Team Asprey

Erectile Dysfunction: Causes, Solutions and Why It’s Normal – Dr. Paul Thompson – #886

EPISODE #886

Erectile Dysfunction: Causes, Solutions and Why It’s Normal

Paul Thompson, M.D.

Ditch the embarrassment and shame of ED and get right to the details of how you can reclaim your sexual function, performance and energy.

Portrait of mature doctor with eyeglasses

In this Episode of The Human Upgrade™...

…urologist, surgeon and age medicine specialist Dr. Paul Thompson discusses the challenges men can experience with their sexual health, energy and performance.

Erectile dysfunction happens to men at all ages and is actually quite normal.

Causes can be physical, and hormones play a role. Nutrition or exercise habits may be culprits. And state of mind factors in.

Dr. Thompson shares his clinical expertise on how getting to the root of what’s going on with men’s sexual functioning will not only improve erectile dysfunction but also support other critical areas of men’s health.

You could take all the testosterone you want, but if you have certain conditions, ultimately, it's not going to help and you have to do things to improve the quality of your erections.

Paul Thompson, M.D.

The conversation looks at the pros and cons of eating meat, what your cholesterol numbers really mean, and why cardiovascular health matters at every age.

Guys, listening to this, if your doctor isn’t asking you for Lp-PLA2, which is an enzyme that’s expressed when there’s damage to your arteries, then you have a problem. If they aren’t looking at C-reactive protein, you have a problem; and if they’re not looking at homocysteine, you have a problem. So, you could ask your doctor for them or you could ask your doctor, “Hey, what do you know about these?”

You’ll also find out why oral health is so important and why you have to pay attention to your nitric oxide production.

Dr. Thompson talks about the at-home device he helped develop at Launch Medical (he’s chief medical officer there) that’s pioneering a solution for erectile dysfunction. It’s based on clinical acoustic wave therapy treatment. “Acoustic wave is really simple and it works, and it has to do with the growth of blood vessels,” he explains. The Phoenix device helps men improve and/or restore their sexual functioning.

Guys and women who love guys or guys who love guys, this thing is real technology. It does work, it is not too good to be true, and it’s worth talking about.

This conversation takes any embarrassment or shame out of the ED equation and gets into the details of plaque, blood flow and how you can find a fix and reclaim your sexual health.

SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: Visit https://getmyphoenix.com/dave and use code DAVE100 to save $100.

Enjoy the show!

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  • As a doctor, as a urologist, did they train you on this in medical school?  – 4:32
  • Some things we can do on our own and some things we can use the Phoenix to help us with.  – 6:43
  • Vascular disease is systemic. We’re treating it locally because there’s marked improvement, but, at the same time, I encourage my patients to use testosterone for the endothelial benefits.  – 13:16
  • I started talking about acoustic wave therapy and about the Phoenix, specifically, get it and they’re seeing changes. These are not people with plaque. In fact, they’re not even people with erectile dysfunction, but they’re seeing noticeable changes because of neurogenesis.  – 19:33
  • Once the vessel, the intima, increases, that’s an indication of damage and that leads to poor quality erections.  – 22:59
  • Oral health is the start probably of cardiovascular disease, maybe through C-reactive protein, but there’s some other things that are really important when we’re talking about performance, erectile dysfunction, and plaque.  – 29:53
  • Do you worry about total cholesterol if HDL is high and triglycerides are low?  – 32:28
  • How we can get our nitric oxide to go into our vascular system instead of into the inflammatory system?  – 41:39
  • Your DNA does not predict your destiny, and that we use things like epigenetics to affect DNA and go in and do things.  – 43:06
  • A lot of those are endocrine disruptors directly that inhibit testosterone. So even if they don’t mess up your gut bacteria, they’re still keeping you from getting a hard on.  – 48:45
  • Acoustic wave treatment, that’s where all the vascular properties were first discovered and the guy who did a lot of that work was one of my early partners in another shockwave company that was kidney stones. – 59:10
  • How many sessions of the Phoenix does it take for the average person to see results?  – 1:04:32

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A Bacteria That Guards Your Gut Lining – Colleen Cutcliffe, Ph.D. – #881

EPISODE #881

A Bacteria That Guards Your Gut Lining

Colleen Cutcliffe, Ph. D.

Akkermansia, a probiotic naturally found in the human gastrointestinal tract, protects your gut lining and stabilizes your microbiome.

Colleen_Cutcliffe_Pendulum_2021

In this Episode of The Human Upgrade™...

…we get into the gut. If you’ve listened to my podcast before you probably know how much the gut is a culprit in disease. I’ve invited experts on the show to explain how without the right balance of good bacteria in your gut, you can have inflammation, poor immune response, GI distress and much more. 

Your gut lining is like a fence, explains Colleen Cutcliffe, Ph.D. It needs maintenance and attention, because that “fence” is what guards your gut from bad bacteria and toxins. Without it, you lose a strong defense system.

That’s where Akkermansia comes in. This bacterial strain naturally found in the gastrointestinal tract helps regulate the mucus lining of the gut, while also fine-tuning immune responses. 

Only in recent years have people understood (and acted on) the gut microbiome’s role in wellness or disease. Dr. Cutcliffe shares the research behind Akkermansia and why this probiotic is changing the gut health game.

“People who are healthy have a ton of Akkermansia, and there are a variety of different disease states where people were low or entirely missing it,” she says. During our conversation, you’ll find out why. You’ll also learn how and when to take Akkermansia, as well as other great probiotics practices that will boost the state of your microbiome.

“The probiotic is the actual bacterial strain.
The prebiotic is the food for the probiotic. And the postbiotic is what the bacteria produce.”

Colleen Cutcliffe, Ph.D.

Dr. Cutcliffe co-founded Pendulum Therapeutics. In the probiotics world, she’s a big deal. The company’s Glucose Control product was the first microbiome intervention for people with Type 2 Diabetes. Clinical studies shows that it reduces post-meal glucose response. Find out more about that on episode #767.

“When you think about the gut bacteria and its role in glucose control, it’s just a big opportunity to bring back these bugs that we’ve always had and lost along the way, in order to help us metabolize sugars,” Colleen says.

I’m looking forward to a world where we know what every bacteria does in our guts. We know what it eats. We know what it does in relation to all the other bacteria in our guts. And we can actually custom engineer ones to make whatever substances we want.

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Enjoy the show!

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  • What got you from your glucose control formula into looking at Akkermansia?  – 4:45
  • Some of the really big pharma companies are starting to invest in clinical trials, where they’re using diabetes drugs to try to treat Alzheimer’s disease.  – 5:24
  • Are you more likely to have leaky gut if you don’t have Akkermansia?  – 9:10
  • The biggest challenge is, you have to grow these things in the ways that I described, where it’s anaerobic and you’re compensating for the lack of a mucin layer in your manufacturing plant.  – 12:46
  • In the case of Pendulum glucose control, the prebiotic is inulin, the probiotics are all the strains that are in the capsule, and the postbiotic is the butyrate that gets produced by those strains.  – 20:29
  • Butyrate has studies that show when you eat it directly, and it’s a post biotic, you mentioned it earlier, it has anti-inflammatory effects in the brain.  – 25:32
  • If someone has higher zonulin levels, they’re much more likely to have leaky gut, regardless of their Akkermansia levels?  – 28:07
  • In our clinical trial that was published in BMJ, we showed that the efficacy of Pendulum glucose control was on top of Metformin. So, if you’re on Metformin and you take Pendulum glucose control, it lowers your A1C even further.  – 30:43
  • What’s your favorite tests for Akkermansia?  – 34:59
  • I think what we’re going to find is that it’s not just about the regulation of this mucin layer, but it’s actually about these receptors and their localization and their concentrations, because those are the signaling things.  – 38:01
  • If my Akkermansia goes way up, I know I’ve got healthy Akkermansia. What am I going to feel?  – 42:35
  • But the truth is that you’ve got one criminal and you’ve got 99… 9,999 great people. So, we’re trying to figure out, how do we maintain that ecosystem and population of diverse, beneficial microbes, while eliminating that criminal, but being much more sophisticated about it.  – 49:35
  • When you change your diet, when you travel, when your circadian rhythm is different, day is night, night is day, we go through these time changes. All of those things, aging, menopause, menstrual cycles, all of these things are constantly changing our microbiome.  – 51:33

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Hack Your Joints and Muscles with Minimalist Footwear

If you’ve ever seen me in public, there’s a good chance you noticed my footwear. Until recently, I practically lived in Vibram FiveFingers –– those weird toe shoes that fit your foot like a glove. 

I chose the Vibrams because they’re minimalist shoes: they allow you to mimic walking around barefoot, which is the way you’ve evolved to move. Minimalist shoes improve your postural alignment and take pressure off your joints. 

If you’re still wearing traditional footwear, it’s worth your time to make a switch. You’re on your feet every single day, and if you’re wearing a standard shoe with a stacked heel and cushioning, it’s probably taking a bigger toll on your body than you’d think. 

In this article, I’ll talk about why standard shoes are harmful and how minimalist shoes improve your posture and take stress off your joints. I’ll also share my favorite new minimalist shoe brand and talk about why they’ve gotten me to switch from Vibram FiveFingers. Let’s get started. 

Normal Shoes Mess with Your Alignment and Hurt Your Joints

Let’s start with the world’s shortest functional anatomy lesson:

Most people don’t know that 1/4 of the bones and joints of your entire body are in your feet and ankles.

Or that you have over 200,000 nerve endings in your soles — more than anywhere but your fingertips and lips.

These amazing structures — your literal foundation — are meant to bend and flex, and to send sensory information to your brain to help you move effectively and efficiently.

The nerves in your feet function on a loop. Your feet tell your brain how to adjust to the terrain you’re on. Then your brain tells your body, often starting with your feet, how to move across it.

If you shut down either the mobility in your ankles and joints or the sensory feedback of contact with the ground, the loop breaks, and you might too.

Now you might think that this is enough of a reason to get into minimalist footwear. It allows your feet to move naturally and safely feel the world beneath your feet.

Frankly, however, the biggest reason is comfort and enjoyment.

If you look at the toe box of a traditional shoe, you’ll notice that it comes to a point in front of your toes. Odds are your foot does not have that pointy shape. And if it does, it’s probably from wearing shoes with this shape, since a healthy foot isn’t pointy, nor does it have bunions that can come from squeezing your toes together.

There’s also a good chance that your shoe has a stacked heel. The heel lift in both casual and performance footwear changes your posture and center of mass, shifting your weight forward and putting strain on knees and backs.

Finally, most shoes have some kind of cushioning in their sole. It seems like you would want cushioning –– after all, walking or running can feel hard on your feet, knees, and hips. When you run, you land with 2.5-4x your bodyweight, and if you sprint, you can land with up to 6x your bodyweight. 

Clearly, you need cushioning to protect you from that force, right?

Well, yes and no.

The “no” is that man-made cushioning doesn’t do what we think it does. It may feel good when you try it on, but research shows that cushioning doesn’t actually protect you from impact force. 

Cushioning is a bandaid for improper movement. It reduces or eliminates the sensations your feet need to tell your brain how you should move. That makes you more comfortable in the short-term, but in the long-term, you actually want that feedback to reach your brain. 

If something hurts when you walk, it’s a sign that you’re moving improperly. Without cushioning, you would adjust your movement to use the shock absorbers built into your body: your muscles, ligaments, and tendons.

But with cushioning, you can move improperly for years and not feel the cost –– until the day that you wake up with unexplained back and knee pain. 

Even worse, cushioning wears unevenly. Check out the soles of an old pair of shoes and you’ll probably see that one side is more worn down than the other. That makes your alignment even worse. 

Minimalist Shoes Improve Your Posture and Reduce Your Risk of Injury

A 2019 study found that walking in minimalist shoes for just 8 weeks increases foot muscle size and strength by over 10%, the same amount you would get from doing a dedicated foot strengthening exercise program (yes, that is a thing)[*].

However, it’s worth noting that not all shoes that claim to be “minimalist” really are –– and the wrong shoe can actually do you more harm than good. 

Harvard’s Dr. Irene Davis breaks down minimalist footwear into 2 categories, “partial-minimalist” and “minimalist.”

True minimalist shoes have wide toe-boxes — so your toes can spread and splay — little to no cushioning (again, your body can give you almost all that you need), no elevated heel, a low-to-the-ground design that can help with balance and agility, and a flexible sole. If you can roll the shoe into a ball, that’s great.

The Vibram FiveFingers that I used to wear do that. So do shoes from companies like Xero Shoes and Vivobarefoot.

The “partial” minimalist shoes are not only missing some of those features, but Dr. Davis’s research shows that wearing them can be worse for you than wearing padded, heel-elevated, flared sole athletic shoes, mostly because they have enough padding to dramatically reduce the ground feedback that you need to adjust your gait to USE those muscles, ligaments, and tendons.

I’ve seen quite a number of shoes sold with the words “minimalist” and “barefoot” that may be flexible, but have narrow toe boxes, or too-thick soles.

Make sure when you’re shopping that your minimalist shoe is truly minimalist.

I’ll talk more about my minimalist shoe of choice in a moment, but first: how do you transition into minimalist footwear?

How to Safely Transition into Minimalist Shoes

If you’re new to minimalist shoes, you want to give your feet time to adjust. You’re in for a lot of pain if you simply put on a new shoe and go for a 10 mile run, or spend all day on your feet at work.

You’ll be able to do both of those sooner than you think, but it’s a good idea to take things slow and give the muscles in your feet (and your posture) time to adjust. 

Waking up your nervous system and teaching it to move better takes a bit of time, and the amount of time differs for each person. It’s a worthwhile transition to make, though. 

Start by wearing your minimalist shoes around the house or going for a short walk in the morning. You may find that your feet, ankles, and calves are sore; that’s because you’re working muscles that you haven’t worked in a long time. 

As the soreness goes away, you can start wearing your shoes more –– taking them on hikes, runs, and so on. Give it a few weeks and you’ll be able to wear minimalist shoes all day. 

Which Minimalist Shoe is Best? 

As I said before, many people know me as a Vibram FiveFingers guy.

One reason I wore the Vibrams is because of the size. I wear a size 16 shoe and most footwear companies don’t go that high.

I always liked Vibrams, but they’re a pain to get on and off (those toe divisions get annoying after a while) and I found that they wore out a bit too quickly for my liking. 

I also know that many people don’t have foot shapes that fit FiveFingers, or need a different style — if you’re a lawyer, you probably don’t want to argue your case while wearing “toe shoes.”

Recently, Xero Shoes custom-made a pair of size 16 shoes for me. 

In short: I’m hooked.

Xero Shoes makes true minimalist shoes: no cushioning, a completely flat sole, wide toe boxes, and thin material that allows you to feel the ground with every step. They’re also built to last –– the soles are backed with a 5,000 mile warranty –– and have a wide variety of minimalist footwear, from everyday shoes to running shoes to sandals. 

Xero is my new favorite, but whichever brand you choose, I highly recommend giving minimalist footwear a try. It’s a simple biohack that you won’t even think about after a few weeks, but it keeps your body in good shape and improves your posture in a way that will serve you for the rest of your life.

Fast This Way

From Bulletproof creator and bestselling author Dave Asprey comes a revolutionary approach to How to Lose Weight, Get Smarter, and Live Your Longest, Healthiest Life with the Bulletproof Guide to Fasting

Break the rules, not the fast with world-renowned biohacker and Bulletproof Coffee founder Dave Asprey, author of The Bulletproof Diet, Head Strong, and other New York Times bestsellers.


For more than a decade, Bulletproof founder Dave Asprey has shared his unique point of view and expertise to help fans become the best versions of themselves. From living longer to getting smarter, maximizing performance to practicing mindfulness, Dave’s followers look to him for his take on the most effective techniques to become healthier and more powerful than most doctors think is possible.

Asprey has been fasting for years, long before it gained widespread popularity, and if you’re a fan of Bulletproof coffee and The Bulletproof Diet, you have been enjoying some of the benefits of Intermittent Fasting too.

In Fast This Way, Dave asks readers to forget everything they think they know about the ancient practice and takes them on a journey through cutting-edge science to examine the ways novice fasters and Intermittent Fasting loyalists can up-end their relationship with food and upgrade their fasting game beyond calorie restriction.  

  • What IF eating the right foods at the right time can actually enhance your fast?  
  • What IF how you work out and sleep could trick your body into thinking you are fasting? 
  • What IF it were easy to skip a meal, or two, or three?  
  • What IF fasting is different for women, can be personalized to your genes, and can impact your mental health? 
  • What IF all fasts could be created equal?

Fast This Way is a compelling read through the latest thinking on fasting and gives readers the manual and toolkit to make the most of their fasts and their personal biology. 

How Strong Are Your Mitochondria?

If you’ve been reading my blog for a while, you know that I’m obsessed with mitochondria.

Mitochondria are little cellular power plants. You have trillions of them all across your body, and they produce the power to fuel just about everything you do, whether you’re lifting heavy weight at the gym or thinking through a big project at work.

Mitochondria also play a central role in longevity – the better your mitochondria, the longer you live[*].

With stronger mitochondria, your body literally makes more energy. As a result, upgrading your mitochondria will give you better performance across every part of your life.

The good news is that your diet and lifestyle play a major role in your mitochondrial health. With a few changes, you can optimize your mitochondria for fitness and longevity.

How Strong Are Your Mitochondria?

Biohacking is all about data: you want to measure your body’s baseline, then track improvements in your performance over time.

Mitochondria are no different. You can measure their efficiency, density (more mitochondria means more power output), and more, and you can see whether or not they get better over time.

Testing your mitochondria used to be both invasive and prohibitively expensive. However, these days you can get a Health Intelligence Test from Viome that includes a full mitochondrial assessment, gut health test, biological age, and more, all without leaving your home.

You can test every couple months to see how much your mitochondria improve. I recommend measuring your mitochondrial health at baseline, then trying the lifestyle changes below.

How to Build Stronger Mitochondria

1. Do HIIT

High intensity interval training (HIIT) involves brief bouts of exercise at high intensity, with just a few seconds of rest in between.

If you want to upgrade your body fast, HIIT is your best option. A single HIIT workout increases human growth hormone (HGH) by around 2000%[*] (an hour of strength training only boosts HGH by 200-700%[*]).

HIIT training also boosts testosterone significantly more than other types of exercise[*].

But HIIT doesn’t just improve your hormones. A 2011 study discovered that your body makes brand new mitochondria after a HIIT workout[*].

Try a basic HIIT workout and see how you feel. It should be absolutely exhausting –– but it’s one of the fastest ways to upgrade your body and create new mitochondria.

2. Hack Your Sleep

Poor sleep and sleep disorders lead to mitochondrial dysfunction, slowing down your body’s energy production and making you age faster[*].

Good sleep, on the other hand, keeps your mitochondria strong –– and if you get a few nights of good sleep in a row, your mitochondria will turn on even more at night and improve your brain function during the day.

Mitochondria power your glymphatic system, which clears out toxic proteins and metabolites from your brain while you sleep[*]. Deep sleep will activate your glymphatic system and make your brain stronger, powering up your mitochondria and starting a positive feedback loop that improves your performance over time.

It all starts with a good night’s sleep. Try a few simple sleep hacks to get deeper, more restorative sleep.

3. Fast

Fasting is another simple way to upgrade your mitochondria.

Research shows that fasting prevents your mitochondria from aging[*], keeping you biologically younger.

Fasting also makes your mitochondria more efficient and protects you from cellular stress that damages mitochondria and slows them down[*].

My book, Fast This Way, teaches you how to optimize your fasting for maximum results with minimal hunger. You can also try basic intermittent fasting.

Start Upgrading Your Mitochondria Today

If you want to build powerful, resilient mitochondria, start by measuring your mitochondrial health.

Once you know where you stand, use these lifestyle hacks to improve your mitochondrial function. Mitochondrial upgrades take time, but you should feel the difference within a few weeks –– you’ll notice more mental clarity, more energy, and faster recovery (and you’ll live longer, too.)

And make sure you retest your mitochondrial function every two or three months. That way you can track your improvement, find out what works best for you, and keep getting stronger.

4 Reasons Why You Can’t Miss the 2021 Biohacking Conference

The 7th Annual Biohacking Conference is on September 17th, and it’s going to be the best one yet.

I’ve been doing these for the better part of a decade now. What started as a small group of self-experimenters has turned into the largest biohacking event in the world. 

This year, we’re going bigger and bolder than ever. Here are four reasons why you don’t want to miss the 2021 Biohacking Conference. 

1. The Tech

This year’s tech hall is the biggest so far. You’ll get to play with the latest biohacking products and technology from close to 100 exibitors. Highlights include:

  • CAROL. An AI-powered exercise bike that gives you a next-level HIIT workout in under 9 minutes. CAROL tracks your exertion and biometrics and changes its workout accordingly, pushing you right to your physical limits. 
  • ARX. Lifting weights is old-school. ARX optimizes your resistance training and tracks your muscle output, changing its resistance level to match your effort. The result is that you can get a week’s worth of full-body strength training in just a few minutes. 
  • 40 Years of Zen. Feel peace within minutes. 40YoZ’s state of the art neurofeedback teaches you to change your brain waves at will. After a week of 40YoZ sessions, you’ll have the baseline brain patterns of a Zen monk who has been practicing for 40 years. 
  • Upgrade Labs. Enjoy a full range of technology from Upgrade Labs, including red light therapy, infrared saunas, cold-fueled HIIT, a virtual float tank, and other machines that enhance your performance.  

You’ll also get a chance to try the best low-carb food, natural wine, keto-friendly juice, high-impact supplements, nootropics. And you’ll be able to attend yoga, breathwork, meditation, and other classes throughout each day. 

2. The Speakers

Attend talks from a rock-star lineup of speakers. You’ll have the chance to explore a variety of biohacking topics, complete with actionable takeaways that you can incorporate into your life.

Topics include:

  • Pushing the Envelope: the Latest in Nootropics
  • How to Radically Extend Your Lifespan
  • Brain Hacking: Unleash Your Mind
  • How to Stop Canceling Yourself: Pushing the Boundaries on Forgiveness and Second Chances

Speakers include:

  • Dr. Joseph Mercola, physician, NYT bestselling author, and expert biohacker
  • Vishen Lakhiani, Mindvalley founder
  • Joe De Sena, Spartan Race founder
  • Dr. David Rabin, Apollo Neuroscience co-founder
  • Naveen Jain, Viome founder

You’ll come out of these talks with a deeper understanding of biohacking—and a few new ideas for how you can further upgrade your life. 

3. The Community

Biohackers are an unusual group. Odds are you do some things that the people in your life don’t understand.

Testing your blood daily? Going on a 3-day fast? Tracking your sleep, stress, HRV, blood sugar, or brain function? Eating nothing but meat for 30 days?

Whatever you’ve been doing lately, this is the place to share it. You’ll be surrounded by fellow biohackers who are running experiments of their own. You can share your hacks, troubleshoot your routine, and find new ways to optimize your life. I’ll be sharing my own data—and talking about hacks I don’t bring up on my blog or podcast. 

There will be mixers every night powered by Dry Farm Wines, so you may make a few new friends or business partners, too. 

The bottom line is that this is the biggest biohacking event in the world. It’s the place to be if you’re a self-optimizer. 

4. The Location

Quarantine has been going on for a long time. You could probably use a vacation. 

That’s why the 2021 Biohacking Conference is happening at the Hyatt Regency in Orlando, Florida. It’s a 4-star hotel with an enormous and sunny outdoor pool— a chance to boost your vitamin D and testosterone levels after spending 2020 indoors—plus world-class food, a spa, an expansive gym, and a special discount for biohackers. 

As you get back to normal life, this is the perfect opportunity to kick things off right. Relax, learn, experiment, eat, drink, and try out all the most badass, elite-level biohacking tech in the world. You don’t want to miss this one. 

You can get your conference tickets today—and for a limited time, you can save 20% if you enter the code “BIOHACKER” at checkout. I hope to see you there. 

Start hacking your way to better than standard performance and results.

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