Solving Huge Problems In Less Time w/ Jake Knapp – #365

Solving Huge Problems In Less Time w/ Jake Knapp – #365

Why you should listen –

If you want to solve BIG problems, spend LESS time on them. That’s the concept behind Sprint, an innovative problem-solving technique developed by Jake Knapp that has taken Silicon Valley by storm. In this episode of Bulletproof Radio, Jake reveals how “Sprint” has helped companies like Slack, Nest & 23andMe achieve success with less time and resources than a typical startup.  If you have a big opportunity, problem, or idea, and want to get the ball rolling, TODAY, this episode is for you.

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Dave:
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Bulletproof radio, the state of high performance.

Dave:
You’re listening to Bulletproof radio with Dave Asprey. Today’s cool fact to the day is that Einstein said that if he had one hour to save the world he’d spend 55 minutes defining the problem and only five minutes finding the solution. In the journal of science researchers came to the conclusion that thinking things through exaggerates the importance of different facets of your decisions and actually harms your judgment.

To put that really clearly, simple decisions don’t get improved by conscious thought, complex decisions are not … Wait, I said that backwards. To put that concisely and clearly, simple decisions are improved by conscious thought, but complex decisions are not improved by conscious thought. That is not what you would necessarily expect, but I found that to be the case throughout my career as well.

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Today’s guest is none other than Jake Knapp. He’s a writer and design partner at Google Ventures. He’s also a former Googler where he helped to create a few things you might have heard of. Things like Google Hangouts. He’s supported a bunch of startups with product design. Started looking at ideas and problem testing process to develop a well known and efficient process that’s now called sprints.

He’s conducted sprints for 100 startups including companies like Nest, Slack, 23 and Me. Then he wrote a New York Times bestselling book about the process along with his other Google Ventures partners, Braden Kowitz and John Zeratsky. It’s called Sprint: How to Solve Big Problems and Test New Ideas in Just Five Days.

The reason that Jake’s on the show for you today is that a lot of us have problems, big problems in our lives, in our careers. Sometimes the problems feel insurmountable. I know I’ve dealt with this many, many times. You feel it gets overwhelming. This is a chance for you to learn a technique that you can apply not just in a business setting, but to yourself to really, really push yourself and to maybe get huge results in a small amount of time.

As a long time listener to Bulletproof Radio you know that’s really what I’m all about. Same thing happens biologically, same thing happens in your life. You basically want to figure out how do you cut a lot of the pain and stress and struggle out so you can make it easier. That’s why Jake’s on the show. Jake, welcome to the show.

Jake Knapp:
Thanks so much for having me.

Dave:
We’ve got to start out with the most important things first. You have claimed publically multiple times to be the tallest designer on the planet. Is this true? How tall are you man?

Jake Knapp:
I claim to be among the tallest because the Dutch have a lot of designers and they’re a tall people. I’m sure I’m not the tallest, but I am 6’7” and a half. That’s good. In most companies that’s usually the tallest.

Dave:
6’7” and a half, you’ve got me. I’m 6’4”. Guys like you, I’ve got to tell you, not a lot of things piss me off, I do this four years, this meditation thing. You know what I’m talking about here, because everyone’s shorter than you. You don’t really notice how tall people are. At least I don’t. whether you’re 5’4” or six feet, you’re all below. When I have to look up to look and meet someone in the eye, it’s so weird because I never do. When I’m standing next to you I feel like, “This feels so weird, what’s going on here?” I feel like something is wrong with my center of gravity or something.

Jake Knapp:
It’s a weird feeling because for you and I that happens once out of 10,000 times we run into somebody. You look up and just think, “Oh my gosh, my whole world view is tilted.” I apologize right off the bat, apologize for edging you out there.

Dave:
I apologize to everyone else that I’ve done it to as well. Sorry, we’re not tall on purpose. Every time you’re sitting in economy looking comfortable we look at you with insane jealousy. We’ll just put it that way. What’s a sprint?

Jake Knapp:
A sprint is a chance for a team to solve a big problem that they’re working on. This could be a team at a business, it could be a team anywhere and sometimes it’s even an individual. The idea is that you clear a week, you get the team together, you run a specific step by step process and by the end of the week you’ve got a realistic prototype of your solution.

On Friday you’re testing it with your customers or you’re testing it in the real world in some way, so you’ve got data. It forces people to move quickly and it gives you a lot of tools to do that in a fast and efficient manner. What we’ve seen is that it really helps people, like you were talking in the beginning, those problems that are just hard to get started on, hard to get moving on. It gives you a way, a recipe to start.

Dave:
I’m going to push you in this interview to think about customers as, we’ll call them stakeholders. Some of the early work that led up to Bulletproof, I was in business school at Wharton. One of my professors who’s been a guest on the show, his name is Stu. He wrote a book about this and I just blanked on his name of course because I hadn’t thought of going here with you. It’ll come to me.

What he wrote about, his name was Stu Friedman, he wrote about this idea that you have customers as stakeholders for different domains of your life and that one of the things that was missing is that we’re putting a huge amount of effort into some things and getting very little results. He was like, “What if you measure the effort and results you get with your friends, with your family, with your health, with your career, with everything else and just realize, I spend 80% of my time where I hate everything, so maybe I could stop.”

The attractiveness to me of sprint for everyone listening, not just entrepreneurs and business people, is that your customers may be your family. Your customers may be the community that you serve in some way through your volunteer activities. There’s a way to take your sprint process and use it with different sets of customers even if they’re not necessarily the ones writing a check for you. I’m going to keep asking you questions like how do I apply this to a situation that might not necessarily be a business and see what you think about it. Are you cool with that?

Jake Knapp:
Yeah, absolutely. The big idea is to get real at the end of the week. Not to just sit off in a corner and think philosophically on your own or with your team about what might be the right solution or what might be the right course of action, but to put it to the test and show it to people and get their honest reaction. If you want an honest reaction you have to make something realistic and that’s what a sprint gets you.

Dave:
That is beautiful. The name of the book by the way, it just came to me, and I did not Google, you guys saw me the whole time. It was Total leadership. I was just waiting for my Aniracetam smart drug to kick in there. At the end of Stu’s process, which takes more than that amount of time, you go to each of your “customers” and ask them for their feedback and all that.

I just see that this might apply to people who maybe don’t think it applies to them. If you’re listening right now going, “This is the business episode,” no. This is how I solve complex problems episode and it may work in business, but you may find it works elsewhere. Walk me through the sprint process. What do you do on the first day of this five day process.

Jake Knapp:
First of all you’ve got your team together. We advise that seven is the perfect number to have involved in a sprint if you’re in a company, buy you can do it quite well with fewer. The first thing you do on Monday is you’re sharing information and making a map for the problem. You can imagine this for all kinds of problems in business and outside of it. There’s some kind of, a list on the left of the actors, all the people who are involved in this problem.

To give you a concrete example, I’ll tell you the story of the hotel delivery robot. There’s a company called the Savvy Oak who we invested in. They make a hotel delivery robot. They wanted to test the idea of giving the robot a personality before they launched. If they launched the robot with a personality and people hated it it’d be devastating for a new startup. People were frustrated or aggravated with the robot, they thought it was annoying. They really wanted to test it in this low stakes, but really fast way.

On Monday the map includes all the people that work in the hotel, the guests. Then as the map goes across the board it’s all the spots where a guest might encounter the robot, not suspecting that there’s going to be a robot and encounter that personality. Then you choose one spot on that map that you’re going to focus on in the sprint. You come up with a lot of questions, all the things you think might go wrong.

Then to go really quickly through the other days, on Tuesday you’re going to sketch solutions. Every person on the team sketches their own solution for that one spot on the map.

Dave:
Separately from each other?

Jake Knapp:
Separately, it’s not a group brainstorm. We can dive into that later if you want, but I’m a big hater on group brainstorms after all the bad experiences with them. Then with those individual, and actually they’re anonymous solutions that have come from each person. On Wednesday we’ve got a detailed process to come up with a decision.

At the top of the show you talked about how a lot of times you can make a decision really fast you can make a really good decision. We basically want to give what we call the decider on the team all of the information that she needs to make a great decision really fast. We make that decision, then we put together a quick plan and on Thursday we’re building a prototype, we’re trying to make a realistic prototype.

Dave:
On day one you choose the decider?

Jake Knapp:
You usually know the decider going in. Sometimes, in rare occasions you’re like, “Who should decide?” Maybe a startup that’s really early on, hasn’t really formalized it, but in most cases you know.

Dave:
You know who the boss is.

Jake Knapp:
Yeah. It’s a good conversation to have for sure, because sometimes it’s a little ambiguous.

Dave:
In any decision, even if you’re talking about a family decision, if you don’t know who owns the ultimate decision … By the way, the answer isn’t we. The answer is someone does. Even if you have two parents. You guys may decide that you’re going to have an agreement, but one of you is ultimately going to make that decision. The other one’s going to agree with that decision. You might as well know who that’s going to be ahead of time.

Jake Knapp:
It’s very important. After doing this 100 times it happens like second nature for me. I have kids. I have a 13 year old and a five year old son. There are situations when I’m at my the house, “Okay, Luke,” that’s my oldest son, “You’re the decision maker on this. Once you have the information you make the call.” It’s always there. Things work easier when you know who makes a decision and everybody feels better. That happens on Wednesday. Then we make the plan for the prototype and then on Thursday we’re building the prototype. We just have eight hours to make a prototype.

Dave:
The prototyping, all of you get together and you work on the number one idea from day three on the prototype?

Jake Knapp:
We usually go for two or three ideas.

Dave:
You take the top three or two.

Jake Knapp:
The top three. What you’re doing sometimes is combining those into one prototype. The example of the robot personality, the ideas that Savvy Oak chose or the CEO chose were a face for the robot, which is actually more controversial than you think because as soon as you put a face on a robot people want to talk to it and I can’t talk back.

Dave:
Also, what does the face look like, what race should the face be. That’s a real question.

Jake Knapp:
It’s a big deal. One of the ideas was should the robot be able to play games, follow the leader? That was another idea that he chose to test out. Another idea was the robot do a dance at the end after the delivery. That slate of three ideas could fit together into one prototype, but sometimes we’ll have competing prototypes.

One of the stories that we tell in the book is about Slack. You mentioned Slack a minute ago. This sprint that they ran that we talk about there, we’re testing different ways to explain Slack to customers on their website when people signed up. They had two totally different ideas and they just prototyped both of them in one day. Then on Friday they could test two totally different, one with a fake brand even, versions of the product. Then on Friday you’re going to run the test.

Dave:
What does the test look like on Friday?

Jake Knapp:
The test is with five customers, but one at a time, not all in the room at the same time. Another thing on my list of things I hate along with group brainstorms are focus groups. Focus groups, often what people think when they say, “We’re going to go talk to customers.” They really often bring out the worst of group dynamics and group think.

What we want to do is show people a prototype in a way that seems realistic to them and they just react to it. The team is watching our video and gets to watch customers just react and draw their own interpretation about what it means. Again, in the case of the robot that meant bringing people into a hotel room and asking them to call and ask for a toothbrush to be delivered.

Then when that delivery came to the door and they opened the door it was a robot. We could see on a drop cam that was stuck in the hallway how they reacted. If you do five of those tests actually in a day you’ll get a really good preliminary set of data.

Dave:
That makes good sense. I remember my first time really dig in with focus groups. I was head of strategy for the virtualization group at a company called Citrix. We were looking at some remote virtual desktop things. This is going back ten years or something where virtual desktops still were a word. We spent hundreds of thousands of dollars and offered people a gift card for Starbucks or something. We got this room full of ten IT executives. I think three of the guys were there just for the Starbucks gift card.

“What do you use your technologies for?” and they’re like, “Like management and stuff.” They had no idea what Inisoft did, but they got their Starbucks card. That maybe wasn’t the most effective group I’ve ever done. Everyone else was trying to agree with everyone else. You’re right, there are big limitations on those things.

Jake Knapp:
Part of the whole idea with this sprint, and the selling point is really you can move fast, you can start a project that’s hard to start. There are a lot of group dynamics with humans that don’t work great on their own and you need a little bit of help to make those work well. Making decisions in a group, not easy. Getting information from a group of people, not easy to do well. If you change that stuff a little bit you get a lot better results.

Dave:
If I wanted to run a sprint, I’ve got, we’ll say a group of four people, I’ve got my wife, I’ve got me, I’ve got my two kids and we want to decide to do something nice for the community around us. That’s our challenge. Is this really going to work? Could I do that?

Jake Knapp:
The big question at the beginning of a sprint is what is the question. What do you want to learn before you go ahead and take action? Is there a risk? Is there something you’re not sure whether it’ll work or not?

Dave:
Maybe want to learn the most effective way that we could feed the homeless or provide a service for older people or something like that. It’s the brainstorming side of things where we want to decide what’s the most effective way we could serve our community?

Jake Knapp:
That’s a great frame, you totally could. What you do on Monday is you’d be sharing information that all of you had. What do we know about what our family can do, [inaudible 19:02] and then making a list of the options. What does that map look like for your family? What’s in your community? What are the places you might go or the services you might go?

Then you’d pick the one that you thought like, “This seems to us at the moment as the best opportunity. This is where we’re going to focus on the sprint.” Maybe you choose, “We’re going to focus on trying to get some food to homeless families in our community.”

Then on Tuesday each person, you, your wife, your kids, would each come up with your own solution. You’d think it through. It’s not just sketching all day. There’s a step in the morning where you look at patterns where people have solved an analogous problem, done something interesting elsewhere. You might spend some time looking at where small groups have come up with interesting solutions for providing food for people or maybe helping people connect with services that are already out there.

In the afternoon you sketch and then on Wednesday you would decide, you’d go through this critique process as a family talking about each idea, but not letting the person who drew it give you a sales pitch about it. Seeing what you can understand on your own about how it works.

Then the decision maker, whoever that is in the family, will make the call about which one or two they’re going to try out. Then you guys would prototype it. You’d have to decide, “How are we going to test this on Friday.” What you might end up with is, “We’ve got one idea that’s actually bringing food to people. We’re going to set up a spot and we’re going to cook meals and see if we can serve people.” Maybe another idea where you think, “What we want to do is test whether we can actually get the information to people about where we’re going to be distributing groceries for instance.”

What you might do is then basically prototype, maybe one of those things can be prototyped with a paper brochure, with a flier that goes up somewhere. Maybe one of them has to be prototyped by actually doing the service. Actually finding a space, setting it up and doing it.

Then the idea is that on Friday you’d actually do it in a really small batch. You’d bake that small batch of cookies to see if the recipe works well. You would see when people reacted to it. What I think is cool about it is if you imagine your family doing that, if you were doing this kind of project you might spread it out over some time. You might compress it.

You get to see the idea … You don’t have to commit at first to doing the whole thing. We’re now delivering groceries, we’re now cooking meals forever. This is a permanent commitment. You’re saying, “We’re going to try it once and see how it works.”

Dave:
It seems like this approach inherently embraces failure throughout it, which is really important and something that maybe is avoided in most business environments.

Jake Knapp:
It’s hard to take risks when, even when you, the culture of Silicon Valley talks a lot about taking risks and failing, but in reality nobody wants to fail. Failing’s not great. I think what people really want is to be able to move fast. When you think, the only way I can learn is to launch something, to get something out in the world. Then we’ll have to build something in order to be able to launch it. That takes time. People naturally become more risk averse. They become more careful. It’s smart to be careful, but people avoid risks.

The sprint allows you to take a lot of those risks in such a short period of time that you’re not out much if you fail. The funny thing is we’ve seen companies are more likely to succeed when they take those risks and they take them fast. They’re more likely to hit on that thing that’s wildly successful than they are if they take a longer time figuring out the safe path.

Dave:
Do you mind if I ask how old you are?

Jake Knapp:
No, not at all, I’m 39 as of last week.

Dave:
I’m basically 44, my birthday’s in a few days.

Jake Knapp:
Happy birthday in advance.

Dave:
Thanks, although by the time this goes online I’ll be 44. There we go. Happy birthday in retroverse. I’m asking because, because we’re about the same age. I can tell you, I’m the last year at the University of California Santa Barbara where I went to school that didn’t have Ethernet in the dorm rooms. I still had a dial up modem.

Jake Knapp:
Yeah, I had dial up.

Dave:
You had dial up? You didn’t have Ethernet in your college?

Jake Knapp:
University of Washington, I don’t want to diss them.

Dave:
That explains a few … We were all too drunk to remember.

Jake Knapp:
[Inaudible 23:39] which is how we used to do emails.

Dave:
Pine and Elm, there you go. I actually did work on a book by Dave Taylor, the guy who wrote, I think he wrote Elm or Pine, I think he wrote Pine, the author of Pine. By the way, for non geeks listening, these are the original ways all of us did email before Gmail, just so we’re all clear on that. Since Jake worked on Gmail we’re just going back through memory lane here.

The reason I was asking that is that your spring process here, that first day, would not have worked when we were younger. When you did research you didn’t even have Alta Vista, did you? Or maybe you’re a little bit younger. I was one of the first people to use that in my university. I always got As and no one knew why because I was doing searches online instead of in card catalogues with micro fish.

You couldn’t do a one day process of fact finding the way you can now thanks to Google and thanks to the internet and all these other tools that seem like they’re a part of it. If you were even five years younger than you, if you were 35 or younger, the world’s always had information on your fingertips and your process is a new thing in all of human history because data gathering analysis couldn’t happen fast enough.

Jake Knapp:
Although actually a lot of the things, on Monday there’s actually very little connectivity on Monday. One of the premises of the sprint is that phones away, computers off, almost the entire week, except for … If somebody is giving a presentation on Monday they might share information in that way, but actually on Monday we try to share information that people already have.

Dave:
The gathering happened before.

Jake Knapp:
The gathering happened before … Or like a lot of the companies or teams or just people in general will come at a problem with a lot of information. If you can do research before I should say it’s wonderful. It’s excellent to do that, but I don’t think teams should wait to start until they’ve done research. Because you’ll do, in the matter of the sprint you’ll end up doing research. By the end of the week you’ll know more. You can always do another one afterwards with that information in hand.

It’s actually laptops pretty much off on Monday. They might be on Tuesday morning when you’re looking at inspiring solutions from other domains. Then they’re not on again until Thursday when you build the prototype, if you need it, unless you’re making a service or making a physical object. It’s an old way, it actually could have worked in almost any time in human history.

Dave:
It just meant it would have taken longer to do data gathering the week before the sprint process really happened.

Jake Knapp:
That’s right.

Dave:
A good deal. I feel like the speed of everything is sped up just because when you don’t know something you don’t have to go to encyclopedia Britannica and look it up. It’s such a different thing. Or even that old, what was that nasty thing from Microsoft, Encarta was it called?

Jake Knapp:
Are you putting me on right now?

Dave:
I am because you worked on it. You caught me.

Jake Knapp:
[Inaudible 26:33] I was like, “Oh no, should I defend myself?”

Dave:
I was trying to get a good look from you. For people listening, if you remember Encarta, Encarta was the first CD ROM encyclopedia that absolutely decimated Britannica because Encarta was available to search in your computer instead of thumbing through in a book. Encarta was a huge jump forward in our ability to access information. Thank you for working on that. Yeah, I was totally yanking your chain.

Jake Knapp:
Now if you search for Encarta, the top result is on Wikipedia because Encarta’s gone, and the second result is Britannica. Britannica came back.

Dave:
It did.

Jake Knapp:
[Inaudible 27:10] gone. It’s sad, but there was, it had its moment.

Dave:
It did indeed. By the way, a lot of time the speed of tech has happened so much that unless you were there, you might not recognize what a world changing thing some of these things have been, like Encarta. It really did change the world of research almost overnight, it was a matter of three years. All of a sudden we’re all shaking. Now I think that happens about every six weeks. In the sprint process, you’ve also talked about something called design thinking. What is design thinking versus the sprint process?

Jake Knapp:
It’s a good question. Design thinking is a philosophy. It’s an approach to doing things. You’d find if you were someone who had studied design thinking, does design thinking, work at a design agency, whatever, you would read our book or do the sprint process and say, “Yeah, this is design thinking.”

What’s often challenging is that people don’t know how to put it into practice. One thing that’s different about the sprint book from a lot of experiences people have had with design thinking is that it’s really specific. You do these things you don’t need to come in with any expertise in advance. If you follow these steps you’ll be doing design thinking, which is a focus on the customer, on the human being at the end.

Then also willingness to try a lot of ideas and use a prototype to learn about things. I think the big benefit of design as a toolset for solving problems is that it can loosen people up to fail. They can move fast when you get into that mode of, “I’m going to build something fast, I’m going to make it real really fast.” You can do that today. That’s almost one of the biggest technology enablers lately, is how fast you can make something. Then design really frees you up.

Dave:
How would I incorporate this into Bulletproof? Let me give you an example here. I come from software and Silicon Valley and cloud computing and all that. You know how long it takes to rapid prototype a collagen bar?

Jake Knapp:
I can imagine it’s not real rapid.

Dave:
I’m like, “Product guys, I want 90 day product cycles where we come up with an idea, we munch some stuff together and we roll it out,” and they’re like, “Yeah, try 90 day microbiological testing before we could ever roll it out,” and it makes me want to stab pencils in my eyes because I’m like, “We could do better.” How do you make this work in meat space?

Jake Knapp:
Let’s do it, let’s talk about it. Like I mentioned earlier, the big thing is figuring out what question is most important. What’s challenging about something like, the bar is a great example because there’s packaging, there’s production. You’ve got to get the flavor right, you’ve got to get the flavor right. There’s so many pieces of it. You’ve got to sell it, you’ve got to figure out how to tell people about it, get it to people, deliver it, whatever.

All that stuff is complicated and when you take it all at once you’re like, “There’s no way we can do that, prototype that in a day.” If you have one question that’s the most important question to answer there is a way to prototype it, even if the thing doesn’t exist yet.

If the question is, “Will people be able to understand what it is if they come across it in a …” I don’t know, just an example, “If they come across it in a Facebook ad, would they be interested enough to click through? Would they maybe order it? Would they try a free sample?”

You can test that. That’s an easy thing to prototype. You can recruit people who are in the target audience. You can built a prototype that looks like their Facebook feed, it looks like that. Take them to a marketing page. It doesn’t exist yet. It has pictures of how you think the product might look, describing the way you think you’d do it, all those things you can do actually really fast. You can answer that one question.

Unlock some of the unknowns that exist around it. Or if it’s about the physical object you prototype the package or if it’s about the flavor you just test it out, but that idea of isolating, it’s a scientific method. You isolate one question and then you try to answer that one question.

I think what’s magic about the sprint is that it’s problem-agnostic, but if you follow through the system you can get an answer to a question in a week. For many questions that’s fast. For some it’s too slow, but you shouldn’t use it to figure out where to eat lunch, but for other things.

Dave:
Unless you’re going to have lunch there every day for the rest of your life.

Jake Knapp:
If it’s the big commitment you might.

Dave:
By the way, the Bulletproof Coffee Shop offers lunch in Santa Monica. If any of you want to come to that as a solution I’m okay with that. What about constraints and deadlines? This has a really tight deadline. What effect does having a constraint like that have on the team?

Jake Knapp:
This is borne out of the realization thanks to my colleague Michael who pointed out to me many years ago that I just so happen to get a lot more work done when there’s a deadline coming up. Perhaps I should start setting those deadlines so I would get more stuff done. He was right actually. I reflected at some point back on my career and I realized that there were these short bursts of time.

One of the early projects that lead to Google Hangouts is a good example where I was working on this thing with a couple of my colleagues in the Google Stockholm office. I was only there for a couple of days. We had to work really fast. We had to make something that we could actually use really fast. That deadline forced focus. It forced to cancel all our meetings, get in a room together, hash it out. As a big time procrastinator I’m probably a the leading edge of meeting deadlines to make progress, but I think everyone benefits from it.

It is remarkable to see and I’ve seen a lot of teams go through this process, how it helps people to focus when their laptops and phones are off and they know that we’re all in this together. We have people coming in on Friday. It’s remarkable what you can accomplish and it feels really good actually to have that clarity.

Dave:
I remember back starting in college. I couldn’t imagine a paper until the night before it was due. Why would you do that without a deadline? I would get really good scores on my papers, but I would often times be up all night. Just like you said, the forcing function of a deadline. Reflecting back on my career and I imagine people listening, same thing. When you just don’t have much time and you do your really best, sometimes it is your very best if you had a lot more time.

Jake Knapp:
That’s right. More time doesn’t always make things better, but more time is comfortable and it gives us more time to do the thing that we know the best. If you’re a software engineer it’s writing code and if you’re a designer it’s just designing and if you’re a sales person it’s selling to people, having those conversations to people. The sprint forces you out of that comfort zone, but that clarity of the deadline is pretty powerful.

Dave:
It is indeed. I, looking back on my career, I probably should have had more deadlines which would have been more helpful. A six week deadline isn’t really a deadline as far as I can tell. Six weeks means later, right?

Jake Knapp:
Right.

Dave:
It’s a tight deadline which seems to do well. I’ve talked about using this in a family, which is the world’s smallest and slowest growing startup. It always takes about 18 years for the first product to come to fruition. Version 1.0 did we call that?

Jake Knapp:
Even then you don’t know.

Dave:
That’s a fair point. They might come back. There’s a return and RMA process after college. What’s the difference between doing this in say a small startup versus Google’s not exactly a small company these days, although sometimes it acts like a group of small companies. If you were to do this at a larger company versus a smaller company what would the differences be?

Jake Knapp:
I actually started doing this at Google. I was working at Google and thought that a new method for the way we did design early on in projects would be helpful. It is, to be honest, been very much forged at Google Ventures and with my colleagues there and this experience of working over and over again with startups.

The startups we work with would range in size from two people to a few hundred, but they’re not these massive companies. What’s different at a massive company, and we still talk a lot with colleagues at Google who are continuing to run these sprints, and also it’s been adopted at a lot of other companies, so we hear a lot of stories about it.

I think one of the big things that’s different at a big company is that you have maybe less access to that decision maker. The real person who decides what goes on may be hard to get into the room. That’s a challenge for people. Again though, it’s a healthy challenge to figure out who that person is, which is often not clear, and to get her or a representative, a duly appointed representative, just so there’s clarity about who makes the call on this project is a big deal. Sometimes it makes people realize, “This isn’t what we should be working on because nobody cares.”

Another problem is often that there are, there’s different groups that need to work together to collaborate. There might be politics involved. That can be a challenge. It can also be a good thing because the sprint can give you a way to bring somebody from another group into the room and actually work together on the problem. Instead of hammering out your differences later on you get to do that right in the sprint.

The other thing is just that the bigger the company often the more meetings there are and the harder it is to say, “We’re clearing the schedule for a week to do this.” That’s a radical thing to say. “We’re not going to have our status meetings, our one on ones, our brainstorm meetings. Our projects, our divided attention between A, B and C, we’re not going to do that for week.” I think when it’s succeeded, when it’s first started to take root at bigger companies it happens because somebody says, “Let’s try this as an experiment and see how it goes.” Then when it works it starts to spread.

Dave:
There are companies who run things like hackathons and things where you have really focus 24 hours or 48 hours to do stuff. Quite often there are performance enhancing substances involved there. There’s a large tech company in Redmond that might have eight Bulletproof Coffee kiosks on campus for the developers. Do you, during these sprints, do you tell people to take smart drugs or use any other things like that?

Jake Knapp:
During the sprint I think that the way people manage their caffeine and what they eat is really important. In fact I’m a big believer outside of the sprint also and how you sleep is important. Because all these things matter a lot. I don’t want to dictate to anyone that, if you’re not a caffeine drinker then you should drink coffee-

Dave:
It’s okay, if you want to do that it’s okay to just-

Jake Knapp:
Maybe we should. Maybe I should work out a little system here because I feel like everyone could win. I actually like, quite honestly, one thing that’s important for us when we’re hosting a sprint in our office is to have coffee available at the right times and to have food that is going to keep people charged. One of the big problems that a lot of companies, startups, is that when they do have snacks they’re not-

Dave:
They’re crappy.

Jake Knapp:
They’re horrible. They’re sugary or there’s just nothing to them and there’s potato chips and things. Candy is a really common … There’s this big mythology around group brainstorms, which are bad enough on their own, and then let’s eat candy while we do it. Bad things happen.

Dave:
It’s good for 20 minutes of productivity and then a crash. You remember Sun Microsystems? One of the big server manufacturers before Oracle bought them. Way back, 20 years ago in Silicon Valley, they used to have a rule, no pasta lunches. Because pasta gives you a coma later, except in their corporate briefing center during negotiation. If they wanted their competition to be foggy they would give them pasta so they could close the deal. How bad is that?

Jake Knapp:
That’s amazing. There are no deviant roles in the sprint, but there is a, in the back of the book there’s literally a checklist. We talk about the kind of snacks that you should have on hand. We also talk about-

Dave:
What kind of snacks that you recommend in the book?

Jake Knapp:
I’ll read to you from the, I have a little book here, I’ll read to you from the checklist. We talk about things like nuts are good, dark chocolate is good. It really needs to be real food. [Inaudible 39:53] is good for some people. Some people like to have cheese. We basically want to have something that, it’s not foreign to your diet because if you have a bunch of people from a team, we don’t want to say, “Everybody has to eat the same thing.”

We want food that’s real food, that feels natural to you to eat so that you’re not thinking about it, but then you’re going to have energy as you go on throughout the day. Because if you want, the sprint is not a long day actually. It’s basically six hours, but that is a long time to focus. You’ve got to eat well to keep that up. No pizza and no burritos at lunch where the energy just tanks.

Dave:
I absolutely love it that you put that in your book. It’s not a typical thing that you would write about in a business process book like this. It so matters. If you’re numb and you’re trying to do this brainstorm thing, I don’t know how to brainstorm when all I can bring up is a drizzle because I’m tired.

Jake Knapp:
It’s a huge deal. You also have to end before people get burnt out. We have the chance to watch so many teams go through this and see when it was too long, when we ate something what happened. One time, there’s a restaurant in San Francisco that’s great called Curry Up Now that has Indian food burritos. They’re delicious, but when we had that for lunch one time everybody was exhausted in the afternoon. You see that happening-

Dave:
That’s MSG. If you go to a traditional Indian household, and living in Silicon Valley it’s happened lots of times, if you buy an MSG spice mix they’ll be like, “That tastes like restaurant Indian food.” They know the taste because that’s what the restaurant seems to be doing. When they make the food at home they use higher quality ingredients, but they don’t use MSGs. It takes different and there’s a little zing, like you’d find in Chinese food.

Jake Knapp:
All that stuff, it ends up playing into the work. That’s something that … I think the funny thing is that office work is such a dominant part of so many of our lives, but it’s been very unexamined how it’s structured and what you should do to optimize your performance in the office to make it fun, to make it match why you signed up to do your job. At least for one week in the sprint process we think we can optimize it. The rest of the year you’re on your own.

Dave:
I appreciated that part of your book. Tell me about sleep since we’re talking about personal productivity hacks here.

Jake Knapp:
This is not in the book. This is-

Dave:
It’s just about you.

Jake Knapp:
Actually my colleague, my good friend John Zeratsky who’s one of the co-authors, he has written a really popular post. You can search for this about how he became a morning person. He’s not naturally a morning person, but his wife was getting up early to go to work. He wanted to have more time with her. He figured out all these things he needed to do at night to get wound down and go to sleep. Then he found that that morning time could be really productive for him once he got into the right cycle.

Similarly I’ve thought a lot about what’s the best time for me to go to bed and how can I make the best use of that time, but with kids waking up early it’s not, as you probably know, it’s not guaranteed productive time. It can happen in the morning.

Dave:
It’s so easy to talk about being a morning person until you have kids and then, oh yeah.

Jake Knapp:
John gets that a lot. What I’ve taken from his inspiration is just this idea that if you’re really intentional about how you go to sleep and when you wake up … For me, I have to keep it on a very regular schedule. I can’t all of a sudden go to bed much later or much earlier or that affects me a lot the next day. I can afford a little less sleep maybe for a night or two, but it’s going to catch up for me.

For me the key working time, and this has been really important for me as a writer, is late at night after everybody goes to bed. I know that there’s this window between my, maybe 9:30 and 11:00 when the house is pretty quiet and I can write. If I stay up too much past 11:00 I know that affects me the next day. I’ve got to get to it.

In order to really optimize that time, and actually I was listening to your interview at [Near Real 44:12] He does the same thing. We actually found out that independently we had come up with the same solution which a vacation timer on the internet router that goes off at 9:30 and then you can’t use the internet and all I can do is write, I’m not going to be distracted. That’s it for me.

Dave:
That’s really cool. You might enjoy a book by Michael Bruce called the Power of When or you can check out the PowerofWhenQuiz.com. By the way he’s just a friend. I’m trying to plug this for any reason other than just it’s cool. There’s different windows of circadian timing. About 15% of people are night people, 15% are morning people. 55% are middle of the day people and 15% of people, by the way, that doesn’t really add up, are just basically never going to sleep well.

He’s a sleep doctor, but I found so much knowledge because I had been myself a morning person. I woke up at 5:00 am every morning for two years before I had kids, even though that’s totally not right for my biology. I do my writing for my books between 11:00 pm and basically 5:00 am. That is my productivity window. 5:00 am is a bit late.

Jake Knapp:
You’re a serious owl.

Dave:
Exactly, he calls them wolves in his book or lions. He’s like, “Night owl’s too vague. It need to be …” These morning people, I’m like, “Screw you guys.” Apparently we evolved in caves so that some of us would take the night shift, some of us would take the morning hunting shift. Some of us would keep one ear to the ground all the time and the rest would get up and pick tubers or something. I don’t know what those day people do.

Jake Knapp:
They’re important too. We can’t dismiss them. The key to all this for me has been this idea of noticing what happens when you do something. When you eat something or when you sleep in a different way, just noticing what happens the next day or what happens over the course of the week. It really affects work. It affects everything about your life, your life enjoyment, people often don’t t think about that part of work. I spent a lot of my career not thinking about that stuff. As soon as I lit up to it I was like, “My gosh, this is transformative.”

Dave:
It’s free energy.

Jake Knapp:
It’s free energy, it’s just sitting there. It’s funny how much we think about the battery charge on our phones and we don’t think about the battery charge in our bodies nearly as much.

Dave:
In fact my next book is about mitochondria. They literally are the batteries in your body. It’s funny. They’re hackable like everything else. What about gadgets? Do you have any tech gadgets for this stuff that you just can’t live without?

Jake Knapp:
One of the gadgets that I love, and this is … I think this could be transformative for people even in their personal life, especially if you have kids, it’s called the Time Timer. it’s a clock and it’s designed originally for classrooms. It’s a clock, it’s like an alarm basically, 60 minutes. It’s got this thing you pull out, there’s a visual chunk of pie basically. You can see this red chunk of pie that gets pulled. As the timer goes down you can visually see time elapsing and when it gets to the end it beeps.

We use these all the time in the spring to time box activities, but for me it’s gotten out of the sprint room and into my everyday life. If I’m sitting down to write I’ll set that time for an hour and then it just brings a focus to what you’re doing.

Or if you are going to have a cup of coffee and just relax for a while, but you don’t want to go for too long, maybe I set the timer for 15 or 20 minutes and then I don’t have to worry so much. It gives me a bit more intentionality about how I spend my time. It’s really helpful with kids. I have a five year old and for him to know what I mean when I say it’s going to be five minutes [inaudible 47:57]

Dave:
It’s called the Time Timer?

Jake Knapp:
The Time Timer. If you go to TimeTimer.com you can see it. I should say that there is a … We’ve talked to the makers of Time Timer because we love it so much. There is a sprint version of the Time Timer, but I’m not making a profit off of that. I really just genuinely thing this is a life changing thing. If anybody has kids you could probably see it in your kid’s classroom. They’re this black clock with a white face and then this red dial in the middle.

Dave:
For getting out the door in the morning for school, that would be so beneficial for a nine year old. “Go to the door and put on your shoes,” and on the way, I just had to draw for a little while. “Stop it!”

Jake Knapp:
The funny thing is I’ll see my kids doing that, but I do the same thing. It’s so easy for me to see that of course, you don’t have a concept of time. I don’t have a concept of time. I’ll be like, “I don’t have to leave to catch the bus for ten minutes, so I’ll check my email,” and then it’s 20 minutes later.

Dave:
You’re totally right. I’m so happy you told me about that, thank you. Do you have any other time saving hacks that you use?

Jake Knapp:
One of the big things that I’ve done for a few years is on my iPhone to remove email, Safari. I don’t have Facebook or Instagram or Twitter on there. That’s a big deal for me because I have a hard time with distraction.

Dave:
You have a Nokia 9600 that looks like an iPhone?

Jake Knapp:
No, I even have the new … I have an iPhone Plus, I am a big iPhone … Because there are all of these wonderful things that you can do on the phone, actually even without those infinite pools of information. The phone has an amazing camera, maps on the phone are amazing, Uber and Lift are amazing. I have a ton of apps on there that I use, but I try to think of it as a tool and if I use the phone I’m using it to get something done. I listen to podcasts on it, I listen to music.

Those things are amazing. I still feel like I’m living in the future with the phone, but I’m not likely to get distracted by it and get sucked into it. Then I feel a little bit more in control of my time, especially with the family, but even at work.

Dave:
That’s an interesting experiment. I am going to ponder on that one. Thanks for that idea. I think you’re the only person who’s talked about that on Bulletproof Radio so far which is really cool. I’ve got one more question for you before we get into our final winding down the interview. What does your work setup look like at home and in your sprint room at Google Ventures? How do you set the environment around you?

Jake Knapp:
I’ll start at home. It’s not super exciting, but at home I’ve got a laptop basically and a stack of printer paper and a pen. I like to whenever possible do work or thinking on paper.

Dave:
But not lined paper, not a pad, not an engineering’s pat. You use printer paper. Why?

Jake Knapp:
I just really like simple tools. I’m a big fan of the simplest tool possible. It’s very easy to get distracted in trying to get the perfect tool. You get to the end of the day, I am very particular about the kind of pen that I use, but I want it to be simple and good. It’s a Paper Mate Flair. I love Paper Mate Flairs, but that’s it.

Dave:
We’re in the same boat there by the way. I despise paper lines on it. How dare you to tell me to color within those lines. If the pen doesn’t feel right I don’t want to write with it. You are already my kind of guy. You have a laptop, paper and a pen.

Jake Knapp:
I have a laptop, paper and a pen. I’ve got the Time Timer on the desk. I’ve got this app called Freedom on the computer which I can use to turn off the internet. You can see a pattern here. I have a lot of self-control problems. I’ll be reading Sea Hawks news for an hour and lose an hour easily if I don’t shut off the internet. I try to be very focused about a task. When I’m working at home hopefully I’m writing, I’m doing design work, I’m doing something that’s pretty focused.

Then at the office in our sprint room, that’s also very intentionally designed space. One thing that’s funny is if you go into a conference room and even the most cutting edge or forward thinking startup in America, you’ll still see conference rooms with conference tables in the middle. It’s just this default, “We’re having a meeting, we need a table. It’s not really clear what the table’s for, but we have to have a table.”

It makes for strange dynamic in the room. It’s not really flexible. In our rooms we have no table. We just have a bunch of chairs that we can move around because at different points in the sprint there’s different configurations. Sometimes we are looking on the screen if we’re working on the prototype or if we’re demonstrating some software.

A lot of the time we just want to be in a circle talking to each other and writing on whiteboards. Whiteboard space is really important and we have as much as we can get. In our sprint room here in San Francisco we’ve got one wall that’s got a couple of whiteboards on it, we’ve got a couple of rolling whiteboards. That space is so valuable, that ability to write something on the wall so everyone can see it. It’s a little bit archaic actually. People are always looking for the perfect software or hardware solution that’ll solve their team productivity. A whiteboard that everyone can see is incredibly powerful.

Dave:
Do you put on the digital things that allow you to draw and project and all that stuff on your whiteboards?

Jake Knapp:
No, I don’t do that and I’m sure that at some point that’s going to be amazing and that’s going to be the way to go, but it is really tough to beat a whiteboard marker on a whiteboard.

Dave:
I haven’t found a way. I taught for a long time with whiteboards. I have the little special things that hold the pen to try and share with the team and none of it works that well.

Jake Knapp:
It doesn’t quite work.

Dave:
Maybe someday.

Jake Knapp:
I’m sure it’s getting close. I recently tried iPad Pro which is the best stylus speed I’ve seen. It was very impressive in many ways, but it still didn’t, for me, have that immediacy of paper or a whiteboard. There’s also something so powerful about something being physically in the room.

You talk about this, we’re basically cave people just walking around in 21st century clothes. It’s helpful when you’re working together, or even if you’re on your own, to have that physical thing, that physical object that you wrote on and your geographic memory remembers, “That’s where that information is. I don’t have to try to hold it in my head.” As soon as it’s in another window or it’s on software we forget stuff. It makes it hard to solve big problems.

Dave:
Very well said. There’s a question that I’ve asked every guest on Bulletproof Radio. If someone came to you tomorrow and said, “Look, I want to kick ass in everything I do in life, what are the three most important pieces of advice you’d have for me?” what would you tell them?

Jake Knapp:
You can only do one thing really well at a time. I think the first piece of advice is to make a list of what’s important to you and then make really hard decisions about what the stack rank should be.

Dave:
That’s a very Google answer by the way.

Jake Knapp:
Yeah, right, search results. Search for your life. I didn’t intend it that way, but you’re right, it is.

Dave:
It’s accurate, yeah.

Jake Knapp:
It’s really helpful for me because as soon as I’m trying two or three things at the same time I can’t really do any of them super well. That’s important. It’s also important to think about the … When we talked about earlier how you spend your energy and being really mindful about when you do this what happens, when you eat this what happens, when you sleep this way?

We all have to keep in mind that we are cave people. We evolved for a world that’s 200,000 years ago to be hunters and gatherers. Our office environment, all of our shiny gadgets that we have today that are engineered to distract us, they stand in the way of us having optimal energy, having optimal focus to do the biggest problem solving.

To achieve the things that are going to be on that stack rank list you need the time and energy. It’s incredibly important that people realize they’re not just … Like Sir Ken Robinson’s TED Talk, we’re just brains moving around from meeting to meeting. The whole body matters. Your energy matters. How you spend your time matters. To get really in touch with your energy is important. It sounds silly, but I think that’s really important.

Then I think maybe the third thig is to be really honest about what you love and to not be embarrassed about doing the thing that you love. Not being embarrassed about being passionate about what you do at work, doing the part that you care about. If you find out that that’s not what your work is about trying to find something else.

It’s important for people to I think wear their heart on their sleeve and really live their lives with passion because it goes by pretty fast. When you turn around and look back and ten years have gone by and you’ve been working on something you want to know that you were giving it your all. That goes back to that idea of the stack rank list, but you’ve got to make sure you’re doing those things with all of your heart.

Dave:
Very, very well put, well considered answers. Thanks for sharing. Where could people buy a copy of your book? I think I saw it at the airport the other day. It’s out there all over the place.

Jake Knapp:
It’s at the airport, but you don’t have to go to the airport. You can get it on Amazon. You can get anywhere fine books are sold, fine business books. It’s not in the stores that don’t have business books.

Dave:
You’re not going to take down Paulho Coelho?

Jake Knapp:
No. There’s a few authors that I like. The business book is never going to eclipse John Grisham and Stephen King. You can find it all over the place. If you go to TheSprintBook.com you can also find that information about it. You can consider whether you really want to buy it, you can see a little bit more.

Dave:
The whole title is Sprint: How to Solve Big Problems and Test New Ideas in Just Five Days. I would recommend this, you listening to this, I tend to recommend good books. You just heard the whole interview with Jake and how he thinks. Even if you’re not someone who’s solving these problems every day in your day life you have problems that probably don’t have very good solutions and you have stakeholders and you have people that support you, take it to your non-profit, take it to your school board and you might just be amazed at what can happen. Jake, anything else listeners should know?

Jake Knapp:
No, thanks a lot for listening. Thanks a lot of having me on Dave, I appreciate it.

Dave:
It’s been a lot of fun. Have an awesome day, thank you.

Jake Knapp:
Thanks.

Dave:
If you enjoyed today’s episode you know what to do. Go out and pick up a copy of Jake’s book and while you’re at it pick up your next order of Brain Octane, or if you’ve never had them, the new Bulletproof Collage Bars. I’m telling you, you eat one of these things, you’re going to think you had desert and then you won’t want lunch because they’re so full. They’re that powerful. Have a great day and if you love the episode I always appreciate a review on iTunes.

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Dr. Doug McGuff – MD: Body By Science – #364

Why you should listen –

Doug McGuff, MD, is an author, personal trainer, and practicing medical professional.  In an effort to prevent, and not just treat disease, Dr. McGuff has developed a unique system of weight training that promises results in as little as 12 minutes a week.  Along with John Little, a renowned strength and conditioning coach, Dr McGuff wrote Body By Science, one of the best books on strength, health, and fitness you’re likely to find.  Dr. McGuff comes on the show to talk about how you can enhance your performance, health, and longevity with an exercise program that takes only 12 minutes a week.

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Speaker 1:
Bulletproof Radio. A state of high performance.

Dave Asprey:
Hey its Dave Asprey with Bulletproof radio. Every now and then I have just the perfect interview happen. When it happens, I can feel it when I’m doing the interview, and I want to share it with you. The odds are pretty high that you haven’t heard this episode. I worked with the team here to remaster the interview, because it was one of the most popular, most impactful ones. I’m re-releasing it as a special edition for you. This has a separate benefit for you, because I’m using some of this time right now to finish the final edits on the brand new book about mitochondria. I’m about to tell you the name of it and where you can find information on it. This book is cool. Its got so many other things in it, I’m going to finish editing the chapters to meet my deadline and I’m offering to you right now one of the most impactful interviews I’ve ever done. I think you’ll really enjoy this.

Today’s cool fact of the day is that humans have evolved to have larger skulls and we’d like to think anyway, smarter brains. Its seems like a pretty good idea, except for the way your skull makes room for your larger brain is by using less bone here in your jaw. What that means is its harder for us to eat tough food, which is fine, because that’s why we have rib-eye. On top of that our teeth have stayed the same size, even though our jaws are smaller, and that’s one of the reasons that you can get impacted wisdom teeth, just because your brain’s too big. You can also say its because your mom, or your grandmother, ate grains, which can also impaction of your teeth.

If you’re a regular listener you’ve heard me share my list of top 10 bio hacks. Lets talk about number 9. Button hacks for the bullet proof mind. It may sound weird, but hanging upside down is a great way to hack your brain. Regularly inverting trains your brain capillaries, making them stronger and more capable to bring oxygen to you brain, its pretty straight forward. More oxygen in the brain means better performance.

I get my daily stretch and my dose of oxygen with my teeter inversion table, which is so essential for optimal focus, concentration, and mental energy. That full body stretch elongates the spine and takes the pressure off the discs so they can plump back up. Less pressure means less pain. If you have back pain, even if you’ve been luck enough to avoid it so far, you really want a teeter to invert everyday to keep your back and joints feeling great. For over 35 years teeter has set the standard for quality inversion equipment you can trust. My friends over at teeter have decided to show some love to Bulletproof listeners.

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Today’s guest has been on the show quite a while a back, and its my great pleasure to introduce a guy who I really consider a groundbreaking exercise guy. This is Dr. Doug McGuff. He’s an ER doctor, he’s an exercise geek, and a weight lifter. He’s one of those few ER doctors who happens to have his own gym, called Ultimate Exercise. He’s one of the authors of Body by Science, along with John Little. Looking at what high intensity training does for you. I’ve used his techniques for a very long time to support my own lifestyle, which is minimal amounts of exercise for maximum gain. Doug does an amazing job of helping people understand what they’re doing from an exercise perspective. Its been more than 100 episodes back when Doug was on. We’ve met in person a couple times, and Doug I’m just stoked to have you back on the show.

Dr. Doug McGuff:
Awesome. I’m really glad to be here. Hey, my wisdom teeth, they came in no problem. I think my brain must be too small.

Dave Asprey:
That’s too funny. Don’t have wisdom teeth problems? Its because you’re dumb, that should be the headline.

Dr. Doug McGuff:
[inaudible 00:04:18] has a study more than most people, but you know oh well.

Dave Asprey:
You did something right because you’ve come up with some new stuff. The reason that I wanted to catch up with you, aside just to get an update because I know you’re constantly researching this stuff, but you’ve been looking at myokines.

Dr. Doug McGuff:
Yeah, its kind of my new obsession these days. I certainly didn’t come up with it, I stumbled across some of the research about it. There were always these things that I just believed but could not prove. The myokines is starting to kind of fill in a little bit of that black box for me.

Dave Asprey:
What the heck is a myokine? I’m sure everyone driving right now is wondering what is this?

Dr. Doug McGuff:
Yeah. A myokine is basically just a chemical signaler. The more generalized term for that kind of molecule is called a cytokine. There are all kinds of cytokines that do chemical signaling, endocrine signaling from one organ to another, or paracrine signaling within a signal organ to direct the body as to what it should be doing at any given moment.

Well, they’ve recently discovered that skeletal muscle is not just this really great tissue that contracts, makes us strong, and able to move. Its actually one of our largest endocrine organs in our body and it signals to other tissues in our body in a very meaningful way. Art De Vany, a long time ago, made mention of this concept, that the tissues in your body don’t necessarily all work together in this harmonious fashion necessarily. In a lot of ways body tissues compete with each other. A lot of this competition takes place through cytokines. Specifically, body fat and muscle tissue have cytokines, these signaling hormones, that work in opposition and in competition with each other. How you eat and how you exercise can give the competitive advantage to one side or the other, such that reaching optimal health, optimal body composition, even optimal neurological functioning, can be augmented by tipping the balance in favor of one verses the other.

Dave Asprey:
What are some of the most famous myokines? I know a lot of cytokines. I monitor inflammation in a lot of the bio hacks in the Bulletproof diet book are around, oh look you can lower this specific inflammatory thing with this nutritional intervention, or sleep, or stress. Myokines are a subcategory of cytokines, correct?

Dr. Doug McGuff:
Correct. Most of the myokines that have been studied are actually cytokines that have an anti-inflammatory effect. Much of the myokines will have an anti-inflammatory effect that directly opposes the inflammatory effects of a lot of the inflammatory cytokines. Probably the longest known and most deeply understood myokine, is one called interleukin 6. That myokine is liberated from contracting skeletal muscle, particularly when its doing high intensity work, but pretty much in any sort of muscular activity it is released to some degree. It is actually, as the intensity of exercise rises, its released in an exponentially greater degree because it is done by an amplification cascade. Meaning that when its triggered, 2 molecules will trigger 4 molecules, and 4 molecules will trigger 8, and that just amplifies very quickly.

Dave Asprey:
That’s a beautiful bio hack because what you’re saying then is by modifying the intensity of your exercise, you’re basically exponentially increasing the amount of an anti-inflammatory substance in the body?

Dr. Doug McGuff:
Correct.

Dave Asprey:
Wow.

Dr. Doug McGuff:
It has this anti-inflammatory effect, but it also has neat biochemical effects. It very aggressively up-regulates the uptake of glucose into the muscle cell, and glucose utilization, and glycogen mobilization. It also ramps up glycolysis, so mobilization of fatty acid from stored body fat. Its ramping through the cell, thorough the mitochondria to do beta oxidation of fatty acids. All of that is augmented and ramped up by interleukin 6. Other things that it does, it stimulates the release of nitric oxide, which causes vasodilatation, increase blood flow into the skeletal muscle, but has a more long term effect of modulating blood pressure towards more optimal levels. It actually acts as a leptin surrogate to increase insulin sensitivity. Just this 1 myokine has so many beneficial effects that we’re looking for. That’s the thing that I always intrinsically felt about high intensity strength training, is that it was so much greater than the sum of its parts. There seem to be something more going on in terms of body composition then could be accounted for simply by the energy that it used.

Dave Asprey:
You mean exercise isn’t just to burn calories?

Dr. Doug McGuff:
Yeah, no.

Dave Asprey:
This is fascinating because nitric oxide has been, really identified as a signaling molecule in the body that we didn’t know that much about even, would you say 5 years ago? As a major signaler? It just sort of popped up.

Dr. Doug McGuff:
Yeah. Lets see, interleukin 6, its probably been known about and some research done on it for the past 10 years.

Dave Asprey:
Yeah.

Dr. Doug McGuff:
The interest in it has gone up exponentially. The neat thing for me, as an exercise geek is, you know I started doing this stuff back in the ’70s, so I’ve always been an exercise geek over the long span of time. What I’ve noticed is that all the major advancements in exercise physiology don’t come out of exercise physiology, they come you of cell biology, and biochemistry.

Dave Asprey:
Amen. Yes.

Dr. Doug McGuff:
Freaking geeks that have never exercised in their whole life. When they find something that’s relevant to exercise, then you really got something. There’s very little that comes out of exercise physiology literature that really has an effect or changes anything at all. When it comes from some biochem geek, man you’re on to something big.

Dave Asprey:
Everything that you just said, probably, in my experience I’m not certain that it applies to muscles, although I think its pretty darn likely in my experience, but you focused on that more. All of the brain training and cognitive stuff that I’ve worked on, the same exact statement about when you change something at the cellular level, everything above it, including the way you think, and your ability to pay attention, all of that changes. I’m going to send you, I think its September 10th I’ll have my early things, a new mitochondrial thing, we’re calling the whole body nootropic, called unfair advantage.

Its the single most exciting new supplement I’ve done, as important to my own performance now as Bulletproof coffee, that up-regulates your mitochondria. Basically you can feel it within 5 minutes of taking it in a big way. I’m predicting there’ll be new world records set from people using this stuff, because just like you said. What happens when you fix something at the cell level, it goes throughout the body, I’ve honestly never been more excited. I’ll send you a box of this stuff, its not even available for pre-order yet, when it comes out, everyone’s going to talk about it.

Dr. Doug McGuff:
That’s cool. Here’s another thing about this interleukin 6, it is an anti-inflammatory molecule, but its not just the effect of the molecule, its the effect of its receptors. Its not only anti-inflammatory, its pro-inflammatory in terms of its receptors. If you’re generating lots of interleukin 6, then you up-regulate interleukin 6 receptor sensitivity. When that happens, it has that pro-inflammatory effect of, actually I’m saying it backwards. More interleukin 6, you down regulate the receptors. The fewer receptors you have, the less inflammation you generate.

Dave Asprey:
Oh wow.

Dr. Doug McGuff:
Not only is the molecule anti-inflammatory, the down regulation of its receptors is anti-inflammatory. Its kind of a double-whammy with the production of these cytokines.

Dave Asprey:
I’m inherently a lazy guy, I call it strategic laziness. Where I’m not lazy because I don’t want to do the work, I just want to do the work faster so I can do something else that’s more important. Couldn’t I just get an IL-6 nasal spray, or inject the stuff, down regulate my receptors and just not even pick up something heavy?

Dr. Doug McGuff:
You know, I’m betting that there are pharmaceutical companies working on that right now. Now there are genetic manipulations that can be done to increase or decrease your production. A lot of the research that’s been done on how interleukin 6 is based on taking it away from experimental animals. The way they do that is by genetic manipulation that produces an interleukin 6 knock out gene.

Dave Asprey:
Wow.

Dr. Doug McGuff:
The DNA is just a big series of bases, cytosine, adenine, guanine, and its this little code, and if you frame shift the code a little bit, whatever transcribes that particular gene will now become gargled nonsense. Then the animal doesn’t have interleukin 6 anymore, and then in an animal devoid or severely hampered in the production of that hormone, you can figure out exactly what its doing.

Dave Asprey:
Wow. What about gut bacteria? Do they make IL-6? Is there a gutbiome component to this whole thing?

Dr. Doug McGuff:
That I don’t know. That’s my other big fascination that I’m way behind the curve on, is the whole intestinal microbiome. I’m certain that is has some sort of interaction, but I’ve not really tweazed that out of anything that I’ve read so far. Like I said, I’ve just kind of scratching the surface of this stuff, but its pretty cool stuff.

Dave Asprey:
Its remarkable how many of the different cytokines are some way manufactured by the gut bacteria to the point that in the research that I’ve been working on, on the Bulletproof diet book, these little bastards, some of them are good for you but a lot of them are there, they’re hacking your system. Your body has its own regulatory system for inflammation, and then these little things sit in there and say, oh we wanted you to be more inflamed or less inflamed for our own nefarious uses, which is mostly keeping their life support system alive. In intrigued to see what happens when we look at both high intensity exercise plus gutbiome. Is there some group of people who work out really hard but have a bad gutbiome, and either it doesn’t work because … that was my experience, an hour and a half a day of heavy lifting for half of it and heavy cardio for the other half. I couldn’t lose weight, granted I was over training like crazy, but I weighed 300 pounds and I was desperate. I’m certain, in retrospect, that my gutbiome was a part of the whole equation.

Dr. Doug McGuff:
Yeah and I think that’s probably going to turn out to be true. It’ll probably be true in a feed forward kind of way. In the sense that, if you’re doing proper training and its high intensity, and its brief enough, and you should be able to recover from it. If you’re one of these people who has trouble with recovery or you’re just totally hammered for 2 days after a workout, I’m highly suspicious that the answer might be that some how your gutbiome is disrupted. In the feed forward mechanism, I think the delivery of an appropriate exercise stimulus may release those myokines in such a way that drives behavior towards reestablishing a better gut flora. I think that both can benefit the other, and both can harm the other, depending on what you’re doing. I think if you’re someone who’s going to chronically over-train, that clearly gut inflammation from ischemia, related to over training marathon runners, can really disrupt your gut biome, and in that process turn you into someone that’s just a poor excersier and poor recoverer.

Dave Asprey:
Yeah. My little memory trickle bookmark was accurate, I just pulled it up. There’s a study from actually 10 years ago, where they were looking at the effect of MCTs, the stuff in brain octane and the MCT, that when you combine that with a bacterial toxin, in other words you have bad bacteria in the gut, that only in that case in rats that MCT changes the secretion of interleukin 6. The primary myokine that we’re talking about. There’s an interesting thing from what you eat based on the toxins made by what’s growing in your gut, changes your inflammatory profile, basically how you respond to it. Its so complex, and its so amazing, that what you’re talking about, which is we’ll just down regulate your receptors by lifting heavy things sometimes. It seems like an elegant way to get around a lot of this complexity. Even if you have a problem with your gut bacteria, you’re still getting less of this problem.

Dr. Doug McGuff:
Yeah the more I read on this, that’s the cool thing about all this complexity. All that complexity and all these feedback loops seem to benefit us by making what we have to do very simple. All that complexity and all that adaptability means that we just have to have a few gross heuristics to operate within, in order to optimize everything. All the complexity of that will take care of it for us.

Dave Asprey:
Doug that’s one of the things I really like about your perspective. You dig in way more than most people would because you’re an exercise geek, and because you have a little bit of training that went into your medical degree. You have this way of thinking, and this body of knowledge. You’ve gone in at that level on exercise which lets you make those basic heuristics. One of the questions I’m sure people have got to be asking themselves, you’ve talked about the benefits of lifting heavy things to up regulate the production of IL-6 and down regulate the number of receptors you have so you’ll have less inflammation, but how often do you have to do it?

Dr. Doug McGuff:
Well that kind of depends upon the individual and the recovery status at any point in time. If someone is interested in optimizing their results, you really don’t have to do it that often. Over time I’ve really, I really like working out, and I will do it as much as I can get away with, even though I’m a huge advocate of appropriate recovery and doing very brief workouts infrequently. To answer your question, I think it is always, in exercise, a great idea to strive for a minimal effective dose, because exercise is pro-inflammatory. Okay, if you’re a person that is not living life right, not eating right, burning at both ends of the candle all the time, you have to understand that the exercise you’re doing, at least in the acute phase, is adding an acute inflammatory event onto a chronic inflammatory state.

When you’re making this transition from, lets say you’re finally going to say, look I’m going to take care of myself, I’m going to live life right. Its most important for that person to do exercise in a way that invokes a pro-inflammatory state, but does it in a way that allows you to make that transition without chronically heaping more and more stress and inflammation onto a chronically stressed and inflamed body. Minimal effective dose is a great way to do that. As a 52 year-old guy, who has no major injuries from training over the longer term, its also important because really what you start to find out is that you experiment with all these different ways of training is that all the extra crap that I did through the years didn’t make a difference. Actually the best results came when I truncated and minimized my training and really paid attention to recovery and diet. Things on the recovery side of the equation.

Dave Asprey:
Yeah.

Dr. Doug McGuff:
I mean you can get the hammer and pound the shit out of the nail, but if you really tune the recovery side of the equation, you don’t have to hammer, and hammer, and hammer. The training becomes a nail gun, not a hammer.

Dave Asprey:
What a beautiful analogy. I wish someone had told me that when I was 20 at the gym, 6,7, days a week. It was exactly what you were describing. I didn’t understand you should recover like a demon, not exercise like a demon.

Dr. Doug McGuff:
You know and I don’t know if a younger guy will every listen to that. So much of having to be tough in your youth, just has to do with the fact that you’re just fucking stupid.

Dave Asprey:
Yeah.

Dr. Doug McGuff:
And you just need to be tough because you’re stupid, until you get to have accumulated enough lumps to actually become smart.

Dave Asprey:
You know I’ve got a 5 year-old boy, and 7 year-old girl, and I got to say maybe the fact that he’s a boy, but I’ll tell him its going to hurt if you do that. Then he looks at you and does it anyway, like well its a learning experience. We’ve got iodine for that or whatever it is. Its funny because it continues and we know the prefrontal cortex really finishes, kind of solidifies around 24, somewhere between 23 and 24. During that time, there’s a whole set of these behaviors that are subconscious that come out.

I beat the crap out of my body, I have a screw in my knee and 3 knee surgeries before I was old enough to have my prefrontal cortex all the way in. Because I wouldn’t listen to my body, also I was doing things that were supposed to be good for me that just simply weren’t. That’s one of my motivations for what I do now, why don’t we just do what works because I was strategically lazy when I was under 23. If I don’t have to do it, I don’t want to do it. I thought I had to do things that were actually bad for me. That’s kind of an obnoxious thing.

You’re saying though that you like to exercise? You work out as much as you can get away with. I get clients like that, when I do coaching. With the Bulletproof diet book coming out, its getting harder and harder to do one-on-one coaching, but I still make some time for this. There are often times, like type A career CEOs, celebrity types, they’re working really, really hard. Not enough sleep, frequent travel, they also want to Iron Man athletes. They want to do some seriously intense stuff, and then you look at their blood panels and they’re clearly, CRPs high, they’re HRV, heart rate variability, is all not right. Classical over training. Then you tell them, you need to back off a bit, and then they sort of look at you like they’re going to cry, I need my exercise it makes me feel good. There’s some opioid addiction there, but there’s a comfortable line between having to beat yourself up every single day, where do you draw that line? For people who want to exercise more a the minimum effective dose? How do you know if its too much?

Dr. Doug McGuff:
Well, the way I tell people to assess it in themselves is, if something comes up in your day to day life, on a day where you’re scheduled to work out, and if something interferes with that and you have to cancel it and move it to another day, if it freaks you out, or if it pisses you off, or if it ruins your day and you’re in a foul mood the rest of the day, or you can’t stop thinking about it, you’re doing too much. That is the weird thing about the over training syndrome is it is a form of OCD. Its like telling someone with OCD, stop flicking the light switch man its not good for you. Well yeah, but if they don’t they’re going to feel enormous angst over it. That angst is the signal that you’re there.

This is why I like your concept of strategic laziness, because that’s what we evolved out of. We want the most results for the least effort, because in the evolutionary environment from which our bodies evolved out of, that was an absolute necessity because there was really severe scarcity. Now in the age of, the modern age where capitalism has provided [inaudible 00:26:11] abundance, we got a mismatch of that. I find that amongst hard driving executive types that you service, is this whole Johnny Quest mentality. That I’m going to work 16 hours a day, I’m going to travel all over the world, and I’m going to run marathons, do ultra endurance events, and climb mountains, and you know all this Johnny Quest crap.

In the end, what you end up figuring out is in order to be super human, you have to realize that you’re only human. When you have accounted for that, and followed the biological imperative to cover and take care of yourself with the appropriate nutrition, and the correctly modulated exercise, its then and only then that you really do feel super human. I think that’s a big, big key in all of this. Its a hard thing to get these hard driving individuals to understand.

Dave Asprey:
Its really something I didn’t understand, but resilience is itself a practice. No one’s like, good job Dave, you were really resilient, its like you were strong, and you didn’t give up. Bottom line is, giving up is one thing, deciding that you’ve had enough and that you need to recover now, so that you can get up again the next day and do it over, is just a different skill. Its not one that we praise, its not one that we train, and its not one really that you’re likely to know about, unless you’ve hit the wall really, really, hard a few times.

Dr. Doug McGuff:
Yeah. I just was watching a Vimeo clip, and the interesting thing is … you talk about a navy seal, or special forces type people, those people are put under huge amount of stress. Both as a weeding out process, but also as stress inoculation to make them.

Dave Asprey:
Yes.

Dr. Doug McGuff:
What they found is in all of their stress inoculation training, the one thing that decreased the wash out rate at BUD/S from 38 down to 23% was one simple thing. That was to teach combat breathing, which is a meditative form of breathing, where when you’re freaking out and you need to slow your heart rate down. Because once your heart rate goes above about 145, motor control and decision making capacity goes to crap. What they did was, they taught these guys how to meditate, and how to breathe. 4 seconds in, hold 4 seconds, 4 seconds out.

Dave Asprey:
The box breathe.

Dr. Doug McGuff:
Yes. The box breathe training, and learning how to mediate, that alone proved more valuable, in terms of stress inoculation, and making it through the BUD/S course than all the other more traditional stress inoculation techniques that they had done. Stress inoculation is a good thing, and its good to challenge ourselves and do big things, but again that whole realizing you’re only human to become super human is important. There are elements of self-care that make you able to handle those stress-able moments. As an emergency physician, I’ve had a 25 career in this including residency, so 22 naught, but a long career in emergency medicine. As going from a new ER doc to an old ER doc, one thing I’ve really come to realize is that the answer to dealing with this uncontrolled pace, overwhelming pace, and sick people and dying people, is not to get yourself all amped up on Red Bulls and all hyped up and crazy. You’ve got to have an ability to calm yourself, to be the eye of the storm in order to function truly well.

Now you can kind of get yourself through it when you’re not as good as you should be, by drinking Red Bulls and going ape crazy, but the better way is to have that kind of calm.

Dave Asprey:
Its funny you mention the medical side of things. I’ve learned those meditative breathing techniques and all the 40 years of zen neuro feedback and all that sort of stuff. I’ve learned to calm myself even at in an ER, which use to be always terrifying. I made a commitment training my kids the same way. Both my kids play the HeartMath game, the inner balance sensor, they clip the little thing on.

Just last night, Anna, who’s 7, was running and she tripped on a stair and landed, skinned all 4 joints you can skin at 1 time. Screamed, and you know it was a disaster. She sat up and literally did 4 full slow in, slow out breaths, stopped crying, picked herself and decided that she wanted to go into the forest before we cleaned up her wounds. I was just flabbergasted to see this. Just teaching those basic skills. What would happen in the ER if everyone who came in, with whatever kind of critical injury they have, knew how to breathe like that? Do you think more people would survive? I don’t want to put you on the spot, I know you have licensing issues or whatever.

Dr. Doug McGuff:
Well yeah, no, you’re talking about surviving. I kind of suspect that it might be, because one thing that we found is that in critical care patients, someone that is a bad multi-trauma, or someone with bad sepsis that you have to put on the ventilator, that if you don’t provide appropriate pain control and analgesics, that their mortality is actually significantly higher. If you have a big dumping of catecholamines during an acute injury or illness, your survival is actually worse. We try to manage that pharmacologically, and through medical intervention, but now that you ask the question, someone that was able to access their own physiology, like in my opinion every human being should be taught to do.

Dave Asprey:
Yes.

Dr. Doug McGuff:
If they were able to do that, I think it could make a real difference.

Dave Asprey:
Probably not in some cases.

Dr. Doug McGuff:
People that are under acute stress. Their ability to manage their own physiology can save their life in a critical situation, but certainly I think it can also diminish the likelihood of developing PTSD during a stressful event, or something. Because all of these … you know this big dump of catecholamines, and inflammatory cytokines, I think has a long term effect for setting the stage for those sort of bad things, so yeah. I’ve not thought this out ahead of time before you asked me, but when you asked me that I think yeah.

Dave Asprey:
You know what you’re doing, because according to my friends over at the HeartMath Institute, I’m an advisor for HeartMath and just a friend and supporter of their kind of technology, they’ve looked at that. People who are trained in heart rate variability before they go into combat are less likely to get PTSD, because they can get out of fight or flight. Its funny that you predicted that based on your knowledge from ER, in fact that’s startling that you did.

Dr. Doug McGuff:
Funny that you asked me that, because now when I think back about it … right now I work, the past 20 years I’ve worked in a high volume, high acuity community emergency department. When I was in residency and we rotated amongst different big hospitals, at the children’s hospital they had a specialist called a Child Life Specialist. Per my recollection, when the children were in painful or stressful situations, they would come in and they would actually talk them through breathing exercises and things for self calming, and it really did make a significant difference. I think we do this for kids, why don’t we do this for everyone, and for adults? That’s probably something that could be applied in the emergency medicine setting that would be beneficial for a lot of people. I tell you, I got the sense that on any given shift on any given day, 40% of what I see is driven largely by anxiety states.

Dave Asprey:
No here’s an odd question, and then we’ll go back to some of the other exercise related stuff, could you set a ventilator to do box breathing?

Dr. Doug McGuff:
Yeah, you can.

Dave Asprey:
Does it calm people down?

Dr. Doug McGuff:
You know, I don’t know.

Dave Asprey:
I’m so intrigued.

Dr. Doug McGuff:
You can set a ventilator, mostly what we manipulate ventilator settings for is to do 3 things. One is to control the level of carbon dioxide that’s circulating in the blood by how well you’re blowing off carbon dioxide, to what extent. The other is to effect oxygenation of the blood, and third is to provide pressure support for when the lung is ill, when its got fluid that’s causing the alveoli to collapse and things of that nature. Mostly the ventilator is tweaked to optimize acid/base balance in the blood, and to optimize cardiac output. To answer your question, some critical care specialist that’s very adept at manipulating- you could.

Dave Asprey:
Wow, I’m so intrigued.

Dr. Doug McGuff:
What we’re finding with ventilator settings is, I mean 10 years ago we would run much higher tidal volumes and respiratory rates than we do nowadays. Now the tidal volume is gone down significantly and the level of oxygenation, and respiratory rates have been modulated some what. I guess in some sort of sense that would be the ventilator version of that kind of approach.

Dave Asprey:
Lets take that back to exercise. Given that you know so much about blood gas mixes, more than anyone with a degree in exercise physiology is likely to, have you applied that to exercising in oxygen tents, high altitude velocity training, lifting heavy things without any air, stuff like that?

Dr. Doug McGuff:
No, not really. The thing with breathing and exercise is the same thing that we were talking about earlier with the complexity of myokines and gut bacteria and how all the stuff beats back is that if you’re doing really hard work, the best ventilatory mechanism that you can use is the one that you don’t think about. Because it auto-regulates very well. When you’re doing hard, high intensity exercise, you start to generate a lactic acid, the production of lactic acid. The automatic response is that pH is received by the chemo-receptors in your carotid arteries and around your brain stem, automatically regulates your respiratory volume and rate to blow off carbon dioxide, to affect carboxylic acid in your blood stream, to normalize the pH relative to the lactic acid doses. That kind of auto-regulates. Go ahead, it looks like you’re going to ask something.

Dave Asprey:
There’s a whole school of training, mostly for endurance guys, around live high train low, or vice versa, depending on stuff. I’ve been for the past almost month or so getting my blood oxygen levels, very short, intermittent phases down into the high 70s for up to 6 minutes at a time. I’m in the middle of basically trying to raise my EPO levels naturally as an anti-aging technique. I’ve noticed huge differences in how I feel after just a few days of that. Its shown to improve athletic performance. Its fascinating to look at high intensity exposures to really heavy exercise, which you just figured out with some of the latest research we’re doing, what its doing to myokines and the number of myokines you have. It appears you can do the same thing with cold, cold thermogenesis, the same thing with blood gas levels. There’s all sorts of ways to reach in to the body and give it a strong signal to make it change, even though that’s a signal that might never have really occurred for most people in a normal way of living. I’m intrigued that we’re going to find a lot more in there.

Dr. Doug McGuff:
Yeah, oxygen is a whole different ball of wax then carbon dioxide monitoring for the body. How oxygen is moved around the body is through hemoglobin, which is a really cool molecule, its a tetramer. It has 4 binding sites per oxygen. It changes its chemical shape as it binds oxygen. If you have a tetramer with 4 binding sites, and you bind 1 oxygen, the remaining 3 binding sites attract oxygen more aggressively. Then you bind the second one, the third one, and the fourth one now bind more aggressively. When they’re all 4 bound, hemoglobin holds on to oxygen very aggressively.

A lot of people think of optimizing their oxygenation means having better oxygen binding, and that’s not the case. What you need is oxygen delivery. The hemoglobin molecule has to be able to let go of oxygen at the tissue level. At sea level, when you chronically have good high levels of oxygen, you’re always binding oxygen aggressively, and its hard for the oxygen to let go at the tissue level. Things that can augment letting go of oxygen at the tissue level acutely are lactic acidosis then signals that there’s tissue hypoxia. That changes again the shape of the hemoglobin molecule so it lets go of oxygen more readily. On a chronic basis, when you train at altitude, or you do what you’re doing, you’re actually up regulating a molecule called 2,3-diphospoglycerte. That is a molecule that changes the shape of hemoglobin over the longer time span, so it binds oxygen less aggressively.

Dave Asprey:
Really?

Dr. Doug McGuff:
That means you’re able to let go of oxygen more easily at the tissue level. What you’ll find is if you train at altitude, you return to a more normal sea level, what you’ll find is that your oxygen saturation rather than always being 99 or 100%, you’ll be at 95%. Someone that’s trained in a hypoxic environment produces more 2,3-diphospoglycerte, and they therefore bind the oxygen to the hemoglobin molecule a little bit less aggressively and are therefore more able to let go of oxygen at the tissue level, and pass oxygen from hemoglobin to myoglobin in the muscle where it can be utilized.

Dave Asprey:
You’re increasing the bioavailability of oxygen to your muscles?

Dr. Doug McGuff:
Correct. By actually holding on to it less stingily to it.

Dave Asprey:
Doug I’m so glad I asked you that, because no ones ever explained that to me. I don’t even know that molecule, now I have to go look it up.

Dr. Doug McGuff:
The cool thing is, if, can you see me on the screen?

Dave Asprey:
Yeah. Although people who’re in their cars won’t, but a lot of people on YouTube watch.

Dr. Doug McGuff:
Well I’ll try to describe it verbally. The oxygen binding curve for hemoglobin is sigmoidal. It starts off very flat, and then as oxygen level rises in your blood stream, when the partial pressure of oxygen is about 20, your oxygen saturation is going to be 50-60%. As the partial pressure of oxygen rises to 30, 40, and 50 you get on the steep part of the curve that goes up. Once you get a partial pressure of oxygen about 70 or 80, your hemoglobin molecule will be about 95% saturated. Then you can drive oxygen up to partial pressure of 200 and you’re not going to get, you’re still going to bottom out at 99-100%. The shoulder where you go from really tightly bound oxygen and fully saturated hemoglobin is at about 95%. Someone that’s trained in a hypoxic environment will sit right at that shoulder.

Dave Asprey:
Oh.

Dr. Doug McGuff:
So that they can drop off on the steep part of the dissociation curve really quickly. That person lets go of oxygen more aggressively at the tissue level. A lot of people when they do this and they put the pulse oximeter on and they’re like damn, I’m only at 95% on room air, this isn’t working. What that really means is that it is working, you should be running around 95-96%, not 100%. They think, I’m getting worse, when they’re actually getting better because you’re binding oxygen less aggressively, you can deliver it to tissue more easily.

Dave Asprey:
Serendipity is awesome, because I put on my pulse oxygen monitor and it was just at 96 and I was like, God damn, literally it happened to me like 30 seconds ago. I was like yeah, I’ve been monitoring my blood oxygen, I wrote about what happens to it when I fly, I’ve been playing with this for years. I guess all this stuff I’m doing, first time I saw it 96 during the day, here it is you predicted that.

Dr. Doug McGuff:
That more is better, but when it comes to hemoglobin binding you want to bind the oxygen less aggressively. Most people that are well conditioned will float around 95-96%, because they let go of it easier.

Dave Asprey:
Oh that’s beautiful. All right. Lets get back into exercise. CrossFit and functional movement. What’s your take on- clearly the intensity’s there and it seems like minimum effective dose isn’t going to give you the benefits of proper form that you would get from a functional movement training, what’s your take on that for a Body by Science perspective?

Dr. Doug McGuff:
I don’t ever want to be a guy that comes across as a hater. In that context, I go to the CrossFit website everyday and I look at it. I like their sense of life.

Dave Asprey:
Amen. Yeah.

Dr. Doug McGuff:
I think there is enormous value in doing hard things. I think that’s cool stuff, okay. The whole functional movement craze is a little off putting to me, because I think its over played. The human body, if its appropriately strengthening and conditioning, its functional and can get into most positions pretty well. I don’t think you have to construct a major training component dedicated exclusively to that for that to be in place.

Now my beef with CrossFit, from the Body by Science perspective, is 2 things. One is that for most circumstances and most people you have crossed the threshold way beyond minimal effective dose. If you follow the WODs and you do what’s going to be going on at most boxes, you’re going to be well beyond minimal effective dose. What that does for CrossFit from a marketing stand point is it creates the fitness version of SEAL BUD/S training. You kind of get rid of all the people that are not intrinsically tough enough to handle it, or don’t have that genetically gifted recovery capability to begin with. You kind of weed out the weak, and you’re left with the strong. Its a great marketing strategy for getting people that respond well to exercise. Its certainly greatly over steps the minimal effective dose concept, which I’m a big fan of.

The second thing is, I think they need to re-think a lot of the different WODs that are named after women. I don’t even know what they are. I think it could be a real problem when you take a highly complex skilled movement pattern and mix it with exhaustion. Motor skills, like we said before, motor control degrades when heart rate elevates above a certain point. Complex motor skills degrade with exhaustion. When you’re going to put a 500 or 2,000 meter row and a 100 burpees before you do some complex Olympic lift, I think that’s a prescription to mess yourself up in a big way.

Dave Asprey:
You’re worried about the injury side of it?

Dr. Doug McGuff:
Yeah. Body by Science, super slow, a lot of the high intensity world, we are way, way on the other spectrum of safety. We invoke so much safety that our margin of safety is almost ridiculous. I mean Ultimate Exercise has been open since 1997, we do 120 work outs a week, we’ve never had an injury in the facility.

Dave Asprey:
Where is your facility? Plug it for a minute.

Dr. Doug McGuff:
We’re in Seneca, South Carolina. Which is right next to Clemson University, if anyone’s familiar. We have this huge margin of safety. I’m not saying that everything they do is unsafe, but I think there are certain combinations where you’re begging for it. I mean if you’re really doing something that’s highly exhaustive, its stacking a lot of fatigue and a lot of lactic acidosis, and then you’re going to do a complex motor movement in a state of exhaustion. That’s when you’re going to drop the bar on your neck, or on your back, you’re going to lose control of it going over head, and tear your rotator cuff, or get a slap injury. I think some of that probably needs to be rethought. People that are doing it well are probably arranging things in a way where that doesn’t happen.

Dave Asprey:
The composition of the WOD really matters for CrossFit, I hear you there.

Dr. Doug McGuff:
That’s their product, and that’s their business, I’ll let them handle it. I’ve got my product and my business.

Dave Asprey:
Neither of us is dumping.

Dr. Doug McGuff:
I love anyone that values doing hard things, I think its cool.

Dave Asprey:
Yeah I even have Kelly Starrett coming to the Bulletproof conference to speak, he’s doing some of both. I’m a supporter of it, but man if you’re going to train that hard you better recover just as hard. A lot of the techniques that I’ve worked on are good for recovering, resilience, whatever kind of your stress is. If you’re working out 6 days a week, your physical stress is pretty high, so lets hope your emotional and job stress aren’t so bad.

Dr. Doug McGuff:
The way they market themselves with all the military devotion and all the workouts named after dead soldiers, the whole Johnny Quest special forces things really appeals to the type A executives, that you’ve spoken about earlier. That can really throw gasoline on the fire of the OCD, over accomplishment, leading to over training problem that we talked about earlier.

Dave Asprey:
Its something that I think is here to stay, its super high intensity and it feels good in the community, there’s a lot of good stuff going. I hear what you’re saying there, the concern about injuries, because me I’m actually grateful that I walk relatively normally. After my third knee surgery at 23 where they put a screw in my knee, they sort of said well, be grateful you’re walking. For me to have gone from constant knee pain in both knees to being able to track to the Himalayas for months, even though my knees hurt some of the time to be honest. It doesn’t matter, I could do it, and it was within my capability and I didn’t have an unstable knee or anything, so wow.

Dr. Doug McGuff:
That’s a cool point that I’ve noticed over the years, both in the emergency department seeing patients and in the training facilities, I see a lot of people with bummed up joints, bad knees, osteoarthritis. The people that are doing high intensity muscular work can have a knee, that by radiographic criteria is horrendous osteoarthritis, but they’re asymptomatic. They don’t have pain.

Dave Asprey:
Wow.

Dr. Doug McGuff:
Where as someone that is not doing exercise that challenges muscle in a meaningful way, those people have osteoarthritis with inflammatory changes and significant pain that limits their activities in daily life. I think it has a lot to do with this myokine stuff we’ve been talking about. One of them, interleukin 15, has a big systemic anti-inflammatory effect mainly by the fact that it antagonizes truncal body fat, which is the major distributor of all these inflammatory cytokines. It also has a direct anti-inflammatory effect as it circulates through the body. That’s one of those things that I observe but could not explain, that I think myokines might explain. It might explain why you got this knee that’s full of hardware, but it doesn’t really bother you that much. When if you look at it on X-ray, anyone in their right mind would go, oh shit.

Dave Asprey:
That may be the case. I did not know you were supposed to be able to walk without pain until some time in my mid 20s, like wow I actually did that. I played soccer for 13 years, it hurts to run, it hurts to move, that’s just the condition of life. Granted I had extreme inflammation because I was exposed to some biotoxins and what not. I ate like crap because we didn’t know any better, so mistakes were made. Still, looking at all this IL-6, IL-15, IL-8, all the different interleukins and all the myokines, its been revolutionary for me and you’ve studied them much more so than I have. I’ve looked at which supplements and in some cases which forms of things like growth and regenesis are going to down regulate inflammation, because I’m aging as a war against inflammation, so how do we win? Are you going to come out with a book on these? It seems like its about time.

Dr. Doug McGuff:
Oh, man. That would be cool to do. The next go around, I’d like to do another exercise book that incorporates all of this sort of stuff again. Yeah, I probably will have to do that. Its not definitely in the plans right now, because there’s so much other crap going on right now. Especially as my understanding of it delved deeper. The cool thing about it, its kind of the cool stuff about what you do, is that all of this complexity and all this stuff that you can really geek out on, the neat message behind it all is that if you just follow some simple heuristics and just do this, then all of that takes care of itself. That complexity is there to make it simple for us.

Dave Asprey:
Its funny, I did not know half the reasons Bulletproof coffee worked. I experimented with this idea of putting butter in, has to be better than the other crap that’s in cappuccino. I felt really good, I just noticed it in Tibet. As I wrote the Bulletproof diet book, I kept coming across research like, oh my God, someone actually did this study? They found the same results I noticed in myself, but I didn’t know there was any thing science behind that. I was able to geek out and find reasons I was getting effects that should not have happened according to my expectations, but did.

Dr. Doug McGuff:
Yeah, and that’s the thing over the years experimenting in the gym and communicating with other people that are experimenting. I started to see the pattern. Everyone thinks science precedes invention and innovation, but it doesn’t. Invention and innovation precedes science. Then we give science something to fill, all this science that’s coming out on high intensity exercise was preceded by 20 years but guys like Arthur Jones and Ellington Darden and people that were looking at the high intensity exercise. The intrinsic intuitive, man this is really good stuff, that preceded any scientific investigation into why it worked. What I’m really starting to understand is that there’s something that precedes innovation, its called tinkering and farting around. You know this farting around and tinkering with shit leads to innovation. Then once the innovation expresses itself, then society’s like, hey what are these guys doing over here lets study it. That’s the way it goes. Science never precedes innovation, that I have ever seen.

Dave Asprey:
You look at observation, little bit of hypothesizing, experimenting, and then you really come in with the hardcore stuff. I just funded some research looking at inflammation. I paid for the IRB approval for a study. Its funny. Its an observation that I’ve made that, I’d say thousands of other people have reported to me, but no ones ever studied it in a systematic way. Either the inflammation numbers are going to go up or go down, according to a set of practices and that sort of thing. There’s no real economic incentive for much of this high intensity, who’s going to benefit from doing the study on high intensity exercise? Some new gym or something maybe? Its not like its a big pharmaceutical company. I’m looking forward to more quantified stuff happening.

Dr. Doug McGuff:
I have this book that’s called Body by Science, and I have been dogged by people for a lack of scientific rigor in some of the stuff I discuss on the internet, on my blog, and in videos, and with you. You’ve gotten a lot of crap, because guys like us what we’re doing, I mean we throw dog shit into the screen door and see what lands on the other side.

Dave Asprey:
Yeah.

Dr. Doug McGuff:
When some stuff lands on the other side, then oh the serious scientists come pick that stuff up and run with it, its like, oh. That willingness to say, this works for reasons I don’t understand and I’m going to keep doing it, even thought I can’t prove it, is enormously beneficial. Sometimes the proving part of it doesn’t happen for 20 years, so you don’t have time to wait around.

Dave Asprey:
Yeah aging doesn’t wait. I’m not planning on dying because I was waiting for a double blind study that said dying was bad for me.

Dr. Doug McGuff:
I’m 52, tomorrow I go to take my board, every 10 years you’ve got to re-certify for your board certification emergency medicine, tomorrow I go take my second 10 year certification. Which means the last time I took it I was 42 and I literally feel like it was 2 weeks ago that I drove down to the testing center and did it.

Dave Asprey:
Wow.

Dr. Doug McGuff:
The thing is, in our day to day lives, the days are long, but the years are short. We don’t have time to mess around with this stuff, I believe that you’ve just got to get on with it, and do things.

Dave Asprey:
Its totally true. I got to say, if you’re watching and you’re looking on Skype, you don’t look any older than I am, and I’m 41, you’re doing something right. I look odd today, if anyone’s noticed me sitting with my eyes closed, 1 of my eyes is fully dilated because I had an eye exam right before this. I’ve been kind of squinting and looking funny the whole time.

Dr. Doug McGuff:
Well you look like Satan.

Dave Asprey:
Now lets see I’ve got 2 more questions for you. 1 of them is, have you looked at inflammation or muscles and whole body vibration at all? It seems like there’s another whole set of hacked warm up stuff going on there, and full disclosure I have the whole Bulletproof vibe its a very small part of what I do.

Dr. Doug McGuff:
No, and this is the second time someone’s really pinged me with that. I had an interview with Joseph Mercola a while back and he pinged me about it. It triggered me just enough to kind of hit PubMed and see, oh is there any literature out here about that at all? There seemed to be a mother-load of it, but I’ve not delved into it yet.

Dave Asprey:
You want me to send you 1 for 3 months to play with? I’d be happy to.

Dr. Doug McGuff:
Sure, yeah.

Dave Asprey:
All right, its yours. The Bulletproof vibe is awesome. I stand on it, probably between this and my next interview, I’ll go stand on it for 2 minutes just to get the lymphatic system going, circulation and all.

Dr. Doug McGuff:
Yeah. To answer your question in any real sense and to be able to comment intelligently on it, no.

Dave Asprey:
Okay, cool.

Dr. Doug McGuff:
It did pique my curiosity enough to go lets look see what the literature is like. There’s a lot.

Dave Asprey:
Yeah.

Dr. Doug McGuff:
Its got to be read.

Dave Asprey:
It goes back to that whole strategic laziness, minimum effective dose. I’m a big believer in movement and one of the things that I love about your book, Body by Science, is that its like look, taking the stairs is movement. Its not exercise, so you’re not getting a hormonal response. Sometimes I don’t have time to go for a walk, but I still want my body to get the movement that happens, if I can accelerate that into a smaller period of time, its maybe inferior but its better than nothing. I tend to look at it like that.

Dr. Doug McGuff:
You know, its not exercise but I think that kind of stuff is important. One thing I’m also becoming a big believer in, the myokines kind of feed into that, is the concept of signaling. I’ve always found that when I spend a lot of time walking, long distances, an hour, 2, walks. Going on walks with the wife, I’m always leaning. I don’t think its because of any exercise effect or calorie burning effect, but I think it sends a biological signal that says, look if you’re going to be moving around that much, the diminishing marginal utility of carrying stored energy on your body is too high. Its cost is too high. Sure you’ve got 2 weeks of stored energy, but the cost of carrying around all that crap is too much if you’re going to be moving around that much. The biological signal adjusts behavior in a way that allows you to be leaner. Its not that you’re burning calories, or 10,000 steps a day burns a certain number of calories, that’s crap.

Dave Asprey:
Its laughable.

Dr. Doug McGuff:
I do think it sends a biological signal that says, the marginal utility of having stored body fat is now diminished.

Dave Asprey:
I think we would both agree that there’s got to be something going on there. Same thing, it doesn’t make any sense because you burn 3 potato chip’s worth on your long walk if you’re really looking at calorie burn. Yeah, you feel better and I always assumed it was something to with the muscle’s effect on lymph. You increase lymph flow, maybe you have more ability to burn fat. There’s clearly some little mechanism that we probably-

Dr. Doug McGuff:
Yeah I think that there’s just so much going on inside that black box that you know we’ve just got to be happy with what comes out the other side.

Dave Asprey:
The other question I really wanted to ask you is something I think that would benefit readers, Bulletproof exec is relatively complex, there’s a bunch of come here, start here kind of stuff. Really, there are people who really get into the weeds and there’s a lot of weeds there that you can get into if you really want to go and do something. When I go to Bodybyscience.net, you’ve got a lot of complexity on there too. I want to know how are you dealing with that, and where should new people want to go and check out your website? Where should they go to start looking at your recommendations? Honestly you’ve got tons of stuff on research, I find it a useful resource.

Dr. Doug McGuff:
Yeah, I mean that’s a great place for, its more of a gathering community for geeks like me that want to come there and geek out. I actually have a website that I run most of my consultancy through that has a direct link to a YouTube channel that’s got some good videos, and lectures, and things of that nature. That’s just Dr. McGuff, D-R-M-C-G-U-F-F .com, so DrMcGuff.com, if you go there you can see all the stuff on consultancy. There’s links on learn and watch and stuff like that. Where you can go and pick up some of the lectures that I’ve given that’ve been recorded, that really kind of parses down into the essentials. It can even be much simpler than that. You have a great visual analog thing for diet that I think is a great heuristic to operate by.

Dave Asprey:
Thank you.

Dr. Doug McGuff:
My heuristic for diet is this, and for exercise is, do something really hard every once in a while and remain active otherwise.

Dave Asprey:
Hold on that’s too hard, let me write that down.

Dr. Doug McGuff:
Do some really hard stuff every once in a while, and remain active. Diet is this, if you draw a straight line between the sun and your body, then that’s a good diet. Your diet can be you getting directly in the sun, and converting vitamin D3 and probably a lot of other hormonally active substances we don’t even know about that come from direct sunlight. Or the sunlight acts on phytoplankton, the sunlight acts on plants that go through photosynthesis, you can eat those like Terry Walls activates.

Dave Asprey:
Yup, which is a good friend of mine.

Dr. Doug McGuff:
There are animals that eat those plants and you can eat those animals. You can move up the food chain. That food chain is a chain that connects between you and the sun in a straight line. When you deviate off that straight line, through processing, that’s where you get into trouble. A diet that stays on that straight line tends to be a single ingredient diet. You don’t pick up a box and its got 40 ingredients that you can’t pronounce, you pick up a, what am I going to eat, I’m going to eat an egg. What’s in egg? Egg. What’s in apple? Apple. What’s in broccoli? Broccoli.

Dave Asprey:
Yeah.

Dr. Doug McGuff:
Single ingredient diets, straight line between you and the sun, and that works out. The heuristic, that little analog thing, good, better, best, for each of the different macronutrients and stuff, that’s a great gross heuristic. I think those are the things, those gross heuristics, that simply everything so that you can do it without having to devote so much mental energy to it, you can go on and do the more important things in life. I think that’s really key.

Dave Asprey:
I think we have a similar way of thinking, because I think you really welled it down in your book, same thing when I read that, I’m like I don’t need to know all the details here, I’m more about feeling really, really good, having a ton of energy, having my brain work all the time, and looking reasonably good. I’m married, I have kids, I don’t have to have a chiseled Hollywood 6% body fat, in fact I would probably die sooner if I did, like most people who look that way. The whole point there is like the goals aren’t really different, but when it comes to exercise, I know you’ve gone 2 levels deeper than I have. I look at yours, here’s the 5 things that you do, and do them about this often with about this little intensity, about there. You’re not too perfectionist about it, love it, that’s perfect.

Dr. Doug McGuff:
Yeah. There’s a letter of the law and I love digging into that. The purpose of letter of the law is so that you can operate with the spirit of the law. If you do that, you’re 95% of the way there, the rest is just icing, and if you just want to geek out its there for you.

Dave Asprey:
Its time to test your memory, because a 100 and so episodes ago, I asked you think question. I want to ask it to you again is the final question in the interview. What are your top 3 recommendations for people who want to perform better at life? If you want to kick more ass, do these 3 things, doesn’t have to be anything to do with exercise, whatever else. You’ve learned a lot, you have an interesting career, the 3 things that everyone should know? We’re going to test and see if this matches what you did before. Not really, there’s no test. There’s no test.

Dr. Doug McGuff:
It won’t match, because I’ve seen your other interviews and I saw the question and I thought what do I want to say this time? Its probably going to be different than what I said before.

Dave Asprey:
That’s actually good. Yeah, share your knowledge.

Dr. Doug McGuff:
Its not going to relate just directly to exercise or physical aspects, but life in general.

Dave Asprey:
Yes.

Dr. Doug McGuff:
Because I’m studying for my emergency medicine boards, third time around, this time the renewal every 10 years, it gets me thinking about things in a more global sense. In the global sense, my 3 things for kicking ass in life are, number 1, just show up. Just show up, that’s 90% of it, whatever it is just do it, just show up and be there and you’re on your way. The number 2 thing is imagine. Actually if there’s something you want to do, some way you want to be, being able to imagine it in your mind sets the stage for it to happen. You give your brain in your mind a target to focus on, and that starts with imagination. Then once you’ve done that, the other thing is rehearsal. Just rehearse it in your mind, over and over and over again. There’s certain big things that you have to have worked out in your mind ahead of time, so you know what you’re course of action is going to be. Because when the shit hits the fan, and you’re freaking out, you’ve got to be able to go there.

When I go to work, in the ER, everyday when I’m driving into work, I rehearse 3 things in my head. 1 is to do a thoracotomy, which is where someones been shot in the chest, they arrive in full arrest, you’ve got to open up their chest, open up the sac around the heart, evacuate the clot, save someone’s life that’s been shot or stabbed. The other is the procedure of cricothyrotomy, which is getting into the windpipe for someone who has had massive facial, or is having an allergic reaction there tongues so swollen that you can’t get a tube into their windpipe by the usual route. You have to do it surgically. The third is a postmortem cesarean section. A pregnant woman that’s beyond 20-24 weeks gestation that’s had a cardiac arrest. Within 5 minutes of cardiac arrest, the only way you’re going to save the mother and the baby is to cut and get the baby out.

The thing about emergency medicine, and the thing about so many things in life, is the greater your need to act quickly and decisively, the greater your tendency to hesitate. The only way to overcome that is rehearsal. Think about the big important issues in your life and how you’re going to behave when those things happen, and rehearse them. Rehearse them everyday, so when it does happen, you’ll know what to do. When you’re on the 114th floor of the World Trade Center and the instructions are, well they told us just to stay put until they give us instructions, if you’ve thought it out ahead of time you’ll be the guy that says, screw that, I’m going down the stairs.

When someone holds you at gunpoint in the parking lot of the shopping center and says get in the car, you’ll the guy that says I’m not getting in the car. You can shoot me right here in the parking lot in front of all the cameras. There’s all sorts of things, you’ve got pick what they are. Whatever these big issues in your life that you foresee coming some time in the future, think about what you’re going to do and rehearse it. Those are my 3 secrets to kick ass.

Dave Asprey:
Well those are definitely more impactful than the last ones, because I’m not sure I remember them without going back to look at the show, but I think I’ll remember these Doug.

Dr. Doug McGuff:
[inaudible 01:12:25] Rabidly scrambling here on my computer, trying to find the old episode.

Dave Asprey:
I would have been sad if you said the same ones because people can always listen to the first interview. By the way, you should if you enjoyed this one, the first interview was good. We talked a lot more in that one about the basics of exercise and all. Doug its always a pleasure to have you on the show, would you toss out DrMcGuff.com and Bodybyscience.net, any other URLs besides those that people should go to?

Dr. Doug McGuff:
I think that will get you to everything that is sort of a portal to what I do. That’s Dr. McGuff, D-R McGuff .com, and Bodybyscience.net you can find me from there.

Dave Asprey:
Wonderful. Have an awesome afternoon and thanks again for being on Bulletproof radio.

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What We Cover

  1. How did you get interested in health and fitness?
  2. Can you share your definition of health, fitness, and exercise so we are all on the same page?
  3. Would you talk about how to balance the relationship between anabolism and catabolism to improve health and performance?
  4. What are the criteria for something to count as exercise?
  5. Can you talk about how exercise is a drug?
  6. Do you think running marathons or doing Ironmans counts as exercise?  Or should it be considered it’s own entity?
  7. What do you think of what most people refer to as “cardio.” Do you need to do “aerobic” exercise to keep your heart and lungs healthy?
  8. What role does nutrition play in improving body composition?
  9. What do you think are some of the flaws of barbell training?
  10. Do you think Crossfit is a good way to build strength?
  11. What do you think of explosive plyometric/olympic type lifting?  Will it really help the average lifter?
  12. Is stretching and mobility type work necessary?
  13. Is balance training like bosu balls and standing on one foot necessary to improve balance or proprioception?
  14. If someone is training for a specific sport, do these principles still apply?
  15. What is the best way to fatigue a muscle and produce growth?
  16. Can you talk about the specifics of your “Big 5” workout?
  17. If progress stalls, should you do more exercise or less?
  18. Does this mean you can’t train more than once a week?  What about other activities, do those have to be limited as well?
  19. Is this kind of training safe or useful for the elderly or people who lack experience?

Links From The Show

Featured

Body By Science by Dr. Doug McGuff & John Little

BodyByScience.net

UltimateExercise.com

Consulting Requests for Dr. Doug McGuff (call 864-886-0200)

Food & Supplements

Upgraded™ Glutathione

Vitamin D3

Vitamin C

Serrapeptase

Upgraded™ Whey Protein

Flaxseed Lignin Extract

Cod Liver Oil/Butter Oil Blend

Kerrygold Grass-Fed Butter

Grass-Fed Meat

Books

The 4-Hour Body by Timothy Ferriss

Body By Science by Dr. Doug McGuff & John Little

The Cholesterol Myths by Uffe Ravnskov

The Better Baby Book by Dave Asprey

Mentions

Link to BBC article on sleep.

Wellnessfx Post (with a $100 discount!)

Dr. Ray Kurzweil

Listener Q & A Summary

  1. What supplements can you take to boost immune function?
  2. Should you sleep twice a day instead of once?
  3. Are flax seeds safe?

Biohacker Report

“Orbital prefrontal cortex volume predicts social network size: an imaging study of individual differences in humans.”

“Quality control, accuracy, and prediction capacity of dual energy X-ray absorptiometry variables and data acquisition.”

“Exposure to soy-based formula in infancy and endocrinological and reproductive outcomes in young adulthood.”

Questions for the podcast?

Leave your questions and responses in comments section below.

You can also ask your questions via…

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Listener Questions

Michael

In addition to eating a healthy diet, what supplements do you suggest to boost the immune system?

Michael

What are your thoughts on this interesting piece of research about sleep [link].

Walter

I know flax seeds suck as an omega 3 source as they are exclusively ALA. For omega 3s I take cod liver oil every now and then but mainly just eat grass fed meats/fish and reduce my omega 6 intake. However, is there anything wrong with ground flax seeds to add some crunch to meals?  I heard they have many of the same problems as soy in terms of phytoestrogens. What do you think of ground flax seeds (not flaxseed oil)?

Don’t forget to leave a ranking in iTunes.  It helps more people find our show.

Chronic Sinus Problems? Try the Bulletproof Sinus Rinse

You might think that the colder months are the only time for sinus infections, but many people suffer from sinus problems year-round. Do you recognize any of these symptoms — constant low-grade congestion, facial pain, headaches or chronic colds? Then you might benefit from this simple sinus hack that’s made my sinus problems obsolete.

[readmore title=”Try these quick and easy methods to clear your sinuses”]

I suffered from sinus congestion for a whole decade. I was living in a house with toxic mold that triggered chronic sinusitis. My nasal cavity was almost always blocked, which is no good for your performance or your happiness.

It got so bad that I scheduled a routine “roto-rooter” sinus surgery, affectionately likened to plumbing for good reason: the procedure manually clears your sinuses as if they were a clogged drain. I was lucky that three days before, I figured out this hack that cured my sinusitis. I am so grateful that I did because most people who get the surgery have to go back and get it again since it doesn’t fix the core problem, which is inflammation. Focusing on the symptom is not sustainable; you have to target the cause.

For millions of years, mold and bacteria have been at war. Mold exposure can cause bacteria inside your sinuses to form a biofilm in response to the moldy threat. According to one study, mold can even cause sinusitis in those who have no specific fungal allergy [1].

In some cases, your sinus bacteria start to produce lipopolysaccharide, an endotoxin that impairs cognitive function in mice [2,3]. Even if you don’t produce lipopolysaccharide, sinus congestion is a background annoyance that robs your body and brain of energy. Here’s how to hack sinusitis.

How to clear your sinuses

There are three methods for effective sinus relief that I recommend.

1. Get a sinus saline spray. This can give temporary relief by moisturizing your nasal cavity, but frankly, it isn’t the best option. If you have a chronic condition, it will simply return when the spray wears off. I use this on airplanes when I don’t have access to other tools. I suggest Xlear, which you can buy at Whole Foods. Their formula includes xylitol, a sugar alcohol that inhibits the growth of nasopharyngeal bacteria [4].

2. One step better is using a Neti Pot. This is a little pot that you fill with boiled and cooled salt water so you can irrigate your nose. The technique has its origins in Ayurveda, the complex system of medicine developed in ancient India, and there are numerous studies showing that saline nasal irrigation is effective [5,6]. Neti Pots are good but can be a hassle to carry with you if you travel.

3. The best nasal irrigation I’ve found is a Bulletproof Sinus Rinse. Boil filtered water, cool it to a warm temperature (not hot enough to burn you, but still fairly warm), and and pour it into a large sterilized salad bowl. Next, add salt; enough to make the solution isotonic (roughly ½ teaspoon for every cup of water). Salt water – the key ingredient in all these techniques – prevents bacterial growth, whereas regular water promotes it. The next ingredient you’ll add is a few drops of iodine, and, if you wish, xylitol.

  • Place your bowl on a counter and bend forward like a dippy bird. Don’t tip your head back or you’ll gag. Your spine should be parallel to the floor.
  • Now blink your eyes two or three times. The iodine will sterilize the lining in your eyes where there is a huge amount of bacteria that result in the inflammation of your immune system. This doubles as a way to beat hayfever by clearing the pollen and pollutants from your eyes.
  • Now, close your eyes and “drink” through your nose. The solution won’t go down your throat if you are at the proper angle; rather, it will collect in the back of your mouth. When your mouth is full, spit the water out in the sink, and repeat.

On another day or at another time, try this version: use GSE (grapefruit seed extract) instead of iodine. You can keep using the xylitol. GSE is a broad-spectrum antimicrobial for fungus and bacteria [7].

Do the Bulletproof Sinus Rinse regularly to break up the biofilms in your sinuses. It’ll reduce inflammation and clear your mind. When I started using this technique, I did it about 10 times a day, because my sinus congestion was so severe. Now, I only do it once or twice a week as maintenance. It changed my life.

One word of advice, however. If you have never done this before, you probably don’t want to try it first on the night of a hot date. If your sinuses are shaped in a certain way, the solution can reach deep into your maxillary cavity. You might hear it sloshing around, and it can sometimes drain out of your nostrils without warning. Not the most attractive thing to happen mid-dinner.

If you have postnasal mucus – the real gunky stuff in the back of your throat – and it is making your congestion extra stubborn, you can try Guaifenesin, an expectorant drug often sold over the counter, followed by the Bulletproof Sinus Rinse. Guaifenesin isn’t the best thing to put in your body because it has artificial coloring, but it will thin out unwanted mucus. The Bulletproof Sinus Rinse should take care of the rest.

Are you experiencing any sinus problems? Give this a try and let me know how it goes in the comments below. Happy biohacking!

 

[expand title=”Click to read the complete list of references.” swaptitle=”Click to hide references.”]

[1] http://www.mayoclinicproceedings.org/article/S0025-6196(11)64808-8/abstract

[5]https://www.ncbi.nlm.nih.gov/pubmed/7956408

[6]https://www.ncbi.nlm.nih.gov/pubmed/11458213

[2] http://www.sciencedirect.com/science/article/pii/0169328X9490197X

[3]http://onlinelibrary.wiley.com/doi/10.1002/(SICI)1096-9861(19960715)371:1%3C85::AID-CNE5%3E3.0.CO;2-H/full

[4]http://aac.asm.org/content/39/8/1820.short

[7]http://online.liebertpub.com/doi/abs/10.1089/10755530260128014

[/expand]

The End of Alzheimer’s w/ Dr. Michael Fossel – #363

Why you should listen –

The end of Alzheimer’s may be only a few years away! That’s the bold claim made by Dr. Michael Fossel, a pioneer in the revolutionary field of telomerase therapy. This ground-breaking technology has the potential to be one of the biggest scientific breakthroughs the world has ever seen by eradicating deadly diseases while at the same time prolonging the human lifespan for hundreds of years.

Bulletproof Executive Radio at the iTunes, App Store, iBookstore, and Mac App Store

Watch

Listen

Follow Along with the Transcript!

[expand title=”CLICK HERE to read along with the transcript!” swaptitle=”Click to hide transcript”]

Click here to download a PDF of this transcript

 

Dave: Hey guys you know I love Dollar Shave Club. I’ve been using the razors for quite a while now and the shave is fantastic. What you probably don’t know is that they’ve got a bunch of other amazing products too. For instance they have a new skin repair serum that’s got a ton of hyaluronic acid in it which is something you really, really want to use to have healthy collagen in your skin.

 

Once you join the club, you’ll see they’ve got a bunch of other great stuff for you and it’s all affordable. Right now is your chance to see for yourself why so many of us love Dollar Shave Club. If you’re not a member yet and you’ve never joined, now is the time. You get your first month of razors for free. Just pay shipping. After that, it’s only a few bucks a month. Join today. Head on over to dollarshaveclub.com/bulletproof. That’s dollarshaveclub.com/bulletproof.

 

Female: BulletProof Radio a station of high performance.

 

Dave: You’re listening to BulletProof Radio with Dave Asprey. Today’s cool fact of the day is that believe it or not many experience Alzheimer’s disease as often as women. It turns out though there are more women with Alzheimer’s disease and other forms of dementia than men. That’s just because there are women on the planet because they live longer than men.

 

Basically us guys we die sooner and that’s why there are women with Alzheimer’s even though we get it just as much as they do. It turns out too that men get a higher occurrence of vascular dementia which is where you’re having problems with blood delivery to the brain which is going to cause you to have the cognitive dysfunction that often comes with aging and a different study found that brain atrophy is more common in men than women. Not only do women live longer, they seem to have brains that don’t shrink as much as men’s. Either way it seems to be a good idea to take really good care of your brain and take good care of the rest of your body so that you can like me live to 180 or beyond. At least that’s the goal. As I’d like to say I’ll die trying.

 

Before we get into the show here’s a big announcement for you today. Actually it’s a small announcement like 3 ounces small. After receiving literally thousands of emails from people requesting something more portable than our 16 and 32 ounce bottles of brain octane BulletProof is finally rolling a 3 ounce travel sized bottle. They’re portable. They’re spill proof. They’re TSA friendly and they come in just under the 3.4 ounce liquid they make for airplanes. That’s really important for someone like me who travels over 100 days out of the year. In order to celebrate the kickoff of the new 3 ounce bottle of brain octane, I’m offering you a chance to try out the new 3 ounce bottle for free.

 

All you have to do is pick up the cost of shipping. Just text the word bpradio to the number 38470 on your mobile phone and then respond with your email address to get a special coupon code for a 3 ounce bottle of brain octane free when you pay standard shipping anywhere in the US. Again just text the word bpradio to the number 38470. That’s number 38470 and reply when you get a text back asking for your email address so I can email you the code for a free bottle. I actually started carrying 6 of these bottles in my quart size zip lock and its still carry on legal.

 

If you haven’t checked out the BulletProof upgraded aging formula in a while, this is one of those profoundly effective things that is on the website that you might not have heard about. It helps your brain function better in 4 different pathways that are tied with aging including mimicking the effect of caloric restriction, helping you to have healthy blood sugar levels as well as helping to protect your neurons from exposure to excessive levels of glutamate. Strange little antioxidant compound that’s a part of the Krebs cycle that you can take. It’s very meaningful. I take it every day as part of my anti-aging stacks. If you haven’t heard about this it’s on bulletproof.com. It’s called BulletProof upgraded aging formula.

 

Before we jump into the show which as you might have guessed has something to do with neurodegeneration and maybe even talking about Alzheimer’s and stuff like that. One of the first problems I worked on solving after I developed the BulletProof diet and shed all of my unwanted fat was I had to shop for new clothing. Everything from pants and T-shirts to shorts and dress suits. Buying a suit was always painful for me. Finding something that’s comfortable, affordable and built with quality materials was a painful experience.

 

Then someone introduced me to Indochino. Indochino is one of the largest made to measure men’s wear brands. They’re making it easy for men to get a great fitting, high quality suit and shirt at an incredible price. Here’s how it works. Visit indochino.com or drop by any of their 9 North American showrooms. Pick from hundreds of fabrics and patterns. Choose your customizations from lapels to pleats to jacket linings and more. Submit your body measurements. Kick back, relax and get ready to step into the best most stylish suit you’ve ever worn in just 4 weeks.

 

This week BulletProof listeners can get any premium Indochino suit for just $389 at indochino.com when entering code BulletProof at check out. That’s 50% off the regular price from made to measure premium suit plus shipping is free. That’s indochino.com promo code BulletProof for any premium suit for just $389 with free shipping. You’ll never have to worry about badly fitting suits or expensive trips to the tailor again. Get ready to look like a million bucks.

 

I’d love it if you want to go to iTunes and just said “Hey give us a 5 star feedback.” BulletProof Radio is not just me there’s a team at BulletProof. We pull together these episodes for you. We film them. We record them. We edit them and we do it with the intent of helping you know some stuff that you don’t know. The side effect is I get to ask people questions I would ask them over drinks anyway although in this case it would have been a high resveratrol nonalcoholic drink if it was my decision or at least high polyphenol.

 

Today’s guest is Dr. Michael Fossel. He’s a highly respected physician, author, lecturer, neurobiologist and he’s pretty famous I would say for his work around telomerase therapy as a possible treatment for we’ll just say for aging or as I call it cellular [senetions 00:06:13]. He teaches biology of aging at Michigan University, has written a bunch of books on ethics and aging and he’s working on bringing telomerase therapy to trials.

 

If you don’t know about telomeres or telomerase there’s a theory that your cells only have so many divisions before they run out of telomeres and telomerase could be the secret to that. The Wall Street journal called Dr. Michael Fossel’s latest book the Telomerase Revolution one of the best science books of the year. This is a book that if you’re a serious biohacker you absolutely should read. In the meantime just to convince yourself that you should read it, why don’t you hear from the man himself Dr. Michael Fossel. Welcome to the show Dr. Fossel.

 

Michael: Hi dude thank you. Let’s keep doing 180 years too please.

 

Dave: It’s a deal. When people call you Dr. Fossel do they automatically just think that you’re either really old into aging or that you work with dinosaur bones? Which is it?

 

Michael: No, I always wished I’d been a paleontologist. It would have been a great thing to direct a museum of paleontology like a fossil. I had to tell you though when I was kid there was five of us in the family. My mother was a single mom and one Sunday morning was quiet around the house. Now if you have five boys and it’s quiet, there’s a problem. She came down to the bottom of the driveway and discovered us putting up a big sign that said 50 cents come and see oldest living fossil. She made us take it down.

 

Dave: For the record for people who might be searching for you on amazon right now it’s F-O-S-S-E-L not F-O-S-S-I-L. That’s awesome. The things kids do, right?

 

Michael: Adults too actually. That’s [inaudible 00:07:55] for that.

 

Dave: You said something amazing at the beginning of your book when I was reading it that I thought was actually worth repeating so that you could tell me why you chose this. In the book dedication you wrote to those with minds open to logic and eyes open to data may others be as open to you as you are to the world around you. To those who aging and suffering hear others tell you nothing can be done, they’re wrong. What made you put that in your dedication?

 

Michael: A couple of things. There are really two separate points three. One is I discovered that a lot of people have very closed minds. Sometimes they have the right idea but they still are not thinking accurately. You see this in politics. You see it in science. You see it in a lot of things. With regard to aging where I see it as that people often don’t focus on logic or even better on the data, they focus on their own prejudices about how things work. As usual nature and biology and medicine is usually much more complex than people realize but they sometimes just make a decision about what can and can’t be done and that’s particularly true of aging.

 

We sometimes divide diseases into a couple of categories. Those things that we think we’ve gotten some place on for example infectious disease. Diseases that we can’t do anything about but we think we’re about to. For example some genetic diseases. Then there’s still this category that people have in our heads of disease they don’t think we can do anything about and that is almost always age related diseases whether its Alzheimer’s or otherwise.

 

I’ll give you an example of this. Last year the World Health Organization, Margaret Chan was the director who put out the annual report this month last year that said it was time we give up the curative model. If you give up the curative model you’re certainly not going to cure it. If we’ve given up the curative model for polio in 1950 we’d still all be on iron lungs and having leg braces. I think that when somebody says you can’t cure age related diseases, what they mean is they don’t know how you could do it but I think it takes a little more imagination, a lot more logic and some careful thinking about all this.

 

Dave: That’s a pretty bold statement to say just flat out cure it. It reminds me of another time in my career. I’m a computer science guy by training. I worked in Silicon Valley for a long time and when I was getting my degree in computer information systems they taught us really carefully “Don’t use the term artificial intelligence because it’ll never come true. It’s just too big of a thing. Use these other words like decision support systems which is what my concentration was in my studies.”

 

Decision support systems are a part of artificial intelligence but we would never call it that. It’s happening now with aging where they’re saying, “Well don’t say you’ll cure aging. Oh my goodness that could never happen.” If you look at the state of artificial intelligence now it’s actually happening and we have self-driving cars and machines that write their own code. They actually did it. It just took them 25 years longer than they thought. Is the same thing happening with aging right now?

 

Michael: I think so. Somebody pointed out the quote the other day. A [Lord Kelvin 00:11:04] back about almost 200 years said that we would never have heavier than air aircraft. It felt that way because if it’s heavier, it falls down but you’re neglecting the Bernoulli principle. You’re neglecting aerodynamics. From his standpoint it made sense that there never could be a heavier than air aircraft but the Wright Brothers less than 50 years later proved him wrong. I think that’s where we are with regard to aging too. If what you think about is a sort of a small molecular approach. Can we cure this with just a few chemicals? The answer is no but if you think more carefully about how [inaudible 00:11:38] works I think the answer is yes.

 

It reminds me about that general point about aging as a disease. There are a lot of biologist who would say that aging is not a disease. To me this is simply a matter of semantics. What [inaudible 00:11:50] is that the very same people who tell me that aging is not a disease are dyeing their hair, getting Botox. It just goes on and on. They act like it’s a disease but they’re telling you it’s not. I don’t really care whether it is or isn’t. The point is to see us improve people’s lives and I think we can do it.

 

Dave: There’s so many different theories of aging. Aubrey de Grey is a friend who’s infamous for his … I just blanked on it if it’s five or seven. It’s certainly an odd number. Anyway, main theories of aging and telomeres are definitely something to pay attention to in that there’s other big theories of aging. Can you walk me through some of them? I know you write about this in your book, but what are some of the historical aging theories that stand out most to you as being interesting?

 

Michael: The problem with most of them is that there are some aging theories that aren’t theories because you can’t test them. My aging theory is that it’s all caused by little green demons and if I can’t prove that then that’s not a theory. It’s just an interesting conversation over that glass of resveratrol and alcohol that you’re talking about earlier. That’s fine but that’s not science and it’s not medicine. There were a lot of theories that are essentially not testable but there an awful lot of theories that fly in the face of what we know about things. I’ll give an example of this.

 

One theory would be that all aging is just a matter of entropy and things fall apart over time. That’s fine except that if you think about it you realize that the cells at the tip of my nose here are now 65 years old and they came originally from a cell from my mother who was 40 something when she had me. It came from her grandmother who came from her mother. In fact in a very real biological sense the cells on the tip of my nose are now 3 ½ billion years old. Why did that cell not age and yet in the matter of six decades I screw up? Why the difference?

 

The same thing will be said for the greater mitochondrial theories of aging. It is true the mitochondria play a big role on aging but if your theory of aging is that mitochondria just fall apart over time then you have to explain why the mitochondria in my body came from my mother that came from her mother and those mitochondria go roughly a billion and a half years. What you have to say is not that mitochondria cause aging but that mitochondria didn’t age for a billion and a half years and then in a matter of decades they age. Why?

 

What you find is a number of these theories they fly in the face of common observations. If what I’m doing is looking just at dogs and cats and horses and pigs and people, animals for example birds or fish, they all seem to age and yet if you go back to the cell line and expand your view biologically, you discover that there are exceptions. Things that don’t age, things that do age common things do but not everything does. It reminds me of physics.

 

Classical physics works fine until you go down to the quantum level or up to the level of relativity and then you find you need to expand your view. The same is true of aging. If what you’re doing is just looking at dogs and cats and people, you’re right. If you expand it and look back the germ cell line and expand your view back through time, you realize that your explanation of aging doesn’t hold on.

 

Here’s another one. There’s that old explanation of how the universe is created. It sits on top of a turtle. What does that sit on the turtle it sits on a turtle? It’s turtles all over the town. If what I want to do is explain aging in terms for example with just endocrine changes, then the question is, “What endocrine gland sets the pattern?” Name it. Then, what times it would end that endocrine gland? Is it turtles all the way down? Why is it that some animals don’t age as fast as others and certain organisms don’t age? Is that all just endocrine and non-endocrine? The answer is it doesn’t actually [inaudible 00:15:43]. When you try to explain there’s turtles all the way down, you’re missing something.

 

The disadvantage of looking at things in terms of telomerase and cell senescence is that those people actually don’t understand. I understand its complex. The advantage is that it actually is consistent with all the data and furthermore when we intervene it works is that we can reset aging in human cells, human tissues and as far as we can tell somewhat in people.

 

Dave: I’ve just finished writing a book about mitochondria and there’s pretty good evidence. We can measure mitochondrial efficiency. There’s pretty good evidence that 48% of us before age 40 have early onset mitochondrial deficiencies. In other words it’s like the engine in your car it blows a gasket. It still runs. It just doesn’t run quite as well as it did. The efficiency of energy production goes down over time and over 40 almost everyone is making less energy per rotation of the Krebs cycle because they’re leaking electron somewhere.

 

I know that you can hack that and when you do you get immediate performance improvements and many of the neurological diseases of aging go away. It doesn’t mean that it makes you live forever. It doesn’t mean it cures aging but it seems like it’s an important variable. Do you support that view or is it even less important in your view of things?

 

Michael: It is important but you’re still not looking back far enough fundamentally and asking yourself why that happens. If we look more example for example at mitochondrial function particular with the Krebs cycle. What you find is that all of the enzymes that are responsible for the aerobic portions of the Krebs cycle who are not from mitochondria but from the nucleus. What you’ve seen is that if you look at the rate at which those are turned over, because it’s a dynamic process, you don’t just get an enzyme that sits there for 100 years.

 

No, it’s continually coming apart and being replaced by new enzymes. There’s a turnover process. What you find is that if you look at the enzymes that are supplied from the [inaudible 00:17:45] they begin to be downregulated as the telomere shortens. What you’re finding is that the turnover rate in your mitochondria goes down.

 

I’m giving you an example. Let’s say that any of your listeners work in a great big building and they have a maintenance budget of $100,000 a year to clean the floors, clean the windows, do the carpets. They decide to save money and they cut it back to $10,000. You get the same cleaners that just don’t come in as often. They’re very efficient they just only now they come in every two weeks rather than every day. Likewise the soap is the same and the vacuums are the same. The amount of dirt is the same but the whole building begins to look dingy it’s all because you turned down the maintenance budget.

 

That’s what’s happening with mitochondria. You’re turning down the rate of which you’re turning things over. You’re not cleaning things up as fast. The outcome is as you’ve already said if I look at a whole mole of sugar I put in and I ask how many ATP I get for that, the answer goes down. If I ask how many reactive oxygen species [inaudible 00:18:44], the answer goes up. It’s worse than that because the same thing is true of the [bilipid 00:18:48] membrane that holds the mitochondria together. What it does is it sequesters reactive oxygen species.

 

Not only you’re making more but now the lipid membranes aren’t being turned over as fast. Again, that’s not just a static membrane. They’re continually turned over so they get leakier. Not only they leaking but then once they get out there, you trap reactive oxygen species, [the peroxide 00:19:10] dismutase, catalase. You have a number of compounds but the ones that you create in your cells for example SOD and catalase turn down also.

 

The efficiency of trapping those escaped mitochondria go down and then your efficiency of repairing the enzymes you destroyed, the protein damage because of reactive oxygen species go down. You make more reactive oxygen species. You leak in your membranes. You don’t trap them and you don’t repair the damage. All of those ultimately go back to changes within the nucleus. The mitochondria plays a huge rule but it’s because of what’s happening in the nucleus that the mitochondria fails.

 

Dave: That is a part of the equation but it’s also because of what happens in the environment around us. We have epigenetics. We have what happens even in the nucleus of a cell is controlled by the environment around you. In other words …

 

Michael: Exactly.

 

Dave: If you don’t get like the circadian component, the idea that your mitochondria are derived from bacteria, they had a night and they had a daytime. You had bright lights at night, you get mitochondrial dysfunction. You’ll probably also get endocrine dysfunction higher up in your brain and all that. it seems like there’s this really complex interaction between our genetics and our nuclear DNA and with the environment. You’re saying that that also then influences telomeres and influences your mitochondria which is why aging is such an ugly problem to hack, right?

 

Michael: Oh yes. I would never say that telomeres cause aging. I’m not sure that the word cause makes a lot of sense.

 

Dave: Fair point.

 

Michael: Before you interne. It’s a practical issue for me. Let me put that whole epigenetic issue in context because you’re absolutely right. First of all, if I look at all of your genes and I ask, how many genes actually express proteins that actually go and do something yourself? The answer is about 1 1/2 %. Then I look at the rest of your genes and I ask myself, what do they do? We know that at least 30% to 40% of your genes actually are regulatory. What that tells you is that approximately 30 times as many genes are involved in regulating genes as they are involved in actually making important proteins.

 

The genes that actually do the work, the protein producing genes, are very tiny component and everything else controls them. That’s why the difference between my hair cells and my toe cells is not genetic. It’s regulatory. It’s what controlled, what’s expressed. The same thing is true with regard to aging. The difference between [TA-6 and TA-65 00:21:34] is not [inaudible 00:21:37] it’s all epigenetic. It’s all just the way they’re expressed. Now what you’ve done is beg an interesting question which is well that’s nice, but what controls the epigenetic change? You’ve already alluded to telomere shortening and that’s fine. Why does that happen? The answer is the rate of telomere shortening depends on what I want you do to.

 

Example, if I’m a professional basketball player and I jump up and down on my knees all day, I’m killing all chondrocytes. They’re being replaced by the other chondrocytes there and those cells of your body. In short, they’re aging faster which is why old basketball players have worse osteoarthritis than old yoga people. The same is true with everything else.

 

Do you smoke? Do you have night shifts? Do you go out in the sun and get sunburn? Are you exposed to radiation? It just goes on and on. That brings us back to the interesting question about what causes aging. The answer is depends what you mean by cause. It’s like, what causes this podcast? What are you asking? What level you want to get an answer here? That’s why I think from my perspective when it comes to aging, the question isn’t so much what causes it is where you can intervene.

 

Dave: How do you like it?

 

Michael: Causation is like little kids asking why. It’s a slippery concept and it’s usually intellectually lazy. What you need to do is specify what you mean and what can we do about it.

 

Dave: What can we do about aging men? In fact, I want to ask you that question but I realize some listeners may not really know what telomeres are and I gave a very back of the envelope perspective but you have been studying them for decades. Can you define telomeres and telomerase so people have a really good picture of it in their head? Then let’s talk about what you can do about it.

 

Michael: Usual analogy and it’s not a good one in some ways. Usual analogy is that little plastic sleeve at the end of your shoelace if anybody have shoelaces these days called the aglet. There’s even a song about that from Phineas and Ferb I think. In any case they are the last several thousand base pairs at the end of each chromosome. What’s interesting is that as cells divide they shorten but what’s important is as they shorten they effect a pattern of gene expression throughout the rest of these chromosomes.

 

They act in some ways like a clock. By the way, they don’t unravel. I’ve heard that before various times in various places on some medical TV shows. They don’t unravel. They just shorten. It also [doesn’t matter 00:23:56] what the length is, the question is what’s the change in length. That’s why some mice have telomeres that are 10 times longer than ours typically and yet they have mice spans that are typically 20 times shorter than ours. It’s not the length, it’s the change in length and what that does to the pattern of gene expression back to which you said with epigenetics.

 

Epigenetics is everything. Sometimes people worry about genes that are involved in 20th century medicine. Very bright people but that’s 20th century medicine. Twenty-first century medicine is epigenetics. It’s much more complex than we realize, much more important.

 

What’s going on is that as the telomere is shorten, it changes the pattern of gene expression. It changes the tune that the orchestra plays and the result is that we begin to fail and get diseases. The question is, what happens if you use to reset it? That was first done 17 years ago. We can do that in human cells and when you do that, you reset the entire pattern of gene expression and the cells act like young cells. It was first done in human tissue 16 years ago, works fine. The question is, can we do it to people and will it have the clinical results that we think it will? The answer is we’re about to find that out.

 

Dave: What do you predict will happen in those studies?

 

Michael: What I predict is a couple of things. One is the major worry which I will [pass by 00:25:13] now unless you want to get into it has been cancer. The answer is no actually telomerase appears to be more protective against [inaudible 00:25:20] causing. There are some interesting little exceptions as ever and they’re complex. The very general way you’re less likely to get cancer if you have a long telomere than if you have a short telomere because it upregulates [inaudible 00:25:32] longer telomeres upregulate DNA repair.

 

The other thing is, what happens to cells and tissues? The answer is they act like more young cells and young tissues. As I said those were first done in human tissue 16 years ago. What you find is you can for example take old human skin cells and grow young human skin. Don’t tell me you can’t reverse thing that was done at least 16 years ago. The question is, can we do with you? That’s a different question.

 

We have a number of ways to do that. I can think of about four or five right of the bat some of which probably are technically very hard to do. There are a number of targets we can use. We’re going to after Alzheimer’s disease for a number of strategic reasons. That’s our first target.

 

Dave: Why Alzheimer’s disease?

 

Michael: let me put it this way. Say I have an experimental gene therapy and I tell you I can get rid of some wrinkles with it but we’re not sure of the side effects. It’s an experimental gene therapy. My response would be, “That’s nice [inaudible 00:26:35] in a couple of years.” I don’t want to take the risk.

 

Now say I say to you also you got osteoarthritis in both knees and we could give you a new replacement. We can put you on Motrin. We can tell you good luck. Would you like to try an experimental gene therapy? Again, practically speaking my personal answer would be, “Let me know how it works for a year or two and talk to me again but not today.”  There are alternatives. You can always get a knee replacement. I’m not recommending it personally but it’s painful. It’s got risks on its own and yet what else could you do.

 

When it comes to Alzheimer’s the answer is there’s no alternative. Alzheimer’s is 100% fatal. The average time to death is eight years. People vary a lot. The only way if you don’t have Alzheimer’s is something else kills you first like pneumonia. There are literally no drugs that really affect Alzheimer’s. There are some 5 drugs in the global market and none of them has ever been shown to have any effect in the course of the disease. There are a number of drugs in FDA trials right now and although they’ve been shown to have some effect on things like beta amyloid or mitochondrial function, none of them have ever been shown to affect the course of the disease.

 

Dave: Nutritional ketosis seems to affect the course of it pretty dramatically like Dominic D’Agostino has been able to show a couple of times that it seems like we made some progress there.

 

Michael: I don’t think so. I just say I disagree.

 

Dave: That will be a fascinating conversation. We probably won’t cover it in this interview but we may have to have you back on. That’s cool. I respect you’re willing to just put it out there the way it is. I didn’t expect that you would experiment …

 

Michael: Let me give you a different thing though. Let me just say that I think that we can cure Alzheimer’s disease. Very few people would say that. For example, if I go to the Alzheimer’s association website, you’ll find one of their webpages says that their goal is to help people live to live with Alzheimer’s.

 

Dave: Terrible.

 

Michael: Not me. I’d like to let people learn to live without Alzheimer’s.

 

Dave: Damn straight.

 

Michael: It’s doable. I think it’s doable in two years.

 

Dave: Wow! Within two years because of the therapies you’re working on?

 

Michael: Yes.

 

Dave: Wow! God speed to you on those because that’s a game changer. Part of my goal at BulletProof is to meaningfully reduce the incidence of Alzheimer’s through basically epigenetics. There’s things you can do that set yourself up to get Alzheimer’s you just do them 20 years before you get it so you can either delay or prevent it just by making lifestyle changes much earlier.

 

Michael: I agree. In fact, let me come back with a couple of historical precedence. This one is not exactly parallel but it’s pretty close and that is polio. If I go back to 1950 and I say, “What are you going to do to keep your kids from getting polio?” People would talk about avoiding public pools. Avoiding large social gatherings. There was a book that was a bestseller in 1952 in the United States that was called Diet conquers Polio. There was a reason for that. I don’t believe that diet conquers polio but I am pretty convinced that probably if you have a terrible diet and therefore a weakened immune system, you probably have better chance of getting polio.

 

Given a choice between a good diet and a polio vaccine to prevent polio, I’d go with the polio vaccine perfectly in favor of diet. If I really want to prevent it, I’ll take the vaccine. However, if I was in 1952 I’d be focusing on diet. I’d be focusing on public pools. I’d be focusing on a lot of things. That’s what we are with regard to Alzheimer’s disease.

 

I know someone who I diagnosed with ALS. He went off to a snake bite clinic and he asked me did I think it would work. My answer was no I don’t think so but were I in your shoes, I’d go to the snake bit clinic. There’s so many things like that with regard to Alzheimer’s disease. There is I think commercially right now available nothing that will cure Alzheimer’s disease but I would be trying everything I can think of whether it was exercise, meditation, diet, you name it. Not because I think it will absolutely work but because what have you got.

 

Dave: Biohacking is this concept that I’ve popularized and the gist of it is you change the environment around you and inside you so that you have more control of your own biology. I feel like I had nothing left to lose in my mid 20’s because I was 300 pounds. My brain wasn’t working. I had massive cognitive dysfunction, arthritis in my knees since I was 14. I feel like I’m old. I feel like I’m dying and I’m 29. They told me I’m going to have a stroke and a heart attack. I got nothing to lose. I’m going to hack this.

 

I spent half a million dollars in 15 years and became known in anti-aging and things like that. For the exact same mindset you have there, you’re like, “I have Alzheimer’s. I have X amount of years. I might as well try everything because if I don’t try everything I know what’s going to happen.” I felt that way as a young man which informed a lot of what I do today. That mindset is something that I think a lot of people maybe don’t have even when they have terminal cancer, may have Alzheimer’s, may have ALS. Are you seeing a change in patients or in the population where people are more willing to experiment because they realizes they’re facing the end?

 

Michael: Yes. I think that in some sense it’s always been true but there have been some remarkable changes in the stress in people’s lives. The other day I was looking at old Cary Grant movie from 1940 I think it was and we’ve all seen old movies like this where the banker for example, the genetic banker with gray hair. Everybody is looking up to this banker and he runs the bank. He’s a remarkable person. You go online to find out how old he actually is and you discover that he is 45 years old and you would swear he’s 85.

 

We’ve all seen people in old movies who look older than you and I would have thought they look these days. Some people don’t think I look 65 but the point is they live different lifestyles. The stress is involved in those lives. Those days were different. Almost all are [inaudible 00:32:28] smokers. They were probably heavier drinkers than most of us are right now. They had different lifestyle. We all have stress but the stress that’s involved in those people’s lifestyles were different than ours. The epigenetics were different. Their genes were the same. The genes in your parents and your grandparents weren’t any better than ours but it’s what you talk about biohacking. Leading a better lifestyle whatever that may be is a good idea.

 

People have sometimes said to me, “How can I live longer healthier lives?” They expect me to say I’ve got this one little thing I’ll give your right here it’s going to solve everything. No, the answer is the same advice that your grandmother gave you that you didn’t pay attention to. Your doctor gave it to you. You didn’t pay any attention how many cost too much but it’s the same standard advice. Eat well, exercise well, avoid people with loaded weapons, fasten your seatbelt. This is not sexy advice. It’s not terribly difficult but it’s not something that most people do and yet there is a cultural change I think in favor of doing things like this.

 

I remember when I started practicing medicine 30 or so years ago, I tried to avoid telling people to take up yoga because it was a religion. Now it’s okay. I can say this. I don’t have to say stretching exercises. I can say yoga. Things have changed. There is an acceptance of this as a standard part of your care for yourself. A better diet whatever that may be. A better exercise program or stretching, yoga, meditation those things were sort of no-no back in the 40s last century.

 

Dave: we’ve definitely shifted there. Let’s go back to telomeres. You talked about what they are. How are we going to go about changing telomere length? Walk me through the types of therapies that you’re looking out for this.

 

Michael: There are a couple of them. What you got is there’s an enzyme that’s actually a two part enzyme but it’s an enzyme in your body in each of your cells and its created from a gene. All of your cells have this gene that’s usually turned off. Some of your cells occasionally make little bits of telomerase but generally you don’t as an adult. The question is, how can we either turn it back on or [provide 00:34:37] telomere so there are a number of ways.

 

You could say let’s fine something that turns on the gene, a telomerase activator and there are some on the market that may not be what they’re cracked up to be but there are there. You could also say, “Never mind turning on the gene, let’s just put in another gene.” That sounds like taking a sledgehammer to a fly but maybe that’s the opportunity to take. Another approach would be to say, “Never mind the gene and never mind turning on the gene, let’s put in the telomerase which is fine if you can get it into the cells without it being destroyed. That is, can I administer telomerase by vein or mouth?” Not so easy.

 

Another way would be halfway between the gene itself and the protein there are messenger RNAs. Could I put one in that tells your body create this? The answer is yes that works fine in the lab but it’s very fragile molecule. There’s at least one or two other possible ways but those are the big four. The telomerase activator as I say have been available on the market. Now let’s see 2007 I think the first one came in the market. Here we’re talking about astragalus [sites 00:35:44].

 

Dave: Yeah.

 

Michael: There is a lot of interesting evidence not overwhelming but good evidence that they have an effect on the age process and the number of clinical ways. For example, blood pressure, blood glucose control, osteoporosis, inflammatory changes, it goes on and on immune function. None of the data is overwhelming. It’s not like somebody suddenly went from being an 80 year old to a 20 year old but there are significant changes and they’re interesting. I think most of us in this field would say that those changes they’re there, they’re probably only about 5% as effective as what we’re trying to get. The other approach is genetic. Go ahead.

 

Dave: Plus they’re very expensive. For two years I took about 250 mg of very high potency astragalus extract every day. It was about 500 bucks a month for the form I was taking. If I was taking the most common brand, it would have been $5000 a month whatever the dose was. Maybe my hair got a little bit less gray but man I’m not really sure. It was a lot of money and there are many other supplements I take where you can feel and see difference more powerfully than you can at least than I could with that supplement from that source. I’m a little bit skeptical that the bang for the buck is there. That cost as much as growth hormone which I know you’re also not a fan of at all. It has as much as some of the other big gun approaches to be more youthful. Do you take that stuff? Do you take astragalus?

 

Michael: I do but I have the advantage of having it given to me. There are at least three issues with taking it. The first is, does it work? The answer is probably. Not dramatically but probably yes. The second question is, how much does it cost? You’ve already alluded to and the answer is far more than most of us would like to unless we’re absolutely sure it was going to turn our lives around and make us healthy. Still it’s a lot.

 

The third question is, are you getting astragalus or not? Are you getting astragalus for example. The answer is one if you pick it up from an herbal store for example in Chinatown the answer is it doesn’t seem to be much effective [astraganal 00:37:57] present in the root that you get. There are certain sources that I think are probably highly reliable and there are others that I can’t comment on because I just don’t know. I’m fairly certain as a guess just knowing human nature that there are number of sources out there in the internet that are ineffective and they’re taking your money and providing nothing useful. I don’t know that that’s true. That strikes me as typical human behavior in any commercial enterprise.

 

My strong feeling is that the TA-65 provided by [TA sciences 00:38:31] is probably the real thing. It probably is effective. I think I’ve got good reason to think that it certainly what is used for the scientific studies but still those same three questions. Does it work? Oh well. How much does it cost and am I really getting the compound I want? Those are realistic questions. Not easy for anybody out there.

 

Dave: For our listeners listening to this and there’s probably somewhere quarter million or half a million people will hear this interview, some portion of them are easily able to spend $500 a month. It’s a small portion of them and there’s some others who could probably do it if they made some cuts and others who are like it’s on the table right now. I’ve got a family to feed and I can get a little bit of ketosis in my life without changing my bills at all. There’s a broad spectrum. For the people who can spend 500 or whatever more or slightly less per month to do it, do you think that it’s a good idea to start taking the high potency astragalus extracts?

 

Michael: You put it exactly right. What you’re doing is you’re taking a bet. You’re betting that that’s really the astragalus side that’s active. You’re betting that it works and you’re comparing that to the amount you’ll spend. If I had $20 million and was not the least bit concerned about paying my mortgage, my health insurance, yeah I’d probably do it in a heartbeat and I’d pick the most reliable source I could find. I [inaudible 00:39:55] but that’s not true to most of us.

 

Dave: It’s not.

 

Michael: They’re trying to figure out how to cover the rent, what to do with the recent changes in healthcare cost and the cost of a million other things. The answer is I can’t. Even if you believe it worked, even if you knew it was a reliable source, you can’t afford it. That’s reality.

 

Dave: One of the functions …

 

Michael: I find something better than that.

 

Dave: One of the functions of this show is to bring attention to the really expensive stuff so that the cost will come down dramatically. If there’s enough demand for things like this, the cost drops by orders of magnitude over the course of five or 10 years so I would hope that because of this conversation, five years from now instead of $500 a month, it’s $100 a month or better yet you disrupt the heck out of it and you tell us what you’re about to tell me which is why you could this more potent. What’s above this?

 

Michael: You’re exactly right. I got it involved with early progeria gets back 30 years ago or 40 years ago now. These are the kids who would age, aged seven look like they’re 70 years old and I used to know them all. We’d get together once a year with these kids. In a typical year you’d have a three or four dozen kids globally that you know about with progeria. If I had a drug that cost $36 million to make which is actually cheap these days, that would be a million dollars a kid and nobody could afford it. On the other hand if I’ve got a world population of billions of people and it cost me billions of dollars to put it together and that’s a dollar a person, that’s not bad. It’s that market question. Have we got enough people out there to make it so that we can afford to treat this? Aging is not an [orphan 00:41:37] disease.

 

Dave: What are we going to do about it?

 

Michael: I look at the cost of putting together the gene therapy that we’re going to try for Alzheimer’s disease. Without getting into the specific numbers, for example when I do the Alzheimer’s trial with 12 patients probably starting about a year from now, the major single cost would be putting together the gene therapy not the actual administration or the patient care, its actually creating the initial run of the gene therapy lead. As it turns out the cost drops to about 40% of that as soon as I open that up to dozens and dozens of people out there but just the first dozen. That’s before you even begin to pull in technical changes and our ability to create these things. The cost drops dramatically.

 

Let me compare the kind of cost you’re looking at and caring for Alzheimer’s disease. Typically right now a month of good quality Alzheimer’s care is not atypical for those to run $10,000 to $15,000 a month. That’s a lot of money. I can’t afford it. You can’t afford it. In fact, globally we can’t afford it but those are the same arguments people had in 1950. I’m serious when they were talking about the cost of iron lung’s rehabilitation and leg braces for polio victims year 2000. The estimated was it will break the bank globally.

 

Polio is not expensive these days. It’s a very small part of the world health budget. I think that’s where we’re going with Alzheimer’s disease. We’re going to start by being able to say, “Listen, instead of spending an average of say $60,000 or $100,000 a year on nursing home care for Alzheimer’s, what don’t we spend $40,000 initially and get rid of the whole thing. What if we lower that cost even further by having more people and being able to do this as a mass treatment so maybe you get down to the cost of $500 once every 10 years to prevent you from getting Alzheimer’s.” Now you’re beginning to talk about something that we’re not yet able to afford.

 

Dave: That’s exactly how it works. It sounds weird but same is true if you look at your cellphone. It’s got amazing compute capacity in it that exceeds the world’s compute capacity 30 years ago. I think I got my numbers or maybe 35 years ago or something like that where it just boggles the mind. The cost is almost nothing whereas we’re putting tens or hundreds of millions of dollars into building those early computers. The difference is shocking. It’s happened with polio and it will happen with diabetes, cancer and Alzheimer’s but it seems like it’s happening really damn slowly right now compared to the amount of tech we have. Why is it so slow?

 

Michael: Dave I agree with you. Actually this becomes a very personal issue for me because I’m going to I think try to avoid naming names here but the principle comes through. There’s somebody I like who has been involved in trying to take the same approach to a one off treatment offshore and avoid the FDA. The thought would be move faster and I agree with this because here I am already talking about being two years away from being able to demonstrate I’ll be able to cure Alzheimer’s disease and that means an awful lot of people will die in two years.

 

On the other hand, if this person is correct, what will happen is no one believe the results because it’s only one person at a time. This person was in the middle age when it happened and the measurements they’re doing may not affect anything about Alzheimer’s disease. If I’m either a national healthcare system, you pick your country, or a major insurer, you pick your insurer, or a clinic, hospital, a physician would I believe the results? The answer is no.

 

The risk is that this person will go on to do something that may be effective but since no one will find credibility in it, it’ll end up costing $5 million say per treatment and they’ll only be able to treat a dozen people who have the $5 million or several dozen whoever they find worldwide. I’d rather take a little longer which disturbs me because I don’t want it to take so long but be able to get to the point where it only cost a couple of hundred dollars and I can treat everybody.

 

Dave: What does gene therapy look like? How would a patient go in assuming that it works and there’s clinical trials? How would it be administered?

 

Michael: There are a number of ways. Ultimately we may be able to administer this with just a nasal inhalation but typically right now what we would do is an IV administration. Our example we’ll probably going to do this through a lumbar puncture only because it’s about 80 times cheaper and it’s a big amount and it matters to us. You end up giving it as a shot and that’s about it. We monitor you for a couple of weeks. In the FDA trial we’re planning on doing, we’ll be monitoring you minimum of six months and see how people do. Of course, following up beyond that. We anticipate seeing changes within a matter of months with our treatment but it would be in this case a lumbar puncture. I don’t like giving [inaudible 00:46:41]

 

Dave: I had a lumbar puncture to have my own stem cells injected into my cerebral spinal fluid to help my brain stay young and probably to deal with some traumatic brain injuries as well as chemical brain injuries just because I plan to live to 180. What do you think about stem cells?

 

Michael: I think that all of medicine is changing. I just became the editor in chief of the new geriatric journal and one of the things that we’re focusing on is not better nursing care, better social equity but actually curing disease. I think what’s going on is that there are a number of thrust in medicine that are just beginning. They include gene therapy, epigenetics, cell therapies in general and stem cell therapy in particular. These are all things that are very different from what we’ve been doing.

 

Let me give you an analogy again. Let’s say that I go back to medieval Europe and the Black Death is coming. There’s a plague coming. You and I have come from the 20th century and in fact let’s say we identify it’s not Black Death. We know its small pox. You and I know something about small pox are trying to convince local people that if we use cowpox, we can inoculate them against small pox and prevent them from dying of small pox. All the local healers are saying, “Well you know we have willow bark and that will keep the fever down. We have a number of other roots and berries and herbs all of which may work but they don’t prevent small pox.”

 

A lot of medicine up until now has been this small molecular thinking. Can we find a better statin? Again these are all small molecules. Those small molecules can be very effective for things. Again, willow bark or aspirin may be very nice for fever and headaches but it doesn’t prevent Alzheimer’s disease. It doesn’t prevent small pox. It doesn’t cure Ebola. If you want to deal with some of these more complex diseases and viral diseases come to mind but sort of age related diseases, you have to think a little further outside the box.

 

You have to realize that small molecules as much as they have a great history i.e. where would we be without penicillin maybe. They don’t do everything. If you keep trying to look in the small molecular box for a solution to a large molecular problem that’s outside the box, you’re going to fail repeatedly. What I’m really saying is that stem cells, gene therapy and so on, this is the wave of the 21st century to treat diseases that we thought we could never treat before, that we can treat and can cure.

 

Dave: What do you do? You’re 65 year old. You’re the head of a new journal geriatrics. You’ve been studying aging. You’re a physician. You’re a neurobiologist. Walk me through a day. What do you do to stay looking as good as you look?

 

Michael: I get up. I meditate. I’ve been doing that for 50 years or something.

 

Dave: What flavor of meditation do you do?

 

Michael: I actually used to teach courses on this too. I used [to teach 00:49:39] yoga as well. I tend to do a Buddhist form of meditation I’ve been doing for 40, 50 years. I garden. That’s my exercise. I’ve had people say “Well that’s not exercise.” My response is, “That’s because you haven’t taken 30 cubic yards of mulch and pitchfork it around the garden.” [inaudible 00:50:00] realize that this gardening can be a full contact body sport. I garden and it’s more than just exercise for me obviously. It’s another form of relaxation and pleasure.

 

Not much. Exercise tends to be daily moving up and down the stairs. Have you ever noticed certain healthy people if they go up the stairs, they move up very quickly and they bounce up. Other people go up slowly and drag themselves up. It seems to me that many healthy people exercise in their day to day movements. I notice that you sitting in your chair and me sitting in my chair have not sat there quietly staring at the camera. We nod our heads. We move around. We move our arms. Sometimes exercise is more than just paying money to go to a health club.

 

Dave: I absolutely agree with that. In fact I spend not a lot of my time doing formal exercise about 15 minutes a week. I do other things that are unusual. What about supplements? You mentioned you take astragalus extract. You take a fistful? I take actually three fistfuls. Do you use supplements?

 

Michael: It probably depends on which year and what my mood is. One of the things that I’ve been doing regularly and I want to make fun of this in some ways is [brewer’s yeast 00:51:12]. This derived from an old story about my mother during World War Two who was told she had to gain weight. The doctor said, “Listens you can either take brewer’s yeast as a supplement or you can take beer which of course had a lot of vitamins in those days.” She said she tasted brewer yeast and I promptly became a confirmed beer drinker. Sometimes I say I take brewer’s yeast for three reasons. One is that it makes me feel good. Two is that it’s pretty cheap because no one advertise it and three is it taste so bad it’s got to be good for you.

 

Dave: Have you looked any of the studies on that form of [inaudible 00:51:48] in cancer? There’s some pretty good relationships between brewer’s yeast and baker’s yeast and incidence of cancer and candida and things like that. It’s one of the reasons I steer clear of it. You may have seen a lot more than I have on it.

 

Michael: No, but I’ve seen some inconsistent results and some curious results. I always tend to look as I think we all ought to. At medical studies with a jaundiced eye not because they’re wrong but because I still remember hiring a brand new physician in our service and probably about three months they came in with an article said this proves A works and my partner and I looked and said, “Yes but two years ago they proved it didn’t work. Five years before that they proved it did work. Seven years before that they proved they didn’t work.”

 

The answer is been there before, seen that. I’ll wait [inaudible 00:52:40]. I think the same is true of a lot of this data. It is interesting and there probably is something in it but sometimes the answer is just aren’t in. I also see the same thing with regard to telomere data particularly where people look at the wrong thing. For example, one of the problem is that people will measure your telomeres in your peripheral white cells. Very easy to do. You got a finger prick I can measure. The problem is that almost nobody dies of aging leukocytes. You die of aging vascular cells. You die of aging cells in your brain. You have problems with your knees because of your chondrocytes. Those aren’t leukocytes.

 

The second problem is that those things are being turned over all the time. They’re turning. If I have a lot of stress, a viral infection, a bad diet, my immune system [inaudible 00:53:29] turning over at those leukocytes so that the peripheral lymphocytes that have short telomeres. If I then begin to meditate, better diet, I lower my stress, I get a dog, you name it, whatever get some more sleep, get rid of night shifts, what you find is your telomere links begin to increase but it’s because you’re no longer turning them over as fast as peripherally. It doesn’t mean you’re younger.

 

It means you’re not as stressed anymore which is good but if I looked at your marrow cells I’d see they’re solely still ticking away, slowly getting older. It’s still good that you did all those things but to measure peripheral lymphocytes as a measure of whole body aging, it’s like me saying, “I’m going to measure one city block in the Bronx 50 years ago and today and if now younger people live there, that means the whole country got younger.” No, it means the [inaudible 00:54:17] moved out and a bunch of yuppies moved in. They started new businesses and they’ve got a bunch of three year old kids. No wonder they’re younger but the rest of the country is still getting older too.

 

Dave: I see that exactly. Now we have that same group of people listening who are happy to spend $500 a month on supplements to at least retard aging. How should they go about getting their telomeres tested? What’s the gold standard test?

 

Michael: that depends on realism too and it’s not easy. There are at least two commercial sites that I would think about. One would be Telomere Diagnostics out in California. The other would be Life Length in Madrid. They measure slightly different things. The Madrid study is looking at average telomere lengths and the one in California is looking at the shortest telomere lengths. Both of them tend to look at lymphocytes. If you want to get some general measure probably it’s easier just to use Telomere Diagnostics in California because it’s in the US. You don’t have to ship things elsewhere. I would just take the result with a grain of salt.

 

Dave: how would a nonmedical professional go about taking the results with a grain of salt? What does that mean? I have actually two test kits from the last American Academy of Anti-Aging Medicine. I went there and picked up a couple of test kits. I don’t remember the name of the lab. Every time I’ve tried to get my blood drawn for them, it’s usually like a quest. “We won’t fill that vial with your blood.” I’m like, “It’s my blood and my vial. Put it in there you bastards.” Anyway, just a side note. I still haven’t done this because I’m not a doctor and I probably could just fill them myself but I’m lazy. I don’t have those results yet.

 

Michael: I’d happily do it for you. I’ll stick you with needles any time Dave.

 

Dave: Thank you.

 

Michael: The telomere diagnostics one in California send you one of those little needle prick things where you prick your finger and you get one drop of blood and that’s it.

 

Dave: That’s convenient.

 

Michael: Yeah. I think its $89 and you could do it in the quiet of your own living room any time.

 

Dave: We’ll put the link on the show notes here and I’ll make sure I get the right name for that. I haven’t done that one. Does it work? Would you use those results or is it so grain of salt that its nah?

 

Michael: It’s probably reliable in a sense that is let’s say that your 60 year old and it comes back and suggest you’ve got a telomere health at 50. That’s good news as opposed to getting one back that says you’ve got a telomere health of 80. The problem is you really have to intercept it in terms of how’s your life been going. As I say if the last 6 months have just been going through hell. I had divorce. My dog died. I got fired from my job. I’m on this terrible diet of eating cardboard everyday plus junk food as well. Then I think you can expect that those numbers are going to be unrealistically bad for you.

 

If what you’ve done is done a lot of good things, then getting confirmation that your telomeres are nice and long, shouldn’t surprise you. That’s why you’ve been doing good things for the past five years. It’s got some value but they tend to get over read. About once every week there’s another study out that suggest that if you eat vegetarian diet or you name it, that somehow it’ll make your telomeres longer. Then answer is it might but on the basis of the data that you published.

 

Dave: I am really interested in once a year. I’ve drawn my blood 97 I’ve gotten tested about every year or so with a whole bunch of biomarkers, with one of the very early A4M guys. It’s been really informative because you can make lifestyle changes and see the change in the curve. Your vitamin D levels go up, you got to get more sunshine. Your inflammation levels go down when you eat less [inaudible 00:58:14] and all these things you can do to get your parameters about where you want them and you can test changes. If I get this $89 test every year, is it going to tell me whether you’ve done good last year son or is it really not going to tell me enough to be useful?

 

Michael: I think it will tell you whether you’ve done well in the last year. On the other hand, I mean most of us not always. Most of us already know that.

 

Dave: Good point.

 

Michael: You knew that when you were young and you said, “I’m going straight to hell physically and you may [check this 00:58:46].” I don’t think it took any deep knowledge to figure that out. Having said this, some people don’t. Some people suspect they’re in trouble don’t want to face it and don’t want to do anything about it. This provides an objective measure that you’re in trouble I suppose or that they’re doing well.

 

Again, I can’t help thinking what I said before is still true which is that your mother is cheaper. Your doctor told you the same advice but having said that, I really do believe that telomeres are a critical measure of what’s going on in terms of cell aging but you’re measuring blood cells and you’re not just blood. There’s a lot more to you than just blood. It’s worth some but it’s not the be all and all of aging. It just isn’t.

 

Dave: I’m still working on getting the big nugget for people listening to the show today. Other than maybe meditate, exercise and eat right, what are they supposed to do given what you know now to influence the length of their telomeres given that the gene therapy isn’t available yet? Is there at least a directional thing you can offer besides the main lifestyle epigenetic things?

 

Michael: Again, most of it isn’t sexy and it boils down to the old moderation in all things. For example take exercise. I could go out and try to run 100 miles a week, what’s the optimal for my body? Am I increasing the aging of my knees even though I’m making it better for my heart? Good question. I could have an optimal diet whatever that is, but is that any better than a really pretty good diet? I think that for me diets are [wine and coffee 01:00:24] in some ways. I can tell a difference between a god awful wine and an okay wine. If it’s okay one versus an incredibly expensive very good wine, the answer is “All right I’ll take your report.” Same thing with coffee.

 

Same thing with diets. If you have a terrible, terrible diet, you’re in trouble. If you have a pretty good diet, that’s good. How much better is an excellent perfect diet than a pretty good diet? It’s probably not worth all the stress you put yourself through trying this all out. As I sometimes say to people, “If I can prove you could live double a lifespan by living in the basement in the dark and easting sawdust, would you do it?” “No, I’d have another chocolate mousse.”

 

The stress of trying to engage in a diet that just does not fit your body, maybe worth it in one sense but costly in another. It needs to be a balance between yes you need a pretty good diet but after a while chill out. I used to get these patients who’d come in and they’d say, “Doctor my blood pressure is too high.” I said, “How do you know that?” I said, “I took it 12 times so far today.” The best thing is to throw out your blood pressure cuff because you’re already causing damage to your body if you’re that nuts. The same is roughly … again I don’t mean to overplay this but in terms of diet. You need a good diet but if what you do is end up stressing yourself worrying about the whole time, you’ll just undercut yourself. Chill out, relax, go meditate.

 

Dave: There’s this thing called orthorexia and the whole point of the BulletProof diet here the way I recommend is look know what direction perfection lies in and just lean that direction. You don’t have to be perfect by a long shot but just know what direction it lies because a lot of people like, “I think I eat healthy. I just eat two cinnamon buns a day instead of four.” Maybe you could just tilt that a little bit better in the right way.

 

Michael: Every now and then you need a glass of champagne or a piece of chocolate but you shouldn’t be drinking champagne and eating chocolate all day. My god, you know.

 

Dave: If you blend them with butter, it’s okay.

 

Michael: There you go. We’re all nuts here. We’re just a little nuts.

 

Dave: We are indeed. This has been a fascinating and fun interview Dr. Fossel. I want to ask you one more question and I think you may have already answered it but I would just clarify it. I ask every guest on the show this. People who are authors and researchers and various other people who have done cool things. If someone came to you tomorrow and said, “Based on your life’s work and on your life, so basically everything you know, I want to perform better at everything I do. Like interview ant to kickass at life by just being a human being. What are the three most important things I need to know?” What would you tell them?

 

Michael: First thing is figure out what you actually want in life. I can’t tell you how many people I’ve run into who want to be famous until they mistakenly realize that that’s a disaster. I have a friend who wanted to be chairman of a department at Harvard who became chairman of the department at Harvard and he’s unhappy. He’s got a divorce. His kids hate him. He doesn’t like his job. Does it occur to you that the goal that you have is wrong?

 

I think that the key for our lives many times is to pick the goal. If your goal is to be the best plumber in the world, you should be that. If the goal was to raise kids that you really enjoy as part of your family, that’s what you … If your goal really is to make $10 million and that will make you happy, you go right ahead. Finding that goal is not so easy. It’s sometimes not a matter of just getting what you want or kicking ass, it’s somewhat figuring out what ass you want to kick and that’s not easy. We’ve tended sometimes to kick the wrong one.

 

Dave: Very well said. There was one. You got two more.

 

Michael: Never give up. Never, never, never give up. I used to say pretty simply in writing that tools of writing are one, stop talking about it, just write. Stop telling your friends you’re going to write a book. Write the book. Don’t talk. The second rule is never give up. The classic was [inaudible 01:04:20] getting turned down by 13 different publishers. Don’t give up. So many people have given up. Stop giving up. Persevere. It’s not easy. It’s painful. It’s annoying. I’ve been working on this for 20 years and [there seems 01:04:34] people just don’t see it and now we’re involved in trying to get the financing to take this Alzheimer’s trial.

 

If I give up, it definitely won’t do. Henry Ford was a real pain in the tush. What an obnoxious human being in many ways but he’s got all number of incredibly good quotes and the classic was one about that he came up about “Whether you think you can do something or cant you’re right.” If you’re thinking you’re going to fail, you’re going to fail. If you think you’re going to do it, you guys still fail but you’re going to find out.

 

When I was in high school, my guidance counselor told me I was too stupid to go to college. Thank you very much for your opinion. Thank you very much, I appreciate it. Kiss off. Never take no for an answer.

 

Dave: I love that one. Know which ass to kick and you never give up.

 

Michael: As I say just do it. That was part of the …

 

Dave: Just do [inaudible 01:05:28].

 

Michael: Yeah. Don’t talk about it. Don’t say, “Someday I’m going to learn a foreign language.” No, that means you’re not. Someday I’m going to travel the world. That means you’re not. Someday I’m going to make a million. That means you’re not. Someday I’m going to marry the right person and have kids. No, just do it. Stop yapping about it. Don’t tell your friends. Don’t put it on Facebook. Don’t tweet it. Just do it. If you go ahead and tell somebody afterwards what you’re doing go right ahead but talking about it and doing about it are not the same thing.

 

One other things we’ve gotten involved in this whole Alzheimer’s work is people come to us for interviews. As I was doing some world report called me I said, “Don’t mention my name. Don’t mention the biotech company because whatever you do I’ve got all these emails to answer. I don’t want publicity. I want to get the work.” I shouldn’t be talking to you at all Dave. Please don’t tell them who I am and don’t tell them anything about me. Publicity is not the same as getting work done.

 

Dave: It’s not the same as getting the work done but you’ve done something that’s actually a gift for people. As a fellow author you spend thousands and thousands of hours on writing a book. You condense so much of your life’s work into this and it takes someone four to six hours to read the average book. In terms of leveraged time, there is no better leverage than buying a book for 20 bucks because you’re getting thousands of hours from an expert. It only takes four of your hours to absorb it.

 

Publicity here is people should read your book because they’re learn this stuff and the odds of them reaching out and talking to you are pretty low unless they’re working for media and you’re looking to sell more books or hopefully to get some support whether its funding or regulatory support or whatever else for the studies you’re doing because its important work and people should know important work is happening.

 

Michael: Dave you remind me of a professor at Berkeley who we were talking about … I was finishing writing a book and she said, “Writing a book is just like having a baby.” She said, “At about eight months through one, can’t you believe you’ve been at it this long. Two, you can’t believe that it’ll ever come to an end. Three, you cannot for the life of you remember why you agreed to do this in the first place.”

 

Dave: Exactly. Having just turned my manuscript in about three weeks ago, I think I’m at that stage right now.

 

Michael: You’ve given birth. You’re happy now. I hope that it was post mental depression for you. Hope you’re enjoying it.

 

Dave: I think my copper levels are high enough but I do believe that I probably shortened my telomeres a little bit writing the book because you’re running a company, you’re writing a book all night long every night for a while I could do that but it was worth it.

 

Michael: Oh you poor you. Good for you. Congratulations Dave!

 

Dave: Likewise, congratulations on your book. For listeners its called the Telomerase Revolution by Dr. Michael Fossel, F-O-S-S-E-L. You can check that out on Amazon. Anywhere else that they should go to find it?

 

Michael: It’s also out in seven languages and 10 global markets now.

 

Dave: Seven languages.

 

Michael: Two different Chinese editions, three English editions, French and Wales, Russian, Spanish, whatever.

 

Dave: Must be in Japan, right?

 

Michael: Strangely enough no although my first book 20 years ago was apparently a bestseller in Japan.

 

Dave: I got back from japan three days ago and it turns out the BulletProof Diet is 160,000 copies number one bestseller in Japan and I had no idea. I went there to do book signings. It was completely unpredicted but I think they would love your book.

 

Michael: Hopefully they do.

 

Dave: [inaudible 01:08:55] rights.

 

Michael: My book will never pay the mortgage, never make me [inaudible 01:08:57] doing. It sounds like yours will do better and I wish you the best.

 

Dave: Thank you so much. I appreciate you being on BulletProof Radio and have an awesome day.

 

Michael: You too. Thanks Dave.

 

Dave: If you enjoyed today’s episode you know what to do. Head on over to your favorite bookseller and pick up a copy of the Telomerase Revolution. There’s a lot you can do to live maybe forever. Certainly to live a lot longer than you were going to live if you did nothing and that’s what I’m doing. You can join me in learning about that stuff on BulletProof and read this book telomerase matter, mitochondria matter, epigenetics. This idea that the environment around you changes your biology is terribly important.

 

The idea that you can take control of that with biohacking is really important. By reading a few books like this, read the BulletProof diet and read books by the dozens and dozens of other authors who’ve been on BulletProof radio, you can have a toolset that lets you not just live longer but actually feel better, have more energy and be a nicer person while you’re living longer and that’s really the golden thing you can find here. Have a beautiful day and if you like this episode, please head on over to iTunes and leave a five star review. Only takes you a second and it actually matters. I look at those every day. Thank you.

 

 

 

[/expand]

Make Bad Decisions? Blame Dopamine w/ Bill Harris – #362

Why you should listen –

Making bad, compulsive decisions might be behavior some of us just can’t control.  Bill Harris, the Founder of the Centerpointe Research Institute, discusses how the effects of stress can flood the brain with dopamine, leading to poor judgment and compulsive decisions that can have disastrous consequences. In this episode Dave and Bill reveal the best defenses against “terrible choice syndrome” with an arsenal of their most powerful biohacking tools.

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Dave Asprey: We’ve all been there guys. You get out from a long drive or a meeting and it hits you, the need to readjust. You know what I’m talking about, it’s the worst. Thankfully, Tommy John has the cure. Tommy John is the 21st Century men’s underwear brand that’s redefined comfort for guys everywhere including me. It’s unbelievable. They combined feather light, breathable fabrics with innovative design. It fits so perfect, it’s almost like wearing nothing at all and it’s impossible to get a wedgie. Tommy John’s next generation design even includes the patented horizontal quick draw fly. Talk about a game changer.

 

Their undershirts are just as incredible. They go on like a second skin and never come untucked and even their socks are engineered to stay up all day long. By the way, I have like giant feet and I can tell you that’s a challenge for me and their socks kick ass. Guys, for a truly mind-blowing undergarment experience, look no further than Tommy John. All their underwear is backed by their best pair you’ll ever wear or it’s free guarantee so you’ve got nothing to lose. Tommy John, no adjustment needed. Hurry to Tommyjohn.com/bulletproof to get 20% off your first order. That’s Tommyjohn.com/bulletproof for 20% off. Tommyjohn.com/bulletproof.

 

Speaker 2: Bulletproof Radio, a state of high performance.

 

Dave Asprey: You’re listening to Bulletproof Radio with Dave Asprey. Today’s cool fact of the day is that ambient music could have a really profound effect on your creativity even more so than playing your favorite power tunes. A recent study on creative cognition showed that moderate noise levels increase thought processing difficulty which leads to heightened abstract processing which inspires creative thinking.

 

Basically, the sounds make you work just hard enough in your thought processing to force you into being creative. On the other hand, loud noises that make you work too hard and that are too distracting can reduce your ability to handle information effectively. Bottom line is sound is one of the environmental variables that you can use for biohacking that could increase creativity or could decrease creativity depending on what you do with it.

 

Before we get into today’s show, here’s a big announcement for you today. Well, actually it’s a small announcement, like three ounces small. After receiving, literally, thousands of e-mails from people requesting something more portable than our 16 and 32 ounce bottles of Brain Octane, Bulletproof is finally rolling out a three ounce travel size bottle.

 

They’re portable, they’re spill-proof, they’re TSA-friendly and they come in just under the 3.4 ounce liquid limit for airplanes. That’s really important for someone like me who travels over 100 days out of the year. In order to celebrate the kick-off of the new three ounce bottle of Brain Octane, I’m offering you a chance to try out the new three ounce bottle for free. All you have to do is pick-up the cost for shipping.

 

Just text the word BPRADIO to the number 38470 on your mobile phone and then respond with your e-mail address to get a special coupon code for a three ounce bottle of Brain Octane free when you pay standard shipping anywhere in the US. Again, just text the word BPRADIO to the number 38470. That’s number 38470 and reply when you get a text back asking for your e-mail address so I can e-mail you the code for a free bottle. I actually started carrying six of these bottles in my quart-size ziploc and it’s still carry-on legal.

 

Have you heard about the new Casper Mattresses? I like these guys because they have an in-house team of engineers who spent thousands of hours developing a new mattress that combines springy latex and supportive memory foams that are low in toxins for a sleep surface that’s got just the right amount of sync and just the right bounce. Plus it’s breathable and it’s an amazing mattress because mattresses are oftentimes well over a couple of thousand dollars. Casper Mattresses cost $500 for a twin-size mattress or up to $850 for a queen or only $950 for a king.

 

They’re very, very fair priced for a low toxin mattress which is almost unheard of. They’re obsessively engineered but it’s a very fair priced and Time Magazine just named it one of the best inventions of 2015. In fact, it’s now the most awarded mattress of the decade and I like it that it’s so accessible. You get free shipping and returns to the US and Canada and best of all, you can get it for a 100 nights risk-free in your own home.

 

If you don’t love it, they’ll pick it up and refund you everything. It’s made in America, not overseas with all sorts of weird chemicals. You can get $50 today towards any mattress purchase by visiting www.casper.com/bulletproof and using Bulletproof as your promo code. Terms and conditions apply. That’s casper.com/bulletproof with promo code Bulletproof. Today’s guest is none other than veteran biohacker, zen monk, musician, composer and all around philanthropist, Bill Harris, the founder and CEO of Centerpointe Research, creator of Holosync. Bill, welcome to the show.

 

Bill Harris: Hi there, Dave. How are you?

 

Dave Asprey: I am doing really well. We’re friends. You’ve been on the show before, you’ve spoken at the Bulletproof Conference, you gave away some copies of your book, The New Science of Super Awareness, at this year’s conference and you’re one of our most popular guest on Bulletproof Radio so welcome back.

 

Bill Harris: I’m glad to be here. There’s always more to share with people.

 

Dave Asprey: Now, you have your Holosync Program, your audio program for train the brain. Something that I first used … Geez, I want to say somewhere around ’96, ’97, I started using your program and you’ve had over two million people in 193 countries that use Holosync which is absolutely remarkable. Even researching the brain, I wouldn’t say ever since but the entire time, how did you get two million people in 193 countries to use your program? Is there a secret?

 

Bill Harris: Well, I haven’t done a count lately but two years ago, it was 2.2 million people in 193 countries. Part of that is because we’ve been doing this for a long time. I started researching this in 1985 and in 1989, I started Centerpointe. The first few years probably shouldn’t count, maybe in terms of refining it they did, I didn’t know what I was doing the first few years so we didn’t grow very fast. At a certain point, it did really take off.

 

I think that the reason Centerpointe has been so … Maybe there’s three reasons why it’s been so successful. One of them is that Holosync really is amazing. In a world of personal growth products that are mostly garbage or warmed over somebody else’s something, I just happen to stumble on something that really, really makes a huge difference. We didn’t know this in the beginning but it creates a profound positive changes in two extremely important parts of the brain.

 

We can talk about this a little bit later and so, it affects people mentally, emotionally, physically, spiritually. It just creates all kinds of dramatic changes. The second thing is that fairly early on, I was fortunate enough to meet some of the best marketing communicators in the world. Some people think marketing is all manipulation and this sort of a thing but I think that marketing is skillfully telling someone how what you have will benefit them and helping them to make a decision that is in their best interest to make.

 

I met people that are really good at this and now, I’m considered to be one of them so I’m a very good communicator. A good product, really good marketing and then I don’t know, I’ve always been a curator of information. I mean, you’re like this too. Both of us don’t have long strings of credentials after our names but we are passionate enough about all these stuff. Just like you, I read voluminously, I read scientific papers, I take courses, I meet people who are smarter about the brain and things like that and I relentlessly pick brains.

 

I’m a curator of information. I do all these stuff because I’m passionate about it and then, I’m really good at communicating it to people in a way that saves them a ton of time. It’s easy to understand, people have big a-has and I think part of it is because as I started to figure all these stuff out and figure out how to get myself straight, because I was such a mess, I hit the wall many, many times and made many, many mistakes, screwed up, got stuck on many things and then, I was persistent enough that I figured out how to get around whatever it was.

 

I had a real appreciation for what it was like for other people to learn this stuff and figure out how to adopt it and make it per their lifestyle. I’m really good at describing that in a way that people go, “So that’s what that’s about.” It really helps people to get better results, to stick with it. I was interviewing Cynthia Kersey not too long ago. She started the Unstoppable Foundation that builds schools in Africa and I give lots of money to her and have built many schools in Africa.

 

Dave Asprey: Yeah, we’re at that dinner together supporting that.

 

Bill Harris: Yeah, exactly. She said something right at the end of her interview, she said, “Do you want me to tell you the secret to being unstoppable?” She had a bestselling book called Unstoppable and her foundation is the Unstoppable Foundation. She said, “You want to know the secret to being unstoppable?” and I said, “Yeah, sure.” “Don’t stop.”

 

Dave Asprey: That is a profound secret. Your comments there, if I boil it down, is have a product that works really, really well and be really good at explaining how people can benefit from it. That seems like the recipe for success. It’s the same thing with [inaudible 00:11:06].

 

Bill Harris: Don’t stop.

 

Dave Asprey: That’s a [crosstalk 00:11:08] point, yeah.

 

Bill Harris: Last year was our 27th anniversary and I’ve seen so many other people in personal growth-related or human potential-related businesses who’ll do something for awhile and then they’ll stop and do something else. First of all, you’ve got to have something that’s really good. If it’s not really good, you’re just a poser in my opinion and there’s a lot of stuff like that out there. If you have something that’s really good, why stop? Keep going. I mean, that’s how I’ve created this huge, iconic brand Holosync and Centerpointe. Everywhere I go, it’s embarrassing almost and I’m sure this happens with you too, everybody knows me. People walk up to me in whole foods and say, “Thank you so much for Holosync.” I’ve never seen the person before but people know who I am because of all this and I didn’t do anything PR-wise to try to make that happen, I just kept making a really good product and putting out good information and helping people and that just happened. Everybody knows what Bulletproof Coffee is too.

 

Dave Asprey: Yeah, it’s happening and it’s a similar spirit there. Let’s talk about your new book, there’s a subset of our listeners who are interested in how does one become successful like that. In fact for you guys, I’m going to do a different podcast on business because most people listening to this, you care about performing better at everything. You want to have control of your own biology but you may not, frankly, care even a little bit about how to be an entrepreneur but that’s my other big passion so I’ll do a podcast on that for you but I will separate it from this one so that you don’t have to hear me drone on about business if you don’t want to but I’ve just had to ask Bill because two million people is big. Now Bill, you’re holding up your book, The New Science of Super Awareness. Tell me about it.

 

Bill Harris: For the longest time, I was trying to communicate to people what Holosync does and one of the things that I said to people was that when you listen to Holosync, it raises your threshold for what you can handle. When you’re under your threshold, you feel pretty good, everything seems okay. When life pushes you over that threshold, wherever it is, you start to become stressed. You start to exhibit various dysfunctional, coping mechanisms and you don’t feel very good.

 

It occurred to me a long time ago that what Holosync is doing is pushing that threshold higher but I didn’t know why. A lot of times what people are doing is trying to regulate their environment, nothing wrong with that, but there’s only so much you can do in regulating your environment. We live in a stressful environment. The world is a stressful place and there’s lots of things about the world that are stressful to human beings.

 

You don’t have enough air for [both of your 00:14:26] lungs, you die. There’s all these different constraints being a person. I don’t know, the last half of the ’90s? I began to get more and more interested in the brain and how the brain worked. I was interested in it already because Holosync is based initially on changing electrical brainwave patterns. I certainly knew something about the brain but all these research started coming out about the brain.

 

I, being a geeky guy and like I said earlier, I’m reading that stuff and being a curator of information that [people are learning 00:15:07] and then, I met Daniel Amen who has taught me a ton about the brain and I met Michael Merzenich who is the godfather of neuroplasticity and Norman Doidge who wrote a very famous book about neuroplasticity and many, many other scientists and people that knew a lot about this and it began to come together for me why Holosync works so well.

 

It’s a little more complex than this but I simplify it just because it makes it easy to hang your hat on this. There’s really two things that traditional meditation does really well. Meditation is a fantastic biohack. Meditation calms the limbic system and it enhances the prefrontal cortex. The problem with an overactive limbic system is that there’s really two main categories of problems: one is that when your limbic system is overactive, you go into fight or flight, the stress response.

 

You create all the cortisol and all these other stress hormones which are very inflammatory for your body, really bad for your health, cause you to age faster and they cause you to feel like crap. It’s just bad news. Plus blood flows away from your brain when you’re in fight or flight to your extremities so you can fight or flee and your IQ goes down, you make bad decisions. When you make decisions through your limbic system, it’s only luck if they’re not a bad decision.

 

Then, there’s messes to clean up because you made bad decisions and also, you become a raging asshole when you’re in fight or flight a lot of times so it’s hard on your relationships and all kinds of things. That’s one downside to having an overactive limbic system. By the way, almost everybody who’s in prison is there because they have an overactive limbic system. Almost everybody that has chronic problems in any area of their life, it probably can be traced back to an overactive limbic system.

 

The other problem though is that when your limbic system is overactive, you tend to be under the spell of a very powerful drug of Dopamine. Dopamine causes you fixate on whatever the latest bright, shiny object is whether it’s a sexy smile or chocolate éclair or something you think you should buy or whatever it happens to be. All those things that we crave that aren’t good for us. All those things that we regret getting involved with later on. Because when you’re under the spell of Dopamine, you cannot look at long-term consequences.

 

I mean, if you’re trying to setup a Bulletproof biohacking lifestyle, you will not be able to stick to it if your limbic system is overactive. It doesn’t matter how much you know about it or how motivated you are or Dave Asprey is your best friend or whatever, you’re not going to be able to stick to it if your limbic system is overactive because every time something crosses your path that you start to crave, you will not be able to do anything about it. You’ll just go ahead and walk by the bakery, crave at the whole foods, you’ll just say, “Wow, look at all those things.

 

I could eat some of them in the car, on the way home, it’s going to be fantastic,” and there you go. Then of course, it causes inflammation. It gives you a sugar crash, you feel crappy, you gain weight, etc. etc. all these negative things and then you go, “God, why did I do that?” Overactive limbic system. Spending money you don’t have on things you don’t need, bitching out someone you love or your boss, just countless things that people do. I got divorced several years ago and it was so stressful. Stress causes your limbic system to become overactive.

 

Anytime you go through a stressful period, unless you’re doing some things to counteract this, like Holosync, like 5HTP and L-theanine and GABA and other things that can help calm your limbic system, your limbic system is going to become overactive. Despite the fact I wasn’t taking supplements then and actually, I had not been doing Holosync very often then either, I have to painfully admit. This is quite a few years ago but I got about six speeding tickets very quickly and I had my driver’s license suspended for a couple of months.

 

Dave Asprey: Is this a first public confession here, Bill? [crosstalk 00:20:24].

 

Bill Harris: I may have said this before but I didn’t know at the time but I realize in retrospect that all that stress of coughing up $5 million and having this horrible divorce and all these stuff, right after the economy crashed in 2008 and that was stressful too. At any rate, despite even the things I was doing, my limbic system became overactive. Actually, what I did, I knew Daniel Amen pretty well and at a certain point, I didn’t even connect this to what was happening in my life, I just had this idea that I should get a brain scan. I mean, I wasn’t saying I’m having a problem, I need a brain scan. I was saying, I think it’d be interesting to have a brain scan. I hadn’t even connected my brain and my life.

 

Dave Asprey: You won’t see the problem. It’s very sneaky, it’s so [crosstalk 00:21:23].

 

Bill Harris: Yeah, that’s right. Anyway, I had a brain scan and the first thing he said to me was, “Are you using your own product?” and I said, “Well, I’ve gotten so busy, blah, blah, blah,” and he said, “You better start using Holosync again.” He told me a few other things to do including getting a hyperbaric chamber which we’ve talked about before which I did. I didn’t have the hyperbaric chamber at first but within three days of listening to Holosync, about 80% of all the stuff I was experiencing from being so stressed just went away. It took about three days. In fact, I became so convinced all over again of how amazing Holosync was just from that. Anyway, I’ve gotten off track. I was talking about the two things that the limbic system, when it’s overactive, does.

 

It causes you to make really bad Dopamine-driven decisions and it puts you into fight or flight which is great if you’re actually in a life-threatening situation. If that’s the case, then the downside of being in fight or flight is probably worth it temporarily but the idea is that after 30 minutes or an hour or whatever, all those chemicals are out of your body and you saved your life and it was worth it. When you go into fight or flight, because somebody said something critical to you or you can’t find your cellphone or some other dumb thing that is not life-threatening. A lot of people are just in chronic fight or flight all the time and they don’t even know because you get used to it.

 

Anyway, one of the things that meditation does and Holosync, about eight times better and faster, is calm the limbic system. Man, once your limbic system gets calm, you go around being so patient and kind to people and things that bothered you really easily before don’t bother you and all that sort of thing. The other part of the brain is the prefrontal cortex which is the source of executive control, long range planning, creativity, learning from mistakes, flow states although in a weird way because in a way, most of your prefrontal cortex goes offline when you’re in a flow state but I don’t know if we have time to discuss that or not. At any rate, your prefrontal cortex is also very sensitive to stress.

 

When you become stressed, your limbic system becomes overactive and your prefrontal cortex becomes less active. In fact, your limbic system actually grows larger when you’re stressed and your prefrontal cortex actually shrinks. When you do certain things to enhance the prefrontal cortex and calm the limbic system such as Holosync, the prefrontal cortex, one of the job it has that I didn’t mention and that is supervising the limbic system. The limbic system, as I know you know, fires faster than the prefrontal cortex. When you go by the bakery case in whole foods, your limbic system tells you, before your prefrontal cortex can engage, “Wow, those look really tasty. I should get some.”

 

Then your prefrontal cortex, if it’s strong enough, kicks in about a third of a second later. If it’s strong enough, then you’d say, “Yeah but the consequences of doing that are not worth it. It would taste good and be fun for about 20 seconds while I’m stuffing that in my mouth and chewing it and then, all the negative consequences and the regret will kick in,” and then, you walk past. You and I are probably two of the most disciplined people about what we are or are not willing to eat. People are always amazed. Somebody just sent me a huge box of Godiva Chocolates and I opened them and took a smell and then, I took them into the kitchen here and I’m going to let everybody else that works here, if they want to, eat that. I’m not going to eat that stuff.

 

Dave Asprey: Aren’t you a fan of chocolate?

 

Bill Harris: Yes but not Godiva Chocolates although it’s very tasty chocolate. I do eat chocolate sometimes but …

 

Dave Asprey: The source matters enormously [crosstalk 00:26:20].

 

Bill Harris: Yeah, right, right. If you’re eating it and it’s got a lot of sugar and all that stuff in it. Once you get yourself purified, you might say and you eat a little bit of something that is inflammatory in some way, you instantly feel it. If I can eat the smallest amount of sugar and I sneeze repeatedly within 10 minutes and so, I just don’t do it anymore. At any rate, I keep getting track off here.

 

Dave Asprey: You’re not off track, I don’t think because what you’re talking about here is you’re talking about awareness. Your whole book is about super awareness and what you’ve done is you’ve developed an awareness of when your prefrontal cortex versus limbic system is most active. That resonated with me very much because when I went to see Daniel Amen, maybe 14 years ago? I had no metabolic activity in my prefrontal cortex, I was basically limbic all the time. I was a successful entrepreneur going to Wharton to get my MBA so it’s not like I was dumb but I was very, very sympathetic, overdriven. My limbic system was on fire and my prefrontal cortex had zero metabolic activity when I tried to concentrate and it affected my test scores, it affected all kinds of stuff. The awareness you’re talking about, the awareness of how food affects you, awareness of what’s going on when you relax and all that, that’s the core part of your book and [crosstalk 00:27:45].

 

Bill Harris: Awareness is a prefrontal cortex activity. The more enhanced your prefrontal cortex is, the more awareness you have. What I always say about awareness and this is probably the main thing that I teach is awareness creates choice. When you are not aware, which really means limbic system and other parts of your brain that are autopilot kind of things are running the show, when you’re on autopilot, you’re just going to repeat things that have been programmed in your brain: ways to respond, ways to feel, ways to engage with food or people or whatever it is.

 

A lot of times, those automatic pilot ways of doing things are very unhealthy and they have all kinds of bad consequences. When you calm your limbic system and enhance your prefrontal cortex, the awareness kicks in. Once you’re aware, I find that there are four categories of things in particular that you become aware of: how you feel, how you behave, which people in situations you attract or become attracted to and what meanings you assign to things. Those four things, anything you become aware of, at least that you’re doing or creating, becomes a choice. Otherwise, it’s running on autopilot.

 

This is what happens when people become super aware which is why I called it The New Science of Super Awareness. When you become super aware, how you feel becomes a choice, how you behave becomes a choice, which people and situations you get attracted to or attract to you becomes a choice and what meanings you assign to things. We could go through all four of those and talk in more detail but those are really, as far as I can tell, the only real things in your life you can have a choice about. You don’t have a choice about what other people do. Most people have a different agenda than you have and you may have noticed that they’re not always lining up to be kind to you or to help you get what you want.

 

Sometimes what they want conflicts with what you want. There’s nothing you can do about it. You can influence people to a certain degree but there’s so damn many of them and you don’t have access to that many of them either. You can’t do anything about all the physical stuff in the universe, cosmic rays and gravity and the fact that human bodies are sensitive and you need a certain mixture of gases to stay alive, you need a certain amount of air pressure, you need food and water. There’s all these things that if you go outside a certain capsule’s limitations, you can’t stay alive. The biggie that you can’t do anything about is the fact that everything in the universe is impermanent.

 

You and everything else eventually falls apart, ends, whatever. You can’t do anything about that either but you can do something about how you feel, how you behave, which people and situations you attract or become attracted to, what meanings you create. Once you’ve got that, the people that you see out there and I’m not just talking to you, I mean all the people listening, the people you see out there that you envy, that you admire, that you’re saying, “Wow, I would love to have that kind of consciousness or that kind of willpower or that kind of whatever, kindness, compassion, etc, focus, concentration, motivation, whatever it is.”

 

The people you see with those kinds of things, those are people who are more at choice about those four things because they’re more aware. Some people were born with a naturally more enhance prefrontal cortex and a naturally calmer limbic system. I wasn’t one of them. I will tell you that I have a naturally overactive limbic system. When I do Holosync regularly which I do now, thank you Daniel Amen for getting me back on track, and I take a lot of GABA, I take a lot of L-theanine, I take a lot of 5HTP, I take a lot of melatonin and many other supplements. I mean you’ve eaten with me and seen my big bag of stuff I take three times a day. If I don’t take all that stuff though, my limbic system can easily get the best of me. You often tell people that I’m one of the original biohackers and all sorts of stuff, I used to watch …

 

Dave Asprey: Durk and Sandy.

 

Bill Harris: Yeah, Durk Pearson and Sandy Shaw. They used to be on afternoon talk shows like The Merv Griffin Show and stuff like that back in the I don’t know, the ’70s. They had started Life Extension [Foundation 00:33:17]. They were telling people to do bizarre things, they were saying BHA and I think, it’s BHT.

 

Dave Asprey: BHT, yeah.

 

Bill Harris: There’s all these preservatives that they put in breakfast cereals and everything, they’d say, “This will preserve you too, you should take this.”

 

Dave Asprey: It does stop Herpes, cold and chicken pox which is useful but it’s a side note.

 

Bill Harris: At any rate, they were experimenting with all these stuff long ago and really getting other people interested in it. Then, they sold Life Extension to Bill Faloon many, many years ago and there’s just a lot of information out there about this sort of thing but the general public doesn’t know much about it. People like you and Life Extension and Daniel Amen and Mark Hyman and Jonny Bowden. There’s a number of people who are evangelists for the kind of diet and the kind of other lifestyle practices that will allow you to have a brain that’s really healthy and that can perform optimally. You were with me at that one XPRIZE Foundation board meeting and I become real involved with XPRIZE since I joined the board and gotten to know Peter Diamandis. One of the things that he is in, and I don’t remember if we’ve talked about this but I think I probably told you about this, is a company called Health Nucleus.

 

Dave Asprey: Yeah, I’ve had the full scan of [crosstalk 00:35:01] full of human genome.

 

Bill Harris: Yeah, it’s a $25,000 all day long, the most complex series of tests that you can possibly take and I did that a number of months ago. I’m 66, almost 67, I literally have the health and the vitality and the endurance and all that of somebody who’s about 35 or 33 or something like that. I was walking up this flight of seven stairs in a parking structure with my daughter who’s 32 the other day and she was like going, “Whoa, who is this guy?” I mean, I was beating her at the stairs and she was breathing hard and I wasn’t. The information that’s out there today, this is not science fiction anymore. You can keep yourself young and really have a sharp brain and all those sorts of things.

 

Dave Asprey: You are a really high energy guy. We’ve known each other for a few years now and we see each other probably five times a year, you’re always full of energy. It’s cool and I’ve transformed myself too. I used to get really tired all the time and I have more capacity than ever before so that, you can absolutely do. Is that a brain state thing or is that a biology like your whole body state of thing, do you think?

 

Bill Harris: Well, I think it’s some of both but I mean, some of it is hormonal and everything. The master controller really is your brain. Daniel Amen is very fond of saying, “Everything about you comes from your brain. Your moods, your emotional responses, your skills, your talents, your superpowers, your ability to set and achieve goals, your ability to bounce back from failure, your happiness, your unhappiness, your success, your failure, your creativity, your confidence, your motivation.” He’ll go on forever naming all these things and of course, other parts of your body are also involved but I have found that if you get your brain optimized, pretty much everything else falls into place. Certainly, if you get your brain optimized and there’s something else that’s out of whack, it’ll be obvious, more obvious, what it is.

 

Dave Asprey: It’s hard or it’s harder to get your brain optimized if your body is really broken. Like if you’re not making enough energy, your brain won’t do what it’s capable of doing.

 

Bill Harris: Sure, you’re talking about mitochondria now I assume and that sort of thing. Of course, [I’ve dialed 00:37:46] the same information that you are too and I take all this pro-mitochondrial supplementation and everything and it definitely makes a difference. Testosterone levels are a big difference. I just had my testosterone checked and it was a little bit over 900 which is for somebody in their 30s.

 

Dave Asprey: Are you supplementing or no? You don’t actually take testosterone.

 

Bill Harris: I am doing some things to drive that higher but I just bought a Vasper machine which I haven’t taken possession of yet but Dan Sullivan who’s in his 70s.

 

Dave Asprey: Yeah, Dan’s a mutual friend.

 

Bill Harris: Peter that makes the Vasper machines, he told me that Dan who is a strategic coach, Dan’s testosterone was 300 about. He’s 72, not bad. 300 isn’t bad if you’re 72. Well, I think it’s bad if you’re 72 but the doctors don’t think it’s bad but after six months using this Vasper machine which does some things to trick your body into making more human growth hormones and testosterone and so on, his was up to 800.

 

Dave Asprey: For people listening, Vasper’s a really expensive machine.

 

Bill Harris: $40,000.

 

Dave Asprey: Yeah, more than $40,000 but you do cardio with cooling at the same time which prevents salicylic acid build up and it prevents heat stress on the heart.

 

Bill Harris: The pressure too on this pressured cuffs.

 

Dave Asprey: They’re cooled pressured cuffs, right?

 

Bill Harris: Right, right.

 

Dave Asprey: It’s an unusual thing and it’s something that we have at Bulletproof Labs whenever we can open Bulletproof Labs. I’m still working on that for you but it’s a powerful technology like this but the idea is by changing the signal that goes into the body. When you’re 70, in your 70s, you’re not supposed to be able to do the stuff that Dan Sullivan does.

 

Dan has been coaching entrepreneurs for more than 35 years. He’s one of the guys who’s helped me learn how to be a good entrepreneur. In fact, Daniel Amen and his program, I think just about most of the really successful entrepreneurs I know have worked with Dan Sullivan at some point or another.

 

It’s an interesting perspective that when you meet guys like you, Bill, you’re 66 and you travel around all over the place doing philanthropy and giving talks about the brain and you’ve got the energy of someone a third your age and you meet Dan Sullivan, the same thing. He’s just bubbling with energy. I don’t know if you’re 18 or you’re 20 or you’re 40, you want to have that kind of energy even then and when you’re old, it’s even more precious. You guys are examples for what’s possible.

 

Bill Harris: When you’re in your 20s, the idea that you’re going to be in your 50s or 60s or 70s just doesn’t seemed that real to you. I think about this and in some ways, I think, “Wow, it’s really going by fast.” Then other times I think about it, I think, “You know, actually when I think about all the stuff that’s happened and all of the different periods of my life I’ve gone through, it has been a long time.” It’s like I’m saying impermanence is one of the things you can’t do anything about. You can extend it and I’m hoping to live, at least, to 220 and be in good health and still be productive.

 

What was it we were talking about? We’re talking about something earlier about being more productive and I didn’t say this because we were in the midst of something else but I think one of the biggest biohacks, in a way, is creating challenges, creative challenges for yourself and then, meeting them. That releases so many beneficial chemicals in your brain and in your body. We’re talking about being a successful entrepreneur, that’s what it was. That’s one of the benefits of being an entrepreneur is that you’re faced all the time with challenges. I just set a goal, maybe 10 months ago or so, to do $100 million in sales a year at Centerpointe.

 

Dave Asprey: Wow, that’s a big goal.

 

Bill Harris: Which is about 100% increase and so, I’m positive that we’re going to do it but I’ve always set goals that just seemed ridiculous. One of the things that happens when your limbic system is calmer, it doesn’t scare the shit out of you to do that. When I was younger and my limbic system was overactive, my hands would shake. People would say you need to write out your goals so I’d write them out but my hands would be shaking and I’d be saying, “God, I’m going to look so stupid when I don’t achieve this.” My limbic system was just making me afraid. It was thinking of all the things that were going to go wrong. If you want to get rid of negative thinking, calm your limbic system. Now you see, I don’t think that way. I just think, “Okay, how am I going to do that?”

 

As soon as you start saying stuff like that, then ideas start to come to you and it starts seeing resources that you weren’t noticing before and you start seeing opportunities you’re not noticing before and you start to feel motivated and you get energized and you take action. When you take action, like Cynthia Kersey said, the way to be unstoppable is don’t stop. You get passionate about something and then, the idea of stopping doesn’t even occur to you and pretty soon, you’re achieving something that seemed ridiculous when you set out to do it. There’s so many benefits of getting your brain to work right. We started talking about this wonderful book. It really is a wonderful book, everyone who has read it is really blown away by it. You know Alex Mandossian, don’t you?

 

Dave Asprey: Yeah.

 

Bill Harris: I gave away copies of this book at a Mastermind that he invited me to and he read it about five times and then, he called me and said, “This is the best book I’ve ever read in my life.” He showed me it and he had all these stuff underlined. He underlined so much that it was all underlined, almost and in fact, he’s helping me do this virtual book tour thing about this book because he was so high about this book. It’s a really great book. What my goal in this book was to make all these new brain science discoveries available to people in a very easy to absorb way. Of course, I’m talking about Holosync in here a lot also because I think it’s the greatest tool that’s come along for optimizing your brain although there are certainly many others. I love all these supplements I take and I love my hyperbaric chamber and there’s many exercise that helps you optimize your brain, sleep helps you optimize your brain, eating a Bulletproof diet helps optimize your brain, all of these lifestyle things kind of fit together.

 

Dave Asprey: They really do, Bill and you tie a lot of them together in your book but you talk about neuroplasticity as well which is something that listeners on Bulletproof Radio understand but you go into it pretty well. It sounds not too long ago in the year 2000, the Nobel Prize for medicine was granted for the discovery of neuroplasticity. In the 80s, when you started your work, they really didn’t seemed to think it was a real thing at the time.

 

Bill Harris: Well, there were people that were talking about neuroplasticity back then but they were the outliers that everybody poo-pooed. Do you know that they poo-pooed Daniel Amen which they still do to some extent for using brain scans to diagnose some things but it works?

 

Dave Asprey: Yeah, Daniel Amen saved my life. Like his stuff is very legitimate.

 

Bill Harris: Yeah, of course. Of course, it is. He often says that people that treat emotional problems and mental problems, they’re the only people that don’t look at the organ they’re treating. He looks at it and it’s very obvious. The three big discoveries that I talk about are that everything comes from your brain. Second, scientists now know what parts of the brain are involved in both all the qualities and abilities that people want to develop and all of the qualities and negative things that people want to get rid of. They know what parts of the brain are involved. There’s more and more and more information about how to change those parts of the brain. Things that were used to be completely a pie in the sky to develop. If you’re not creative, you’re probably not going to become anymore creative no matter how many creativity courses you take but now, that’s not the case.

 

You can become more creative. You can learn to get into those states. You can become an amazingly accelerated learner. You can become really calm and patient if you’re really the opposite of that. All these things are attainable and that’s what this book is about is how to attain those things that used to be attainable because it’s possible now. It’s a spectrum lifestyle thing because it does involve sleep and diet and exercise and all these things. One of the things I talk about in the book that I think would be really interesting for people and maybe your people are already hip to this is I talk about the Walter Mischel and the Marshmallow Test. Back in Stanford in the ’60s, he put these little kids at a bare table in a bare room and put a plate in front of them with a treat on it.

 

One of the treats was a marshmallow and it became known as the Marshmallow Test although they let the kids choose what treat they really wanted. Then they said, “You can eat that marshmallow right now if you wanted. I’m going to leave the room though for a little while,” and it was up to 20 minutes in some cases. “If you can wait ’till I get back, I’ll give you two marshmallows,” and some could wait and some couldn’t. About 30% of them could wait and 70% of them could not wait. Then later, he got the idea of following these kids to see if there was a difference between those who could delay gratification and those who couldn’t. They found that those who could delay gratification got this huge list of benefits.

 

They had better grades in school, they had higher SAT scores, an average of 210 points higher score. That’s like 20% higher, more than 20%. Higher income, lower body mass index, more friends, better relationships, better cognitive function, intelligence, more self-control. They could resist temptation better obviously, less distractibility, they were more self-reliant, more resilient. They could bounce back when there were setbacks, less drug use and other addictions, an ability to reach their goals and all that. The ones that couldn’t delay gratification had problems in all these areas. Then I think it was 2007 but maybe even later 2011, at some point though, they got the idea of doing brain scans. They brought as many of these people as they could find, now in their 50s, and did brain scans and they found that those who could delay gratification had calm limbic systems and enhance prefrontal cortices.

 

Those who couldn’t delay gratification were having all these string of problems in their life, Dopamine-driven decisions and all these other stuff that I talked about earlier, they had overactive limbic systems and underactive prefrontal cortices. If you want to have a really productive, happy together life, this is the, to me, the biohack. Enhance your prefrontal cortex, calm your limbic system. One of the reasons why I wanted to wedge that a little bit in is one of the things that this implies is more willpower. Now, I know people that I’m trying to educate about using supplements for instance. Then, they’ll start using them and then, the next time I’m meeting with them, I say, “Where are your supplements?” “I don’t know, I forgot to blah, blah, blah.”

 

They have not enough willpower to create an organized way to make sure they take them or they start to use Holosync and then they stop or they can’t sustain exercising. All those blowing off lifestyle things is an overactive limbic system and a weak prefrontal cortex. Once you get that willpower thing going, then all the rest of this becomes easy because then you can add all those lifestyle things that are very important. I will give up something else that I really like in order to make sure I get enough sleep. If I end up going to sleep really late, I will e-mail my assistant and say, “Cancel my early morning appointments because I have to get at least seven hours of sleep.” I just will not, I will refuse, unless the house is on fire, to not do that. I have lots of willpower but I wasn’t born that way, I’ll tell you.

 

Dave Asprey: You and I, both at the end of the day, study willpower because you talk about self-control, you even talk about awareness. Like all of that is driven by willpower and willpower is driven by do you have the level of energy it takes to overcome the desire to do something lazy or something else so it’s an equation there. One of the things that I discovered makes me and many other people more limbic active is unstable blood sugar. When your blood sugar crashes, your body is like, “You’re going to die. There’s not enough energy in the brain.” It triggers the hormones that activate the limbic system: adrenaline and cortisol.

 

Bill Harris: Eat carbs.

 

Dave Asprey: Yeah, eat carbs and then you get another crash so you end up basically spiking and crashing your limbic system multiple times a day. It’s no wonder that you do things you’re embarrassed about later. You yell at your family, you eat 16 eclairs but at least they were good, no but you go through this whole cycle and then you feel guilty about the whole thing. You get a poor night’s sleep because you did all this and you just do it over and over and pretty soon, you’re fat and unhappy. That happens over and over and it’s driven by …

 

Bill Harris: I’ve been fat and unhappy. I’ve been there. I actually, right now, weigh about the same as I did in high school. I think I might have weighed two or three pounds less in high school. At one point, I weighed 207 pounds. I know you beat me on that one, you weighed more than I did.

 

Dave Asprey: Yeah, I’m a little taller so …

 

Bill Harris: That’s it. You’re a little taller.

 

Dave Asprey: I’m just big-boned, Bill.

 

Bill Harris: As far as this book is concerned, if people go to Centerpointe.com especially if they spell it right with an E on the end of the point. The word center and the word point with an E in the end of the point. You can get a free copy of this. There’s an icon right at the top or near the top of the page and if you click on that, it’ll take you to a page where you can download a PDF or if you want to pay the shipping and handling, we’ll send you this paperback version or you could come to the next Bulletproof Biohacking Conference. I don’t know, the last one I brought hundreds of books and sat out there in the foyer. I need a biohack, Dave, for signing hundreds of books without your hand cramping up and your handwriting getting really bad.

 

Dave Asprey: I just did that in Japan last week. I was there, I sold 160,000 thousands of the Bulletproof Diet there without knowing it so I went there for a signing and yeah, after awhile, your hand gets tired. It’s awesome. It’s the best fatigue to have.

 

Bill Harris: I always learn a lot from meeting people and in the early days of Centerpointe, I was the one on the phone talking to everybody. Now, I have a staff of people who’s on the phone talking to everyone and answering e-mails and some of it filters through to me and I have some courses where people have a lot more access to me but I’m not on the firing line as much. When I go out and speak, I’m not like the primadonna who disappears backstage right away. I want to mingle and talk to people. I was just at Mary Morrissey’s Dream Builder thing in Dallas which is amazing by the way and I couldn’t take a break. It was like when you’re doing an event and you’re running it, you can’t take a break unless you escape backstage because everybody wants to talk to you and they don’t realize, “I have to pee now.” I needed a couple of minutes of silence where I sit down but it wasn’t even my seminar and I was surrounded by people because probably 20% of the people there were Holosync users.

 

Dave Asprey: It’s interesting when you make a big impact on people’s lives and you’ve reached a lot more people than I have, Bill. I understand what you’re talking about. People, they genuinely want to say thanks and it’s an honor to be able to be there to do it but also sometimes, it’s like, “Yeah, just need to take a breathe now.” It happens.

 

Bill Harris: Yeah, yeah, yeah. Anyway, go get a copy of this book. I know you will love it. It really, if I do say so myself, it’s a really great book and I really poured a lot of myself into it. Now, I’m thinking of the next one.

 

Dave Asprey: [inaudible 00:57:27] creativity is a side effect of all the stuff you do which means you have to keep writing books. I do recommend like you’re listening to the show, the Bulletproof Radio episodes are free, Bill is giving away a book that he wrote. This isn’t like a free crappy, I wrote it in 20 minute kind of book, it’s actually a real book and it’s …

 

Bill Harris: Yeah, this is 280 pages long, something like that.

 

Dave Asprey: It’s a solid book. He’s giving it away for free because he published it himself.

 

Bill Harris: There’s also a link in this to countless videos and also, there’s an audio version of the book. There’s a link in it to that. If you don’t like to read, you can listen. There’s all kinds of other things in here. If we put everything that was in here, it would have been 500 pages long but I put a lot of it as links and so on.

 

Dave Asprey: Just knowing you, Bill, you’re doing it this way out of a sincere desire to get people to have this information. Of course, we all know and our audience knows that some of them will probably end up becoming Centerpointe users because it works and you talk about it but the book is anything but a brochure of that. I found it to be a really impactful, useful, well-considered read and since it won’t cost you anything to download and read it which is cool, do it and if you like the paper version, Bill will send it to you essentially for a nominal cost. It’s different than going out and having to actually buy a book but it is a very valuable book. The book is available on Centerpointe, Centerp-o-i-n-t-e.com and it’s called The New Science of Super Awareness.

 

Bill Harris: Also, I interviewed you for a documentary that I’m making about new brain science discoveries and it was awhile ago and we got a little sidetracked but we’re getting ready to go into post-production on that. That’s going to be coming out pretty soon and as I remember, you were brilliant in that interview and we’re going to want to see you and Dr. Michael Merzenich, the grandfather of brain research. He’s in it and Daniel Amen is in it and Dr. Joseph Annibali who runs another one of the Amen Clinics is also a brilliant guy. He’s in it, some people using brain research for leadership, developing leadership and all kinds of cool stuff in there.

 

Dave Asprey: We should have got 40 Years of Zen in there. Earlier this year, I opened the newest version of this with custom hardware and custom software in Seattle. It’s a five day experience but I think when we were filming that, I hadn’t quite opened the facility yet.

 

Bill Harris: I can’t remember if we talked about or not.

 

Dave Asprey: Too bad if we didn’t.

 

Bill Harris: We might have. It was awhile ago that we ordered that. It was months ago anyway.

 

Dave Asprey: It’s amazing. Just to me, it’s an honor to be in a video with luminaries like these guys so thanks for putting it together, Bill and thanks for being on Bulletproof Radio. I’m not going to ask you the question that I asked every guest because you’ve already answered it twice, I think, on Bulletproof Radio so I don’t know that I have another …

 

Bill Harris: Boxers or briefs, is that … ?

 

Dave Asprey: It’s usually the top of your recommendations for kicking more ass at life. If you only had three pieces of advice for someone, what would it be but you’ve already answered it pretty darn well. I don’t know that we need to do it again.

 

Bill Harris: There’s a number of things that everybody needs to do and you’re telling them pretty much the same thing. The thing is do it. Don’t sit there and think about it, take action. Once you start taking action at anything that you’re going toward, the other actions appear. At some point, you start to get really enthused because you start to see some results. You start to biohack and you start to feel better and you think more clearly and all these stuff happens and pretty soon, you’re going, “Wow, this really works.” It’s really good to think back to before you were doing it and remember how many aches and pains you had and how much brain fog you had and how you get tired in the afternoon and these sort of stuff and realize, “Wow, it is better.”

 

Dave Asprey: It’s all gone. It feels natural when it goes away so you don’t notice the absence as much as you notice it when it comes back like, “I used to feel that way all the time but wait, I don’t anymore.” That’s a big one.

 

Bill Harris: Yeah, yeah, yeah.

 

Dave Asprey: Bill, thank you so much for being on Bulletproof Radio. People can go to Centerpointe.com to download The New Science of Super Awareness for free and you can certainly check out the Centerpointe Holosync technology there. I’ve been a lifetime member for a long time, I definitely use it and it’s [crosstalk 01:02:15].

 

Bill Harris: Yeah, you can try Holosync for free too. I mean, we have two ways to do that. One is a one-time demo but what I would suggest is that people do our Holosync five-day challenge. You’re listening to it once everyday for five days and I have a video everyday, just a very short like four minute video and then, there’s a big Facebook plugin where people are saying what’s happening. My God, I couldn’t believe it when I go to read what they’re saying and people are just raving about it. This is just like from one or two times, “God, I’m getting all these creative ideas. I can’t believe how calm I am. Two days ago, I was freaking out about my life and today, everything just looks wonderful.”

 

Dave Asprey: Your brain can do fantastic things when it gets the right programming, no doubt about that.

 

Bill Harris: Absolutely, absolutely. Well anyway, thanks for doing what you do, Dave. I remember when you came on the scene and how great it was when we finally met in person and we’ve become good friends. I really feel fortunate to know you and you’re doing great stuff, keep it up.

 

Dave Asprey: Likewise, Bill. I appreciate being your friend, appreciate you sharing your time and your new book for free with Bulletproof listeners. It’s been great fun getting to know you.

 

Bill Harris: You bet. I have to interview Daniel Amen here in 25 minutes so I got to get off.

 

Dave Asprey: Give him a hug for me. Bye.

 

Bill Harris: All right, take care.

 

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Is Cannabis The New Wonder Drug? – #361

Why you should listen –

Is Cannabis the new wonder drug? Dave aims to find out if it is as he sits down with CW Hemp founder Joel Stanley to talk about getting healthy instead of high with world’s oldest domesticated crops. Joel reveals how Cannabinoids, one of the compounds found in Hemp, has been found to have potent antioxidant and neuroprotective properties. Scientist are currently studying Cannabinoids and their potential to create revolutionary and life saving treatments for neuroinflammation, epilepsy, oxidative injury, sleep disorders, anxiety and schizophrenia.

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Dave: If you’re a regular listening, you’ve heard me share my list of top ten bio hacks. Let’s talk about number nine; fun hacks for the bulletproof mind. It may sound weird, but hanging upside down is a great way to hack your brain. Regularly inverting trains your brain capillaries, making them stronger and more capable to bring oxygen to your brain. It’s pretty straightforward. More oxygen in the brain means better performance.

 

I get my daily stretch and my dose of oxygen with my Teeter Inversion Table, which is so essential for optimum focus, concentration and mental energy. That full body stretch elongates the spine and takes the pressure off the discs, so they can plum back up. Less pressure means less pain. If you have back pain, even if you’ve been lucky enough to avoid it so far, you really want a teeter to invert every day to keep your back and joints feeling great.

 

For over 35 years, Teeter has set the standard for quality inversion equipment you can trust. My friends over at Teeter have decided to show some love to Bulletproof listeners. For a limited time, you can get the Teeter Inversion Table with bonus accessories and a free pair of gravity boots, so you can invert at home or take the boots with you to the gym. To get this deal, which is a savings of over 138 bucks, go to GetTeeter.com/bulletproof. You’ll also get free shipping, and a 60-day money back guarantee, and free returns, so there’s absolutely no risk for you to try it out. Remember, you can only get the Teeter with bonus accessories and a free pair of gravity boots by going to GetTeeter.com/bulletproof. G-E-T T-E-E-T-E-R.com/bulletproof. Check it out.

 

Speaker 2: Bulletproof Radio, a station of high performance.

 

Dave: You’re listening to Bulletproof Radio with Dave Asprey. Today’s cool fact of the day is that there’s a lot of talk about hemp versus marijuana these day. Actually, I am going to share a couple of cool facts with you that are relevant to today’s show. Both come from the same plant. Both are from the same genus cannabis, and they are both the same species sativa.

 

Do you know the difference between the two? It’s just one genetic switch that was only discovered in 2011 at the University of Saskatchewan. Go Canada. The biochemist found that genetic differentiation that allows marijuana to have the psychoactive properties that hemp doesn’t. Hemp doesn’t produce the enzyme called “TCHA.” That’s a precursor to THC. If you look at marijuana plants, they make TCHA, and they do not produce CBDA, which is cannabidiolic acid, a word that I never can say very well. That what we’re going to talk about today, which is basically a CBD oil.

 

Before I get into the show, which I definitely did a little foreshadowing on, you might have noticed we’re going to be talking about CBD oil, but we’re going to talk about another kind of oil first.

 

Here’s a big announcement for you today. Well, actually, it’s a small announcement, like three ounces small. After receiving literally thousands of emails from people requesting something more portable than our 16 and 30 trans bottles of Brain Octane, Bulletproof is finally rolling out at three-ounce travel size bottle. They are portable. They are spill-proof. They are TSA-friendly. They come in just under the three point four-ounce liquid they made for airplanes. That’s really important for someone like me who travels over 100 days out of the year.

 

In order to celebrate the kick-off of the new three-ounce bottle of Brain Octane, I am offering you a chance to try out the three-ounce bottle for free. All you have to do is pick-up the cost of shipping. Just text the word “BP Radio” to the number 38470 on your mobile phone, and then respond with your email address to get a special coupon code for a three-ounce bottle of Brain Octane free when you pay standard shipping anywhere in the US. Again, just text the word “BP Radio” to the number 38470. That’s number 38470, and reply when you get a text back asking for your email address, so I can email you the code for a free bottle.

 

I actually started carrying six of these bottles in my quart-size zip lock, and it’s still carry on legal. In fact, I took it up to 22 thousand feet altitude in my atmospheric pressure. Why? Because I could. I even put it on top of my wife’s really expensive purse to prove that it would work. You can find it on BulletProof.com.

 

If today’s podcast rocks your world as much as I hope it does, I’d love it if you’d follow BulletProof Radio in iTunes and leave some feedback. Just a little bit of a five-star feedback takes you about three seconds to do, and it’s seriously helps people find the show. Thanks if you decide to do that.

 

One of the first problems I reckon solving after I developed the BulletProof diet and shed all of my unwanted fat was I had to shop for new clothing, everything from pants and t-shirts, to shorts and dress suits. Buying a suit was always painful for me. Finding something that’s comfortable, affordable, and built with quality materials was a painful experience.

 

Then someone introduced me to Indochino. Indochino is one of the largest made to measure men’s wear brands. They are making it easy for men to get a great fitting high-quality suit and shirt at an incredible price.

 

Here’s how it works. Visit Indochino.com or drop by any of their nine North American showrooms. Pick from hundreds of fabrics and patterns. Choose your customizations from lapels, to pleats, to jacket linings and more. Submit your body measurements. Kick back, relax, and get ready to step into the best most stylish suit you’ve ever worn in just four weeks.

 

This week, Bulletproof listeners can get any premium Indochino suit for just $389 at Indochino.com when entering code “Bulletproof” at check-out. That’s 50% off the regular price for a made to measure premium suit, plus shipping is free. That’s Indochino.com, promo code “Bulletproof” for any premium suit for just 389 bucks with free shipping. You’ll never have to worry about badly fitting suits or expensive trips to the tailor again. Get ready to look like a million bucks.

 

Today’s guest is Joel Stanley. He’s the CEO of Charlotte’s Web, one of the pioneering hemp oil extract companies that’s trail blazing in the medical cannabis industry. Joel and his brothers Jessie, John, Jordan, Jarred, John and Austin. Why Austin doesn’t start with a “J,” I don’t know, but man, I’m going to have to ask this, Joel. They’ve earned the reputation for being the top cannabis breeders and cultivators. We’re talking like weeds level, except, well, real.

 

They’ve been features on National Geographic, Time, CNN, New York Times and a bunch more. They created something called “The Realm of Caring,” which is a non-profit that provides cannabis education, funding for studies, and helps families with access to cannabis treatment. When I say it helps families, I mean, there were about 15,000 what they call “medical refugees” who moved in the US to go to Colorado in order to get access mostly for their sick children in order to get access to Joel’s oil from Charlotte’s Web, which is pretty amazing.

 

Today, Joel and his brothers run greenhouses, dispensaries and labs that produce their hemp products. They’ve made a big difference for a lot of people, and that’s why I’ve had them on. Joel, welcome to the show, man.

 

Joel: Thank you for having me, Dave. I appreciate it.

 

Dave: What did you think of that intro. Did I nail it or did I miss half of the cool stuff?

 

Joel: No. That was great. That was great. If fact, that was flattering. Your question about Austin being the only brother without a J name, his first name is actually “J.” Period. Not J-A-Y. It’s J. Austin Stanley. There’s 11 of us total, seven boys, four girls. They named all the boys. I guess, at some point, my parents just said, “What’s his next name?,” and they just said, “J. Period.”

 

Dave: I named my kids all starting with “As.” Kind of a similar way of thinking, I realize that I only needed three letters to spell my wife’s name and both of my kid’s names, because I’m a computer science guy, high compression ratio for my family’s name. The 14 people who look at compression rations are laughing right now. It’s good to play with your family’s name. More importantly, and more to the point, what made you get into medical cannabis as opposed to just getting high?

 

Joel: You know, I actually wasn’t a believer about six months before. This is hard to admit. About six months before I got into the industry with my younger brothers, my older brother had started the first dispensary medical cannabis dispensary in the city of Denver. When I heard about it, I just started laughing. I just didn’t see cannabis what I called at the time, of course, “marijuana” as big in medicine. I think that it was an excuse.

 

By the same token, it was not in prohibition, and so I wasn’t against it. I just didn’t really understand it. I flew back to Colorado. At that time, I live in Texas. I had to go see his dispensary. As luck would have it, the first three people that I met who walked through the door after me were cancer patients, stage three, stage four type cancer going through severe rounds of chemotherapy. I got their story, and that immediately change my mind. I’ve never thought of something what we call the “munchies” as being therapeutic when it’s extremely therapeutic when someone can’t eat, can’t hold food down. That was my first selling point on medical cannabis.

 

I went back to my job in Texas and started reading about it, started pumping through Pub Med. I looked at all of these research papers, and I couldn’t believe how many research papers had been written on the topic of cannabis. At the very beginning, we found this funny word “cannabidiol”, abbreviated “CBD.” That’s a lot of what we’re talking about here today.

 

You have studies showing a neuroprotective benefits, study showing anti-inflammatory, study showing that it could potentially treat the underlying disease of cancer. This is extremely promising, but when you look into cannabidiol, you see this is non-psychoactive, not like THC, which is the psychoactive cannabidiol we all associated with getting high. Cannabidiol, CBD does a lot of the same things that THC does without that euphoric effect.

 

Some of us don’t really like smoking high THC cannabis. I personally don’t. It doesn’t jive with me. Many people benefit from it, but some of us would like to enjoy this plant without getting sky high or paranoid or whatever happens to us when we smoke. Some people have fits, some people doesn’t. We started breeding for it.

 

Dave: I went on a podcast once. The host of the podcast was stoned out of his mind. It was like, “Here. Have some.” I’m like, “I’m sorry. I want to be coherent when I offer something to your audience here. I just couldn’t do it.” Like you, THC is not my drug. Like CBD oil is cool, but THC … I’ve always been supporting people when it works for them, but man, I don’t do well on high doses of that stuff. I just get tired.

 

Joel: I’m the same way. I actually tend to freak out a little bit. There are some people who are so functional, and you are just like, “How are you doing that?” It’s when people get through their day with that. I mean, whether they have a … They may have an endocannabinoid deficiency or something like this, and it just seems to balance them. Some of us, I think it’s about 15% of us so far that have been able to tell that it doesn’t jive with them or probably better off without the psychoactive side of cannabis.

 

Dave: I don’t mean to interrupt you there, but I was just comparing where I would be disabled if I took three or four hits of really strong stuff, and then try to give a coherent interview. I just would ramble, but other people wouldn’t. What’s going on there? Dig in on that about chemically to the extend you know.

 

Joel: We have two specific receptors inside our body, maybe more, but two that we know of called “CB1” and “CB2” receptors. These are cannabinoid receptors. Cannabinoid are only made by two things on the planet, that’s our bodies; mammals, and those are called “endocannabinoid.” Then the cannabis plant makes phytocannabinoids. THC is a cannabinoid. CBD is a cannabinoid.

 

Most of the cannabinoid are non-psychoactive. We can get them from hemp, which will go into. Mentioning he endocannabinoid system is very important, because this is an infant scientific discovery. 1994 was when we found out about the system that this system is integral to every other system in our bodies. It’s kind of the regulator of the regulators.

 

Those CB1, CB2 receptors are found at almost every cell in our body prolific throughout our central nervous system throughout our brain stem, and then in our gut. That’s another important place where we find CB2 receptors.

 

CBD and THC and then the various cannabinoids do very different things at these receptors. While there are still a lot of research to be done, unfortunately, the prohibition, also a prohibitive research, we at least understand that CBD is doing amazing things at these receptor sites for many people. I mean, as you mentioned, we have one time waiting list of 15,000 people with thousands and thousands of pediatric epilepsy, autism. Now, we see a lot of Parkinson’s.

 

Research hasn’t been done to actually make a claim on these things, but the anecdotal evidence, and the reports we get every day are just phenomenal. We started to look at this and say, for a guy like me who doesn’t enjoy THC, now I can enjoy the cannabis plant, those health benefits without getting high. We started to look at it and just explore what can these compounds, especially the non-psychoactive ones, the ones that are legal, what can they do for every day health for preventative maintenance, because they are helping so many people right now.

 

Dave: Because you sell CBD oil, you are using the careful dance of language where … Is it things like maintain proper health and all the other … I don’t know if I should really say this. I don’t swear that often, but I will say all the other bullshit that is required when you sell something, I have a similar problem with coffee, where I am not allowed to say most of what coffee does, because they I would be making claims that would be considered to be pharmaceutical, so I’m like, “Coffee, it’s like black and stuff.” I’m allowed …

 

Joel: You know the drill.

 

Dave: I know the drill. For people listening, when you care enough about something to become an expert and then just start manufacturing it, there are gag orders. I’ve actually had people say flat out, you have left the realm of free speech. You are now in the realm of controlled speech. This is from a government regulator. You and I are both in this interview if we talk about our own stuff limited about what we are allowed to say. I can say whatever the heck I want about CBD oil, because I don’t sell it.

 

Joel: You sure can. You sure can, but I am the CEO of CW Hemp that makes that product, Charlotte’s Web. I can’t. I do point to many of the stories that the reason why this whole phenomenon happened was because of a little girl named “Charlotte.” She was five years old at the time. She was taking this product and no other drugs worked. She had been through all of the pharmaceutical options, which by the way, for her disease state after her age there was not one FDA-approved drug, and it’s all experimental.

 

Back then, we took a lot of flag for how could you give some probe of cannabis to a kid? It’s like, well, she had the approval from neurologist and two other doctors, because she was end-of-life. She had nothing else to try. That phenomenon made this story.

 

For a while, we live in a system where if something appears to work, now it has to be a drug. That’s just insane, but that’s the system we have. The word “drug” inspires a lot of things in a lot of people’s mind. A lot of people thinking just psychoactive or recreational or damaging drugs, harsh drugs.

 

The truth is what makes a drug a drug from a regulatory perspective, from the FDA’s perspective is whether or not you make a specific health claim about it. This could be done … If I hold up an apple and I am trying to sell apples, and I say that this apple has vitamin C, and this vitamin C is good for the common cold. If that’s not an FDA approved claim they can come and confiscate all the apples that I’m selling and say, “You were selling a drug.” That’s how it works here in the US.

 

Dave: Even if you have 50 studies that say apples are good for a cure, until they approve the claim you still can’t do it. The same thing. I am not allowed to say healthy saturated fats around brain octane, so I doubt, even though I would argue very, very well that it’s healthy given that healthy is a big word. They apply healthy to corn flakes and like low fat weird crap. The bottom line is if it’s not like rubber stamped by a regulatory … I’m not allowed to say it. I just want people listening to know that when I ask you questions when we’re interviewing like that that you are subject to what I would call gag orders. All people who make foods and supplements are limited in what we can say about them. I think listeners often times don’t understand that.

 

Joel: That is helpful to them and to me, so thank you. Thank you.

 

Dave: Some of the things that I am aware that CBD oil has been used for would be things like epilepsy. My mother has had epilepsy for my entire life. She had surgery that helps pretty dramatically, because the doses of drugs she was taking were getting to be toxic to the point they were just building up in her body after 20 something years or using it. I’m definitely familiar with the effects of epilepsy on things. It works really well for that. Diabetes, rheumatoid arthritis, all these other immune conditions that I certainly have auto immunity. I had arthritis on my knees since I was 14, cancer, antibiotic resistant infections, alcoholism even. I had PTSD, neurological disorders. That’s a pretty long list of things. There aren’t studies, like big studies in all those things. There’s lots of other evidence though.

 

Joel: When you look at the fact that the US government national institute of health in 2003, division of the US government actually filed a patent on behalf of we the people, I guess, on cannabinoids as neuroprotectants and antioxidants. We consider just a word like “neuroprotectant.” Now, a lot of the disease stage you imaged, whatever that’s something occurring that is neuroprotective and the US government admits to it, now you are onto something for those neurological disorders as well. It just makes sense. We know they are protective. We know that we have the CB1, CB2 receptors for our central nervous system. Of course, it is going to impact some of those disease states potentially. As I mentioned, prohibition didn’t just prohibit us from possessing all those years, it also prohibited research.

 

Dave: Yeah. We’re dealing with that right now. There’s people calling for let’s say banning of research on certain topics that are taboo and I find that to be insane. You never ban research on anything, because understanding let’s you know how dangerous or useful something is. When you stop looking at it, it’s like willfully putting on blinders. Some of the skeptics out there do that. Like you cannot research X, because I don’t believe that there’s a way it can work. Really? In that case, maybe you shouldn’t research, and someone else might know more than you should research it. Just a thought.

 

Joel: That’s why all of the great research going on around the world on that not just cannabis, but psychedelics in general is just been prohibited, just blindly blanket prohibited. That’s what I am saying way to approach anything. Until we lift the vale and star approaching the topic of drugs and psychotropic drugs with information and education instead of just as blindfolded fear, we’re not going to get anywhere. We’re going to continue to see a rush of teams wanting to use whatever we prohibit. You look throughout history and cannabis itself has been used by almost every civilization, sometimes in major ways, and you can’t find a record of teams in mass numbers trying to get their hands on it until we said, “Oh, you can’t have it.” It’s just a silly way to approach it.

 

Dave: You just gave me a great idea. What if we banned high-intensity interval training? Like would teenagers ever go out and start exercising? I wonder.

 

Joel: We should maybe ban that. Yeah. We should maybe ban that. We should ban building fruits. and condone playing Nintendo. Maybe that will get their blood satisfied.

 

Dave: That’s awesome. Now, there’s some other stuff. I’ve spent a lot of time. I have a new book that’s coming out in April about mitochondria. I spend basically the last year really digging in mitochondria, even though I have been modifying mine for about 15 years. When you look at Alzheimer’s, Parkinson’s and pretty much every neurodegenerative disease, ALS, it all comes down to these energy forming organelles that are inside the neurons. They get weak and you get these things. CBD has really strong antioxidant and neuroprotector properties. Do you know, is it affect your mitochondria or is it doing something to the neuron? Do you know how it’s working there?

 

Joel: I would love to be able to explain that to you, but I know a few people who could, but they are not here right now.

 

Dave: There are not here.

 

Joel: I only get too deep in other ways. I’ve learned a lot of medical and technology. I’ve met with some of the world’s top neurologist simply because of Charlotte’s lab, and I love for them to speak, but I am just not versed enough to address that.

 

Dave: All right. I don’t want to go too deep for the audience either. I am just always so interested when you see these common elements where you see something that’s as broadly effective as CBD. It always makes me wonder like is it happening at a very low level in the cell. What’s a normal … First you listen to this. I have a psoriasis, let’s say, or I have some other immune stuff, Hashimoto’s, thyroiditis or something. If they said, “You know, I think I want to try CBD oil.” Should they do to their doctor? Should they start experimenting? Should they spark up a bowl? What’s the right pathway for them?

 

Joel: The right pathway for them is to start with CBD. Anyone who is interested in trying cannabis, because they has anti-inflammatory, any of them, neurodegenerative disorders or just people that want to take it for preventative maintenance, because they are afraid of neurological disorders. CBD is the very place to start, because we actually can derive it from hemp. Hemp is a legal product. The US in fact imports more hemp than any other country in the world. They only have 5% of the world’s population. It’s been legal for decades, but just legal to the cultivated in the US as of 2014.

 

That was even prohibited for a while. They can seek out CBD from hemp sources no matter what state they live in now. Our products Charlotte’s Web. They can go to CWHemp.com, C-W-H-E-M-P dot com. I also have the nonprofit organization, “The real Of Caring.” As you know, if someone calls my customer service team and says, “Hey. I’ve got Parkinson’s, or ALS. How do I dose this?,” we absolutely cannot handle that question. We’re not allowed to. We formed “The Realm Of Caring,” which is an organization that collects most of the volunteers and most of the call center staff there are actually families that have already been through this, already learned how to dose cannabis appropriately for XYZ condition.

 

We connect the new client with old clients. They can discuss that behind their own closed doors. We have nurses there, so they can discuss with their doctors. This is a very viable tool, and I would recommend that anyone with an inflammatory disorder or whether neurological disorder to try cannabis as a safe option. The cannabis has never killed anyone. We’re talking about a safety profile on CBD. That’s much like vitamin C. It’s safer than common household sugar. It’s worth the try.

 

Then beyond that, beyond someone that says okay I’ve got this inflammatory disorder, just for general health, I mean I told you earlier that I’ve been doping Bulletproof coffee for over a year now. I add my own product to it. My product to your product because that’s my daily dose of CBD, right away take it while I have … Not regular inflammation, but it seems to keep the airway from certain problems associated. I don’t want to get the weeds there. I need to be really careful here. I take it because it’s preventive maintenance, and I think that the average person especially once we start to understand a little bit more about what this is doing at that cellular level, once we get the research, I think we are definitely going to see that this should be a part of everyone’s diet just like vitamin C, just like your B vitamins, just like your omegas. We have endocannabinoids system. Why wouldn’t we have cannabinoids to supplement daily? It’s just been locked out by prohibition.

 

Dave: That’s right. I am planning to live to 180 or longer. That’s a real number, and some people are like, there’s no evidence that … Yes, there’s no evidence any of us is going to live for more than one more minute. That’s okay, but I am doing everything I can to minimize all of the thousands of things that just whittle away at your ability to maintain and repair your own system, and 180 seems pretty reasonable given the rate of change attack. It’s like it’s that preventative maintenance really matters, and doing something for your nervous system actually do a lot of things for you, but doing another thing for the nervous system and working with the endocannabinoid system seems like a pretty good candidate for that. Do you have any studies on ageing?

 

Joel: We don’t. We don’t, but we are engaging certain universities to do these studies and find what is the right cannabinoid combination, what is the right plant for preventative maintenance for ageing especially neurologically. Again, it goes back to prohibition. I am sure there will be a plethora of those studies out there if we hadn’t prohibited researchers from actually handling that substance for so long.

 

Dave: It’s funny when we compare your biggest competitor, which should be big tobacco. They are freaked out about all these new thing pot gars. The amount of research available on nicotine and tobacco is unbelievable. Of course, they suppress those stuff and said it caused cancer, because it was bad for business. I’m really hoping that if they do find some downsides for marijuana that we don’t make that mistake again. I think the internet makes it harder to hide research for 50 years like they did in big tobacco.

 

I have found that low dose nicotine when their studies going back 10, 15 years, it increases mitochondria function. Entirely separate from smoking, I think a lot of the problems with pot where people burning stuff and breathing it, which is clearly ageing, not anti-aging. Then you are like, okay, am I getting moldy pot, like quality control wasn’t there. All these things went into people say, oh, like the pros and the cons were so intermix it was hard to sort them out, but with what you are doing you have a scientifically controlled product. You’re taking out the THC variable, which actually could be anti-inflammatory in it of itself in some people. You are also allowing us to use something that now we can do and for proper research on, because it doesn’t fall into this crazy prohibition area thing, but if we haven’t prohibited it, we have much more data than we did.

 

You’re talking about adding it to your Bulletproof coffee. Awhile back, I tried some kind of … I did a podcast a while back we talk about hippy speed ball adding a CBD oil to a bulletproof coffee and it was pretty funny. The problem though I had is that I had some CBD oil butter blend that someone made for me that was non-THC. I took it and I swear I thought my skin was going to fall off. Like I got extremely dry skin, like rashes. I was like this is not good. I think it was actually that brand of stuff. Is it possible that …

 

Joel: Is it possible that people would have a bad reaction to CBD itself. I would say, of course. I mean, that’s possible to be allergic to any plant. Of course, it’s possible someone could be allergic to the plants we use for the Charlotte’s web product. That’s really possible. We haven’t really seen that yet. Now, I mean, we’ve been through thousands of folks where we gotten that report, but …

 

Dave: This wasn’t Charlotte’s web. This was another brand. I thought it might have been like a purity issue with it. I’ve used CBD oil in other forms without problems. I can smoke pot. I’m a hitter too. I’m fine, but you give me more than that …

 

Joel: You are not allergic to cannabis.

 

Dave: No, I’m not.

 

Joel: Sorry.

 

Dave: Like a solvent issue or something.

 

Joel: I don’t like to thrill the industry here with a buzz, but in a lot of ways, it’s already under there.

 

Dave: It’s a great one.

 

Joel: Nothing in the industry that was born out of closets and basements and products made in dingy garages that same places people working on their cars. A lot of that isn’t because those folks making it wanted it to be that way, but it was because it was prohibited. Now that it is not prohibited even the manning of the states if you want to do it the right way, you don’t want to have access to conventional lending. Banks aren’t going to lend to you to start a business to do this.

 

We can be real hard on the industry for its quality control, but at the same time it doesn’t have the same tools of access for conventional businesses, and so if you all you control has been very low. That’s one thing we [inaudible 00:31:59] ourselves on. I can’t tell you how freaky it was to have this five-year-old years ago, Charlotte who was medically fragile, end-of-life. It’s on the resuscitate for her, and we’re going to create a product now for her to try out of cannabis with all the stigmas associated with cannabis. I was shaking. I was literally shaking. We tool all the control seriously. We had with predominantly cancer patients before those. We took it very seriously.

 

That took my thinking to the next level. I mean, we just took it to extreme levels of testing and just overall cleanliness, documentation how you make these products. Back then, I was making these products for maybe 40 or 50 people whoever had just heard about Charlotte’s story through Facebook or whatever. You can have quality control. It’s kind of like if you can make a batch of brownies for house guest or past or whatever, it’s going to be consumed right then and there.

 

When you’re going to make a product for thousands and thousands of consumers and you have to understand how do I package this, what can happen in the process to make this potentially have something that can grow inside of that some type of biocontaminant, and then how long is it going to store. Those studies take time. When you’re developing a new product especially you need to take every institution to make sure that there are no toxins in that products, and this from the pesticides at the farm.

 

Even having metals. Hemp is a great land reclamation crop, but the problem is I mean we all consume some small amount of led every day, every time you had an apple you’ve got some trace acceptable amount of led. It might even be important. We don’t really know. You might even need that small level. When you have a land reclamation crop, like hemp, and it pulls up led into itself, like most plants do, and then you can concentrate that plant. Now, you are also concentrating those potential contaminants. It might not have been harmful. The actual plant itself at plant levels, but now you’ve concentrated it. I don’t know exactly what happened with you, but I can assume that it’s likely an issue of quality control and some type of contaminant that the manufacturer didn’t take care of.

 

Dave: That was my guess as well just because I know other stuff works. That was a bit spooky and worth paying attention to. I know many other people who’ve had really strong benefits, so I will try some of yours now that we’ve talked a little bit about the quality control aspects of it. People listening to our interview probably haven’t thought about what you just said, but the scale of error, you’re scraping your kitchen, whatever, but you scrap and you’re making something for hundreds of thousands of people, you could make them sick. Like you must not do that. Also, it’s going to be stored for a while, so cares if your brownies had a little something in them, because you ate it.

 

I deal with that. We make the bulletproof collagen bars. Getting those right took two years to get out of the door where they have the brain octane, and they hold together. They don’t have the microbial stuff. We just launch our key, which you can use with CBDF. A lot of people actually use [key 00:35:31] and CBD together. We make it from 100% grass-fed butter, but our first batch, our first commercial batch of 8,000 bottles or 8,000 jars of it was ruined, because one person didn’t change a filter they were supposed to change.

 

Like you, I’m almost certain you do this, we test every thing religiously. We test before. We test during. We test after, and we test it after like what’s going on here. A little bit of protein made it through that shit and it made it through. It didn’t meet the standards, and it would have grown stuff eventually. Yeah. That was just a waste of butter, but it was better than sending it to people, because that would have been even worse. That thing is entirely invisible to the world, but it’s not present when you are doing like a real early stage supplement you’re doing, someone making stuff in their garage, which you can’t do. They are just like pretty regulatory, so the quality control things are in place. It’s actually a little bit frustrating to deal with that. I imagine you have that problem, too, right?

 

Joel: We had similar story, this one had nothing to do with our manufacturing processes internally, but what had happened was I walked up to our lab one day and I went back, and they’re dumping full bottles of Charlotte’s web. Actually, this coming from a guy with a 15,000 person waiting list that was heavy that was scary. Every milligram was so precious. Now, we’ve got plenty. We’ve entered the waiting list, but still they’re doubling these full bottles of Charlotte’s Web and into those absorbent material. They are basically rejecting a batch. This happened a few times for various reasons, which is really a batch of bar. When a company finds something in says, “We’re not going to take this batch, because it doesn’t meet our quality specs.” I asked what happened, and they said, well, we went through the entire process, and we test everything for aflatoxins, molds, solvents through the whole process. It gets tested several times while it’s an oil after it’s infused, before it’s gt bottled, and then it goes as final bottles, random bottles go to the lab to test for these things.

 

When we have the final packaging, we have aflatoxins present. What were the levels? My QC guy, awesome guy, says, “Well, they were acceptable for certain foods, a lot of foods, but they weren’t acceptable within our spec.” I said, “All right. That’s awesome. We have higher spec. Great.” How did that happen? A couple of weeks later, he gets back to me and says, “You now what? It was in the little droppers from the bottles, from he manufacturer, those foods supposed to be food-grade dropper bottles have residual levels of an aflatoxin. It wasn’t even anything we did wrong. It was inside those jars, those cells, those little glass droppers, so we rejected that whole batch. We look that as a company and to say, that hurts.

 

You get to the finish line with something, and you just see someone dump it. Sometimes hurts a thousands of dollars retain into a [inaudible 00:38:37] material. That can freak you out, but it’s the right thing to do, and in any company that is making products, dietary supplements, food, drug on this scale, you’re just going to run into it, because there are variables that are not always within our control, and you set those measures to make sure you catch them.

 

Dave: It’s interesting you brought up aflatoxin. That is the single most cancer-causing substance known to man. Here it is you have a product that other people without your knowledge or permission might be using for their cancer. You would never do that. I’ve run into that, too. I wanted to launch a mock up product because there are seven kinds of Maca. Maca is useful for testosterone in men, it’s useful for hormone stuff in women as well, depending on what species you use. I was getting these samples back that had like 13 parts per billion of aflatoxin, like very high-end manufacturers, because it’s a starch product that’s dried in a jungle. You might imagine mole will grow. Finally, I just gave up. I’m like, I’m not going to do this, because I don’t think I can reliably make a micro toxin free version of this. Maybe someone does. There are several good brands of it out there, but these little things I’m required to test for them in a lot of products, but if you care, you do it anyway.

 

Joel: That’s right. We have a … Within the dietary supplement vitamin world, which is really where Charlotte’s Web fits, we have what’s called “good manufacturing practice” that was dictated by the FDA. We went through a third-party CGMP audit, pass with flying colors. I was very happy about that. Really, what’s more special about what companies like us do is that we also adhere to the standards of the American Noble Products Association, which dive deeper into topics like aflatoxins. Our regulatory system that is okay to make sure the manufactures have some quality control. You have some other industry groups that have really set the bar, and they have set the bar at the right place. When people are looking for products like this or any dietary supplement, look for organizations like AHPA, American Herbal Products Association.

 

You’ll see that companies that comply with that, you can rely on those products every time. They are going to be consistent. They are also going to be the same. I mean, that’s another major problem we have in our industry. It’s when our story hits CNN, we knew that there were very few milligrams of CBD existing in the whole world, and that we didn’t have enough for our waiting list, and we had more than anyone in the world most likely at that point in time, because people in the industry couldn’t even pronounce the word “cannabinoid” back them.

 

Suddenly, now that it’s on CNN you start to see on Amazon.com all these products that are popping up. People get really excited. They get their hopes up, because they are on this waiting list for Charlotte’s Web. They order these products. Nothing happens, and they are like, “CBD is BS.” They sent us the product. We test them. There’s nothing in it. 10 times out of 10 back then, there was nothing in it. That’s a black market in our industry, but dietary supplements have that same problem. Consumers need to just be aware of that there are people out there that will take advantage of you within dietary supplements, within food products in general, vitamins. Look for the seals of approval from trusted organizations.

 

Dave: Yeah. It’s interesting. Some of the more powerful things you can get like anirasetam, one of the smart drugs. I’m a fan of this stuff. I would love to make anirasetam for people. I think I know the good suppliers and all that, but it’s not prohibited, but it’s not allowed by the regulatory people. I’ve been using this stuff every day for more than 10 years, because it increases your blood, it gets things in and out of your memory. I’ll probably live longer as a result of using it. You have to go and just buy it formerly on Amazon, and then last year, one day Amazon just decided we won’t sell any of these anymore. All of the various like small garage brands of anirasetam just disappeared and it’s gotten harder to find.

 

Amazon has the ability to take these down, but they usually don’t. If they do, it could just be a broad spectrume, and all of a sudden it’s gone. People oftentimes when there’s an emerging technology like CBD was a few years ago when you pioneered it, it was hard for people to get. They had to come to Colorado, and then you get where you can ship it, but then there’s inter state commerce regulatory things. All of that is invisible to people.

 

Like, why don’t they just send me CBD oil? That’s wide and where are there chloroforms? Well, because you couldn’t get distribution, and because people were opportunistic. They something and said, We’ll copy that. We don’t know if we are doing it right. You get these copy cat brands, and these fly by night operations that don’t grow without the quality control, but that seems like most innovation happens there, just like yours did, but you kept at it, and now you are beyond the early stage where people are coming to you because they are going to die if they don’t. Now, you still have those same people who can use their product if they choose to, but you have the ability to scale it. How did you do that? That is really unusual. I know, because I did it with what I do, but almost no one listening. Tell me the story of how you went from doing it literally like in a small facility for end-of-life people. How did you go from these where you are now? Give me the story.

 

Joel: You know, when we met Charlotte, her mother, Page, sought us out and said, “I hear that you guys have been breathing this CBD. I think it might be something that could help my daughter. She had been pouring through a research, and oddly enough there’s a decent amount of research out there for something that is prohibited.” She found it, and she would have known about CBD. She had searched, scour the industry, found us. At that time, we had only eight plants of the genetics that go into the Charlotte’s Web product. We had, at that moment in time, we’ve just called it “hippy’s disappointment.” We’re very proud of it. We thought it was going to be great for people like me who didn’t want to get high, but still wanted the health benefits, but lots of the cancer folks who didn’t want to get sky high. We took in his disappointment. It was eight plants. We renamed our entire breeding project after Charlotte’s Web, but we were stuck within medical marijuana regulations here in Corolado.

 

In fact, you couldn’t grow hemp domestically. This is 2012. Under those regulations, very expensive. You have to have a camera from every angle, all the security. You have RFID tags on every plant, very … Yes, because it is such a dangerous plant. Very expensive to scale, and it was heavy, and does this waiting list just grew and grew and up to 15,000 people. We did everything we could for people. We had a bone fires with this whole community, mostly of pediatric epilepsy, but a lot of autism, too, developed in my own town of Colorado Springs. There’s just whole community of people. Many of them still live there even though they can go home. They still live there just because of the community that happened out of the Charlotte’s Web story, but it was really heavy. We couldn’t scale under medical marijuana program. Fortunately, in 2013 when Colorado ironically legalize recreational campus, in that same piece of legislation, they also legalize the cultivation of industrial hemp.

 

Shortly after, in 2014, the Federal Government allowed the provision that allow for the first time in many decades the cultivation of industrial hemp through the state departments of agriculture. Everything fell into place. Those plants genetics, the original hemp is disappointment. Now going into the product Charlotte’s Web. Those original A plants really fit within what we know as hemp. Thank God for industrial hemp regulations, or else we’d still have a waiting list. We would never been able to scale the way we did. We went out from greenhouses, RFID tags on every plant to agricultural center pivot, irrigation, still organic practices, all of these, but we were able to go from a few hundreds plants to a couple of hundred thousand plants on acres. Our first harvest in fall 2014 while we were doing that we were building this laboratory.

 

Fortunately, our story had reached some folks that were willing to invest in this. At that time, that other CDB products were out there. As I mentioned, most of them without any CBD in them. The price per milligram of CBD at that time was 50 cents per milligram, average out there in the industry. Ours was five. It is still five cents per milligram for anyone who signs up with the Realm of Caring. That means that they are serious about it.

 

They might really need it. But we were able to go into this hemp agricultural economy has scale, which five cents actually made sense. They used to be a cost of good. Now, it actually makes sense for us as a company. We had investors. We set the lab in Boulder Colorado in which we had access to all of these great minds, analytical chemist coming out of the University of Colorado, and just many strokes of luck, a lot of hard work. We came to, what I believe is the best cannabis laboratory in the world right now that it all came together over a couple of years, and now we’re able to do what we do. High level quality control, and we don’t have a waiting list.

 

Dave: Congratulations. That’s a fantastic story. I did a bunch of research on CBD receptors a while back on a piece on the bulletproof blog. It looks like there’s some evidence for vaping CBD. I don’t know if you can talk about that if vaping maybe some like drug delivery technology or something if you can talk about it just tell me.

 

Joel: I don’t get it.

 

Dave: Is there a merit to vaping CBD oils versus swallowing them?

 

Joel: I believe that there is and there isn’t. It depends on what you saw. Typically, then you get a CDB oil for vape, it’s been more fractionated. This has been through a process called “winterization” where the fats and waxes and many of the turbines, all other plant phytochemicals that actually do work with CBD, many of those are gone. If you need CBD and you need CBD quickly, and a lot of people that report vaping. In fact, I ask people with certain things that people that happened to get a aura before they have one of those nasty things …

 

Dave: Well said. Look at that.

 

Joel: What a funny thing we have to do here. The reports are amazing. I would highly recommend it for people that need quick delivery, because inhalation therapy, we will call it, gets things right into the blood stream quickly. Where as if you take things as a supplement under your tongue or as a pill, swallow it, you are going through it [] entirely different system that’s going to change the bioavailability of every compound in that plant extract. Both ways are good. I wouldn’t say one over the other. It depends on you as a person, your biochemistry, and what you’re using it for.

 

Dave: Is there some sort of a system you could get where you could take your oil, put it in a device and vape it? Or is it not set-up that way?

 

Joel: We actually … We had vape pens out there, a test run for a little while, because we do believe in it, as I just said. We’d pull them recently, because we are basically recalibrating. We think we can do it better. We figured out some things through RND, thought great scientist up in Boulder. We’re going to relaunch that one both vape oils that you can put in your own vape pen, but also pre-packed vape pens with Charlotte’s Web.

 

Dave: You said something else, too, about your cost of goods. One of the benefits of vaping is it requires less of the raw material to get the active amount in, but you can just take it orally if it’s affordable, and you’ve got because you changed how you grow it, because there’s some regulatory changes you’ve got the cost down. It might be just more convenient to pop a capsule and be done with it, unless you have an urgent need, because you are starting to CRS, and because you have a massive headache or some other rapid onset neurological thing. There’s a bunch of those where people are like, I was feeling good five minutes though I can feel some thing is about to happen. If there’s a rapid intervention there, it really matters.

 

Joel: It does. This goes right to the issue as well. The Charlotte’s Web when I take the most popular product at he every day events, and I put it on my tongue or just swallow it, I am getting a real whole punch from it. As I mentioned, these cannabinoids are not the only thing that work at the CB1, CB2 receptor sites. They act differently when there’s a presence of simple plant [] like beta [], or kinane. These are found in regular fruits and vegetables, but they are also found within Cannabis. It acts differently at those receptor sites when other cannabinoids and other plant compound are present, and we you vape you just don’t get the same thing. It just really depends on what you’re using for and who you are on your won biochemistry.

 

That’s also why the [] genetics matter. The first level of quality control that every one in cannabis [] look at, whether you’re in CBD or CHC and in medical marijuana friendly state. When you are making a product that works for someone, don’t change it. Don’t change it. Don’t change those plant genetics. I mean, people just buy random material. Drug into an oil. Put it into a carrier, and then [] with the same label.

 

This should apply for Acacia and every botanical there is out there. Use those same genetics, because just as you and I are different, Dave, these plants vary in their individual fingerprint, their individual profile.

 

Dave: It’s kind of shocking, but coffee is the same way. Like if you buy it from a bulk broker like 99.9% of the coffee world, yeah, I went there. Taste it about just wait … The genetics of the plant, everything about the process matters. You’re right. It’s a different view. You are looking at the system of it starting at the genetics and cultivation all the way through to the delivery system.

 

Joel: Yeah. There’s a [] reason why a botanical medicine has been laughed at for so many years by the medical community, which is actually changing. I think cannabis is actually changing the medical community’s mind, pushing that pendulum back over towards plant-based medicine. When you look at it, because we now understand that every plant, every genetic, every phenotype in any one of these botanical medicines is potentially special and going to work for a certain subset or people, now, we understand how to standardize this a little bit better, but the lack of standardizations has just created a bad rep for plant medicine in general.

 

Dave: Another guess on the show, a guy who’s become a friend, is Alberto Viodo. He’s a cultural anthropologist and a trained shaman. He went down about 30 years ago to the jungles to find medical plants for drug companies and came back trained as a shaman into that med doing that. For similar reasons where if you take the one compound out, you miss the co-factors that signal other parts of the body.

 

We have this, I will call it a hubris and you’re saying. We’re going to do this. We’re gonna find the drug that’s in the plant. What if the plant was the drug, and it turns out that this one part of the plant by itself has a strong effect, but the other supporting co-factors actually make it work better or have less side-effects, but just the way we set-up our drug system, we sort of rejected that. I think the consciousness is changing that people would rather have a tea or an herbal extract than a drug made from the same herb. You are follow those footstep saying have the whole oil versus even just vaping it, because vaping it you get less of it even if it’s you faster.

 

Joel: Yeah. That single compounds approach that we had taken to the pharmaceuticals and medicine in general, I’m not going to say that that’s bad science or that [] a good tools there. At the same time, exactly as you said, all of our medicines originally came from plants. Then we started isolating molecules, so we can understand better what each molecule is doing. Then we started finding side-effects. Now you know that a pharmaceutical research company that goes to an indigenous tribe and says, “Oh. They use this product for migraines. This plant for migraines.”

 

They find out what molecules likely cause any effect on migraines or what [] sometimes. Then they isolate them, or synthesize them. Then they found these side-effects. They’re like, “Well, wait a minute. These indigenous tripe [] all these side-effects [] be genetics, or what’s the deal?” They go back to that plant sometimes and say, “What molecule offset those side-effects?” Now, they’ve got another drug they can sell you. You can have six pills [] one plant just to offset the side effects going around the original condition you were going after. It just makes sense. If you’re a scientist I don’t care whether you believe that God made these plants for us or we have [] side them. It just makes sense that our bodies recognize them as they are have all of these compounds that can work synergistically.

 

When you approach the FDA or a research scientist that’s familiar with the anti-approval process, nobody told, “Why can’t I get my plant, the [] medicine through this process?” They’ll tell you basically it’s a square pack through a round hold have altered that. They will say that, “Because you have hundreds and sometimes thousands of these different compounds all working within your plant extract, because we can’t quantify what each one is doing, it’s bad science.” What they are really saying is that because we, humanity, are not smart enough or lack the tools to understand what all those compounds are doing together, it’s bad science. That’s just a terrible approach for that same approach we find for a year. Again, I believe cannabis is going to lead the way back to plant-based medicine, not for cannabis itself, but because these cannabanoids, there are so much evidence now. There’s going to be more and more as we study this that they work in conjunction with other plant compounds.

 

Dave: Your industry has now reached a critical mass where you have the billions of dollars? That means you can fund research on par with pharmaceutical and big tobacco kind of companies. At that point it gets harder and harder, because the earliest stage stuff, it sounds like there’s a machine out there to play whacamole with innovation around health. They just bunk companies on the head all the time. The industry is too big to do that right now. Maybe big tobacco could take down the cannabis industry, but I think it’s about two years too late for them to do that. They missed that.

 

Joel: I think so, too. You’re absolutely right. Now, there are tools. This is out of the closets. This is out of the black markets, out of our basements. Now, there’s viable businesses that can invest in that research and development. Ultimately, at the end of the day what the medical community wants to have that final push back over into advocating for botanical classes of medicines what it wants and what it needs, and this is fine. This means that these are smart people. It needs that, and it needs that information. We’re going to be able to get it now. This next decade of research is going to be very exciting of what we’re going to find out.

 

Dave: Joel, thanks for your []. It’s fantastic stuff. Speaking of data, like you just said, I want to gather three more pieces of data from you, something I’ve asked every guest on the show, more than 350 episodes, except that one episode, number 77, where I forgot. If someone came to you tomorrow and said, “I want to kick ass at every thing I do. Like I want to perform better as a human being.” What are the three most important pieces of advise you have for me? What would you offer them, not just from your business, but just from your life?

 

Joel: I would say meditation has been one of the most important things for me. It’s that tool allows you to be who you truly are, not who you think you are, not who you were trying to be. It’s that thing that resets you. I think that that’s very important. It’s also very difficult to meditate when you’re not healthy already. Diet. Diet is very important. When you put diet and exercise in it, they only get another thing in, so diet and exercise. We count. Let’s have two things as one thing.

 

Then I will say from my life, not for everyone’s life, one of the things that set me on the habit for meditation and for caring about my body and my consciousness, we’re actually exploring plant-based medicines, many of them that are psychotropic. Been through []. That’s been a huge piece of my waking up and becoming who I am supposed to be.

 

Dave: Very well said. I’ve had a couple episodes where we talk about [], and I’ve certainly did it a long time ago, and Peru with the shaman, so I appreciate that you brought that up. Not a lot of people talk about that, but they can be so profound when it’s done right and not at Disney Land.

 

Joel: Those are more things that we need to understand and not just say, “Oh that’s bad.” Why is it bad? We don’t know why, but it’s bad.”

 

Dave: That would be anti-science right there. Joel, where can people find out more about Charlotte’s Web?

 

Joel: If you want to know about Charlotte’s Web, if you’re interested in trying the product, go to CWHemp.com, C-W-H-E-M-P dot com. Also, there’s a great compilation of the research on cannabis in general, but CBD as well at the Real of Caring Foundation website, which is www.TheRoc.us, www dot T-H-E-R-O-C dot US.

 

Dave: R-O-C not R-O-C-K.

 

Joel: R-O-C.

 

Dave: Got it. From the Realm of Caring.

 

Joel: You got it.

 

Dave: Awesome. Thanks again for being on Bulletproof Radio. Keep putting your Charlotte’s Web CBD extract in our bulletproof coffee. Have an awesome day, Joel.

 

Joel: Thank you so much for having me, Dave.

 

Dave: If you enjoyed today’s episode, you know what to do. Head on over to iTunes, and leave bullet Proof Radio a five star review and tell people why you like listening to it. While you’re at it, you might consider trying the new Brain Octane 3-ounce bottle. You want to have a couple of these, you can refill them from your 32-ounce bottle, but getting a little brain octane in your body every day or like I do with every meal every day totally changes your brain. Have an awesome day.

 

 

 

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