie:           Away from them.

 

Dave:  You’re taking it away so it’s not in the decision loop so it doesn’t intervene. Are you able to sieve people, quit smoking or people sub really hard habits using these techniques

 

Natalie:           I haven’t had anybody who want to quite smoking as far as but one person but I didn’t know them very well. For me, I told them, “To be honest, I could try but I don’t think that this is going to work. We don’t have enough of a vested interest in each other for you to really listen to me,” basically. For other people yes. I got somebody to lose 100 pounds.

 

Dave:  That’s pretty legit. How did you do that? I want to hear the other exhibit. How do you get somebody to lose 100 pounds by spanking them?

 

Natalie:           There is a couple of people who’ve lost more than 50.

 

Dave:  Wow.

 

Natalie:           Yes, I’m so proud of them, it’s absolutely amazing. Again, accountability is a large part of it. They don’t want to disappoint me. That’s another really huge aspect to this because we already have a relationship and they don’t want to come in and be disappointed. Then there’s always the fear of, if I’m disappointing and I’m not living up to what I said I’m going to do I’m not going to get to participate in this activity and have this relationship anymore. Make it very clear that if they’re not serious then I’m just not going to see them. I’m not going to invest my time and energy into this relationship unless you come to me with the same amount that I’m going to bring because I’m always going to bring 100% so I expect the same out of my subs. That really, really drives them because they know I never phone it in.

 

If I’m preparing and I’m planning and I’m putting things together and then being very particular to their needs or interests, they need to sort of give me the same in return. As far as the 100 pounds it was very interesting being 240 pounds at one point myself, 100 pounds more than I weigh now I completely understand what it’s like to be on that side of things. If someone comes to me and they’re heavy or overweight, I’m almost blind to it. People bring up the need to lose weight or this or that but I don’t see people in that way just because I think I had different perceptions visually as myself and other people so that doesn’t come into play. I’ll never force it but if they come to me and say, “Hey I really want to lose weight. I know you have lost a lot of weight. Can we sort of work on this. We come up with a plan that I think could work for them given all of their little triggers that I know about the particular person.

 

The person who lost the 100 pounds, we had traveled for a session and they were having a really hard time getting around. They couldn’t even come close to keeping up and they saw I kept having to slow everything I did down and their lack of energy and abilities really hindered the trip that we were on and that prompted them to start to lose weight and ask me all sorts of health advice right away. It wasn’t like a contract situation or a weekly weigh in situation. It was that they saw how their weight really impacted being around and physical. Then after maybe the first 40 pounds planning another trip that person really wanted to go and do a physical activity that they hadn’t done in many many many many many years.

 

I was really, couldn’t believe in their physical condition they could do. I said, “If you think you can physically handle it, I’ll go on that trip with you.” When I saw them 2 months later they had dropped I don’t know, like 20 pounds. Then I was like, “Perfect.” I was like, “Let’s start planning the trip.” In planning for this trip every time I’d see them 20 pounds, 20 pounds, 20 pounds and then they said to me which is what I suspected is that I didn’t want to go to a beach area and walk around with you looking the way that I used to look because I would have embarrassed you.

 

Dave:  Wow.

 

Natalie:           Talk about powerful.

 

Dave:  That is powerful.

 

Natalie:           That really almost brings tears to my eyes to just think, just the relationship that we had would make them do something like lose 100 pounds after trying and struggling for so long. Did I know that that little trick was going to cause this effect? Absolutely not but when once I saw what it was doing, I totally picked up on that and then started having all the things that I could do putting in place to make sure that they would continue down that path.

 

Dave:  What other big behavior changes have you seen in clients?

 

Natalie:           Definitely getting more physically active. I deal with a lot of people who have very high stress jobs, lawyers, finance and they are just standing at a desk, sitting unfortunately at a desk for so long so getting people to be physically active. Literally forcing them to go to yoga with me, go rock climbing with me, I literally make it part of our session. They’re probably wearing panties or other things on underneath which makes it a little interesting. Rock climbing and chastity that’s fun but yes, definitely take that and start to physically bring them with me. Then again with the whole I don’t want to disappoint you, they start to do it on their own. That way the next time we do it they’re better at what they do. It starts to incorporate them, starts getting incorporated into their routine. I’ve turned many many people onto yoga because I think that especially for men in high stress jobs, just sitting, breathing and stretching a little bit is one of the best things.

 

People who are more into being physically fit, going for hikes or rock climbing things of that nature. That’s been huge. Then diet change. Really getting rid of the standard American diet and giving them a lot of information and resources about Bulletproof Diet and Paleo and Keto seem sort of what can fit into their life and imparting all of the things I’ve learned to experimenting with myself on that. Since I’ve known them for so long, they’ve seen the changes in me. They have seen when I was vegetarian, vegan, endurance, compulsive exercising to sort of the lifestyle that I have now and they’re like, “You look 5 years younger now than you did. What are you doing?” I was like, “Oh if you want to know … ”

 

Dave:  You’re in ketosis now right? You use Bulletproof coffee I think? You’re very faithful.

 

Natalie:           Yes I sure do, every morning for the past probably almost 3 years now.

 

Dave:  Oh wow, okay. You’re a ketogenic dominatrix which is cool.

 

Natalie:           I am. I go in and out.

 

Dave:  Thank you. I’m a huge fan of going in and out as well especially for women it’s maybe profitable.

 

Natalie:           Yes. I do do usually about two, two and a half months of strict keto right before a photo shoot because. But then after that the last time I went for a long stretch more than three months, I did have issues. I go to the doctor every 3 months for my blood work and thyroid dropped and my hormones got all off balance, my hair started falling out again and my amenorrhoea came back so I was like, okay, for me personally being in strict ketosis everyday for more than 2 months, it’s not good for me but going in and out for sure especially for the cognitive benefits. My grandmother passed away with Alzheimer’s and I have the gene so I’m like, this is something I should do.

 

Dave:  Yes and the question of do you want to do it every week, every month, as long as you’re in it some of the time or in my case when working with women especially just having some ketones present seems to be really important. Even if you’re not full blown in ketosis, if you’re using brain octane you can get enough ketones that you’ve got the brain benefits even if you do you some carbs which maybe helped with your monthly hormone fluctuations. It’s very individualized.

 

Natalie:           Yes, i’m usually anywhere between 0.5 and 1.4.

 

Dave:  Beautiful.

 

Natalie:           If I could get 0.8 I’m really happy. I’m like, all right that’s good, that’s all I need. Just right there.

 

Dave:  What we were talking about for listeners is just a number you get when you stick your finger with a ketone monitor. I’m happy with a 0.5, anything above 0.5 is cool but 0.5 is where the hunger changes happen and where cognitive benefits kick in and anything above that, I’m not dealing with cancer or Alzheimer’s or neuro degeneration at least not anymore. I probably was dealing with neuro degeneration when I was in my 20s but I think the ketone number for each person varies dramatically based on who they are. Let’s see, there’s a couple more questions I have for you. I’m just looking through all the stuff that we’ve talked about so far. One of them is, you mentioned slut training. What is slut training?

 

Natalie:           Yes. Slut training is actually one of my favorite things to do. It plays into a lot of role reversal. Basically it’s taking this guy who’s probably pretty guys guy kind of guy, either Wall Street or lawyer or a construction worker and taking the role and reversing it. One we never call men sluts. That’s a term that’s only used for women and pretty derogatory one. It’s fun to sort of take whatever sexual arousal that they’re feeling and sort of call him a slut just because it’s something that’s counter culture or something you’re supposed to do. Then emasculate them with a pair of panties, stockings and make them do sort of feminine things.

 

A lot of my clients are very into the whole imagery of a female with a strap on it. It’s a fetish, so putting them in a position where I’m literally wearing the genitals of the guy and they are forced into this position of being more like a woman, a maid, crawl around, nails painted, lipstick, it could go pretty far to full transformation. Even if it’s just embracing sort of their sexuality in a non masculine way, I think men approach sex in a certain way and they always have to be the one in charge and it’s all about the orgasm but when you sort of flip it on them and make them moan and touch their own body and sort of get in touch with that more feminine side of themselves, it’s an interesting mind flip. Just to see what it does to them and the sort of creativity that they come up with and the letting go of preconceived notions and boundaries and just sort of diving into this place.

 

If you were outside looking and you would think it was ridiculous. Here’s a six foot four guy who’s burly with a beard and a bra and panties rolling around on the floor or touching himself and moaning like a girl. The imagery is literally …

 

Dave:  It does sound a little ridiculous.

 

Natalie:           Honestly if the outsider looking in would be like, “This is just stupid,” but when you’re in the moment and you’re sort of being told to do these things that are really challenging to do. Challenging your masculinity, challenging who you are as a person, doing all these feminine things that you’re not supposed to do. You’re breaking all of these boundaries and notions of who you are as a person and sort of putting yourself in that situation is very challenging but I also think pretty cathartic for a lot of guys. Getting them to just be in tune with their emotions and their intuition.

 

I had one person say after a couple of years we did lots of slut training, he’s like, “This whole thing, I have to thank you for the huge boost in the career that I have had because I’ve literally been able to change the way that I think when I approach things now and it’s no longer from the sort of narrow focused masculine, this is the way the job is supposed to be done kind of way and I really started thinking outside of the box and going in areas other people were scared to go.” He was like, “My business has just shot through the roof,” and he was like, “I have you to thank for it,” my sissy training.

 

Dave:  Is sissy training the same as slat training?

 

Natalie:           Mm-hmm (affirmative)

 

Dave:  It’s the same thing?

 

Natalie:           Yes it’s interchangeable. These are words that if you look them up in Urban Dictionary or whatever will have a lot of definitions but it’s basically role reversal with elements of feminization usually clothing thrown into play.

 

Dave:  Got it. Okay. This is basically making people or men in positions of masculine energy or positions of power visually face more of a feminine side of things?

 

Natalie:           Yes and the terminology also at least in the state of New York, any sort of play with a strap on is not legal.

 

Dave:  Is it wearing it’s not legal or using it’s not legal?

 

Natalie:           No wearing it’s fine but any insertion where there is an exchange of money. If you look at the law I believe the technical law for prostitution is if there is sexual gratification that is paid for it’s prostitution. It’s very loose. If you get off on getting a root canal and you pay for it, technically that can be considered prostitution. You have to be sort of very creative with how you come up with things because you never want to get in trouble for doing something that you’re not supposed to do. On a legal standpoint, the whole sissy slut training generally also implies there could be strap on worship or penetration with it to some degree.

 

Dave:  Okay, got it. You definitely take it all the way then.?

 

Natalie:           Mm-hmm (affirmative)

 

Dave:  Do you find that there’s a kind of guy who’s a stereotypical client? You always here stuff about people who are in the position of power all the time, that they’re the ones who are most likely to be going to a dominatrix. Is that actually true or is it just like a mismatch?

 

Natalie:           80% of the time it is really true at least for me. Also the type of client and sub that I see, they’re not lifestyle submissive. They don’t live 247 as a submissive. I like it much better when they’re in a relationship or have a career and this is just part of their personality because I can’t dedicate as much time as would be needed as if they wanted to do this all the time. The person coming to me generally is stereo type A personality, always in charge, always in control, head of household, has a position of power at job, a lot of responsibility. That responsibility could vary, they’re not always making tonnes of money, it could just be high stress, lots of people beneath them that they’re managing, whatever it is.

 

I could say a good 80%, 85% are your total type A, total in control, always in charge person. They want to not be in control in a very controlled way because obviously all the parameters are set up before hand. It’s this huge relief and they’re like, “Oh wow, I get to listen to somebody else for a change and I actually trust this person. It’s okay to let go of being in control because I have confidence in this person and listening to them. A lot of people who are that type A, they don’t let go of that control because they don’t feel that there’s anybody around them who would do the job as good as they would do or have the abilities that they do. If I can come across in a way that they understand that I can handle being in charge of them, it’s really excited to be like, oh my God. I get to just totally let go.

 

Dave:  You send these guys back to work in padlocks and panties and things like that?

 

Natalie:           I often time think when I’m sitting on a crowded subway train, how many people have a garter belt on, how many people are in chastity, who’s wearing nipple clamps, who has a remote controlled vibrating butt plug inside o them?

 

Dave:  Do you think that there are people on every subway car doing that?

 

Natalie:           I don’t know if it’s every subway car but maybe the whole train. I definitely …

 

Dave:  There’s definitely people like that so just start looking around for panty lines on your favorite executive and … Actually don’t do that. You probably don’t want to know.

 

Natalie:           Was so fun. I went to a great restaurant here in New York city Le Bernardin, one of my favorite restaurants and think that was kind of cool out but literally under his suite he had a full latex jumper. He was wearing latex from here to his mid thigh.

 

Dave:  Oh wow.

 

Natalie:           Completely covered in latex, a chastity device he had an electric remote control electric plug. It was inserted anally and it was like a astem. I have the remote on my side of the table and the little box is in his suit pocket that’s going to the jacket.

 

Dave:  Oh my God.

 

Natalie:           He’s just about to take a sip of wine and zap.

 

Dave:  Were you just sitting there in a restaurant in public and no one has any idea? My God.

 

Natalie:           No clue, and the best is when it could be sort of visible bondage but no one has a clue. I have one of the neck braces that you wear for trauma when they put you on a board so you take someone out and you put them in something like that and they’re sitting there and they can’t move. You’re like, “Good luck eating.” People just think they’re hurt.

 

Dave:  Oh my God. I see you’re totally just taking them out there. I never would have imagined that.

 

Natalie:           Oh yes, my domination is definitely … I like to bring it beyond the room if possible especially when you know somebody. Some of my sessions are of a course of a couple of days and we do do outings to various places like I said, rock climbing in panties, out to dinner with all sorts of things going on, nipple clamps, bras under your cloths.

 

Dave:  Don’t people see a bra under cloths? When people are in the restaurant if they saw that, feel uncomfortable about it?

 

Natalie:           The wonderful thing about living in New York is unless you are on fire, I don’t think anybody’s going to notice anything.

 

Dave:  Fair play.

 

Natalie:           Also I’m personally taking it on as a project of mine to bring a little bit of grit and fun back to the city because I think the city’s become way too sanitized. Whenever I get the chance to do something in public that maybe turns few heads like walking down the street handcuffed to somebody, I think it’s a good thing from Manhattan.

 

Dave:  You’re fine to push the buttons. Apparently that’s like your day job is pushing people’s buttons so you’re happy to do it.

 

Natalie:           I’m fine with totally discreet, that’s perfect and I can do that very, very well especially if bra, panties, stockings, under a suit, no one’s going to notice that. There’s absolutely no way. If you have a jacket on and as long as it’s not … You’re not wearing a tight, tight shirt you’re wearing a fitted shirt, no one’s going to notice but the person wearing it will feel like everybody’s going to notice.

 

Dave:  Got it. It’s really a mind game.

 

Natalie:           Yes.

 

Dave:  Okay. Who would have thought? I’m never going to ride the subway again thinking the same thing. You’re also an entrepreneur. You run your business for 20 years and you’re doing it in a very unusual niche market but you’re one woman operation and you’re sort of put on this pedestal is like an unattainable kind of thing. What’s it like behind the scenes actually running your business?

 

Natalie:           Oh it’s crazy. I loved working for commercial houses and the woman who I was with for many years, I think it’s 11 years ago now. I officially started 11 years ago and I also had a custom baking business at the time that I was sort of launching and building my dungeon and studio. It is challenging. There is very little delegation can be done in my job. It’s sort of like, almost everything does have to be done by me which becomes a lot of work and just like any other business, it’s like, I have to make sure supplies are bought and place is clean and bills are paid and …

 

Dave:  Don’t you have subs to do all that for you for free?

 

Natalie:           Well one … The thing about subs … I do have one who will help clean when they’re available. Most of my subs they don’t have time like me.

 

Dave:  They’re all CEOs or Wall Street people.

 

Natalie:           They have to survive in New York.

 

Dave:  Okay got it.

 

Natalie:           They don’t have time. It’s one of those things and the few that do definitely do give an effort but there’s also that thing, I hate to say it but unless you do it yourself, it’s never going to get done 100%. There’s that aspect of it.

 

Dave:  You have control issues as well? Sorry.

 

Natalie:           I do delegate a little bit. It is very challenging especially the email and content, it’s like I can’t put that off to somebody else. This is personal.

 

Dave:  I feel the same way about the Bulletproof content. It’s hard when I work with people. I hear you.

 

Natalie:           I do have one slave who when I need my packages he will definitely make himself available especially lifts big, heavy things, he will come and clean my studio, he just fixed the light switch that needed to fixed for ever. He was in there this morning, I gave him the keys he was able to fix that so that’s a big help but my people don’t see the real business side of it. It’s more challenging doing what I do, getting a lease, doing my taxes, it’s like there’s no line for dominatrix. Then you have to be really creative with sort of what you do to make all of that work as well and things go wrong and you just have to sort of navigate it and fix it and make sure that everything is in order and the lights turned on and the equipment is clean and you have the suppliers that you need, then you can go in and have fun and then go back out and do your social media and Facebook and emails and bill paying and everything else.

 

Dave:  How many hours a week do you work?

 

Natalie:           I think a better question is, how many I don’t and it’s probably the seven hours that I sleep.

 

Dave:  So you work a lot then?

 

Natalie:           I do. It’s too much. This is not … I’m not promoting this for anybody who’s trying for better health, don’t think I don’t know that this is not optimal but there’s a lot of things for me. One, maintaining my own private studio plus my own apartment in Manhattan. My overhead is ridiculous. That is a big portion of this as well as I have to be realistic about the future of what I’m doing. I’ve had my studio for 11 years and the rent is extraordinarily high right now. My lease is coming up soon.

 

I realistically don’t know how many years I have left doing this in this format so I’m really trying to make the most of it in the next couple of years. If I need to sort of change what I do to a certain degree, I will have enough to cover me if I need to take a step back and sort of regroup. That’s driving me a lot right now to sort of get to that place where I feel a little bit more comfortable but I love what I do too. There is this … I feel I put a lot of pressure on myself to make sure everything is perfect which we know it can never be and I put a lot of time and thought probably way more than is necessary to what I do because it means a lot to me to make sure when I step into that room, I really am giving 100% and making sure that person is going to have the best session every time even if it’s our 500th session.

 

Dave:  What percentage of your time do you spend in sessions versus the other part of running your company?

 

Natalie:           The session time is very little. Maybe 2 to 3 hours with a client in the room, a day, five days a week. The rest is … basically for every hour that I’m in the room, it’s usually about 3 hours of work. Putting the plan together, getting the equipment ready, prepping before hand, cleaning up afterwards. In general, one to three sort of ratio.

 

Dave:  You’re working really hard, you make $400 an hour but you’ve got two things in New York and I can see why where you’re working a lot of hours that you’re in a pretty expensive market.

 

Natalie:           Yes and I’m in Midtown so it’s definitely very, very expensive. There’s the whole thing. There’s no sick days, there’s no paid vacation, there’s none of that sort of stuff. That always plays into it. Taking time off is a little challenging.

 

Dave:  Talk to me about financial domination. You mentioned that earlier which I came across that as I was researching for this show. I don’t think we talked about that earlier. What is financial domination and couldn’t that be a solution to all of your problems?

 

Natalie:           Financial domination, it is basically where somebody fetishizes giving you money. I have not mastered the skill. There are women out there who that is their thing. They really are into financial domination. I could say it’s something that I didn’t quite understand when I first started getting into it because I always felt like I was cheating them.

 

Dave:  What?

 

Natalie:           Just as a person and that was probably my own misconception because they want to be in that position but I obviously had a hang up about money and taking something. I’m feeling like I wasn’t doing something for that something so it was neither a specific area that I sort of grew my skills in unfortunately at this point, I’m like, that would have been a better path and avenue for me to take but I have with a few people who I see more over Skype or the phone that I do do some financial domination with.

 

Dave:  It’s basically like … I’m having a hard time imagining that. This is someone who actually just derives pleasure from being like, “Take my money”?

 

Natalie:           Pretty much. There’s the, you’re going to pay me and you’re not worthy so go sit in the corner or turn around and leave or I’m going to do 30 other things while you sit there and watch me and pay me for it. I know some other girls, they do a lot and it’s like, okay, I’m going out to dinner with my friends and you’re going to pay for the entire dinner for the 6 people and you’re just going to listen to us on the phone. Then they’ll make little comments and some humiliating comments while they’re having dinner and yes …

 

Dave:  You’re pushing buttons about self worth or something basically?

 

Natalie:           Yes. Definitely.

 

Dave:  Okay. That is interesting but I guess if you have someone who’s consenting as an adult and that pushes buttons for them, I don’t have any problems with it but it seems like that’d be convenient to have in New York.

 

Natalie:           It definitely would be but I guess from my perspective, it’s always really important for me to make sure my sub leaves feeling way better when he walked through the door. Until I have an established relationship with you, I don’t know if I could tell right away unless you had experience in financial domination if that was sort of your thing. I would always be hesitant to sort of suggest that right off the bat.

 

Dave:  It seems ethically risky for some reason.

 

Natalie:           Yes, from my perspective it could be and I think like I said, a lot of people they have their skills honed to know how to navigate that situation but it was something I never really sort of fell into. I heard some horror stories I think probably the first five or six years I was doing it were sort of giving their credit card or bank account access and it went sort of horribly wrong and the person changed their mind. It was legal troubles and I was like, “I think I’m going to step away from that one.”

 

Dave:  That just feels sketchy to me but I wouldn’t judge someone who really, genuinely derive pleasure from that.

 

Natalie:           Yes and there are. I know it and I’ve seen it. I just feel I don’t have … That’s not one of my top skill sets. A few people once I know them, I’ll be like, “Okay.”

 

Dave:  Got it.

 

Natalie:           But if there’s anybody out there who wants to be financially dominated, feel free to contact me.

 

Dave:  All right Mistress Natalie.

 

Natalie:           I’ll take you on.

 

Dave:  Now, we’re coming up on the end of the show. I guess we went longer than a normal show because well frankly that’s pretty fascinating to see it, just to ask a bunch of these questions that I’m sure a lot of listeners if they’ve ever thought of it and like what? I want to ask the question that I’ve asked all the guests on the show which is that, someone comes here tomorrow and says, “I want to kick ass at everything. I’ll perform better at life, what are the 3 most important things that I should know? What would you tell them given your very unusual journey through life?

 

Natalie:           Let’s see. I would say the first thing would be, be self aware and if you’re not, definitely look into finding out who you are as a person and what it is that you like and what really makes you tick or who do you really want to be because I think too many times in life we are stuck doing a whole bunch of stuff that we don’t really want to do because everyone tells us we should and it’ll make us happy and most people wind up being miserable. Really finding a lot of self awareness is going to be the first thing that’s super important. Then have some sort of practice of being grateful for things even things that you might think you shouldn’t be grateful for. Finding some way to really look at your life and be like, wow. I’m grateful for X, Y and Z. Do that on a pretty consistent basis because I think that gets lost in looking for me, trying to better or getting down on yourself. That would be number two.

 

Number three would probably be to make sure to confront your fears. Challenge yourself in some way. I like to personally do one thing that’s going to scare the crap out of me every year, like one big, this is really scary to me and I’m going to do it and it doesn’t have to be a big thing. Even if they’re small fears. You’d be surprised how amazing it feels to actually confront the fear and then you realize the fear of the fear was way worse than the fear itself, then it could hold you back for a lot in life. Those would probably be the 3 things that I would suggest for anybody who wants to really kick ass in this world.

 

Dave:  That’s a fantastic list. The thing about confronting something that makes you afraid every year is not an answer I’ve heard that often but it’s so important and it’s something that I’d certainly practice. If I find anything that makes me uncomfortable and I must have some sort of a trigger around that, I guess I’ll try it and see what the trigger is so I can deep program the triggers. I don’t want to have unconscious reactions to things so pushing your own buttons, there’s value to that.

 

Natalie:           I’ve a huge fear of falling completely off the charts and this year’s big challenge is a thousand foot climb in the Flat Hours for rock climbing.

 

Dave:  Nice.

 

Natalie:           I will be wearing my diaper and having lots of tissues for when I cry and poop myself, it’s all good. I’m ready for it.

 

Dave:  That actually takes a lot of courage to do something that really, really makes you afraid. So that’s cool. Now Mistress Natalie, where can people find out more about you?

 

Natalie:           My website is mistressnatalie.com. That would probably be the best place. There are some videos up. Another interview that I did and some videos of my studio and a plethora information, photos going back to the early years and the early 2000s and sort of my statement about what I do and philosophies. Then I have my blog which is definitely more graphic. If you’re squeamish that might not be the place to start.

 

Dave:  You just tripled your traffic levels when you said that. Please, oh no, not a graphic blog, that’d be terrible. Then if people wanted to work with you just for life coaching without you tying them up, do you do that?

 

Natalie:           Yes. I do. It’s definitely something that I don’t do as much of just because I don’t have the time.

 

Dave:  Okay, got it.

 

Natalie:           Obviously just from the financial aspect of it, it doesn’t make as much sense for me to spend more time doing that. Also I really love the BDSM aspect in combining the two. If somebody wanted to separate the 2, totally up for it. Love to do it especially if it’s on a health nutrition self exploration sort of front. If you want life coaching and you are in the business world and you want that, it’s not really my expertise but entrepreneurs, that sort of stuff.

 

Dave:  All right. Well thank you for being on Bulletproof Radio. I’m sure given that summer training a quarter and a half million people will hear this interview that you might find at least one or two of them who are probably going to come and meet you in New York. Maybe we can keep your studio thriving for a while longer.

 

Natalie:           That would be great.

 

Dave:  If you’ve sat and listened to our relatively long interview today I hope it was valuable to you in your car or if you’re watching on YouTube. That’s bulletproofexec.com/youtube to find the YouTube channel. You can subscribe to that. There’ll be a transcript of all this in case you need to go back and look up what slat training actually is or any of the other unusual things that we talked about that are pretty different from what you probably read in 50 shades of grey if you could actually make through that book. On that note, Mistress Natalie, anything else you’d like to say to the audience before we sign off?

 

Natalie:           Just keep listening to this absolutely amazing podcast and I hope that there are a lot of people out there who got something beneficial out of it.

 

Dave:  Thanks for being on Bulletproof Radio.

 

Natalie:           Thank you.

 

Dave:  If you enjoyed today’s show, you know what to do. Head on over to iTunes and leave a review. One of the most important things you could do to help other people find the show is to just go in there and give it a five star rating if you feel it’s worthy of five stars. We’re usually number one ranks on iTunes. If you don’t know where to go for that, you just go to Google and Bulletproof Radio iTunes. We’ll come right up. It takes about five seconds to leave a review. We just spent about an hour and a half plus many hours of prep time creating the show for you. If you can spend 5 seconds to say thanks, I’d really appreciate it. Just leave a review and tell me what you think. I actually read the reviews all thousand plus of the five star reviews. I’d love to make it 2000. Have an awesome day.

 

Thanks for watching. Don’t miss out. To keep getting great videos like this to help you kick more ass at life, subscribe to the Bulletproof YouTube channel at bulletproofexec.com/youtube and stay Bulletproof.
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Owning Your Testosterone with John Romaniello – #340

Why You Should Listen –

John Romaniello is the New York Times bestselling fitness author of Man 2.0 Engineering the Alpha: A Real World Guide to an Unreal Life and a superhero fitness geek. He has been featured on programs such as Good Morning America, and is an adviser to nearly a dozen fitness and tech companies. On today’s episode of Bulletproof Radio, Dave and John talk about proper testosterone use, sleep cycles, chronotypes, understanding hormone levels and more. Enjoy the show!

If you are attending Austin Man Camp and want to take advantage of Dave’s half-price Bulletproof Conference deal, just email Bulletproof Customer Support with your Man Camp receipt and you will be hooked up. See you there!

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Dave Asprey: Are you ready to take your life to the next level, especially in the realm of professional networking, dating, and relationships? You need to check out the Art of Charm podcast. In a recent episode, this inspirational podcast talked about mentorship and how you have to be a good mentee in order to be a good mentor. To take your life to the next level, go to podcastone.com, or download the free mobile app to listen now.

 

Speaker 2:      Bulletproof Radio, a state of high performance.

 

Dave Asprey: You’re listening to Bulletproof Radio with Dave Asprey. Today’s cool fact of the day is that micro-estrogens are Kryptonite for your testosterone, just like xeno-estrogens found in plastics and personal care products. Fungi and mold from foods, like produce, can make these estrogens. It can be found in the environment around you because of water damage in houses, which is why I made a documentary called “Moldy” about it. The biggest source of these estrogens is actually corn, wheat, rice, barley, and sorghums. These can be thousands of times more potent estrogens than what your body would naturally make if you turned your testosterone into estrogen.

 

If you’re like me right now walking around with a bigger than normal case of man boobs, I actually spent a night in a moldy hotel room and woke up the next morning with some interesting swelling. They’ll go away in a couple days. I don’t know if you can see, but I’m looking somewhat muscular, but I’m a little bouncier than I ought to be. This is an issue I’ve always had, because I grew up fat in a basement. Anyway, you don’t want mold or estrogen in your environment, and particularly not the combination of the two.

 

I totally appreciate you listening to Bulletproof Radio, and I want to do something to say thanks. I contacted my friends at dollarshaveclub.com and arranged for them to give new members a month of the executive razor for free, just for trying a tube of Dr. Carver’s Shave Butter. Anything that says butter is going to get me kind of excited, but this is not the kind of butter you put in your coffee, just so we’re clear. This is shave butter. I’m really excited that they agreed to do it for you.

 

Let me remind you why millions of others have joined as proud members of the club. Dollarshaveclub.com delivers amazing razors right to your door for a third the price of what the greedy razor companies will charge. That means when you join DSC, you can afford to shave with a fresh blade any time you want, which feels fantastic. I get a first class shave when I use the Executive Blade, and that’s without even hurting my wallet. When I use the executive with Dr. Carver’s Shave Butter, the blade just gently glides for the smoothest shave ever.

 

Shave butter isn’t your average shave cream. It’s a unique conditioning formula with high quality natural ingredients, leaving your skin unbelievably soft and smooth. Now is a great time to join Dollar Shave Club. New members who buy a tube of shave butter get a month of the executive razor for free. Take advantage of this special offer today. It’s available by going to dollarshaveclub.com/bulletproof. That’s dollarshaveclub.com/bulletproof.

 

Before we get going on the show all the way today, check out Bulletproof Upgraded Whey Protein. I’m actually not a big fan of whey protein, because it’s inflammatory when you get too much of the amino acid cysteine. A little bit is good. Too much is bad, but I make a whey protein which is made from grass fed milk, not a cheese byproduct. It’s low temperature processed. It’s 20% colostrum, and it’s got some of the XCT powder built into it. You get a little bit of boost from it. It’s one of the more creamy, satisfying, and biologically active whey proteins that I can manufacture. I tell you even then, even though I sell the stuff, two tablespoons a day, no more, because there are other proteins that can be better.

 

By the way, today’s guest may completely disagree with me, and he knows a thing or two about this kind of stuff. I have no idea what his perspective is. Pretty well known guy. His name is John Romaniello. John, I just realized something. We’ve hung out a few times, and I always just called you “Romanello”, but there’s an “I” in there that I never noticed. Have I been saying your name wrong this entire time and just being a dick?

 

John:   No, no, no. No, we don’t use the “I”. It’s a silent I. I assume many generations back it was “Romaniello”, but we’re particularly Americanized, and we just say “Romanello”. The “I” is-

 

Dave Asprey: “Romanello”. Okay, that’s what I’ve always said, and I just noticed the “I”. I’m like, “My God.” It’d be kind of embarrassing. People call me “ass spray” all the time, so I’m pretty resistant to that.

 

John:   That “I” has plagued me since elementary school. For whatever reason my teachers would always take it and throw it at the end of the name, and it would become “Romanelli”, which it’s not my name. It’s very strange. Yeah, the “I” has caused all sorts of trouble, as “I’s” tend to do.

 

Dave Asprey: Are you Italian?

 

John:   I am what we call miscegenous. I am quite racially mixed. I am probably more Italian than anything else, but I’m not as Italian as my name implies. My birth name is Giovanni Vincenzo Romaniello the Third for no good reason, except now it’s tradition. This is just of interest, if you like history, but my father’s mother, she was a beautiful woman named Willy Ellen Barrow, and she was from Buckaloo County, Alabama. She was half black, a quarter Irish, and a quarter Native American. Then she married my grandfather, who was Italian and Polish. I think I present to most people as a Guinea from Long Island, but I’m actually this mixed race guy with southern roots.

 

Dave Asprey: You’re quite mixed with some redneck in there, too. Wow, I’m impressed.

 

John:   Oh yeah.

 

Dave Asprey: I’m not quite redneck, but I’m from New Mexico.

 

John:   That’s sort of redneck.

 

Dave Asprey: Kissing cousins. We don’t have enough water to be real rednecks, and we make tequila, not moonshine, but otherwise …

 

John:   Otherwise it’s the same.

 

Dave Asprey: For people who don’t know your name, you’re a fitness expert, pretty well known. I keep coming across your stuff, so when I finally met you, I was like, “Oh, this is really cool.” John, you write for Men’s Health and Fast Company. You’re an angel investor, advisor to a bunch of fitness and tech companies. Your company Roman Fitness Systems is one of the top rated sources for online information, particularly around exercise an fitness, and you’re sort of a walking wall of muscle, but not a balloon animal. You’ve got that think down about right. Where I think most people have seen your name is because you wrote “Engineering the Alpha,” which is a book that I’ve definitely talked about before. I’ve seen some really good information in the book. Welcome to the show.

 

John:   Thank you. Thank you so much. I appreciate that introduction.

 

Dave Asprey: Let’s talk a little bit about hormones. This is going to be a short episode for people today. Tell me about how men produced estrogen. I kind of opened up with my story about my man boobs. Tell me what’s going on with estrogen, because you’ve really looked into this.

 

John:   Yeah, so obviously the hormone that we talk about most with regard to men is testosterone. I think that there’s probably this misconception that more is better. There’s a point where that’s true, but obviously there’s a line of diminishing returns. With regard to estrogen, men produce it naturally, and it gets naturally produced in our bodies, but it also gets produced in response to heightening testosterone. Really what I talk about is the balance, because I work with a lot of professional athletes, and I have over the course of my career. A lot of those guys use performance enhancing drugs, particularly testosterone derivatives. If they’re not careful, what can happen is as they inject exogenous testosterone, some of it will convert directly to estrogen through a process called aromatization. Then there can also be an increase in endogenous production of estrogen.

 

Really what I talk about is maintaining that balance. Obviously it’s impossible to quantify like you want a four to one balance of testosterone to estrogen, but in general, you do want to keep natural estrogen production stable. You don’t want any of these massive spikes. Spikes of testosterone are typically not going to harm you in any way, whereas spikes of estrogen, as you mentioned, even some short term environmental exposure to mold or dietary exposure to phytoestrogens like soy or sorghum or xeno-estrogens in our plastics, that can have some acute physiological effects, in your case, you had the swollen breast tissue or anything surrounding the chest. For a lot of people it results in some sort of emotional instability. For others it can result in sexual dysfunction. These are things that we need to be really aware of.

 

With regard to sex, I personally view sex drive and typical sexual function as probably the most reliable barometer of health. If you are a guy who typically has a normal or a very high sex drive, and then you wake up one day and you’re not interested, that is particularly telling that something is wrong. Then also in terms of sexual performance, if one day out of absolutely nowhere you are struggling to achieve or maintain an erection or achieve orgasm, those things are very, very telling that something could be wrong hormonally. Obviously it could be any number of things, physiologically or psychologically, but I just find that in general, if there’s one thing you walk away from this podcast with, it’s that for men, I think sexual function is the most reliable barometer of general endocrinological health.

 

Dave Asprey: My first book was about fertility, and it involved men and women. What do you do before you get pregnant and during pregnancy to have really healthy kids? One of the biggest things that tells you whether your mitochondria are working or not is whether your sperm can swim. I looked at that as well. If people are having fertility problems, whether they’re men or women, but if you’re a guy and your little guy’s can’t swim, your brain can’t think either, because the same thing that makes them swim makes you think. That’s how you make electricity in your head.

 

When I was 26, I used to weight 300 pounds. I had already lost some of the weight by the time I was 26, but I went and I got my first full anti-aging hormone panel. This was going back, jeez, 17 years or something. I came out of it sort of shocked, because my testosterone was very low, and my estrogen levels were higher than my mom.

 

John:   Goodness, wow. At the time, I assume your mom was post-menopausal.

 

Dave Asprey: Yeah, she was.

 

John:   Her estrogen was slightly suppressed, relative to what it would have been during the prime of her fertile years.

 

Dave Asprey: Absolutely.

 

John:   Yeah, no. Yeah, it’s amazing. I see guys who have all sorts of elevated estrogen and suppressed testosterone. There’s this sort of drive, I think, it’s like, “How do I fix it?” For elevated estrogen, a lot of times the immediate response is aromatase inhibitors, going on clomiphene or arimidex or nolvadex or something like that. Those things are fine, although clomiphene is not technically an aromatase inhibitor. Those drugs are great, and they work really, really well for a lot of people, but I think that in general, the first response should be to try and address those things, in terms of lifestyle, diet, nutrition, and environmental factors.

 

Dave Asprey: By the way, for listeners, that’s pretty much what you talk about in your book, “Engineering the Alpha.” You go through all this. If you’re a guy or you’re a woman with a guy who’s got man boobs or any of these other dysfunctions, it’s worth a read.

 

John:   Thank you.

 

Dave Asprey: It was one of the … I say that as a compliment, because there’s a lot of just testosterone good, eat eggs good. It’s a little more complex because of this dynamic with the environment coming in and feedback loops. I thought you nailed it in a way that was pretty approachable.

 

John:   Thank you. I appreciate that. Yeah, the book thankfully was very well received. Again, I think that because it was a book intended for men, it is a little heavier on the testosterone than the estrogen stuff, but I think that one of the main things that we really focused on in that book, which is it’s both the easiest to do and the hardest to execute is sleep. That’s this massive thing. As an entrepreneur you know. If you get nine hours, it’s like the best day ever. To get those nine hours is very difficult, to carve nine hours away.

 

It really is important, particularly for men with regard to testosterone production. What people don’t realize is that if you sleep … First of all, let’s establish this. After the age of 30, testosterone drops about 10% per decade, in terms of natural endogenous production. That’s about 1% per year. That quantify is that 1% per year testosterone will drop after the age of 30, but regardless of age, if you sleep six hours per night or less for as little as two weeks, testosterone production can drop up to 15%. If you think about that, it’s getting six hours of sleep a night or less for two weeks. You’re physiologically, endocrinologically aging your body by 15 years, in terms of its ability to produce testosterone. That is something that we harp on all the time.

 

I know that people want all of these fixes and they’re willing to spend money. Sleep is free is the great thing. Sleep is a free thing that you can do. It’s ideally a third of your life, but it is also the hardest thing to execute, because we’ve got all these other things going on. We have stresses. A lot of people suffer from anxiety-induced insomnia where they are actually, even when they’re sleeping, their anxiety is working, their brains are working over time, and they actually get pulled out of REM sleep because their autonomic nervous system is massively stimulated from whatever stresses are happening in their life. That’s a very, very different thing from purse physiological insomnia where you can just take melatonin. As long as you can fall asleep, you’ll stay asleep.

 

Addressing those things through other means is interesting, and also we’re very busy people. I’m not going to touch on the … I’m not going to be your dad. I’m not going to tell you don’t look at your cell phone before you go to bed, because the blue light is going to … Just try to get to bed earlier. It’s that simple. 15 minutes a night, and just start. You’d be surprised that you can go to bed at 10:00 and wake up at 6. It’s hard, I know, particularly, listen, when you’re a parent. Dave, you have three kids now?

 

Dave Asprey: Two, yeah.

 

John:   Two kids, okay. They go to bed at probably 7:00, 8:00.

 

Dave Asprey: Sometimes, yeah.

 

John:   Ideally, right? My kid is 10. My son is 10 years old, and he goes to bed at 9:30. If I’m going to go to bed at 10, that leaves me a half hour of alone time with my wife. That is obviously a challenge, in terms of fostering our intimacy and really spending quality time building our relationship. I understand that there are all of these factors, in terms of things that prevent you from getting eight or nine hours of sleep, but it really comes down to what else can I cut out? A lot of times it’s as simple as maybe we’re not going to watch that hour of TV that we love at night until the weekend. Instead we’re just going to go in bed and read together, and talk, or have sex, or whatever it is. You’d be surprised, if you and your wife go to bed a half hour earlier, how the frequency of sex goes up.

 

Dave Asprey: It’s amazing what laying in bed together does.

 

John:   It’s like, “While we’re here, what else are we going to do?” We don’t have a TV in the bedroom, so I guess. Yeah, so there’s all sorts of things around sleep that I think it’s this really interesting thing. I work with a couple of mattress companies, and I’ve been very fortunate to … A company called IntelliBED recently sent us this unbelievable mattress. It’s really great. What stuck out to me is that I am a health professional, and I have never spent more than $2,000 on a mattress. Even that seemed like a lot. I know guys who they’re saving money so that they can buy that Tesla, which is a great car and an amazing thing to have, but I think that the … This comes from Tesla directly. I think Elon put out that the average automotive owner uses their car less than 10% of the time, less than 5% for most people. You own this $150,000 car that you use 5% of its life time, and then you spend a third of your life in bed, and you’re going to skimp on your mattress.

 

It’s this interesting thing. Invest in your sleep, your time, your energy, your money. Make sure that you get quality sleep. It’s been this massive thing that has been hugely helpful to me, because if I can get really great sleep and my clients can get really great sleep consistently, then those high stress periods where you are working on a launch, or a new book, or a product, or you have a new baby, you can absorb those a little bit more easily.

 

Dave Asprey: Yeah. Have you looked at chronotypes? Michael Breus was just on the show, who is a sleep doctor for Doctor Oz, and just wrote a book talking about how 15% of the population is night owls, and they actually do better going to bed after 11. There’s a number of people, I think 55% of them go to bed with the sun basically. Then there’s the early riser crowd. I was interested in that, because it seems like testosterone production, which is circadian, it goes on a daily basis, it may shift, depending on what your type is.

 

John:   Yeah, it’s interesting to talk about. I became very interested in that, because I have always classified myself as a nigh owl, in terms of not only when I feel best, but also when I’m most productive. When I was living in New York City, I found that my best hours for writing were from around 11pm until 4am.

 

Dave Asprey: That’s what I did last night, exactly that.

 

John:   Yeah, and the great thing was at that time I was a New York City bachelor, and I could go to sleep at 4 or 5am, and I could wake up at noon and it was fine. Now obviously having a child who has a school schedule, he has to be there at 7:30 no matter what. That’s just how it goes. I have adapted to a more traditional life of going to bed when the sun is gone. I think that you can adapt. I think that there are certain … Like everything, you have proclivities and things that maybe you gravitate towards, but you can adapt. It took about a year and a half, maybe two years for me to be able to have the same level of production from noon to 5pm as I used to from 11 to 4. I can do it now, and it’s fine. It just took a while to adapt.

 

Dave Asprey: That’s impressive. For about 2 years I taught myself to wake up at 5am every morning, and wake up and meditate and all that. I finally realized at the end of it that I had adapted, but that it was just not natural. It’s not working for me.

 

John:   Now is it? When do you wake up?

 

Dave Asprey: I actually go to bed at 2, and I wake up when I get … During the summer I wake up at 8:50 so I can start calls at 9. My average amount of time in bed is 6 hours and 1 minute for the last 3 years. I didn’t used to require that much sleep, and I’ll wake up without an alarm clock that way. It’s not an insomnia thing. It’s like I’m good to go. That shifted by about 2 hours as I improved my mitochondrial function as I basically got rid of stuff that wasn’t working biologically for me. I’ve seen some data, and it’s really interesting, because my testosterone was absolutely in the shit, but I wasn’t following any of that advice.

 

There’s a study of 1.2 million people that found the ones who lived the longest were sleeping 6 and a half hours a night, that people who slept 8 hours, they were dying more of all causes of mortality, including diseases and all that than people who slept 6 hours. It was really weird. That’s not to say that this is prescriptive. I think it’s just that people who are abnormally high performing biologically, they just require less maintenance at night, because things are working.

 

John:   Yeah, I agree. I can do 8 hours if everything is dark and I have a mask on and I take some supplements to facilitate that, but in general, yeah, no, I’m a 4, 5, 6 hour guy.

 

Dave Asprey: You are, too?

 

John:   I’m fine. I function. Here’s an interesting thing. I don’t know that I’ve ever admitted this on a podcast. When I was a kid I was a bed-wetter, which is a horrible thing to-

 

Dave Asprey: Weren’t we all?

 

John:   Until I was 10.

 

Dave Asprey: Oh wow. Okay.

 

John:   It was late. I was a bed-wetter. I had some issue where I could not, when I was sleeping, realize that I had to go to the bathroom. I went on what was then an experimental drug that eventually got approved by the FDA called DDAVP. This was a drug. It was a nasal drug that you take. After 2 weeks it stopped. I was able to wake up and go to the bathroom. However, I have not slept through the night since then, because my bladder is so sensitive that the moment I need to use the bathroom, I wake up and I go to the bathroom. I probably get up to pee 4 times a night, 3 times a night, because I drink a lot of water.

 

The interesting way that this has affected me is that I slip in and out of sleep like nothing you’ve ever seen. I wake up. I go to the bathroom. I hit the mattress, and I am out immediately. I’ve done sleep studies where how quickly it takes me to get into REM sleep, it’s phenomenally quick. That is really interesting, because it also allows me to be very, very high performing and high functioning when I’m awake, but if I want to take a nap, I can close my eyes and fall asleep pretty much instantly and wake up without any … I always wake up with the same amount of energy. I can get 3 hours of sleep or 8 hours of sleep, and I wake up. I’m always in the same mood. I’m always ready to go, happy. I’m very confident that this will be pushed to the limit when my wife and I, should we have biological children of our own, where now I’ve got this baby that’s up at all hours. I came in as a stepfather, and he was 5. I missed all of that.

 

Dave Asprey: John, from that perspective, I did an experiment with sleep where I’m like, “I’m going to get 5 hours or less every night to actually trigger obesity.” I could eat stupid amounts of calories. I was just going to do it for a month or 2, and 4,500 calories a day on average, just to sort of prove I didn’t gain as much weight as I should have from eating all this fat, and just because I’m curious. I felt amazing, but what I haven’t really told people is that experiment started the day after my second son, because I’m not going to sleep more than 5 hours a night anyway.

 

John:   No matter what, yeah.

 

Dave Asprey: It’s a great time for a study, 2 birds with 1 stone. You’re absolutely right. Your sleep will be wrecked for the first 9 months, no matter what you do..

 

John:   Yeah, and I think I’m probably better equipped to deal with it than most, but no matter what, it’s going to be hard.

 

Dave Asprey: Yeah, you are.

 

John:   In terms of the testosterone stuff-

 

Dave Asprey: Yeah, let’s go back to that.

 

John:   I was always very, very naturally high. I got my testosterone tested for the first time when I was 22 or 23 years old, because I was a data driven guy. I was really into Charles Poliquin at the time. He talked about that.

 

Dave Asprey: Yeah, smart guy.

 

John:   I got tested, and I was close to 1,100, like 1,070, so very, very naturally high testosterone levels. Then I was 23, and I was building a business. Things were going well, and then I hit a wall. I was 25 years old, and I was in this relationship with this woman, and she approached me and she’s like, “Hey, do you know we haven’t had sex in like 2 months?” “That’s weird.” I had gained all this weight, and things were just not going well for me at 25. Eventually that relationship ended as things do if you don’t have sex with someone for 3 months. They’ll leave. I’ve detailed it elsewhere, but I got my testosterone levels checked, and I was at 540, which is still reasonably high.

 

Dave Asprey: Yeah, but not for that age.

 

John:   Not for that age, and not for some … My testosterone levels were roughly half of what they had been.

 

Dave Asprey: Yeah, around 1,000 in your mid 20s is a reasonable number, from memory, or maybe 950 I think is-

 

John:   Yeah, for high testosterone guys, around 1,000. Most guys could be at 7 or 8 and be fine. I was experiencing all of these ill effects from being in the … Depending on when I got tested, it was the high 400s, low 500s. The range for testosterone, for anyone who doesn’t know, is about 230 nanograms per deciliter to 1,150 nanograms per deciliter, depending on the lab you go to. Being in the 500s, I was still high enough that I was in the normal range and could not get any medical treatment. I had to figure this out myself. At the time, listen, I was 25 years old, and I was being an idiot. It was when I first started social … I didn’t drink alcohol until I was 25. I didn’t have that high school and college experience. Now I’m 25, I’m drinking on the weekends.

 

Dave Asprey: Yeah, beer estrogen, huh?

 

John:   I never drank beer.

 

Dave Asprey: Okay, smart.

 

John:   I never acquired the taste. I dove right into whiskey, because-

 

Dave Asprey: Better choice

 

John:   Yeah, something about the way brown liquor looks in a glass, it looked really cool to me, so I dove in. I was drinking on the weekends. I was not getting a lot of sleep, because I was building my business. I was running around chasing girls after that relationship ended, but honestly I just wasn’t taking care of myself. I was training probably 10 hours a day, training clients, and wasn’t making time for my workouts. My diet went to crap because I just kept eating less and less, because I noticed I was getting fatter. I was trying to maintain low body fat. Eventually I got my testosterone levels checked, and it was in the 500s.

 

Now I reversed course. I started sleeping more, start trying to stress out less, eat a lot more fat, made sure that my carbohydrate intake was where it needed to be. I wasn’t overindulging on carbs. It was whatever I needed to recover from workouts, but the sleep made the biggest impact. Inside of 6 weeks my testosterone was back in the 900s. Then 6 weeks after that it was back over 1,000. This became this very interesting thing to me where I realized lifestyle really does affect this. Alcohol is probably not something that most people are willing to cut out, but lowering it, pretty significant impact there.

 

I noticed that as I was on this increase, the estrogen did go up, but I had no ill effects. Then after my testosterone remained elevated for about 6 months, the estrogen levels dropped naturally. I think there was just some biological feedback where it’s just like, “All right, testosterone goes up, estrogen needs to go up.” My testosterone has stayed very, very high since that point. However, I’m 34 now. I get my testosterone checked every 1 to 2 years. When I was 28 it was at around 1,100. Then when I was 30 it was 900. Then when I was 31 it was 850. Then I recently got it tested at 33, and it was 690-ish. That’s still high, but I notice the downward trend, and I know that I’m doing everything right, in terms of lifestyle. There was nothing else that I could do, so I made an educated decision to get on some low-dose testosterone replacement therapy.

 

Dave Asprey: High 5, by the way. Thank you for just putting it out there.

 

John:   Sure.

 

Dave Asprey: I went on it when I was 26. I went off it for several years and measured my levels, went back on when necessary. How did it feel when you went on there? What did you notice?

 

John:   This is, I guess, it was right before my 34th birthday, which was in April. I want to say this is probably 2nd week of March of this year. It is now July, so it’s been close to 6 months. What I noticed immediately was how much better I felt, just overall feeling of well being. Again, by the way, very low does, 200 milligrams a week it’s enough to keep me back up where I was in my late 20s, but I’m-

 

Dave Asprey: Are you injecting or cream?

 

John:   Yeah, I’m injecting. Yeah, but I’m not in super physiological ranges. The first thing overall quality of life, recovering from workouts more quickly, generally feeling a lot more happier. I sleep better. Sex drive is a littler higher. I did not notice anything in terms of physique or body composition until I went on a family vacation. We took Isaac to Italy for his 10th birthday. I was gone for I guess 11 days. I have a prescription, so I was able to take my stuff with me. What I noticed is that I was eating gelato and pizza and being in Italy for an extended period of time, and not really … The only gym that we could find was at a train station in Rome. I think I got to work out 3 times in 10 days.

 

What I noticed is that I made the decision to under eat on calories, because I knew my food choices weren’t going to be great. I normally was eating around 2,800 calories, so I dropped down to around 24. I was in Italy eating pizza and gelato and not training, and I lost body fat. I think that’s because obviously when you’re on higher levels of testosterone, you can under eat and not sacrifice lean body mass. For me, that was the first time I noticed anything, in terms of my physique. That was when I had been on for about 9 weeks.

 

Then since then, I decided to, “Let me get a little bit more dedicated with tracking my macros and training a little harder.” My body composition has continued to improve, not drastically. I don’t look like I’m about to step on stage, but I’m leaner than I would be without it. Overall, honestly, David, for whatever reason, I had this thing in my head where I was going to wait as long as possible to go on TRT. Having now been on for several months, I’m just like, “Man, why did I wait so long.” I think that it’s freeing.

 

Dave Asprey: It’s life. It’s life-changing. It’s like your zest for life comes back. Even if you didn’t really not have a zest for life, it’s just better. I know Mark Sisson, who’s been on the show a couple times, he’s older than I, though. He’s in his early 60s. I’m 43. You’re basically 10 years younger than I am. I think you did the wisest thing you could do, and I would encourage everyone who is listening, men and women, get your hormone levels tested, even if you’re 25.

 

John:   That’s the key. Yeah.

 

Dave Asprey: Even if you’re 30. Know your numbers, what’s natural for you.

 

John:   Right, exactly. That’s the most important thing. Tell all guys, “Get your levels checked,” and women, too, because here’s the thing. Even if you’re not experiencing any ill effects right now, and that may continue, and hopefully it will for you, the important thing is that getting tested, it establishes that baseline. For me, had I not gotten tested when I was 22, 23 on a whim, then when I was 25, if I had gotten tested and I was in the 500s, I would have been like, “I’m fine. This is not the issue.” Having had that baseline from three years prior allowed me to see that normally I’m at 1,000, and now I’m at 500. My testosterone had dropped 50%. There was no way that couldn’t have deleterious effects.

 

For me, I think that there’s this really interesting conversation that goes on where everything around testosterone is like steroids. Then TRT is generally a little bit more positive. There’s this middle ground where there’s no good information. I’m really trying to help fill that void. I think everyone will come to the point where they get to make that decision. If you have the knowledge and the supervision of a doctor and the means and the will to do it, listen, I’m not going to tell you injecting 4 times a week isn’t a pain in the ass, a literal pain in the ass of where you’re injecting, but the trade-off is fine. I feel great.

 

I have an apartment in New York, and our house here in California. I have a supply in both places so that no matter where I am, I can keep my levels steady. It’s made me really, really interested in experimenting with other things. I talked to my doctor, and I’m like, “I’ve got this nagging lower back injury.” I’m like, “All right, maybe if I did a 3 month course of growth hormone while I was going through aggressive treatment, like muscle activation therapy and active release therapy, maybe that would really help fix the issue.”

 

Dave Asprey: It’s absolutely worth trying. I did growth hormone when I hit my head as a way of working with TBI. There’s good data for it, and it’s not an admission of weakness. It’s just controlling your biology. There’s this weird puritanical thing like, “Someone in the ’70s used a derivative of testosterone had liver problems. Now if you use it to stay young, you’re somehow cheating.” I’m like, “Okay, I’m cheating. Whatever. I just want to feel lie this all the time.”

 

John:   Yeah, if you’re not competing it’s not cheating. For me, I’m fine with it. For me, one of the interesting things about having build the muscularity that I have, and having the types of pictures of me that are on the internet is that for the entirety of my career, I’ve been accused of using steroids. I was always very vocal. I was like, “Listen, I don’t think anything is wrong with steroids. I have plenty of friends who use them. I’m not currently, but, and this is the most important thing, if I ever decide to start injecting shit into my body, I will tell you.”

 

Dave Asprey: There you go.

 

John:   I put it out there, and it’s really interesting. The response has been universally positive. Not one person has pushed back.

 

Dave Asprey: Good.

 

John:   It’s crazy I thought I was going to get all sorts of hate, but everyone just has … I came at it from a very objective, scientific, and very honest perspective. Here’s why I did it, because I noticed a downward trend. I didn’t want that. I’m good. Now instead of people hating, I just get all these great questions about it. The interesting thing is that when you come out about using at 34, any question about using when you were 24 sort of goes away. I thought that there might be something about it potentially damaging legacy, but it’s been universally great.

 

Dave Asprey: What about ball shrinkage? After 5 years of testosterone, I went off of clomid and arimidex because I didn’t appear to need them anymore, which my physician had me on. I wasn’t cycling, even though I probably should have been. Eventually I noticed that the guys were a little smaller than they should have been. What are you doing to protect yourself from that?

 

John:   I’m on low does clomid. I think I’m on 50 milligrams every other day.

 

Dave Asprey: Smart.

 

John:   I have not noticed any testicular shrinkage yet. I think it’s more of a long term thing, but again, a lot of it is dose dependent. I was talking to a friend of mine who works with a lot of body builders and professional athletes. He says, “Everyone has different genetic responses to everything. There are some people like myself who are genetically predisposed to putting on a lot of muscle,” but he’s like, “What people don’t realize is that the same things happens with steroids, with testosterone replacement. There are people who respond like crazy to 200 milligrams. Then there are people who can be on 3 times that dosage and not have the same results. Everything effects everyone a little bit differently.

 

I feel like I am getting a lot out of the dose without any ill effects. Yeah, I’m very curious to see how it goes, but obviously the main thing is even at this dose, once you cross the 8 to 12 week threshold, sperm production drops dramatically. Should my wife and I decide that we do want to have another child, I will need to come off for 3, 4, 5 months and allow sperm production to come back up.

 

Dave Asprey: You could probably turn up your clomid and have no problem with that.

 

John:   Yeah, you know what? I’ve thought about that, except I’ve just spoken to a lot of guys who say they just get a lot of emotional damage from clomid where they just find they’re very weepy. Right now I’m good. I’m not interested in adding another emotional hiccup to the mix.

 

Dave Asprey: I hear you there. All right. Next question. I know you’ve got another call after this.

 

John:   Yeah. No, no, it’s good. I got a couple more minutes.

 

Dave Asprey: You got a couple more minutes? All right, cool. Next question is the question I’ve asked everyone who’s been on the show, and it’s if someone came up to you right now and said, “Look, given everything that you’ve learned in your life, what 3 pieces of advice would you have for me if I want to kick more ass at everything I do? I just want to perform better as a human being. What matters most?”

 

John:   Environmental exposure is the number one thing. Just surround yourself with awesome people who are doing awesome things. If you want to get stronger, hang out with strong people. If you want to make more money, hang out with people who are making more money than you. Yeah, and that goes for everything. I think environment and community are everything. That would be the number 1. Number 2 is data. Track as much as you can as often as you can without it becoming inhibitive to your enjoyment of life. For me, that means journaling. I’m a writer first before I’m anything else. For me it means journaling and taking stock of the day, and really trying to see if I’ve grown as a person year over year. For a lot of people it’s like tracking the quantifiable data, like testosterone levels and whatever else. I think keeping a record of your life is important. Who knows? Maybe your biographer will need those notes one day.

 

Then the third thing, I think you need to know what your guiding pillars are, and the things that guide your decision making processes. I think it’s worth writing those down and also vocalizing them. I think that so many times we get caught up and we don’t know how to make the right decision, or we don’t know how to make the decision that’s right for us. I think that for me, if all other things are equal, just do the right thing.

 

I think that I don’t like to talk in absolutes. There’s not always a right thing and a wrong thing. Everything is shades of grey, but usually there’s one that’s less douchey. There’s a decision that’s just like it’s going to … Usually it’s the harder decision, but if you can’t figure out how to make the decision, then just choose the option that is going to allow you to … If people told the story about you, you’d feel the best about it. Do the right thing. Always be above board. Always go out of your way for other people. Exhaust every possible avenue before cutting ties. Just leave it all on the field.

 

For me, it’s very important, before I end any relationship, whether it’s business or otherwise, that I’m able to walk away, and knowing that no one can say I didn’t try. I think that in business, and I’ve always gone out of my way to try everything before I shut something down, because I like to know that I tried everything. I like to know that when the story of my life is told, the thing that will be said about me is he always tried to do the right thing. That, for me, is huge.

 

Dave Asprey: That shows a lot of integrity. I can tell you out of more then 300 episodes, you’re the first guest to ever say, “Choose the least douchey option.”

 

John:   Thank you. There you go.

 

Dave Asprey: Great tweet right there.

 

John:   Put a little feather in the cap there.

 

Dave Asprey: Truly funny. Let’s see. We already mentioned “Engineering the Alpha”, which is one of the books that I absolutely endorse. You’re working on a new book about the hero’s journey and kind of superheroes. Certainly there’s a superhero vibe with what I do. Do you have time to talk about that?

 

John:   Sure, sure. For those who are not familiar with the work of Joseph Campbell, I highly suggest that you read a couple of his books. The most well known of which is his seminal work, “The Hero with a Thousand Faces,” which is the introduction to his thesis of the monomyth, or the hero’s journey, which is a storytelling cycle that is apparent in all great stories, whether it’s the Messianic myth of Jesus or Krishna or Buddha, or the more recent tales of Luke Skywalker, Harry Potter, King Arthur, any. They all follow this same 17 stage cycle. I became introduced to Campbell in college, and it’s been very, very helpful to me, in terms of writing, but I believe that the hero’s journey is portable and applicable to any great change we go through in our lives.

 

My next book basically takes the hero’s journey and applies it to life, both in terms of personal development as sort of a thesis for self-directed growth, but also as a tool set for problem solving. I think if you look at the hero’s journey and you’re experiencing something difficult right now, for some people it’s building a business, for some people it’s going through bankruptcy or divorce. For some people it’s becoming a father, or mother, or anything, or jumping into this health transformation. One day your doctor gives you this wake-up call, and they say, “You need to make this change or you’re going to die.” That is what Campbell calls the call to adventure, or the inciting event.

 

Now at first you’re resistant to that, because you’re like, “It’s too hard.” That’s refusal of the call. That’s stage 2. Then eventually somebody comes along who makes you believe you can do that. Maybe you listen to Bulletproof Radio. Maybe you pick up “Engineering the Alpha”. Maybe you find one of our websites. Maybe it’s Doctor Oz. Maybe it’s Tim Ferriss or whomever. There’s this character that appears in every great story. Whether it’s Obi-Wan or Mr. Miyagi, or Morpheus in the Matrix, there’s this mentor figure. That is the person that you learn from as you begin to go through this journey

 

Then it just goes on from there, crossing the first threshold to the ordeal, all the way to the master of two worlds and return with the elixir. I think that every major endeavor in your life and many of the smaller ones, again, marriage, divorce, writing a book, starting a business, they all follow this step-by-step plan of the hero’s journey. I highly recommend that everyone read “The Hero with a Thousand Faces”, but I will mention it is a little dry. It’s very cumbersome, in that Campbell makes most of his points through analogy and comparison. In order to really get that, it’s better to have a strong basis in mythology, which most of us don’t.

 

For the time being, the book that I would recommend is one called “The Writer’s Journey” by Christopher Vogler. This is a great introduction to Campbell. Vogler makes these same points using comparison and analogy, but rather than using these myths that you’ve never heard of, he uses movies and TV shows that you have heard of, and books that you’re more likely to have heard of, everything from “The Lion King” to “Beverly Hills Cop” to “Romancing the Stone” to “Zoolander” and things that are just a little bit more pop culture oriented and more part of the zeitgeist to which you are probably accustomed. You don’t have to go and try and figure out which version of “The Red Knight” to read and which one has all the shit that’s been expurgated. Vogler’s work is really, really fantastic.

 

Then my goal for my book is twofold. First, I think it will help a lot of people, but my big, hairy, audacious goal as we say in the marketing world is I would like my book on The Hero’s Journey to be the book that Campbell scholars and Campbell devotees recommend to people who have never read Campbell in much the same way that I say, “Hey, you should read Vogler before you read Campbell. It will help,” my goal is 5 years from now, people who love Campbell will be like, “Oh you should read Romaniello, that will be a good entry point to Campbell. Then you can read Campbell.” It’s really a big goal.

 

Dave Asprey: What an awesome goal, though, and very clearly delineated. I love that.

 

John:   Thank you.

 

Dave Asprey: Also, John, I appreciate just having had a chance to ride on a bus with you at Master My Talks with Jason Ganard. Just to sit in and chat, you think about a lot of stuff, and you’re totally willing to go there on the personal development front. There’s always been a perspective that that’s not masculine to do it. You’re definitely a masculine guy, and you’re totally like, “No, I’m going to own this. I’m just going to look at it, and it’s just part of the whole equation.” Tim Ferriss is similar. There’s just a lot of people. Maybe it’s because I’m old at 43. My generation, we didn’t do it that way. The shift is really cool, because if you get your testosterone up and you’re feeling really good and you’re still anxious and unhappy and you haven’t done that level work, you’re still going to act like jerk all the time, right?

 

John:   Yeah. I think that I feel very fortunate to be part of the generation to which I belong, in that I think there’s a lot of negative talk around millennials. I’m right on the cusp of pre-millennial, but I will say this for millennials. They’re generally working really hard to establish equality. I think that it’s really interesting. I was raised by women, and so I have a really strong feminist bent. I have been very, very fortunate in my male friendships that I have never been made to feel weird for feeling very, very strongly or projecting very vocally in terms of women’s rights or rights for the LGBT community. This is stuff that I feel very passionate about. I’m aware that as a white male, I don’t really have a lot of problems. I’ve never had an issue getting pulled over. I really am very dedicated to using the platform that I built to helping people.

 

To that end, I’m running an event in Austin, Texas September 16th to 18th with a friend of mine named David Dellanave called Man Camp. We are going to have more traditional … We’re going to eat steak and shoot guns and talk about sex, but it’s also we’re going to have deep, deep conversations about what it means to be a man in sort of the modern world, in the current environment, and how we can be masculine, while at the same time promoting feminism. I’m really excited about it. I think that there’s deep conversations worth having.

 

Dave Asprey: Are you sold out on that event? Do you want to drop a URL for people?

 

John:   Yeah, honestly it’s austinmancamp.com. I think we have 6 spots left, but yeah, if anyone is interested in coming, we’d love to have you. It’s going to be great.

 

Dave Asprey: That is right before the Bulletproof Conference September 23rd.

 

John:   Is that also in Austin?

 

Dave Asprey: No, that’s in Pasadena.

 

John:   Oh, okay. That’s right. I knew that

 

Dave Asprey: I was just thinking, I don’t know if it will be helpful, you may have sold those spots out already, but I’m willing to knock 50% off the Bulletproof Conference rate for anyone who goes to Man Camp.

 

John:   I am willing to knock 50% off for Man Camp for anyone who is coming in through Bulletproof, just let us know when you’re at the URL, and we will give you 50% off. If you go to both, it’s like going to 2 events for the price of 1. I’d be happy to do it.

 

Dave Asprey: Beautiful, awesome.

 

John:   We have 7 spots left. David, I know that you’re going to be busy planning your event, but if you can make it to Austin, we’d love to have you.

 

Dave Asprey: I would absolutely love to be there. Maybe next year. This year I don’t think I’m going to make it, but I appreciate the invitation. It would be great fun.

 

John:   Awesome. Thank you for your time, man. I really appreciate you having me on and letting me just chat with you. Means a lot.

 

Dave Asprey: Great fun. See you soon.

 

John:   Bye-bye.

 

Dave Asprey: Thanks for watching. Get tons more original info to make it easier to kick more ass at life when you sign up with the free newsletter at bulletproofexec.com. Stay Bulletproof.
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7th Biohacking Box Helps Upgrade Your Environment

The seventh Biohacking Box (#BIO07) just dropped, and you’re going to want to read about the leading-edge biohacking items we included this time.

The #BIO07 box is all about cultivating a better environment whether that’s at home or on the road. That means you’ll be more resilient and will perform better no matter where you are. With more than $260 in biohacking gear and around $10k in additional Golden Ticket giveaways, this box contains a pretty major value.

Click here to subscribe to receive the next box.

“The Quarterly Boxes from Dave have been a treasure trove of healthful finds. Thank you, Dave, for making “real health” not a trend but a lifestyle. I sleep better. I think better. I feel better. I laugh better. I live better. “ – Erin R.

Mother Dirt Starter Package

The gut microbiome is getting a ton of attention these days in the medical and scientific communities, but you have bacterial environments on every part of your body, not just in your gut. This means that there’s good bacteria on your skin, doing its job to protect you and your immune system as your body’s first line of defense. Mother Dirt is the first product developed to restore and maintain beneficial microorganisms on your skin for better skin quality and a robust skin microbiome. The Mist contains Ammonia-Oxidizing Bacteria that convert the ammonia in your sweat into beneficial compounds such as Nitric Oxide and work to calm irritation and decrease body odor. The Shampoo and Cleanser are devoid of the harsh chemicals and additives that are present in most commercial hygiene products. The Mist, Cleanser, and Shampoo make a profound difference in the quality of your skin.

Mother Dirt offered a special coupon for Bulletproof – use code “BPROOF25” when checking out on their site to receive 25% off and free shipping on your order!

Connect with Mother Dirt on Facebook, Twitter, and Instagram

 

Air Oasis Indoor Air Quality Testing Kit

What you can’t see CAN hurt you! Invisible mold is making millions of people sick every day and affecting brain health and function over the long-term. There’s no safe level of mold toxins in your environment, so it’s important to get levels as low as possible. You can’t fix what you don’t know is there! With the Air Oasis Indoor Air Quality Testing Kit, you can test your home or office for mold, yeast, harmful bacteria, and pathogens. Only then can you treat the affected areas accordingly. Using testing kits like this in tandem with preventative measures like Homebiotic and the information in the Moldy Movie can help make your home safe for you and your family.

Connect with Air Oasis on Facebook and Twitter

 

ZivaMIND Meditation Package

Meditation can change your body on a cellular level, boosting energy and mental performance. Bulletproof Radio guest Emily Fletcher has taught thousands of people how to meditate with her fun and irreverent style. The ZivaMIND modules can help you become more resilient and efficient in some important areas. Emily’s cheeky privacy door tag will help you maintain privacy when you’re meditating, and the essential oil blend promotes a state of relaxation and focus. Meditation is one of the most potent biohacks we have to improve performance, but learning how to meditate doesn’t have to be difficult or boring!

Check out Emily’s free zivaSLEEPS guided meditation, as well as a discount on her online meditation program that has helped thousands learn how to work meditation seamlessly into their busy lives. Click here to download your free zivaSLEEPS audio module.

Connect withZivaMIND on Facebook, Twitter, Instagram, and YouTube

 

Acurite Humidity Monitor

Keep your eye on the humidity levels inside your home year-round. Monitoring humidity levels is a simple first step for preventing mold growth. The ideal relative humidity for most of the year is about 40-50%, while in the winter months you may want to stay a little lower than 40%. The Acurite humidity monitor gives you both temperature and humidity readings and has both tabletop and magnet fittings so you can place it conveniently anywhere in the house.

Connect with Acurite on Facebook, Twitter, Pinterest, and YouTube

 

BlenderBottle GoStak

Stackable travel containers are the hack you’ve been looking for to transport all the pills, powders and potions you use to function at your highest level while traveling. GoStaks fit into tiny spaces and are perfect for work and travel. The jars are BPA-free, stain, and odor-resistant, and you can either stack them or pack them individually.

Connect with BlenderBottle on Facebook, Twitter, Instagram, and Pinterest

 

Limited Edition Bulletproof-Branded Smart Cup

This custom BPA-free smart cup is made from high-quality stain and odor-resistant materials and was made specifically for Quarterly Box subscribers so it can’t be purchased anywhere else. It features a spill resistant lid, a non-slip grip, and double-walled insulation to keep your coffee hot for hours. Pairs perfectly with InstaMix so you can take your Bulletproof Coffee on the road!

 

Brand New 100% Coconut-based Brain Octane

This month’s box includes a 16-oz. bottle of Bulletproof Brain Octane Oil – now 100% sourced from coconut oil without any trace of palm oil used at any time during the process, regardless of season or availability. While Bulletproof had always been a part of the Roundtable for Sustainable Palm Oil, we worked hard to eliminate palm from the product supply chain because of the horrible deforestation practices that are prevalent in the palm oil industry.  As far as quality, our products haven’t changed. They’re chemically identical to the old version, and you’ll get the same results. The difference is that now you can use them with a totally clear conscience.

 

Biohacking for one and all (aka discount codes)

Not every amazing product Dave finds can fit into a box. Plus, one of the big goals with the subscription box was to make biohacking more accessible to everyone. That means huge discounts with companies doing badass things.

Check out these Golden Ticket items from some of our amazing partners in health, wellness and biohacking.

Air Oasis

Along with the Indoor Air Quality Kits included in the box, Air Oasis also produces the most powerful air purification units on the market. Third-party lab verification confirms that these units eliminate 99% of allergens, odors, germs and mold to improve air quality as well as sanitize surfaces, which is something no other air purifier can claim. This NASA-derived air purification technology creates polarized ions via UV light that neutralizes contaminants and breaks down pollutants, then reverts the ions into harmless water vapor. The units are energy-efficient and maintenance-free since there is no filter to change, and they cover a far larger range than typical ionizers. Hospitals, nurseries, government facilities, casinos, and even sewage treatment plants use this technology to maintain air and surface cleanliness.

Air Oasis generously offered a coupon code off of their Air Purification Technology for the Bulletproof community. Use code “bulletproof” on their site for 20% off anything in your cart. Offer expires 10/01/16.

Connect with Air Oasis on Facebook and Twitter

 

Human Charger

The Human Charger helps to treat jet lag by shining UV-free, enriched light into your ears. It is the only device that has an EU Medical Device certification for the treatment of jet lag and has been in commercial use for mood disorders since 2010. The Journal of Aerospace Medicine and Human Performance published a peer-reviewed jet lag study featuring the Human Charger, and it has numerous safety certifications to support consistent use. It has a convenient and anonymous travel design since it looks like an iPod, and the device needs only a short 12-minute cycle to achieve the effects. It also has applications beyond jet lag, ranging from altering sleep timing, to improving mood and energy levels.

Visit their store and use code “BULLET20” for 20% off a Human Charger unit!

 

AquaTru

The EPA regulates roughly 100 harmful contaminants in tap water, but studies show that there are more than 300 total contaminants present, with the majority going unregulated. Reverse Osmosis is the gold standard in water purification technology, but installing these systems requires big changes to your plumbing and lots of cash. AquaTru is the first countertop reverse osmosis unit that does not require complex and costly installation. It uses a 4-stage water purification process that meets the National Sanitation Foundation (NSF) standards for 128 chemicals and gasses. For comparison, faucet filters meet 58 standards, and pitcher filters only meet 13. As a bonus, filtering your tap water at home can help to save the planet and reduce the number of plastic bottles from bottled water that end up in landfills, which currently sits at a dreadful 50 billion per year.

AquaTru also stepped up with an offer for Bulletproof readers. Visit their site and enter code “100” in the discount code field to save $100 off one of their countertop reverse osmosis filters.

Connect with AquaTru on Facebook, Twitter, and YouTube

We’d love to hear your feedback on how you like the box and how we can continue to improve the quality and value. 

 

quarterly box

“Dave Asprey’s boxes are always filled with awesome goodies for those who are looking to bio-hack their life. I’m not even sure how he’s able to put all of the stuff in there for the price you get it at. I’ve liked some of his boxes so much that I’ve bought more to send to my friends as gifts.” – Cristina L.

 

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