What Are Stem Cells And Why Do People Get Stem Cell Treatments?

What Are Stem Cells And Why Do People Get Stem Cell Treatments?

[tldr]

  • Stem cells have a reputation for being an ultra-advanced, super expensive, and controversial biohacking procedure.
  • That’s changing. Treatments that you once had to go overseas to get are now available all over the U.S..
  • The government already approved stem cells as a treatment for a narrow assortment of cancers, and as safety and knowledge around stem cells expands every day, a wider range of applications should follow.
  • Keep reading to find out what a stem cell does and to see what happens at the stem cell clinic.

[/tldr]

Stem cells have a reputation for being an ultra-advanced, super expensive, and controversial biohacking procedure. That’s changing at lightning speed. Just a short time ago, most people who wanted stem cell treatments had to go overseas to get it. Now, there are stem cell clinics all over the U.S., and regenerative medicine, the science behind tissue repair, is solidifying into an accepted medical discipline.

Stem cell research breakthroughs are happening every day. For example, scientists have been able to create primitive human kidneys and restore vision in blind patients using stem cells.

Costs have already fallen through the floor. As more and more facilities begin to offer stem cell procedures, you’re going to see costs come down even more. When the government starts approving stem cells as a legitimate treatment, you may someday get treatments covered by insurance. As of now, stem cell treatments are not approved for injuries and overall aging benefits, even though people use them for just that.

The government already approved stem cells as a treatment for a narrow assortment of cancers, including cancers of the blood and bone marrow, and as safety and knowledge around stem cells expands every day, a wider range of applications should follow.

Keep reading to find out what a stem cell does and to see what happens at the stem cell clinic.

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What are stem cells?

Stem cells are cells that are undifferentiated — meaning, they’re not assigned a cell type, like bone cells and nerve cells, when they’re in stem cell form. Depending on what kinds of stem cells you’re talking about, they can differentiate into many different types of cells to build brand new organs when you’re a fetus, or regenerate and repair damaged tissues when you’re an adult.

Types of stem cells


You have several types of stem cells in your body right now, and other types are available for treatments.

Adipose-derived stem cells

You get adipose-derived stem cells from your adipose tissue, aka your fat cells. These are ideal for regenerative therapies like IV stem infusions for overall resilience, because you can extract them over and over without much pain or risk of infection.[ref url=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040903/”]

Mesenchymal stem cells (from your bone marrow)

To get to mesenchymal stem cells, you have to get to your bone marrow, which is as painful as it sounds. Mesenchymal cells can differentiate into some of the same types of cells as adipose-derived stem cells, and also into different types of cell lines. Your doctor will know which types to use for your goals.

VSEL stem cells – very small embryonic-like stem cells

You have a small number of very small embryonic-like stem cells (VSELs or V-cells), circulating in your bloodstream. These are made in the bone marrow and organs,[ref url=”https://www.sciencedirect.com/science/article/pii/S0531556508001642″][ref url=”https://link.springer.com/article/10.1007/s12015-008-9018-0″] and are small enough to cross the blood-brain barrier.[ref url=”https://link.springer.com/article/10.1007/s12015-008-9018-0″] Extraction is as simple as a blood draw, but they’re more plentiful in umbilical cord blood. VSEL treatments are a cutting-edge science that not many stem cell centers offer to the public yet. It’s legal to use them in humans for research, but not yet approved as a treatment.

Cord blood stem cells and placenta stem cells

Instead of extracting your own stem cells, you can purchase stem cells that have been harvested from newborn umbilical cords and placentas that have been donated and would otherwise be incinerated and disposed of.

Stem cell secretions

The fluid that stem cells secrete is rich in growth factors, which are a mix of vitamins and hormones that stimulate cell growth. This is how stem cells signal for repair and anti-inflammatory compounds to promote healing.[ref url=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197270/”] Some stem cell clinics will offer stem cell fluid in combination with stem cells themselves.

What does a stem cell do?

There’s a common misconception that stem cells float around your body and become whatever they need to become. That’s not the full story. Here’s what actually happens.

The stem cells that are already in your body will sense things like:[ref url=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197270/”]

  • Low oxygen (hypoxia)
  • Inflammation
  • Abnormal cell proliferation (tumors)

Stem cells will migrate to the site of these stimuli and hang out there for a few weeks. While there, they will secrete a fluid that is rich in anti-inflammatory compounds, chemicals that regulate the immune system, antitumor compounds, and growth factors for regeneration.[ref url=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197270/”]

So, if you’ve hurt your wrist, you probably tore up your collagen. Stem cells will sense inflammation, and the stem cell juice will signal to your fibroblasts (collagen-producing cells) to start linking up amino acids to make collagen for the injury site.

Related: How Adult Stem Cells Can Help Stop Pain and Reverse Aging

If your body does this already, why do you need a doctor to take stem cells out and put them back in?

Your body’s own healing mechanisms only take you so far, and your pace of healing and repair declines with age. That’s where regenerative medicine comes in. There are two main reasons stem cell clinics can boost healing and regeneration using stem cells: growth, and direction.

Stem cell growth

Depending on your treatment goals, the doctor may extract your stem cells and put them right back in, or opt to grow your cell line, or reproduce them in a culture dish. If you plan to get a series of treatments or get on a stem cell maintenance program, it may be a good idea to grow the cell line so that you don’t have to extract them over and over. They’ll be ready when you are.

How labs grow stem cells

After the doctor extracts your stem cells, they will flash-freeze them and send them to a lab for culture. From there, the lab thaws your vial and spins it in a centrifuge to separate out the live stem cells. Stem cells are immediately placed into an incubator with a “feeding” solution — a mix of growth factors, amino acids, and other compounds to encourage cell replication. Lab technicians feed and monitor the cell culture every day, and freeze and send them back when ready.

That means you’ll need two appointments — one to extract your cells, another several weeks later to use them.

Targeted regeneration with stem cells

Once the doctor has your stem cells, she can then put them back into your body. If your goals are to address an injury or arthritis, the doctor can simply inject them into the injury site.

If the goal is to act on your aging clock, improve the body process you cannot see, and increase your overall resilience, the doctor may administer stem cells intravenously (IV). That way, the stem cells can course through your bloodstream and find their home in areas of low-level inflammation that you don’t even know you have.

Who should get stem cell treatments?

Stem cell treatments will be much more common in the near future than they are now. For now, people get stem cell treatments to address things like:

  • Injuries
  • Arthritis
  • Localized pain (muscles, joints)
  • Cancer
  • Autism
  • Multiple Sclerosis
  • Parkinson’s disease
  • Alopecia (hair loss)

Stem cells have not been approved as a therapy for many of these conditions.

Clinics will also administer IV stem cells for general wellness and as an anti-aging preventive measure, and the procedure can be repeated yearly or twice a year. The idea is that stem cells in your bloodstream will find places in your body in need of repair and distribute to multiple sites to strengthen them.

“The two main contributors to aging are inflammation and oxidation,” says Dr. Harry Adelson in an episode of Bulletproof Radio (iTunes) featuring himself and Dr. Amy Killen, both doctors of regenerative medicine at Docere Medical in Utah. “Your body’s biologic aging really is a response to how well you can cope with and respond to inflammation and oxidation. Both of those processes are entirely controlled by stem cells.”

Stem cells aren’t just about injuries. The hallmark of a youthful body is your cells’ ability to recover from everyday stresses and strains. As long as you get as much out of its way as possible, your body’s ability to heal itself is amazing. Stem cell therapy takes self-healing a step further. Working with a qualified doctor to direct the stem cells that you already have can make incredible strides in reversing aging and recovering from injuries and everyday wear and tear to reverse your aging clock.

 

3 Things It Takes to Be a Genius (and How to Hack Them)

[tldr]

  • Intelligence researchers have two definitions of a genius: either someone with an IQ of above 140, or someone who makes radical, enduring contributions to their field (Beethoven in music, Michelangelo in painting, or Einstein in physics, for example).
  • Typically, geniuses have three specific traits: high IQ, high creativity, and exceptional work ethic.
  • Being a genius is more accessible than you might think. With the tools in this article, you can train your brain to raise your IQ, permanently increase your creativity, and build extraordinary work ethic.

[/tldr]

In a recent Bulletproof Radio podcast episode [iTunes], intelligence and creativity researcher Dean Simonton talked about what it takes to be a genius.

“There are two main definitions of genius,” Simonton says. “In the American Heritage dictionary, it says that if you have an IQ (intelligence quotient) of 140 or above, you’re a genius. An IQ of 140 puts you in the top one percent of the population.

“The other definition, which I use in most of my research, is outstanding and unique achievement. You’ve gone down in history for doing something where you really, really stand out.”

Genius definition: 3 specific traits

Simonton has spent his career studying geniuses who make radical, enduring contributions to their field — Beethoven, Michelangelo, Einstein, and others. He’s found that most geniuses have three specific traits:

  • High IQ
  • High creativity
  • Strong work ethic

It’s easy to think of genius as something unattainable — the result of a genetic lottery. In reality, however, you can hack all three hallmarks of genius and increase your odds of making a lasting mark on the world. This article will go through the tools you can use to raise your IQ, permanently increase your creativity, and build extraordinary work ethic.

3 hacks to becoming a genius

1. Raise your IQ with brain training

IQ isn’t exactly your overall intelligence. It’s more your ability to learn. The higher your IQ, the faster you’ll be able to understand complex information.

Speed of learning is often what sets geniuses apart from their peers. If you can learn twice as quickly as the average person, you’ll be able to accomplish much more in your lifetime.

The average person’s IQ is 100, and the scale goes up to 140, which is the top one percent of the population. That said, you can score higher — Einstein and physicist Stephen Hawking had IQ scores of 160.

For years, people thought it was impossible to increase IQ. In 2008, however, researchers discovered that a particularly challenging mental task called dual N-back training can permanently increase your IQ[ref url=”https://www.pnas.org/content/early/2008/04/25/0801268105.abstract”]. Since then, other researchers have confirmed that dual N-back training increases your fluid intelligence — your ability to solve new problems quickly[ref url=”https://www.sciencedirect.com/science/article/pii/S0160289610001091?via%3Dihub”][ref url=”https://ieeexplore.ieee.org/document/5454984″]. Dual N-back training also makes your brain cells measurably denser and stronger[ref url=”https://www.academia.edu/24511273/Increased_integrity_of_white_matter_pathways_after_dual_n-back_training”].  

Check out this guide to dual N-back training to give it a try. Save the training for days when you don’t have anything important going on, and make sure you set aside time to recover afterward. It’s intense.

2. Increase your creativity

Geniuses are also almost always highly creative, which makes sense: if you’re going to do something nobody in your field has done before, you have to be creative enough to dream into existence something that didn’t previously exist.

The best measure of creativity is “openness”, one of the metrics in the Big Five Personality Inventory[ref url=”https://www.ncbi.nlm.nih.gov/pubmed/18341234/”]. The Big Five Inventory is the most scientifically-backed personality test in psychology (and by the way, it’s worth taking if you want to learn more about your personality. You can find it for free online). Openness measures two things: how open you are to new ideas and experiences and how interested you are in abstract thinking.

There are two reliable ways to increase creativity (openness) long-term.

  • Meditation increases openness, as long as you do it on a regular basis[ref url=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3146707/”]. All it takes is ten minutes a day. To start, check out the Bulletproof 30-Day Meditation Challenge.
  • Psychedelics also reliably and permanently increase creativity[ref url=”https://www.ncbi.nlm.nih.gov/pubmed/29452127″], possibly because psychedelics decrease latent inhibition, your brain’s tendency to screen things in your environment as irrelevant or unrelated. Decreasing latent inhibition makes you more likely to see connections between things that you wouldn’t normally see, which increases creativity (especially if you have a high IQ)[ref url=”https://www.ncbi.nlm.nih.gov/pubmed/14498785/”]. It’s worth noting that psychedelics are illegal in many places. You can read more about them in this guide to psychedelics. Always biohack responsibly.

3. Build up your work ethic

The other common trait in geniuses — and, according to Simonton, the most important trait — is strong work ethic. Geniuses tend to work hard toward something for many hours a day.

When you combine strong work ethic with the ability to learn fast (high IQ), you get exponential progress compared to the average person in your field. If you put in 60 hours a week and the next person puts in 40, and you learn twice as fast as they do, at the end of a year you’ll have about 6,000 hours in work, compared to about 2,000 for the average person.

This is why geniuses can do so much more in their lifetimes than the average person can. Strong work ethic plus high IQ makes you unstoppable. And like everything else, work ethic is something you can improve. There are a few ways to increase work ethic:

  • Follow the Bulletproof Diet. When you get rid of foods that make you weak and replace them with foods that actively improve your biology, your focus and energy go through the roof. The Bulletproof Diet is designed to feed your body and brain with the best foods possible so you can perform at your best. You can download the Bulletproof Diet Roadmap for free; it has everything you need to get started.
  • Upgrade your mitochondria. Your mitochondria are the power plants that create energy for your cells. The better your mitochondria run, the longer you can go without burning out, and the sharper your thinking will be. Here are five ways to build stronger mitochondria.
  • Challenge yourself every day. This is the one that nobody wants to do because, by definition, it’s hard work. But the best way to build up work ethic is to do hard things, and the sense of satisfaction you get from succeeding gives meaning to your life. Learn how to set good goals and actually achieve them. It’ll be challenging, but over the course of a couple months, you’ll find you can handle a lot more than you think.

Being a genius isn’t as out of reach as it seems. Use these tools to increase your IQ, creativity, and work ethic. You’ll be amazed by how effective you become.

 

6 Challenges for Women on Keto — and How to Overcome Them

  • Weight loss plateaus — or even weight gain — are a common stumbling block for women on keto. One way to fight back is to incorporate more fat or try periods of intermittent fasting.
  • Restricting your carbs and calories too much on a keto diet can lead to out-of-balance hormones.
  • Adjusting your eating habits along with your cycle can keep your keto lifestyle and hormones more in-sync.
  • Women who notice their energy is dragging should do carb cycling — “carb-up” once or twice a week with starchy vegetables.
  • If emotional eating is thwarting your keto efforts, break habit loops by switching your routine in small ways.
  • Ditching a deprivation mindset can help you reframe the narrative around your diet, enabling you to stick with it.

It’s no surprise that the eat-fat-to-lose-fat ethos of a ketogenic diet is an appealing one — in fact, keto was the most searched diet of 2018, according to Google. However, despite the diet’s popularity and keto’s myriad benefits, it can pose some unique challenges to women. Here, six common stumbling blocks for women on keto — and how to overcome them in order to maximize your results.

The problem: your weight loss plateaus — or you’re gaining weight

woman standing on scaleIf you aren’t losing weight on keto, there are a number of ways to kick your keto diet into high gear, says Leanne Vogel, nutrition educator, host of The Keto Diet Podcast, and author of The Keto Diet.

Up your fat consumption, Vogel suggests. “Make sure at least 60 percent of your diet is high-quality fats, like olive oil, avocados, grass-fed beef, coconut oil, pastured eggs, grass-fed butter, and ghee.” In fact, most keto diets, including the Bulletproof Diet, recommend upwards of 80 percent of your calories come from fat.

Use coconut-derived MCT oil. MCT oil boosts ketone production in the body, explains Vogel. This gets you into ketosis faster and gives your body more ketones to use as fuel. MCT oil also curbs food cravings, increases your energy levels, and boosts your metabolism.

  • Put MCT oil on your food throughout the day to keep ketone levels high. It’s flavorless, so you can blend it in coffee or smoothies, and drizzle on salads, sushi, or vegetables.

Bulletproof intermittent fasting, aka fat-fasting or fast mimicking, is another surefire way to deepen ketosis and kick-start weight loss:  “You eat only healthy fats, and your body believes it is actually fasting, so you get all of the benefits of fasting while enjoying your favorite fatty foods,” Vogel says.

  • To mimic fasting, skip breakfast and drink Danger Coffee, made with grass-fed butter and MCT oil, instead. Because there’s no protein or carbs, your body thinks it’s in fasting mode. Meanwhile, the MCT oil accelerates your fat burn.

Use a food tracker. Keto diet specialist and certified nutritionist Carole Freeman says that when people gain or stop losing weight, it’s typically because they’re not actually measuring and tracking their food. “They’re guesstimating. Or they’re eating keto food and assume however much they’re eating is okay,” she says.

Suzanne Ryan, best-selling author of Simply Keto recommends using a fitness tracker, such as My Fitness Pal, to keep tabs on your macros. “It can be helpful to track, even just for a week or two, to see if things are sneaking in that might have more carbs than you think or are kicking you out of ketosis,” she says.

The problem: You’re struggling with hormone imbalances on keto

how keto impacts women's hormonesHormones present a unique challenge to women that male keto-dieters don’t have to reckon with. “The ketogenic diet is an endocrine-based diet, meaning we are relying on hormones to run the show, unlike other diets where calories in/calories out have a larger significance. Because of this, when women go keto, if we have any hormone imbalances, they’re often brought to the surface,” Vogel explains.

Fibroids, heavy periods, endometriosis…these can all be signs of estrogen dominance (having too much estrogen in your body).

Related: What Your Body Type Says About Your Hormones and What to Do About It

Keep body fat at a normal range: Hormonal-related challenges can become especially pronounced if you are restricting too much and are trying to achieve a suboptimal level of body fat, Freeman says. “Women’s bodies are healthiest at around 22 to 29 percent body fat. Hormones function optimally in that range for women. If women are already very lean or low body fat and try to achieve a lower body fat, keto can wreak havoc on hormones, but that’s not keto’s fault,” she says.

Aim for a happy weight: “Understand that there’s happy weight instead of your ‘ideal weight,” Vogel adds. “If you have to fight tooth and nail to get to your ‘ideal weight’ it may not be worth the hassle and could be affecting your hormones. Instead, aim for a weight that’s easy to maintain on keto.” Generally, provided you aren’t too restrictive, keto is compatible with your hormones.

“If you stay the course with keto, eventually your hormones will be able to regulate, your brain will light up, your energy will improve, and you’ll feel more in sync with your body,” Vogel says.

Sync your diet with your cycle: Another way to manage your hormones on keto is to eat with your cycle.

  • As a rule of thumb, Vogel recommends upping your protein macros on days one through five of your cycle (aka during your period). From days six through 11 (from the day after your period ends to two days before ovulation), aim for really low carbs and a moderate protein intake. On days 12 through 16,” opt for glutathione-rich keto foods, such as avocado, broccoli, garlic, and parsley and carb up every night.” At the end of end your cycle, on days 17 through 28, carb up once or twice with starchy vegetables.

Read more about cycle syncing here.

Practice carb cycling, aka keto cycling, to keep your hormones in balance. On a cyclical keto diet like the Bulletproof Diet, you eat a moderate amount of carbs one day a week during a “carb re-feed.” Cycling in and out of keto each week gives your body the carbs it needs to keep the endocrine system humming along happily.

The problem: You don’t have enough energy to work out

women doing push-ups at the gymYes, keto is a low-carb diet. However it’s possible that you’re restricting your carbs too much — experts say they see this especially with female clients. In addition to affecting your hormones, this could impact your exercise routine. “Your body might not be getting what it needs for balance,” Vogel says.

Carb cycling: “You may need to cycle carbs to get to a healthy level.” Vogel suggests doing carb re-feeds once or twice a week, which means taking most of the fat out of your evening meal and replacing it with Paleo-friendly carbs (think: sweet potatoes, plantains, or cassava.)

The problem: Emotional eating is thwarting your keto efforts

woman pouring snacks into her hand“Women are told we can do it all, so that means we feel like we have to do it all,” Freeman says. The combination of this increased pressure and diminished sense of self worth can send some women down the path of emotional eating — and off keto.

Freeman points out that some women might not feel entitled to special treatment, so food often becomes one small indulgence we’ll allow ourselves.

Break bad snacking habits: To combat emotional eating, you need to break free of habit loops that are leading you astray, Freeman says.

In prehistoric times food was scarce, so our brains would memorize how we got that food again. Now, we have food on every corner, but the brain still has the ability to memorize exactly how to get food.

So if you fall into a pattern of every night after work sitting on the couch with a bag of chips in front of the TV or digging into ice cream every time you’re upset, your brain goes into autopilot. “The brain reinforces those habit loops. The first thing the brain does is release dopamine. That turns on cravings and desire,” Freeman says.

Soon, every time you sit on the couch, your instinct is to reach for a bag of chips or every time you feel down, you automatically go to freezer.

  • To break out of the cycle, you have to do something different. “I recommend for clients things as simple as sitting in a different spot on the couch at night. Do something out of your routine,” Freeman says. Research shows taking a short, brisk walk also helps eliminate cravings.

Address emotional issues: Of course, you may also need to examine if there’s something deeper going on emotionally that’s holding you back. “If you don’t address these underlying emotional issues, you’re just putting a Band-Aid on the cause,” Ryan says. “For me, it was important to work on my self-esteem. It’s important to put yourself first and see yourself as a worthy investment when your self-worth is in question.” Follow these strategies to help eliminate emotional eating.

The problem: You keep cheating on keto

woman eating a bacon cheeseburger that isn't keto-friendlyChange your mindset: Simply sticking to keto poses a hurdle for many women — one that can be overcome, in part, with a shift in mindset, says Ryan. “I think especially for people who struggle with weight, it’s easy to go into a new way of eating with a mindset that you have to do it because you have to lose weight. It feels like a punishment,” she says. “For me, it was helpful to shift from the mindset that there was something I couldn’t eat to the mindset that I didn’t want to eat those foods because of how my body would react to them.”

Freeman says she’s seen the same thing in the people she’s worked with. “People get stuck in the deprivation mindset. They see everyone eating high-carb foods and think, ‘poor me, I’m so deprived.’ This propels them into the mindset of, oh I’ll have just one thing,” she explains. “Instead, look at those people and think, ‘I feel sorry for them because they’re stuck in that trap and worsening their health.”

Cut out sweeteners: If it’s sugar cravings in particular that are leading you astray, there is something physical you can do as well. To beat back sugar cravings, Freeman recommends getting rid of all sweeteners — even ones that are keto-approved — for the first 30 days. “Even if you’re using a keto-friendly sweetener, it reinforces your craving instead of breaking the habit,” Freeman explains. “What that tells your brain is, ‘good job craving, come again tomorrow.” Do this 30-day no-sugar challenge to wipe out cravings for good.

 

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