Let Teens Sleep in Already: How Early School Start Times Harm Their Brains

Let Teens Sleep in Already: How Early School Start Times Harm Their Brains

[tldr]

  • Teens are biologically wired to need 8 to 10 hours of sleep per night. Early school start times are causing teens to suffer from chronic sleep deprivation.
  • Teens who don’t get enough sleep are more likely to suffer from symptoms of depression, engage in risky behaviors like drinking and using illicit drugs, and perform poorly in school.
  • Leading organizations and sleep scientists recommend that schools start at 8:30 a.m. or later.
  • Parents can help improve teen sleep quality by minimizing blue light exposure and encouraging kids to develop good bedtime routines.

[/tldr]

Want an immediate upgrade in your quality of life? If you have teens, call their school and explain that your kids will be missing first period. The value of sleep is higher than anything they could possibly get from that one class.

Here’s why. Study after study has shown that kids’ brains are harmed by making them wake up early to go to school.[ref url=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5074885/”][ref url=”https://www.dublinschools.net/Downloads/apa.pdf”][ref url=”https://link.springer.com/article/10.1007/s10964-014-0170-3″][ref url=”https://www.cambridge.org/core/journals/journal-of-the-international-neuropsychological-society/article/effects-of-partial-sleep-deprivation-on-information-processing-speed-in-adolescence/AB9B33862198AB97AB8D4A35AE2E2050″][ref url=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315345/”] 

The state of California is the first in the U.S. to align school policy with sleep science. The governor of California just signed a bill requiring that middle schools start no earlier than 8:00 a.m., and that high schools start no earlier than 8:30 a.m.

Teens are wired by nature to sleep in. They need 8 hours of sleep at a minimum to promote good health.

And really, they should be sleeping even more than 8 hours. Think closer to 10.

The New York Times recently ran a post that echoes what I’ve been saying for years: school starts too early, and it’s interfering with adolescent brain development. That’s a problem. Here’s what the science says — and what parents can do to help their kids.

The value of a good night’s sleep

Student slumped over desk

The American Academy of Sleep Medicine recommends that teens should sleep 8 to 10 hours every day to promote “improved attention, behavior, learning, memory, emotional regulation, quality of life, and mental and physical health.”[ref url=”https://aasm.org/resources/pdf/pediatricsleepdurationconsensus.pdf”] Teens who don’t get enough sleep are more likely to suffer from symptoms of depression, engage in risky behaviors like drinking and using illicit drugs, and perform poorly in school.

In fact, a lot of the negative behavior people associate with teens — like moodiness, irritability, laziness, and depression — is a by-product of sleep deprivation.

What parents need to know about sleep biology

Teen trying to fall asleep

Teens experience shifts in their biological rhythms during puberty. They become sleepy later at night. So, they need to sleep in later in the morning to hit that 8-hour minimum — but early school start times make that impossible.

That sets the stage for disaster. You have to drag them out of bed in the morning, and for the first few periods of the day, they’re wiped out.

In a talk for TedXManhattan, sleep researcher Wendy Troxel noted that waking up a teenager at 6 a.m. is the biological equivalent of waking up an adult at 4 a.m. Can you imagine trying to function with that amount of sleep lag every day?

Listen to circadian rhythms

Close-up of clock

I’m a naturally late riser. My peak productivity time is from 11 p.m. to 2 a.m. Over the years, I’ve learned what works for my body and how to maximize my sleep performance — but teens don’t have that luxury. They’re expected to beat their biological clock. (To learn more about your natural rhythms and sleep chronotypes, check out my conversation with sleep expert Dr. Michael Breus on the Bulletproof Radio podcast.)

This isn’t just a matter of feeling well-rested in class, either. Chronic sleep deprivation can actually increase the risk of serious diseases because it disrupts circadian rhythm — the brain’s natural sleep-wake cycle.

In my conversation with circadian biologist Satchin Panda on Bulletproof Radio, we talked about the impact of messing with your circadian rhythm. In Panda’s lab, he found that animals with circadian rhythm disruption had a higher risk of diseases like diabetes, obesity, cardiovascular disease, anxiety, ADHD-like symptoms, and even cancer.

Sleeping in is better for your teen’s health and academic performance, but most schools are still far behind. In 2014, the American Academy of Pediatrics recommended that middle and high schools start at 8:30 a.m. or later to give students the time they need to properly sleep.[ref url=”http://pediatrics.aappublications.org/content/early/2014/08/19/peds.2014-1697″] Despite that, only 9.4% of middle schools and 7.7% of high schools start at 8:30 a.m. or later.[ref url=”https://www.cdc.gov/healthyyouth/data/shpps/pdf/shpps-results_2016.pdf”]  

What parents can do

Teen using phone

There’s still a lot of work to do before teens can get the sleep they need. In the meantime, one of the best things parents can do is encourage their teens to reduce their screen time before bed.

Electronic devices radiate blue light, which disrupts circadian rhythm by suppressing melatonin — the hormone that signals when it’s time to sleep. On average, teens are exposed to over 6 hours of screen time daily.[ref url=”https://www.commonsensemedia.org/the-common-sense-census-media-use-by-tweens-and-teens-infographic”] That’s 6 hours’ worth of melatonin disruption — and if your teen uses their phone before bed, odds are high that they’re having trouble falling asleep.

You can protect your teen (and yourself) from blue light by taking the following steps:

  • Wind down two hours before bed: Limit screen time as much as possible. If they need to use a screen, switch to install a light filter app like Iris. This app reduces blue light exposure by adjusting screens to warmer tones at night.
  • Sleep in a pitch-black room: A dark room = better sleep, period. Install blackout curtains and tape over any electronics that emit blue light, like LEDs.
  • Wear blue light-blocking glasses: They might not be pretty, but their orange- or red-tinted lenses help block blue light wavelengths. (You can also use Night Shift mode on your iPhone or iPad. It cancels out blue light so you can look at your device without looking like a dork.)

Here are two more tips, not related to blue light. Your teen should limit their caffeine consumption at least 8 hours before bedtime. That includes coffee, soda, and tea.

Finally, talk to your teen about their sleep time and quality. If they have to wake up at 6:00 a.m., they should set a goal to start winding down by 8:00 p.m. It should be lights-out at 10 p.m. at the latest. Between homework and friends, that’s not always realistic, but setting a goal can help your teen start to learn how to develop healthier bedtime routines.

Related: How to Hack Your Sleep: The Art and Science of Sleeping

Sleep is one of the most important investments you can make. Now is the best time to help your child hack their bedtime habits. After all, everyone deserves to feel alert, balanced, and productive. A good night’s sleep will make a big difference in your teen’s happiness. (And yours, too.)

 

Why Mitochondria Are the Key to Slowing Down the Aging Process

  • A lot of people can still quote their middle school science teacher: “mitochondria are the powerhouses of the cell.” Mitochondria are structures in your cells that make energy for day-to-day activities.
  • When you don’t have enough mitochondria, and when the ones you have aren’t working well, and when you don’t produce them consistently, you get mitochondrial dysfunction.
  • Mitochondria decide how you feel. But, you’re still in charge of them. Read on for some things you can do to keep your mitochondria happy, so that they can keep you operating at full power.

If you’ve been poking around the blog, you see a lot of talk about mitochondria. If this is your first time here, you’re about to change the way you think about everyday functioning.

These microscopic overlords are responsible for how you feel right now. They determined what size free weights you picked up for today’s workout. They established whether or not you read these paragraphs fluidly, or whether you mindlessly scanned, then had to go back and re-read so that you can process the words in front of you. The influence they have is not an exaggeration.

Preserving the mitochondria you have, and coaxing your cells to make more of them may lengthen your lifespan. Mitochondrial dysfunction is one of the main characteristics of aging and disease. In fact, researchers can link mitochondrial dysfunction with nearly every age-related disease, including Alzheimer’s and cardiovascular disease. Symptoms of weakening mitochondria have an almost perfect overlap with the things we associate with aging, like fatigue, excess fat, and declining cognitive ability.

Your mitochondria are in charge, but you can own them. Read on to learn about the function of mitochondria and how you can strengthen them, and do life better (and possibly longer) as a result.

Mitochondria are the key to living better, longer. Grab a copy of my new book to learn more about aging backward. 

Where did mitochondria come from?

There is compelling biological evidence that mitochondria were once independent, single-celled organisms. Millions of years of progression shows that mitochondria started as bacteria that worked together with other cells for mutual benefit (symbiosis), then started living inside of other organisms for mutual benefit (endosymbiosis). Over time, these cells became dependent on each other to survive, and now mitochondria are in every cell in every creature on the planet.

Because they started out as their own independent creature, your mitochondria are semi-autonomous. That means they have their own DNA that’s separate from the DNA that you find in it’s cell’s nucleus. And, they can make some of their own proteins and enzymes.

What are mitochondria?

What Are Mitochondria And Why Should You Care_What are mitochondria

Mitochondria are organelles, which are structures within cells that have a specific job.

A lot of people can still quote their middle school science teacher: “mitochondria are the powerhouses of the cell.” Mitochondria are structures in your cells that make energy for day-to-day activities. Think of them as battery packs in every cell in your body.

Ample, strong mitochondria form the basis for your body- and brain- power. How strong your mitochondria are and how many you have determine how you feel at any given moment.

For a strong body and brain, you want strong mitochondria that create a steady flow of energy, and you want a lot of them. Cells with strong mitochondria work well, and systems with robust cells keep the whole body humming.

Quality and quantity matter. Some cells require more energy than others, and healthy cells have the quantity of mitochondria they need to keep the party going. For example, your brain is a system of electrical impulses, so it is naturally a huge energy hog. It burns through more energy than any other organ, up to one-fifth of your body’s total energy. So, brain cells have a ton of mitochondria.

Weak mitochondria and mitochondrial dysfunction

Producing energy releases free radicals. Even though mitochondria are part of the reason free radicals occur, they’re just as vulnerable to stress and damage from free radicals as anything else. Over time, your mitochondria become weaker and die off as you age. All the not-so-fun aspects of aging – fatigue, fat storage, and a decrease in muscle mass and cognitive decline – are all symptoms of impaired mitochondria.

Especially as you age, you want to continue producing new mitochondria to generate as much energy as your cells and organs need, and to have enough energy to live the kind of life you want to live.

On the flipside, when you don’t have enough mitochondria, when the ones you have aren’t working well, and when you don’t produce them consistently, you get mitochondrial dysfunction. Mitochondria problems tank your energy levels and you end up with problems you wouldn’t expect have anything to do with your ability to make energy, like cardiovascular disease and obesity.

Related: The Secret to Longevity: Keep Your Heart (and Mitochondria) Strong

How to support your mitochondria

Sure, mitochondria decide how you feel. But, you’re still in charge of them. Here are some things you can do to keep your mitochondria happy, so that they can keep you operating at full power.

Get better sleep

What Are Mitochondria And Why Should You Care_Get better sleep

Sleep disorders and mitochondrial dysfunction go hand in hand. Even without a sleep disorder diagnosis, poor sleep habits make your mitochondria weak. That’s because sleep is when cells, especially your brain cells, clean house. When cells go about their day-to-day functioning, they make waste, and when you’re sleeping, mitochondria make energy for your cells to take out the trash. Here’s how to hack your sleep so that your cells can unload the junk and make way for more power.

Keep inflammation down

What Are Mitochondria And Why Should You Care_Keep inflammation down

Inflammation and mitochondria don’t mix. Mitochondria are extremely vulnerable to inflammation, and you want to keep as many intact as you can. Ways to calm inflammation include:

  • Bulletproof protein fasting. Once a week, keep your protein low to induce autophagy, which is the healthy destruction of damaged cells to make way for new ones.
  • Omega-3 fats. Too many omega-6s and not enough omega-3s contribute to inflammation. A high-quality omega-3 supplement, like krill oil, will shift your omega-6:omega-3 ratio to a low range, which will lower inflammation.
  • Lower your toxic load. Eating clean helps to reduce your toxic exposure, and you can use these methods to ramp up detoxification. When the energy from your mitochondria aren’t wasting so many resources on your waste, it can go toward making you feel amazing instead.

Exercise

What Are Mitochondria And Why Should You Care_Exercise

Your mitochondria respond to the increased demand for energy by making more energy, and by making more mitochondria. One study found just two weeks of HIIT “significantly increased mitochondrial function in skeletal muscle. Here are some quick and effective 10-minute routines to keep your cells strong and inflammation to a minimum.

Related: Feed Your Mitochondria and Boost Your Workout With MCT Oil, Says Study

Adopt a cyclical ketogenic diet

What Are Mitochondria And Why Should You Care_Adopt a cyclical ketogenic diet

Mitochondria love using ketones as fuel, and if you give them what they want, they’ll love you back. Here’s how to do high fat, low carb correctly to get into the fat-burning, ketone- generating state as quickly as possible.

Your microscopic mitochondria are in charge, but only to the extent that you let them rule you. Remember, you own them, you feed them, and you create the environment that makes them decide whether to serve you or hold you back.

 

Hack Your Longevity to Look Younger, Feel Stronger, and Think Clearly

  • You have more influence on your longevity than you think.
  • Chances are, you expect aging to come with a declining body, brain blips, and wrinkles and sagging skin.
  • The reality is, your habits and your environment have a lot of influence on how you’ll feel and look throughout your life.
  • Read on for ways to keep your brain, body, and your appearance in top shape as you age.

When you think of aging, what comes to mind? Do you picture yourself crushing it like you are today, or do you imagine wheelchairs and medicine cabinets stuffed with pill bottles?

You might assume that you’re destined for the latter. But, it doesn’t have to be that way. You can be an active participant in your own aging process. While the average life expectancy for Americans is 78.7 years, your habits and your environment have a lot of influence on your longevity, and how you’ll do life in your later years.

Here are some things you can start right now to age not just gracefully, but powerfully.

You: Better at every decade. Order my new book, Super Human to start aging backward today.

How to keep your brain young: focus on energy

If you’re of a certain age and you mention to your doctor that you’re misplacing your car keys and forgetting why you entered a room, chances are, she’ll reassure you that it’s part of getting older. Fair enough, it’s common for older people to not be as sharp as they once were. But, you don’t have to accept that as the way it will be for you. You can grow your intelligence and extend your longevity at any age.

Your brain requires two main things to work well: energy, and protection. Everything else that goes wrong with the brain stems from shortcomings in these two areas.

 

How to maintain energy and stamina as you age

Your brain uses almost 20% of your energy, even though it accounts for only 2% of your body weight. Your brain cells are an electrical system, and you need sufficient power to keep the lights on and shining brightly. That’s why if you’re dieting, or if you have a condition that affects your body’s ability to get energy out of food, like mitochondrial disorders, you find that you’re not thinking clearly.

Your brain will use sugar and carbs for energy, but glucose gets stored away quickly so you have to keep eating to replenish the supply. That spells distraction throughout the course of the day.

The better way is to switch to burning fat for energy. You get more energy gram for gram from fat, and if you keep your glucose low, you encourage your liver to make ketones, which is the best kind of brain fuel. When both ketones and glucose are available, the brain will choose ketones for certain jobs.

How to protect your brain

When your cells use energy, they leave behind free radicals, the part of oxygen that it can’t use. Too many free radicals damage surrounding cells. That’s a big problem for the brain, since it burns through so much energy. You end up with a high concentration of free radicals in a vulnerable organ. Here are ways you can protect your brain from free radicals.

  • Pile on the veggies. All vegetables, especially brightly colored ones, contain polyphenols that neutralize free radicals and prevent them from making a mess. The brighter, the better. Polyphenols also help you make more BDNF (Brain-derived neurotrophic factor), a protein that builds new brain cells.
  • Supplement with antioxidants. Antioxidants sweep up harmful free radicals. You can take vitamin C and polyphenol supplements for an extra boost.
  • Get your stress in check. Life stress translates to oxidative stress, which means more free radical damage. Incorporate a meditation practice and make necessary lifestyle changes to keep your moods as level as possible.
  • Intermittent fasting. A brain cell’s daily work creates waste products that have to go. When your body goes a stretch of time without food, your cells get the signal that it’s time to clean house. A few times a week, give them the opportunity to take out the trash by allowing at least 12 hours (ideally up to 18) between dinner and your first meal the next day.

More ways to love your brain

If you have something specific you want to address, like focus or mental energy, you can experiment with nootropics — which are targeted supplements that boost brain function. Here’s how to get started.

Since your brain’s energy demand is so high, it’s a use-it-or-lose-it system. Keep your brain nimble and fit by visiting new places, getting out of your comfort zone, and incorporating logic games and brain-training exercises.

How to look younger: it’s all about the collagen

You’re not vain because you want to stay attractive as you age. Your looks have a lot to do with not only longevity, but how people perceive you. People see attractive people as:

Even if you don’t care what other people think, your skin is a reliable indicator of how everything is working below the surface. For example, if you don’t have a lot of wrinkles, it means your body is still good at making and maintaining collagen, which is crucial for every organ you have. If your skin is well-hydrated, there’s a good chance you’re maintaining a good mineral balance and the rate of your cells’ turnover is spot on.

Vitamin C, inside-out and outside-in

Vitamin C works in two ways to support your skin. First, it is a powerful antioxidant, so it protects your skin from damaging free radicals you’ll come across in your day-to-day. Too many free radicals break down collagen and elastin, making skin saggier and less apt to snap back into place. Second, you can’t make or repair collagen without it, so having enough vitamin C ensures that your body can assemble peptides into collagen when it’s time to make more.

You can get skin benefits from vitamin C by eating vitamin C-rich foods, taking a vitamin C supplement, and applying vitamin C serum topically. Vitamin C serums are notoriously unstable, so look for formulas containing vitamin E and ferulic acid to keep it potent.

Copper peptide creams

GHK-Cu is a peptide (a chain of amino acids) that reduces inflammation, enhances brain function, and prevents oxidative stress. Your body makes its own GHK-Cu, but you make less and less with age.

GHK-Cu can keep your skin stretchy and bouncy because it stimulates collagen production. To take years off of your skin and increase its longevity, look for topical creams that are 2% GHK-Cu or higher (the label may indicate copper peptides — it’s the same thing).

Cryotherapy to increase collagen

whole body cryotherapy

Brief cold exposure, or cryotherapy, increases collagen production and blocks enzymes and hormones that destroy the collagen you have.

Cryotherapy also boosts your body’s own detox and defense systems, which keep your skin from having to pick up the slack when there are toxins to get rid of. Steep temperature drops increase your production of the antioxidants glutathione and superoxide dismutase, which help support your liver and immune system. That will help the gunk leave through the digestive exits and not through your pores, where it shows.

If you don’t live near a cryochamber, give yourself a five-minute cold blast in the shower. For a DIY cryo-facial, do a few quick face dunks in ice water. The below-freezing temperatures of the a cryochamber will produce more drastic results, but you will benefit from a brief cold blast that you do in your bathroom.

Microneedling or dermarolling for younger-looking skin

Microneedling essentially inflicts tiny injuries all over your face (that sounds bad — it’s not). As a result, growth factors flood to the skin’s surface for some repair action, which includes collagen production. After a few times, you’ll notice smoother rough spots, improved acne scarring, reduced wrinkles, and generally thicker skin. You can get an inexpensive roller for home use or visit a professional who has extra tricks up their sleeves.

Typically, you’ll follow microneedling with a vitamin C serum or plant stem cell serum, although there is no evidence that following with plant stem cells does anything more than microneedling alone.

For advanced anti-aging action, your dermatologist can isolate beneficial cells from your blood and infuse your skin with them. If you’re super advanced and you have a few grand to put toward the cause, you can hit up a stem cell clinic to follow dermarolling with a stem cell treatment for your face.

Charge up your cells to reverse decline, feel younger, and increase your life expectancy

Mitochondria are a direct link to longevity

Mitochondria are the parts of your cells that make energy, determine how you feel, what you want, and how you think right now. Well-fueled, plentiful mitochondria keep you energized and happy, while mitochondria that don’t have what they need distract you, make you feel hungry, and keep you looking for something to satisfy what you’re missing instead of doing the things you need to do.

The key to strong cells and the energy for daily life is having lots of strong mitochondria. Preserving the mitochondria you have, and signaling your cells to make more of them, may lengthen your lifespan. Researchers can link mitochondrial dysfunction with nearly every age-related disease, including Alzheimer’s and cardiovascular disease. Symptoms of weakening mitochondria link directly with the things we associate with aging, like fatigue, body fat, and declining cognitive ability.

Your mitochondria are in charge, but the things you do for your body makes them serve you better. Here are ways to support your mitochondria.

  • Get good sleep. Crummy sleep makes your mitochondria weak. Here’s how to hack your sleep to keep them strong.
  • Keep inflammation down. Mitochondria are vulnerable to inflammation, so avoid it where you can. Here are some herbs you can use in cooking to take care of inflammation you may not even realize you have.
  • Move. Exercise, especially high-intensity interval training (HIIT), prompts your muscles to make more mitochondria.
  • Get into ketosis. Ketones as fuel make mitochondria happy. If you give them what they want, they’ll give you what you need. Here’s how to do high fat, low carb correctly to get into the fat-burning, ketone- generating state as quickly as possible.

NAD+

Nicotinamide adenine dinucleotide, or NAD, is a coenzyme (a compound that certain enzymes need to work) in every cell in your body. It helps shuffle electrons around for the basic reactions that keep you alive.

Your NAD+ levels drop as you get older. Part of age-related decline is failing cells, and since your cells can’t function without NAD, not having enough will age you faster.

Good news is, you can do something about it. Here are some ways to boost NAD+ levels.

  • Take NAD+ supplements. NAD+ comes in capsules and is easy to find.
  • Practice intermittent fasting. Restricting your eating increases NAD+ levels. since you read that intermittent fasting helps your brain, too, it’s like a two-for-one deal.
  • Take oxaloacetate. Oxaloacetate converts to malate, which raises your NAD+ to NADH ratio, which in turn makes more NAD+ available for your cells to use.

PQQ

There is a lot of research supporting PQQ’s potential as a mitochondria enhancer. Studies show PQQ increases the number of mitochondria you have, reduces inflammation, and prevents free radical damage, all of which slow down the aging process in the body and brain.

Unfair Advantage is a highly bioavailable form of PQQ and also contains CoQ10, which helps you absorb it.

Preserve and grow your telomeres for longevity

Scientists compare telomeres to the plastic tips of shoelaces that keep them from fraying. They are essentially caps at the ends of chromosomes that keep DNA strands from unraveling. Research has linked telomere length with life expectancy.

Telomeres naturally wear down with age and cellular stress. Short telomeres are a common thread with weakened immune system, chronic and disease, and advanced aging.

With a little care, telomeres can grow back. Here’s how to keep them long and even grow them longer as you age.

  • Meditate. One study showed that women who meditated had longer telomeres than women who didn’t. Another study linked the stress-reducing properties of meditation to its potential to preserve them. No need to make a big production of it. Even box breathing when you’re feeling stressed will give you a benefit.
  • Watch for environmental toxins. The toxic compounds themselves and the cellular stress they cause can be detrimental to telomeres.
  • Exercise. Exercise reduces oxidative stress and boosts proteins that help keep telomeres strong.
  • Clean up your diet. High-quality foods that are low in toxins and high in restorative nutrients are the most consistent thing you can do for your telomeres. Here’s how to get started.

Aging is part genetics

Some people are genetically wired to live longer.

James Clement, lawyer turned anti-aging scientist, is president and director of Betterhumans, a research organization that aims to extend your lifespan, end disease, and improve brain function. One of the research project the organization runs is the Supercentenarian Research Study, which studies the genes of people who are over 105 years old.

On an episode of The Human Upgrade (iTunes), Clement talks about finding common threads in the gene sequences of supercentenarians, and how they can use that information to not only extend the human lifespan, but also to extend the healthspan — the years of healthy, independent functioning.

“There’s going to be a lot more that we have to do and that’s going to be where more radical therapies, which include nutraceuticals, pharmaceuticals, lifestyle changes, and also genome editing will all be necessary to get us far beyond the 100 threshold,” he explains.

There are certain parts of aging that come with the territory. Some, you have to accept. For example, one day you’ll hit the age where you’ll start getting AARP mailers. You do have influence over other aspects of aging, like how you look, and how you feel, how you think, how you move. Self-care goes a long way on the path to longevity.

Fisetin: The Flavonoid That Slows Aging and Protects the Brain

[tldr]

  • Fisetin is a special antioxidant found in strawberries, apples, persimmons, onions, and other plants, that’s particularly good for slowing down aging.
  • Recent research found that eating fisetin regularly increases lifespan by about 10% and improves quality of life in aging mice. There are clinical trials going on right now to find out whether fisetin can slow down aging in humans.
  • Fisetin also protects you from future inflammation and gets rid of existing inflammation. Low inflammation means your cells can run at full power and you can recover faster.
  • Fisetin shows a lot of promise at fighting cancer, too. It prevents cancer cells from spreading and destroys them. Fisetin seems particularly good at destroying breast cancer cells.
  • Strawberries are a rich source of fisetin. You can also get some fisetin from cucumbers and onions. Check out the recipes below for ideas about fitting more fisetin into your diet; it might help you live a longer, better life.

[/tldr]

Have you heard of the flavonoid fisetin? It’s a plant chemical, found most abundantly in strawberries, with promising health benefits.

Anti-aging scientists have been researching fisetin and its benefits for a while. They expected it to perform as well as other antioxidants do at decreasing inflammation and making cells more efficient. However, a couple recent studies have found that fisetin is much more powerful than anyone expected, in a couple different ways. Let’s take a look at the benefits of fisetin, and why you definitely want to supplement your diet with fisetin.

You: Better at every decade. Order my new book, Super Human to start aging backward today.

Benefits of fisetin

  • Improves brain health and memory
  • Slows down aging
  • Shows anti-cancer abilities
  • Protects against stress and inflammation
  • May protect against stroke and Alzheimer’s[ref url=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527824/”]
  • May improve symptoms of depression[ref url=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356956/”]

Fisetin slows down aging…a lot

anti-aging benefits fisetinOne of the main reasons you age is senescence — your cells stop dividing as they get older. When cells no longer divide, they become mostly useless, start to accumulate in your body, and trigger inflammation, gradually impairing your cellular function and increasing your risk of age-related disease.[ref url=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4748967/”]

Senescence isn’t pretty, which is why anti-aging researchers are on the hunt for senolytics, compounds that delay or reverse aging by destroying old, damaged cells.

New research has found that fisetin is a particularly powerful senolytic. Scientists fed aging mice either normal diets or fisetin-rich diets and watched for signs of aging. The mice that ate fisetin daily lived about 10% longer and their bodies worked better, even at a very old age.[ref url=”https://www.ebiomedicine.com/article/S2352-3964(18)30373-6/fulltext”]

A 10% increase in longevity means living to 110 instead of 100. That’s a big deal. If you plan to live to 180, like Bulletproof founder Dave Asprey, hacks like this can move the needle a lot. There’s a clinical trial going on right now that will shed light on how well fisetin slows down aging in humans.[ref url=”https://clinicaltrials.gov/ct2/show/NCT03430037″] In the meantime, it can’t hurt to eat foods rich in fisetin, or even take a fisetin supplement. For a therapeutic dose, supplements are the way to go. Studies suggest that a dose of 50mg to 150mg per day can be beneficial, though more research is needed.

Fisetin protects you from stress and inflammation

benefits fisetin inflammation stressFisetin protects your cells from stress-related damage so they can run at full power. Fisetin regulates inflammatory pathways[ref url=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985520/”] and deactivates several major inflammatory compounds.[ref url=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689181/”] It also helps you make more glutathione, the most powerful anti-inflammatory substance in your body.[ref url=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689181/”][ref url=”https://www.sciencedirect.com/science/article/abs/pii/S0003986114002082?via%3Dihub”]

In other words, fisetin both prevents future inflammation and boosts your body’s ability to deal with existing inflammation. Low inflammation means your cells can make more energy and you look better, feel better, and recover faster.

Related: Why Reducing Stress Will Protect Your Telomeres and Help You Live Longer

Fisetin may fight cancer cells

benefits fisetin cancerAmong fisetin’s benefits, a few studies have found that fisetin keeps cancer cells from multiplying and spreading.[ref url=”https://www.sciencedirect.com/science/article/abs/pii/S0003986114002082?via%3Dihub”][ref url=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985520/”] Fisetin seems particularly good at destroying breast cancer cells.[ref url=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080104/”][ref url=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034928/”]

Foods that contain fisetin

fisetin food sourcesYou can get fisetin from a few different foods.

  • Strawberries are particularly rich in fisetin. This strawberries and cream smoothie is a great way to get some strawberries, as well as a bunch of quality fats. Strawberries are pretty low in sugar, but you probably don’t want to eat a whole carton of them in one sitting.
  • Cucumbers and onions both have a moderate amount of fisetin. You can combine them in this easy Bulletproof pickle recipe to get a nice boost of fisetin. Just be sure you aren’t sensitive to onions — some people don’t tolerate them.
  • Grapes and persimmons also have fisetin. They’re both high in sugar, so save them for an occasional treat, or skip them entirely and stick with strawberries when you want some fruit.

Related: Superfoods That Destroy Inflammation in Your Brain

One last thought: Fisetin is one of many polyphenols, antioxidants that often have unique benefits. There are a lot of different polyphenols, and it’s worth your time to include as many of them in your diet as possible, from foods like coffee, green tea, blueberries, chocolate, and more. Check out this article for a deeper look at what different polyphenols do for you and where to get them.

 

3 Ways to Reverse Your Biological Age

[tldr]

  • When it comes to your age, there are two numbers. There’s your chronological age, which is how many birthdays you’ve had. There’s also your biological age — how old your body appears to be, based on how it functions and how much wear and tear your cells have gone through.
  • You can’t change your chronological age, but you can do a lot to reverse your biological age. With the right tools, you can have the body and brain of a 25-year-old, even when you’re pushing 50.
  • This article teaches you how to reverse your biological clock by upgrading your mitochondria, turning on autophagy, and managing stress to keep your cells young and healthy.

[/tldr]

How old are you?

Researchers are discovering that there are actually two answers to that question. The obvious one is your chronological age: the number of birthdays you’ve had. But there’s also your biological age. Your biological age is how old your body appears to be — how well your organs, hormones, muscles, and brain work, and how much wear and tear your cells have gone through.

In the last few years, researchers have developed tests that figure out biological age[ref url=”https://www.ncbi.nlm.nih.gov/pubmed/28396265″]. They’ve also discovered that your biological age is a much better predictor of longevity than your chronological age[ref url=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865564/”][ref url=”https://www.ncbi.nlm.nih.gov/pubmed/28958059″] 

If you take great care of yourself, it’s possible to be 50 years old chronologically with a 30-year-old biological age. Conversely, if you eat junk and neglect your body, you can have a 50-year-old biological age when you hit your 30th birthday.

With the right tools, you can change your biological age to make your body younger, and you can do it more quickly than you might think.  

In his recent Bulletproof Radio podcast episode [iTunes], anti-aging expert and investor James Peyer talks about the many things you can do to reverse your biological age, and about how anti-aging helped him cope with mortality as a teen.

Age backward and maybe live forever with my new book, Super Human. Head on over here to get your copy! 

“My grandfather got cancer [when I was 15]…I thought about life and what life meant and what we were all moving toward,” he says. “Then, after a little more reflection and a lot of reading and so on, I was like ‘Oh, wait, there’s something I can do here.’”

Thanks to Peyer’s work, and the work of other anti-aging researchers and experts, it’s now clear that you can do quite a lot to live a strong, healthy life, no matter how old you get.

This article will look at how you can turn back the clock at a cellular level and keep your body young, regardless of the year you were born.

3 ways to reverse your biological age

1. Upgrade your mitochondria

Your mitochondria are the power plants of your cells — they crank out the energy that runs everything your body does, from breathing to moving to thinking.

Typically, your mitochondria slow down as you age, and you produce less and less energy. Slower mitochondria are a hallmark of aging, and come with fatigue, decreased muscle mass and brain function, declining cardiovascular health, and more.

However, just because most people age that way doesn’t mean you have to. There are dozens of ways to power up your mitochondria and make them stronger than ever before. Upgrading your mitochondria does a tremendous amount for reversing your biological age; it can make you feel like you’re in your twenties again.

Building better mitochondria keeps your brain strong, which can ward off memory loss, dementia, and even neurodegenerative disease like Alzheimer’s[ref url=”https://www.nature.com/articles/nature25143″][ref url=”https://www.sciencedirect.com/science/article/pii/S0925443909002427″].

Stronger mitochondria also keep your heart and muscles strong, which can help you stay in phenomenal physical shape as you age[ref url=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709858/”].  

In fact, better mitochondrial function links to overall longevity in a dose-dependent manner — the stronger the mitochondria, the longer people live[ref url=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319988/”].

How to turn on your mitochondria 

  • Eat a keto diet (or a variation). In animal studies, a keto diet (lots of fat, very few carbs) makes existing mitochondria more efficient, and also grows new ones (called mitochondrial biogenesis)[ref url=”https://www.ncbi.nlm.nih.gov/pubmed/30027365″]. A keto diet also increases mitochondrial density in the liver and skeletal muscles of mice[ref url=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260463/”]. In humans, ketosis increases mitochondrial function and protects mitochondria from stress-related damage[ref url=”https://www.ncbi.nlm.nih.gov/pubmed/29607218″]. You don’t have to eat keto all the time; if a full keto diet doesn’t work for you, try a cyclical keto diet or a targeted keto diet. Both allow more carbs while still giving you the benefits of ketosis.  
  • Do HIIT. Exercise in general is amazing for your mitochondria, but high-intensity interval training (HIIT) is the best type of workout you can do for mitochondrial function. HIIT causes dramatic improvements in mitochondrial energy production[ref url=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482849/”][ref url=”https://www.ncbi.nlm.nih.gov/pubmed/30072155″]. It also increases the maximum amount of energy your mitochondria can produce, giving you a bigger energy reserve in your day-to-day life[ref url=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139713/”]. HIIT involves short bursts of intense, all-out exercise, followed by brief rest periods. Here’s a great introductory HIIT workout.  

Related: Why Mitochondria Are the Key to Slowing Down the Aging Process

2. Trigger autophagy

Autophagy is like spring cleaning for your cells. It’s Greek for “eating of self,” which is exactly what autophagy does: your cells sift through their various parts, getting rid of anything that’s old or damaged and replacing it with a shiny new version. Even better, a lot of the old stuff gets recycled and packaged into new materials your body can use.

Autophagy keeps your cells young and new, which means they run faster while producing less cellular waste. Your whole system becomes more efficient.

But when autophagy breaks down your cells age, and you, age with them — disturbed autophagy leads to significantly faster markers of aging[ref url=”https://www.ncbi.nlm.nih.gov/pubmed/21884931″].  

How to trigger autophagy

  • Work out. Exercise is one of the best ways to turn on autophagy. Research shows that working out increases cellular turnover (how quickly your cells replace themselves) and cleans out damaged cellular parts, which links to decreased aging[ref url=”https://www.ncbi.nlm.nih.gov/pubmed/30430746″]. Any kind of exercise works, but you might as well do HIIT so you also capitalize on the mitochondrial benefits you read about a moment ago.  
  • Do intermittent fasting. Caloric restriction is one of the most powerful ways to activate autophagy, especially for your brain[ref url=”https://www.ncbi.nlm.nih.gov/pubmed/27473756″]. Long-term caloric restriction is rough on your body — you’ll get hungry and have a dip in energy levels, and over time may start to lose muscle. A better option is intermittent fasting, where you take short breaks without food and then eat until you’re full afterward. Intermittent fasting triggers “profound autophagy,” to quote one group of researchers[ref url=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3106288/”]. Fasting also corresponds with longevity and overall healthier aging[ref url=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919445/”]. Check out this complete guide to intermittent fasting to figure out a fasting schedule that works for you and learn about the benefits of fasting.

Autophagy is one of the best tools you can use to age well.

3. Control stress

Stress ages you faster than anything else. If you want proof, compare photos of presidents before and after their time in office. After a term or two of round-the-clock pressure and stress, they look like they’ve aged 20 years.

Chronic stress ages you in two ways. First, it increases free radicals — compounds that damage your cells and cause inflammation. Free radicals increase when you push yourself past your limit, and if you do that chronically, they speed up aging at a cellular level[ref url=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579396/”].

Second, chronic stress interferes with your cortisol production. Cortisol is the hormone you release in response to an immediate threat; it shuts down non-essential functions like metabolism and executive brain function, saving that energy so you can escape whatever danger you’re in. Cortisol also breaks down muscle tissue so you have more glucose in your system to use for short-term fuel[ref url=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579396/”].

That’s all great if you’re running from a tiger. But your brain isn’t good at distinguishing between immediate, tangible threats and more abstract ones (fear of getting fired or too many emails in your inbox, for example). When you have constant, lower-level stressors running, your cortisol continually interferes with your metabolism, brain function, muscle mass, and more. Over time, you’ll end up aging faster than you would otherwise[ref url=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428505/”].

Tools to manage stress:

If you live your life well, age really can just be a number. Use these tools to turn back your biological clock and stay young, even as you get older. You’ll feel better than ever.

Read next: Hack Your Longevity to Look Younger, Feel Stronger, and Think Clearly

 

Start hacking your way to better than standard performance and results.

Receive weekly biohacking tips and tech by becoming a Dave Asprey insider.

By sharing your email, you agree to our Terms of Service and Privacy Policy