Archives for 2020

How to Get Fitter Cells, Stronger Muscles and a Longer Life – Timeline Nutrition with Dave Asprey – #772

December 15, 2020 by Dave Asprey

In this episode of Bulletproof Radio, I’ve invited two experts who know a lot about plants and how plants interact with our cell biology. We discuss the exciting new discovery of a molecule called Urolithin A that’s a breakthrough in mitochondrial health. Urolithin A promotes mitochondrial function, muscle strength and longevity.

Navindra Seeram, Ph.D., is professor and chair of the Department of Biomedical and Pharmaceutical Sciences at the University of Rhode Island and is one of the most highly cited scientists in Agricultural Sciences.

With a background in cell and molecular biology, biomedical engineering and engineering, Chris Rinsch, Ph.D., has been immersed in the biotech and life sciences industry for more than two decades.

Our conversation centers on Mitopure™, the first clinically tested form of Urolithin A available through Timeline Nutrition.

One of the most important things Urolithin A does is revitalize the energy factories inside our cells. Each of our cells contain mitochondria, and the cell has an innate process of cleaning up the damaged mitochondria and recycling them. This process is called mitophagy. Urolithin A supports cellular health by stimulating mitophagy to keep cells fit and running efficiently.

“It’s really important to keep your mitochondria at its peak performance,” Chris says, “no matter what your general health conditions are.”

Urolithin A is generated by the gut microflora as a natural food metabolite of ellagitannins, a class of compounds found in the pomegranate and other fruits, nuts and tea. Their studies have shown some pretty amazing results.

“We saw that when we started incubating and feeding worms with Urolithin A they were increasing their lifespan by about 50 percent,” Chris says. “And when the studies moved to mice, they ran 40 percent further and longer after taking the Urolithin A.”

Listen on to find out more about how Urolithin A is such a breakthrough for mitochondrial health and how it’s a game changer for cellular nutrition.

Enjoy! And get more resources at Dave.Asprey/podcasts

BULLETPROOF LISTENER SPECIAL OFFER: Go to timelinenutrition.com/DAVE and use code Dave 10 to get 10% off.

WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!
Build Immunity: https://leakygutguardian.com/dave, use code DAVE10 to save 10% on the Bulletproof Gut Stack
Nature’s Nootropic: https://gettrukava.com, use code Dave15 for 15% off
SEO Skills: https://www.stephanspencer.com, use code DAVE for a special discount

Follow Along with the Transcript

How to Get Fitter Cells, Stronger Muscles and a Longer Life – Timeline Nutrition with Dave Asprey – #772

Links/Resources

Timeline Nutrition: timelinenutrition.com/DAVE
Mitopure: mitopure.com
Amazentis: amazentis.com

Key Notes

In botanical, the underpinnings of botanical medicines and understanding plants and phytonutrients is that whole matrix effect. – 4:35
Sometimes we’re extracting, we’re doing cooking to maybe, again, as you just said removing or maybe increasing, fortifying, increasing that bioactive constituents or group that we would want. – 7:59
A lot of the plants that contain polyphenols have stupid amounts of sugar, or other toxins that I don’t really want to get in large doses in order to get the polyphenols. – 10:27
A green tea from India is going to be different from green tea maybe of the same species or sub variety, or whatever it is from California. So, how are you going to ensure that you’re getting that perfect quantity, or that number of polyphenols. – 12:50
Polyphenols are probably the most abundant and ubiquitous phytonutrients, and in the pomegranate the class of polyphenols which are most abundant are known as ellagitannins. – 16:56
I may be a converter, or a responder, or someone who is able to produce because of my microflora urolithins from ellagic acid, but you are not. – 19:47
You guys partnered around this idea of urolithin A, which you can’t get in pomegranate, but you might get if you ate a lot of pomegranate, if you have the right gut bacteria, and isolated this compound. – 22:13
We saw was that when we started incubating and feeding these worms with urolithin A, they were increasing their lifespan by about 50%. – 24:31
The first study that we did in humans was a single ascending dose and a multiple ascending dose study with urolithin A. And we did that, the multiple ascending dose, we studied the effects over a month. And what we saw was an impact directly on the mitochondrial function in the skeletal muscle tissue. – 28:07
Each of our cells that are containing mitochondria, they have an innate process of cleaning up the damaged mitochondria and recycling them, and this process is called mitophagy. – 29:55
Why can’t I just take a urolithin A capsule? Why do I need a powder? – 32:37
People were taking a Timeline on a daily basis over a period of four months at 500 milligrams. And what we saw was an improvement in leg muscle strength after that four month period. – 34″31
We saw was that there was about a six fold higher level of urolithin A looking at this area under the curve for that first 24 hours when you take one sachet of Timeline versus one eight ounce glass of pomegranate juice. – 37:57
Urolithin A is really optimizing the actual function of your mitochondria where the L-Carnitine is more helping the processing, and the functioning in general of the mitochondria. – 42:18
It’s really important to keep your mitochondria at its peak performance, no matter what your general health conditions are. – 44:44
We’re in the process of getting the NSF certification, and we’ll have that this next year. – 46:16
Are people going to see an immediate energy boost from this if they have mitochondrial problems? – 48:05
Last year, we partnered up with Nestle Health Science, which is one of the leaders globally in nutrition. And so, we are conducting new studies together to analyze different pathways and different mechanisms of actions and benefits that we can bring people. – 50:18
For people listening to the show. Timelinenutrition.com/DAVE and you can get 10% off if you use code Dave 10. – 51:10
You need to have a mixture of the right foods, but also having that right gut microflora to be able to extract those, the benefits from these compounds that are found in the foods we’re eating. 56:24

If you like today’s episode, check us out on Apple Podcasts at daveasprey.com/apple and leave us a (hopefully) 5-star rating and a creative review.

Go check out my new book “Super Human: The Bulletproof Plan to Age Backward and Maybe Even Live Forever“ and also “Game Changers“, “Headstrong” and “The Bulletproof Diet” on Amazon and consider leaving a review!

Want to help others reach their full potential? Check out the incredible Human Potential Coach Training program I set up with Dr. Mark Atkinson.

Control Stress and Regulate Your Nervous System in 5 Steps – Lisa Wimberger with Dave Asprey – #771

December 11, 2020 by Dave Asprey

In this episode of Bulletproof Radio, my guest Lisa Wimberger was struck by lightning at age 15 and lived. That lightning strike set in motion a grand mal seizure disorder that she lived with for the next two decades and ultimately influenced her life’s work with neuroplasticity.

The seizures became life threatening, but that condition inspired her to find ways to protect and rebuild her body and mind. She went on to explore neuroplasticity, a process that helped her to disrupt her seizures.

“There’s a seizure halo from stress and maladaptive vagal tone and then there’s a seizure. Well, there’s a gap in space and time between those two things and it might be a fraction a second, but that is a response pattern that I’ve gotten really good at. Neuroplasticity says I can change those things. It doesn’t tell me how exactly, but I’m going to figure it out. I had all of this meditation that I was not using for my well-being, and then all of the science, and I just backwards engineered.”

The most profound insight she learned was that the way she was meditating was actually harmful to her. “When you hear the word meditation, it’s not one size fits all,” Lisa says. “There’s all different kinds and you have to know what works for your body.”

Lisa founded the NeuroSculpting® Institute in Colorado, where she teaches people and organizations who suffer from stress disorders, including law enforcement teams. She created NeuroSculpting®, a 5-step meditation process that can help an individual release the grip of old patterns and entrain their brain to creating new and more supportive patterns, habits and behaviors.

“The benefits are you still get to hack into your nervous system, and you get to file down the sharp edges of any thought that might have triggered you into arousal at any point in time, or you can create brand new thoughts,” she says. “Neuroplasticity doesn’t care if it’s an experience you’ve never had or an experience you’ve had. It only cares that you’re programming it with buy-in, and it’s going to store that in your mind as a pattern.”

Lisa earned a master’s degree in Education, a Foundations Certification in NeuroLeadership, and certificates in medical neuroscience, visual perception, and the brain, and neurobiology. She’s written numerous books on neuroplasticity and stress management, including Neurosculpting: A Whole-Brain Approach to Heal Trauma, Rewrite Limiting Beliefs, and Find Wholeness and New Beliefs, New Brain: Free Yourself from Stress and Fear.

She’s also co-creator of a digital app made up of interactive NeuroSculpting® modules that shift brain neuroplasticity and support well-being, called NeuroPraxis. This unique app helps people re-pattern trauma and nervous system suffering through guided meditation.

Listen on as we talk about Lisa’s discoveries in brain entrainment, stress management and meditation practices that do no harm.

Enjoy! And get more resources at Dave.Asprey/podcasts

WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!
Great Skin: https://alituranaturals.com/shop/, use code DAVE20 for 20% off storewide
Cool Sleeping: https://chilitechnology.com/asprey, get 22% off sleep systems for a limited time
Mood Control: Go to www.hapbee.com/dave, get $50 off the Hapbee device, which retails for $379

Follow Along with the Transcript

Control Stress and Regulate Your Nervous System in 5 Steps – Lisa Wimberger with Dave Asprey – #771

Links/Resources

Neurosculpting Institute

Website: neurosculptinginstitute.com
Facebook: facebook.com/NeurosculptingInstitute/
Instagram: instagram.com/neurosculpting.institute/
Twitter: twitter.com/neurosculpting
Pinterest: pinterest.com/neurosculptingi/
YouTube: youtube.com/c/LisaWimberger/featured

NeuroPraxis

Website: neuropraxis.com
Facebook: facebook.com/NeuroPraxisApp/
Instagram: instagram.com/neuro.praxis/
Twitter: twitter.com/neuropraxisapp

Lisa Wimberger

Facebook: facebook.com/Lisa-Wimberger-217432405062877/
Twitter: twitter.com/lisawimberger
LinkedIn: linkedin.com/in/lisa-wimberger-6331361/
Books by Lisa Wimberger

Key Notes

What’s it like to get struck by lightning? – 2:06
It was the gift. It was a gift because it’s the reason I do my life’s work. But it was really, really a rough time. – 5:37
It heightened pretty much everything, including my maladaptive disorders like dissociation. It heightened intuition, it heightened fantastical perception, it heightened some kinds of synesthesia, and it heightened the dissociation and delusion, definitely heightened delusion. – 8:08
I absolutely benefited from the ascension techniques. – 11:02
I’ve gotten to be a part of some cool studies at CU Boulder and the Energy Engineering Labs. – 13:19
He says, you’re vasovagal extreme syncope. I’m like, “Well, I don’t understand any of those words.” So, I left with a diagnosis, which caused me to go find out what that meant. That’s what pushed me towards neuroscience. – 18:16
Meditation can be dangerous for people who have maladaptive vagal tone. – 18:48
Coming back from those seizures was so painful and so embarrassing and humiliating. Why would I want more of these? – 20:01
Meditation can be dangerous for people who have maladaptive vagal tone. – 25:29
When you hear the word meditation, it’s not one size fits all. There’s all different kinds and you kind of have to know what works for your body. – 28:48
What’s dangerous about being a freeze predisposed person and not really knowing anything about it, is that it’s extremely socially compliance. – 30:05
There’s an induction that’s necessary in hypnosis that gets you safe, comfortable, and building trust. That’s missing in most meditation forms I’ve ever studied. – 32:32
The five steps with neurosculpting, the first two steps are to create that induced brain state through words, through guidance, that you can then do on your own. There is a checklist that quiets the midbrain. – 34:04
The things that get the prefrontal cortex really activated, novelty, humor, wander creativity. In neurosculpting, if I were guiding you through an induction, I would ask you for three to five minutes to just notice your comfortable cushion, soft texture of your shirt, your breath is breathing itself, your environment is as you like it, and then I would slam you into your prefrontal cortex. – 35:40
At the end, you’ve got a trigger word, you’ve got a trigger hand gesture, and you’ve laid down the content in a ripe, receptive, nervous system because you followed an induction, and that is phase one. That’s the five steps. – 39:32
Neuro practice app will give you a library of guided meditations. It’s not an instructional platform, it’s an experiential platform. – 40:39
The benefits are you still get to hack into your nervous system and you get to file down the sharp edges of any thought that might have triggered you into arousal at any point in time, or you can create brand new thoughts. Neuroplasticity doesn’t care if it’s an experience you’ve never had or an experience you’ve had. It only cares that you’re programming it with buy-in, and it’s going to store that in your mind as a pattern. – 42:32
I’ve been able to get paraplegics and quadriplegics to move again, which I did not start out expecting that. But it stemmed from my first case, which was a quad. My dear, dear friend, Heather. – 46:19
Three recommendations to retrain my brain. – 55:24

If you like today’s episode, check us out on Apple Podcasts at daveasprey.com/apple and leave us a (hopefully) 5-star rating and a creative review.

Want to help others reach their full potential? Check out the incredible Human Potential Coach Training program I set up with Dr. Mark Atkinson.

Your Guide to Psychedelic Psychotherapy – Dr. Phil Wolfson with Dave Asprey – #770

December 10, 2020 by Dave Asprey

In this episode of Bulletproof Radio, my guest is Dr. Phil Wolfson, the creator of Ketamine Assisted Psychotherapy. He shares his vast knowledge about the benefits of ketamine, and other healing chemicals like mushrooms or MDMA, as a treatment for depression, PTSD, addiction and other conditions. Dr. Wolfson leads patients through psychedelic psychotherapy sessions, guiding them through their past and present in an open, altered state of mind.

Dr. Wolfson is a specialist in psychedelic psychotherapy, a practicing Buddhist, and a “psychonaut.” His invaluable work is the result of an intense, many-decades-long clinical psychiatry/psychotherapy practice that focuses on new pathways for healing.

“There’s really no right or wrong with psychedelics,” Dr. Wolfson says. “They have special properties. People go through either a low dose or moderate to high dose experience. That experience is separated from your life here. And then the real work is the integration as people come back, [asking] How am I different? What have I learned from this?”

For example, in the first hour of mushrooms or psilocybin, you’re going to go through a psychological scrape, he says. “All the misdeeds, and things you owe to people, and how you’ve been hurt or hurt others.”

“It’s about how do we integrate our lives and relationship in this very difficult time with people and in our beings, and what practices we bring to this whole thing. So, it’s not just about substances.”

“We use our medicines in a sacred way,” Dr. Wolfson says. “We’re not doing traditional medicine; we’re not doing intravenous anesthesiology practices. We bring people in, we do invocation. We help people move into a state of contemplation before we do substances.”

He’s also the CEO of the non-profit Ketamine Research Foundation, the director of the Center for Transformational Psychotherapy and a founding member of the Heffter Research Institute (HRI), a non-profit scientific organization. HRI has been helping design, review and fund the leading studies on psilocybin (the active ingredient in psychedelic mushrooms) at research institutions in the U.S. and Europe.

Dr. Wolfson leads the newly founded Indra’s Net Coalition, which brings people around the world together in the midst of crisis for healing, self-expression and connection.

“Indrasnetcoalition.org is a worldwide universal concept about connection,” he says. “It’s about forming a network that is exists because we’re all connected.”

Enjoy! And get more resources at Dave.Asprey/podcasts.

WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!
Cleaner Teeth: www.davesdentalkit.com
Good Meat: www.butcherbox.com/DAVE
Mood Control: Go to www.hapbee.com/dave and get $50 off the Hapbee device, which retails for $379

Follow Along with the Transcript

A Guided Tour Through Psychedelic Psychotherapy – Dr. Phil Wolfson with Dave Asprey – #770

Links/Resources

Website: philwolfsonmd.com
The Ketamine Research Foundation: ketamineresearchfoundation.com
The Ketamine Training Center: theketaminetrainingcenter.com
The Center for Transformational Psychotherapy: ketaminepsychotherapy.com
Ketamine Psychotherapy Associates Program: ketaminepsychotherapyassociates.com
Book: The Ketamine Papers: Science, Therapy, and Transformation

Key Notes

Ketamine is originally an anesthetic and analgesic put together off of PCP analog research in the late 1960s. – 1:38
You don’t want to loosen people up too fast and panic them. You want people to begin to flow into an experience. – 9:09
The first hour of mushrooms or psilocybin, you’re going to go through a psychological scrape, where all the misdeeds, and things you owe to people, and how you’ve been hurt or hurt others, – 12:03
Ketamine heads the list right now about causing addiction. – – 16:05
Any spiritual risk using psychedelics? – 19:14
Cannabis is a wonderful hallucinogenic. For 60% of people it works, for 40% they don’t do well. – 22:55
Dr Wolfson walks listeners through a demonstration of a sensory experience. – 24:08
The hardest part, the most anxious part of ketamine journey is moving into a reality state. – 28:45
Why Dr Wolfson started the Ketamine Research Foundation. – 29:54
What about MDMA and ketamine? Do they increase growth of neurons in the brain? – 37:32
Indrasnetcoalition.org is a worldwide universal concept about connection. It’s about forming a network that is exists because we’re all connected. – 45:10
I went through a long PTSD period in which I worked but I was still struggling to recover, I became more in touch personally with trauma, and how people suffer in my particular format. – 50:27
Burning Man is an aberration in the sense that we don’t do that ordinarily. And we don’t take enough of it back into our daily life. But I think that in its essential elements, what we really want to do to live together in harmony.. – 52:33

If you like today’s episode, check us out on Apple Podcasts at daveasprey.com/apple and leave us a (hopefully) 5-star rating and a creative review.

Want to help others reach their full potential? Check out the incredible Human Potential Coach Training program I set up with Dr. Mark Atkinson.

How Trauma Travels Through Generations and Changes Your Genes – Rachel Yehuda, Ph.D., with Dave Asprey – #769

December 8, 2020 by Dave Asprey

In this episode of Bulletproof Radio, I dive into an intriguing discussion about trauma with my guest, Rachel Yehuda, Ph.D. We touch on what her latest research is uncovering about the role epigenetics plays in trauma and how to identify signs of trauma in your own life.

“Trauma affects everybody,” Rachel says. “Having a traumatic event will definitely change you in some way in terms of how you view the world.”

Rachel is a professor and vice-chair of Psychiatry and professor of Neuroscience at Icahn School of Medicine at Mount Sinai in New York. Her work focuses on the fields of psychology, trauma, and epigenetic research. She has authored more than 300 high-cited journal articles and book chapters and developed fascinating insights about risk and resilience. Her research on cortisol and brain function has revolutionized the understanding and treatment of PTSD worldwide.

With her in-depth knowledge of PTSD and epigenetics, Rachel walks us through how our parents’ traumas can be passed down through the generations and how those triggers that you’re working on today may not have originated in your lifetime.

“It’s not just that you carry the genes of your parents,” Rachel says. “You carry their history. You carry a lot of the sum total of their experiences.”

We also discuss:

The often misunderstood role that cortisol plays in the stress response and how this “stress-hormone” may be better identified as an anti-stress hormone.
How previously banned drugs like MDMA, DMT, and psilocybin may hold therapeutic potential for people working through traumas, and the road ahead for research into these drugs.
The importance of finding the right practitioner to work with you on traumas that you may experience or have emerge in your life.

Enjoy! And get more resources at Dave.Asprey/podcasts

WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!
Build Immunity: https://leakygutguardian.com/dave; use code DAVE10 to save 10% on the Bulletproof Gut Stack
Light Therapy: https://joovv.com/pages/dave-asprey; use code DAVE
Fitness Tech: https://www.fitbit.com/global/us/home; six FREE months of Fitbit Premium with the purchase of a Fitbit Sense

Follow Along with the Transcript

How Trauma Travels Through Generations and Changes Your Genes – Rachel Yehuda, Ph.D., with Dave Asprey – #769

Links/Resources

Website: Icahn School of Medicine at Mount Sinai
LinkedIn: www.linkedin.com/in/rachel-yehuda-9a653382/

Key Notes

Does trauma get defined based on the actual experience like combat, or violence, or something like that, or is it in the eye of the beholder? And this, right off the bat, is one of the big debates. – 1:59
What clinically PTSD is and why are some people getting it and some people not when they’re right next to each other? – 3:57
With PTSD, that you tend to see the world, not for what it is, but filter through the lens of really negative experiences so that you really can’t give new experiences a chance. – 11:49
People who have been traumatized need to forgive themselves, most of all. – 12:50
Trauma survivors tend to think of themselves as victimized but they’re actually survivors. – 16:10
Is intergenerational trauma something that you believe comes because the parents were raised by people who were traumatized so the trauma behaviors get passed down sort of subconsciously, or do you think it’s even a genetic. – 21:23
The mother’s lineage and father’s lineage are both important in different ways. – 25:25
Cortisol is a stress hormone that is released by the adrenal gland under stress, it’s also a hormone that is kept very, very busy throughout the day. – 30:36
I started supplementing cortisol, it was amazing. My resilience went up, my resilience to infection went up, my sleep quality improved, my brain got better. – 37:35
Before you want to improve things, try to really figure out also, what purpose is being served by having things the way they are and you need to be really thoughtful about it. If you’re having even a symptom like not being able to sleep, wonder why you can’t sleep. – 42:02
Compounds that people are using for PTSD. – 44:20
What would you recommend are the first steps for someone who says, “All right, I’m going to step up and work on my trauma”? – 54:21

If you like today’s episode, check us out on Apple Podcasts at daveasprey.com/apple and leave us a (hopefully) 5-star rating and a creative review.

Want to help others reach their full potential? Check out the incredible Human Potential Coach Training program I set up with Dr. Mark Atkinson.

New Solutions for the Growing Food Allergy Epidemic – Dr. Kari Nadeau with Dave Asprey – #768

December 4, 2020 by Dave Asprey

In this episode of Bulletproof Radio, we take a look at how and why food allergies affect so many of us. Conquering mine has helped me immensely on my Bulletproof journey and I want to share a conversation that could help you do the same.

Dr. Kari Nadeau is considered one of the world’s leading experts on food allergy, and is the author of the new book ““The End of Food Allergy, featuring Immunotherapy: The First Program to Prevent and Reverse a 21st-Century Epidemic”. For more than 30 years she’s focused her expertise on the environmental and genetic factors that affect the risk of developing allergies and asthma, and the molecular mechanisms underlying the diseases.

Allergies play a growing role in every part of our lives. They happen because of the products we put on our skin, the foods we eat every single day, and the products we use in our home and work environment. Dr. Nadeau offers ways to spot the allergens all around you.

“We have the science,” Dr. Nadeau says. “We should do better and make people’s quality of life better in general: on the therapy side, on the convention side, as well as on the diagnostic side.”

Here are some quick allergy facts:

One in three Americans has some form of allergies.
It is estimated that one in 20 adults in America (5%) has a food allergy and 1 in 13 children in the U.S. suffers from food allergy
The rate of people with food allergies is doubling approximately every 10 years.
Adults with food allergies have a 65% chance of passing those allergies to their children.
90% of food allergies are caused by the following 8 allergenic foods: cow’s milk, soy, wheat, peanut, tree nuts, shellfish, fish, egg.

“If you don’t treat your body well within any given year, you might develop a food allergy,” Dr. Nadeau says. “You’ve got to take care of yourself because any one person can develop a food allergy newly, even if they didn’t have an allergy before. This is a growing epidemic; it’s just not a US-based disease anymore. It’s growing around the world.”

In the midst of a growing epidemic, Dr. Nadeau shares information about a potential upcoming treatment process that could help you find out what your allergies are, manage them if you already have them and potentially end them.

Listen on to find out the differences between food sensitivities and allergies; thresholds for bodily stress, and ways we can both cure and prevent asthma and allergies. Dr. Nadeau answers all these questions and much more.

Enjoy! And get more resources at Dave.Asprey/podcasts

WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!
Alternative Sweetener: https://www.lakanto.com, use code Dave15 to save 15% off
Cool Sleeping: https://chilitechnology.com/asprey, get 22% off sleep systems for a limited time
Mood Control: Go to www.hapbee.com/dave and get $50 off the Hapbee device, which retails for $379

Follow Along with the Transcript

New Solutions for the Growing Allergy Epidemic – Dr. Kari Nadeau with Dave Asprey – #768

Links/Resources

Website: theendoffoodallergy.com
Facebook: www.facebook.com/EndOfFoodAllergy/
Instagram: www.instagram.com/endfoodallergy/
Twitter: twitter.com/StanfordAllergy
Book: “The End of Food Allergy, Featuring Immunotherapy: The First Program to Prevent and Reverse a 21^st-Century Epidemic”

Key Notes

You say 32 million Americans have food allergies. How do you know? – 1:44
If you go to the emergency room, for example, it might take nine months before you get to get into the office of an allergist. That nine months is too long. – 3:27
Everyone could get food allergies, but some people are at higher risk of having bad reactions that could lead to fatalities because they don’t have the access to those medications. – 7:42
We test for the match that lights the fire underneath allergies, and that’s called IgE. IgE is a blood test that you can get in your doctor’s office. – 9:45
We have that science, we should do better and make people’s quality of life better in general on the therapy side, on the convention side, as well as on the diagnostic side. – 13:18
In Italy, they don’t really have a lot of peanut allergies. They have hazelnut allergies. Nutella is hazelnut. Nutella, it’s been in the diet of a lot of Italian food. – 19:03
When you get food poisoning, sometimes it’s the bacteria in those foods that are causing the release of histamine. So that oftentimes can look like an allergy, but it’s actually food poisoning. – 25:01
Are lectins allergy triggers? – 25:54
Our skin is our most critical organ to combat the outside world. We have skin inside our lung, skin inside our gut, anything that touches the air is made of skin cells. – 28:38
The liquid soaps tend to have antibiotics or tend to have these nanoparticles and microparticles in them, those aren’t helpful. Those are like little plastics on your skin. So soap is probably better. – 32:26
Oils, if they’re really well made, they don’t have any traces of protein, if they don’t have protein in them, you don’t have to worry about getting allergies from them. – 34:31
When we look at people with milk allergies, they can have allergies to different portions of the protein. A lot of it is the fact that the proteins are so riddled with detergents at the end of the day, that that’s what they’re allergic to. – 36:39
As a Stanford scientist, to say that grass fed matters, I really appreciate that. It was a core part of my learning on health and everything I do is grass fed. – 37:15
If you could diversify that diet early and often between four to six months of age in a baby, that that can reduce your likelihood of having allergies in general, as well as asthma and food allergies. – 39:10
Food sensitivities can be related to the immune system in a very different way. – 41:08
It used to be thought that while you’re pregnant, you should avoid the peanuts. And when you’re a baby, you should avoid the peanuts, and that’s actually turns out not to be true. That was based on really small studies. – 42:58
A lot of the dishwasher detergents, if you don’t do that extra rinse, they can definitely poke holes in the gut skin. The other thing that you need to be super careful about are preservatives. – 44:36
So how do I turn off my egg allergy? – 48:27
We look at stress levels. We do questionnaires on stress. We do menstrual cycles. We’ll actually pay attention to that. We’ll look at their circadian rhythm, how much sleep have you lost? Then the other thing we look at is have you been exposed to wildfire smoke? Have you been exposed to tobacco smoke? Do you vape? Because that changes your threshold. – 52:03

If you like today’s episode, check us out on Apple Podcasts at daveasprey.com/apple and leave us a (hopefully) 5-star rating and a creative review.

Want to help others reach their full potential? Check out the incredible Human Potential Coach Training program I set up with Dr. Mark Atkinson.

How Hacking Your Gut Bacteria Can Regulate Your Blood Sugar – Colleen Cutcliffe, Ph.D., with Dave Asprey – #767

December 3, 2020 by Dave Asprey

In this episode of Bulletproof Radio, my guest is Colleen Cutcliffe, Ph.D., CEO and co-founder of Pendulum Therapeutics. We explore exciting new discoveries in the body’s gut microbiome and discuss how Pendulum is disrupting what we know about probiotics.

Pendulum uses biological and computational insights into the microbiome to develop solutions for health and disease conditions.

“Rather than calling a disease by what the symptoms are, we are actually looking at the microbiome as an underlying infrastructure within our body,” Colleen says.

Pendulum also identifies and isolates new bacterial strains, then combines those new strains to create unique probiotics. These are backed by clinical research studies. Using this discovery platform, Pendulum created the world’s first microbiome intervention for people with Type 2 Diabetes.

“Managing your blood sugar is at the core of so many health issues, including your immune system,” Colleen says. “You really are more vulnerable and susceptible when you’re not managing your blood sugars properly.”

In Pendulum’s clinical testing, they found out some interesting things.

“We have people with type 2 diabetes on multiple drugs,” Colleen says. “We have people with pre-diabetes who are looking to avoid crossing over into taking drugs. And we’ve had people who are healthy that are really concerned about “how is my body metabolizing sugar and fibers.” And so we offer free A1c testing, actually at baseline, and then three months in so that people can see their results. And I think that really helps people kind of believe the results that they’re experiencing.”

Our conversation goes in a lot of directions related to the science of gut health–both your inner environment and the one around you. We’re learning so much, so fast, that science is seeing all sorts of connections. The gut microbiome is the frontier of how we’ll define better health.

“Where we’re heading is understanding that the microbiome is foundational in a lot of things like the immune response, allergies, digestion, metabolism, and that once you start to make sure that you have the right flora and all the right plants in your garden, you’re actually going to be tackling a lot of these different things,” Colleen says. “And so, you won’t have to have a specific thing for every disease because I think we’re going to transform the way we think about disease.”

Enjoy! And get more resources at Dave.Asprey/podcasts

SPECIAL OFFER FOR BULLETPROOF PODCAST LISTENERS: Go to pendulumlife.com and use promo code “DAVE20” to get 20% off your first bottle.

WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!

Cleaner Teeth: www.davesdentalkit.com
Nature’s Nootropic: https://gettrukava.com, use code Dave15 for 15% off
SEO Skills: https://www.stephanspencer.com; use code DAVE for a special discount

Follow Along with the Transcript

How Hacking Your Gut Bacteria Can Regulate Your Blood Sugar – Colleen Cutcliffe, Ph.D., with Dave Asprey – #767

Links/Resources

Website: pendulumlife.com/
Facebook: facebook.com/PendulumLife/
Twitter: twitter.com/Pendulum_Co
Instagram: instagram.com/pendulumlifeco/

Key Notes

We’re going to talk about using the microbiome almost like a drug, using artificial intelligence as a part of this. – 00:58
DNA sequencing technologies really started to become affordable in the mid 2000s. – 2:38
We decided to hone in on metabolic syndrome, which of course personally was very tied to my daughter in thinking about that and we came back and that was actually when we got our first round of funding. – 9:52
We offer free A1c testing, actually at baseline, and then three months in so that people can see their results. And I think that really helps people kind of believe the results that they’re experiencing. 12:41
Do you have to take prebiotics with Pendulum or does it grow no matter what you eat? – 13:08
How did theprobiotic industry get to be the way it is now? – 18:04
When we lose certain types of flora, we lose certain types of bacterial functions, that’s when we start to experience different diseases. – 21:12
Diet and environment have such a big impact on your microbiome that trying to eradicate a particular specific species is probably less relevant than thinking about it holistically and saying, all right, how do I put the right flora into my microbiome? 24:32
It’s a phenomenal world we live in now where there’s all these new measurement devices that we as consumers have access to. You can measure anything that you want to measure. – 27:16
We had to have a talk about, this is not an enabler of bad behavior. – 32:27
How regulated are you as a probiotic company?33:39
A product we’re working on as a pretty strong collaboration with Johns Hopkins looking at IBS, irritable bowel syndrome, which is a really complicated, it’s not even a disease, it’s a syndrome. – 37:07
The microbiome around us is a whole nother issue. And we think about metabolic syndrome, which is a chronic disease of aging. Because as we age, we start to lose our ability to metabolize these sugars. – 39:31
This study, they showed that if you have a dog, you tend to have a more diverse microbiome than if you don’t have a dog.– 42:41
You’re harder to kill when your blood sugar is more normal. – 44:07
Normally when your blood glucose regulates better, you lose weight or you maintain a healthier weight better. Did you see any of that in your trials?– 51:07

If you like today’s episode, check us out on Apple Podcasts at daveasprey.com/apple and leave us a (hopefully) 5-star rating and a creative review.

Want to help others reach their full potential? Check out the incredible Human Potential Coach Training program I set up with Dr. Mark Atkinson.

Get on
“The Inside Track”
with Dave

See What Trouble Dave’s Getting Into on Social

Start hacking your way to better than standard performance and results.

Archives for 2020

Follow Along with the Transcript

Links/Resources

Key Notes

Follow Along with the Transcript

Links/Resources

Key Notes

Follow Along with the Transcript

Links/Resources

Key Notes

Follow Along with the Transcript

Links/Resources

Key Notes

Follow Along with the Transcript

Links/Resources

Key Notes

Follow Along with the Transcript

Links/Resources

Key Notes

Get on “The Inside Track” with Dave

See What Trouble Dave’s Getting Into on Social

Start hacking your way to better than standard performance and results.

Get on
“The Inside Track”
with Dave