Dave Asprey

Relationship Goals: Your Gut Microbiome and Immune Function – Kiran Krishnan, Ph.D., with Dave Asprey – #864

IN THIS EPISODE OF BULLETPROOF RADIO…

Research microbiologist Kiran Krishnan, Ph.D., explores the world of microorganisms inside your body. He studies the human microbiome and knows just how much inflammation damages your gut and how your immune system fixes it.

He’s particularly adept at explaining practical ways to apply the latest science he’s uncovering.

His expertise lies in the newest frontier in microbiology—gut commensal spore bacteria. He partners with Just Thrive Health on prebiotics, probiotics and other gut health product development.

When he was on the show previously, we got into probiotics and immune health. (Don’t miss those! Support Immune Health in Two Steps: Modulate Gut Bacteria & Neutralize Inflammation – #677 and Armor-Plated Immortal Probiotics from Space – #629. This time, he makes connections between your microbiome and immune function.

“The inflammatory response is the biggest driver of gut related damage that occurs,” Kiran says. “You can also eat foods that are absolutely toxigenic to your microbiome.”

The good news? Up to 80 percent of your immune system lies in your digestive tract, Kiran explains. “Your immune system is there, ready and waiting to help with the situation.”

In this episode, you’ll learn that lipopolysaccharide (LPS) is the unknown villain of virtually everything. Kiran says it causes damage to the brain, contributes to metabolic disease, drives Alzheimer’s, Parkinson’s, and is the No. 1 driver of diabetes (to name a few).

“LPS is the most pervasive toxin we have to deal with and it’s an endotoxin, which is a key because we can’t get away from it,” Kiran says.

Kiran has a strict research background in the fields of molecular medicine and microbiology. For nearly 20 years, he’s conducted dozens of human clinical trials in human nutrition through his research organization: Clinical Research Organization.

His recently published leaky gut study showed reversal of gut enteropathy within 30 days. He’s now involved with a longer, more extensive leaky gut trial.

His current research also includes nine other ongoing human clinical trials. Some test the effect of gut commensal spore probiotics on conditions like Thyroid/Hashimoto’s, Irritable Bowel Syndrome and liver failure.

Listening to this extensive interview, you’ll find out cool stuff, like what faecalibacterium prausnitzii is and how it helps you.

“We all have all kinds of damage occurring in our large bowel all the time,” Kiran says. “But if you have faecalibacterium, it’s constantly repairing it. If you don’t have faecalibacterium, at some point, the damage overcomes the repair and you start getting significant inflammation in lining which then puts you at risk for things like inflammatory bowel disease. Right, so we’re constantly battling this state of damage, oxidative stress, inflammation, and all that, and then repair recovery and so on. And then as it turns out, microbes are so important for that repair and recovery phase.”

You’ll also gain new perspective of your own body biomes and the broader world:  “I’ve always referred to the human system as a walking, talking rainforest,” Kiran says. “We are a holo-biome which is a super organism. We are an organism made up of a collective of organisms that together in a certain balance will function and work. But we are also in constant osmosis with the ecosystem, and we’re designed to be that way.”

Another positive for your gut and immune health is the vast number of microbial genes in your system.

“We have such limited amount of genetic capability as a species,” Kiran says. “We barely have enough genetic material as an earthworm does, and so we’re not that cool or sophisticated. What makes us as sophisticated as we are, is the two and a half million or so microbial genes in our system. And so, being able to outsource functionality to microbes is a big part of being human. There are sets of organisms that we have outsourced through the course of evolution, the ability to modulate and monitor the rest of the microbiome. We’re finding that when you start putting in these microbes back into your system, you really start getting the positive changes. They start refereeing the ecosystem and making things more balance and improved.”

Enjoy! And get more resources at Dave.Asprey/podcasts. Got a comment, idea or question for the podcast? Submit via this form.

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Relationship Goals- Your Gut Microbiome and Immune Function – Kiran Krishnan, Ph.D., with Dave Asprey – #864

Links/Resources

Website: https://justthrivehealth.com
Facebook: https://www.facebook.com/justthrivehealth/
Twitter: https://twitter.com/JustThriveHlth
Instagram: https://www.instagram.com/justthrivehealth/
YouTube: https://www.youtube.com/channel/UC-7z1Mi_Ju7BKQYdbqY_27g/featured

Bulletproof Radio:
Support Immune Health in Two Steps: Modulate Gut Bacteria & Neutralize Inflammation – Just Thrive Health – #677
Armor-Plated Immortal Probiotics from Space – Just Thrive Health – #629

Key Notes

  • Coming Soon!

If you like today’s episode, check us out on Apple Podcasts at daveasprey.com/apple and leave us a (hopefully) 5-star rating and a creative review.

Go check out my new book Super Human: The Bulletproof Plan to Age Backward and Maybe Even Live Forever and also “Game Changers“, “Headstrong” and “The Bulletproof Diet” on Amazon and consider leaving a review!

Want to help others reach their full potential? Check out the incredible Human Potential Coach Training program I set up with Dr. Mark Atkinson.

How to Build Strength Faster – John Jaquish, Ph.D., with Dave Asprey, Part 2 – #863

IN THIS EPISODE OF BULLETPROOF RADIO…

In Part 1 of our two-part episode with John Jaquish, Ph.D., I talked with him about building bone density—an important factor in your strength and longevity. Don’t miss! Building Strength Isn’t About Weight Lifting Anymore – John Jaquish, Ph.D., with Dave Asprey, Part 1 – #862.

This inventor, author, and scientist created OsteoStrong and the X3 System, a series of devices that combine rehabilitation and advancements in human physiology to build bone density. His extensive research into bone density and strength found that you can approach weight lifting much differently than you may think.

“It appears that the most biological adaptation comes from not the area under the curve, the total volume of work you did, but has to do with how quickly did you go from zero to 100 and back to zero,” John says. “So, a very brief spike of almost anything causes way more adaptation than spiking up to 70% and holding it.”

Now in Part 2, our conversation dives into John’s other findings and lifestyle choices, both as a public figure, a mentor for professional athletes and a fasting enthusiast. We go off the beaten path on a few things:

  • Anabolic rebound after fasting (what fasting does to build muscle mass)
  • Tendon mutations (and how they make people outrageously strong)
  • Taking Viagra (or other non-pharmaceuticals) and carbs to trigger a muscle cell splitting
  • The difference between fructose, glucose and sucrose (is there any real difference in the body?)

We also talk about ways to eat for strength and the quest for longevity that guides him. He knows about the tempting danger of eating to only look good (but you feel like crap). He offers tips to make sure you don’t go there.

Check out John’s book to learn more: Weight Lifting Is a Waste of Time: So Is Cardio, and There’s a Better Way to Have the Body You Want

Enjoy! And get more resources at Dave.Asprey/podcasts. Got a comment, idea or question for the podcast? Submit via this form.

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How to Build Strength Faster – John Jaquish, Ph.D., with Dave Asprey, Part 2 – #863

Links/Resources

More About John Jaquishhttps://doctorj.com
BookWeight Lifting Is a Waste of Time: So Is Cardio, and There’s a Better Way to Have the Body You Want
Websitehttps://www.jaquishbiomedical.com
Facebookhttps://www.facebook.com/drjaquish/
Instagram: https://www.instagram.com/drjaquish/
YouTubehttps://www.youtube.com/c/JaquishBiomedical

Bulletproof Radio: Exercise Biohacks To Induce Bone Density and Grow Muscles in Less Time – #427

Key Notes

  • If you’re dealing with an elastic band, gravity is not the accelerator, and because of that, you’re not getting the same risk of injury because you can’t wobble and have it continue to accelerate almost indefinitely like it’s in free fall, which is what happens if you drop a bar. – 1:14
  • People are fatter and sicker than ever, especially those who consume more aspartame. – 2:59
  • Where are you normally targeting when you do TRT?  – 6:59
  • The control group lost a little bit of muscle because they were on caloric deficit, which is to be expected.  – 12:24
  • Hyperplasia is the splitting of muscle cells. It’s very rare. Professor Jose Antonio at Florida State University has done the most work.  – 17:37
  • Now when I stretch, the facia is put at such an extreme that it is stretching with the objective of triggering hyperplasia.  – 20:50
  • Is there any peptide you could use there, like PT141 doesn’t cause vasodilation, but it sure has other Viagra-like effects. Anything like that?  – 23:44
  • 1% of the population that has this tendon mutation, and so they’re the ones that can become outrageously strong – 30:30

If you like today’s episode, check us out on Apple Podcasts at daveasprey.com/apple and leave us a (hopefully) 5-star rating and a creative review.

Go check out my new book Super Human: The Bulletproof Plan to Age Backward and Maybe Even Live Forever and also “Game Changers“, “Headstrong” and “The Bulletproof Diet” on Amazon and consider leaving a review!

Want to help others reach their full potential? Check out the incredible Human Potential Coach Training program I set up with Dr. Mark Atkinson.

Building Strength Isn’t About Weight Lifting Anymore – John Jaquish, Ph.D., with Dave Asprey, Part 1 – #862

IN THIS EPISODE OF BULLETPROOF RADIO…

Inventor, author, and scientist John Jaquish, Ph.D., downloads his knowledge about the importance of bone density. When his mom was diagnosed with osteoporosis he set out to develop bioDensity, a system that builds bone density by triggering the effects of weightlifting without the risk of injury. He’s talked about it on Bulletproof Radio before.

He’s developed a way to put on muscles three times faster than you can by weightlifting. I’m asking him to explain why that matters and what devices and routines can help you get there. He created OsteoStrong and the X3 System, a series of devices that combine rehabilitation devices and advancements in human physiology to build bone density.

Why so much focus on bone density?

“You’re avoiding the potential for fragility fractures later in life,” John says. “The bone you build through the osteogenic loading process, through this heavy loading, you’re getting bone built that’s going to last in your body for 30 years. It doesn’t go away like muscle. Detraining of a muscle starts in 10 days. If you stop working out, you lose your muscle in 10 days. It takes you 30 years to lose the bone.”

In Part 1 of this two-part episode, we talk about John’s inventions and research, as well as the three aspects of strength that most people don’t think about when they start a fitness routine. You’ll learn what vitamins and protein habits matter and what kind of exercise truly increases your longevity.

You can also check out John’s book: “Weight Lifting Is a Waste of Time: So Is Cardio, and There’s a Better Way to Have the Body You Want”

And don’t miss Part 2! 

Enjoy! And get more resources at Dave.Asprey/podcasts. Got a comment, idea or question for the podcast? Submit via this form.

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Building Strength Isn’t About Weight Lifting Anymore – John Jaquish, Ph.D., with Dave Asprey, Part 1 – #862

Links/Resources

John Jaquish: https://doctorj.com
Book: Weight Lifting Is a Waste of Time: So Is Cardio, and There’s a Better Way to Have the Body You Want
Website: www.jaquishbiomedical.com
Facebook: www.facebook.com/drjaquish/
Instagram: https://www.instagram.com/drjaquish/
YouTube: www.youtube.com/c/JaquishBiomedical

Key Notes

  • I got down this path because my mother was diagnosed with osteoporosis and built a series of medical devices to emulate high impact forces.  – 4:13
  • If you just ate the protein and didn’t work out, would you grow muscle? Everybody seems to know the answer to this question, which is no.  – 7:04
  • The more bone density you have, the more muscular tissue you have that’s active, that’s participating in GLUT4 signaling.  – 9:47
  • Since the last time we hung out, I probably have adjusted a little bit to just more animal protein.  – 14:01
  • I do bacterial fermentation product called Fortigen. That is it’s essential amino acids, very high concentration of essential amino acids.  – 17:27
  • My X3 comes everywhere with me. My current X3 probably has 600,000 miles on it.  – 25:31
  • People who go to the gym couple of days a week and have been doing so for years and they have never seen anything change, nothing.  – 35:21
  • Talk to me about ligaments and tendons and that interstitial strength without bulk. How does all that work?  – 37:39

If you like today’s episode, check us out on Apple Podcasts at daveasprey.com/apple and leave us a (hopefully) 5-star rating and a creative review.

Go check out my new book Super Human: The Bulletproof Plan to Age Backward and Maybe Even Live Forever and also “Game Changers“, “Headstrong” and “The Bulletproof Diet” on Amazon and consider leaving a review!

Want to help others reach their full potential? Check out the incredible Human Potential Coach Training program I set up with Dr. Mark Atkinson.

Mini-Episode: Cool Facts Friday #15

Cool Facts are quick hits of new human and world science curated into short bursts of information just for you. This fun compilation publishes one Friday a month. Enjoy!

Here’s the current lineup for episode #15:

  • A ketogenic diet impacts brain cancer.
  • A surprising connection links calf muscles, blood pressure, and dementia risk.
  • A dose of sunlight boosts romantic passion.
  • An energy process involves brain cells, memory and sugar levels.
  • A bunch of benefits support time-restrictive eating.
  • An innovative way to transport mouse sperm.

EPISODE SPONSOR: Monitor your glucose and ketone readings using the GK+ meter and sign up for MyMojoHealth to start connecting today. Go to keto-mojo.com/mymojohealth. Use code DAVE15 to get 15% off a meter kit — MyMojoHealth is free!

 

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Cool Facts Friday #15

Links/Resources

Web: daveasprey.com/
Instagram: instagram.com/dave.asprey/
Twitter: twitter.com/bulletproofexec
Facebook: facebook.com/bulletproofexecutive/
Bulletproof Radio
Dave Asprey Blog
Dave Asprey Box
The Upgrade Collective

If you like today’s episode, check us out on Apple Podcasts at daveasprey.com/apple and leave us a (hopefully) 5-star rating and a creative review.

Go check out my new book Super Human: The Bulletproof Plan to Age Backward and Maybe Even Live Forever and also “Game Changers“, “Headstrong” and “The Bulletproof Diet” on Amazon and consider leaving a review!

Want to help others reach their full potential? Check out the incredible Human Potential Coach Training program I set up with Dr. Mark Atkinson.

Hack Your Neurochemistry with Customized Nootropics – Mr. Noots & Matt Gallant – #861

IN THIS EPISODE OF BULLETPROOF RADIO…

We’re going deep on all things nootropics. Stacks, timing and what works for your brain. You’re going to learn a lot in this episode, like:

  • The promise of nootropics vs. the reality of nootropics
  • Problems with typical nootropics
  • How brain chemistry and nervous systems are incredibly unique
  • How every high-performance state has a corresponding neurochemistry stack
  • Nine Nootopia base blends that have specific goals and purposes
  • Why Nootopia nootropics are different
  • Tips to get the most out of your nootropics

One of today’s guests has been on the show several times to talk about psychobiotics, magnesium, enzymes and blood sugar.

As co-founder of BiOptimizers, Matt Gallant keeps researching and innovating ways to keep your whole body healthy. He sees important connections within body systems and finds unique ways to maximum human performance. He especially likes the brain and will be talking about new developments in nootropics that can be customized to your own body system.

Matt Gallant: “A lot of nootropics rely on brute force,” Matt says. “They hammer one receptor or one pathway and they just push it to the max which has negative consequences, receptors downregulate, you can have more side effects. As a former addict, I thought, and I was hardwired to believe that more is better. And now I know better and optimal is better. So, it’s about really finding the optimal dose for each person. And that’s why we’re all about customization and personalization.”

He’s joined by Mr. Noots, his partner in custom nootropic development.

Between ages 5 and 10, he built radio, conducted dangerous chemistry experiments and built a Helium-Neon Laser from scratch. His favorite childhood activities were science, chemistry and physics. He spent his 20’s in the US Air Force, which was the perfect platform to become an endurance athlete and eventual bodybuilder. Life happened and as Mr. Noots moved from sick to superhuman, he dove deep into performance-enhancing nutrition. That, in turn, led him to become a Chief Product Officer for the mind-enhancing compounds and stacks of nootropics at Nootopia.

“This is one of the things where I want everyone listening to just say, “Okay, I admit to myself that it is possible for plant extracts or other compounds to improve cognitive function because it’s abundantly obvious,” “says Mr. Noots.

Enjoy! And get more resources at Dave.Asprey/podcasts. Got a comment, idea or question for the podcast? Submit via this form.

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UPGRADE YOURSELF WITH DAVE ASPREY
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DAVE ASPREY BOX
This quarterly subscription box gives you access to biohacking resources that can support you in achieving your health goals and unlocking your potential. Go to https://daveaspreybox.com/

 

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Hack Your Neurochemistry with Customized Nootropics – Mr. Noots & Matt Gallant – #861

Links/Resources

Nootopia: https://nootopia.com
Braverman Test: https://www.bravermantest.com
BiOptimizers: https://bioptimizers.com
Facebook: https://www.facebook.com/BiOptimizers/
Twitter: https://twitter.com/BiOptimizers
Instagram: https://www.instagram.com/bioptimizers/
YouTube: https://www.youtube.com/user/BiOptimizers

Bulletproof Radio:

Key Notes

  • All right, Mr. Noots, what is your true identity? Unveil yourself.  – 8:39
  • For me, it was quite a journey. But I don’t know if we’re going to get back to that later. But I first started to do it as a way to get off coffee back in the ’90s.  – 11:40
  • Huperzia serrata, right, it’s an extract and it increases choline flow, right? It also reduces cholinesterase enzyme so that the choline keeps flowing through the synapse.  – 13:27
  • As a former addict, I thought, and I was hardwired to believe that more is better. And now I know better and optimal is better.  – 15:20
  • We found that there were interesting ways that during the extraction process of herbs and the conversion process of pyroglutamic acid, you could get them to weave each other together and create these bonds that would go in various directions.  – 19:24
  • When your body doesn’t have a load, if it doesn’t have an oxidant load, an oxidation load, if the adaptogens are effectively reducing stress levels, stress hormones, inflammatory conditions, then the nootropic works significantly better.  – 23:18
  • If you get energy in the morning, maybe you don’t need nootropics at that time, and just tend to crash out in the afternoon. Well, around 12:00, 12:30 or 1:00 p.m., take your nootropics and you’re going to be rocking all afternoon. – 25:13
  • How do you know, though, how to customize the stack? I mean, yeah, the surveys are good, but how much science is between the survey, and the tech?  – 28:27
  • It really depends what am I trying to achieve? And what state do I need to be in in order to maximize my performance in that moment. – 30:38
  • Anandamide actually comes from tobacco. Is that in there?  – 33:06
  • I was working on stacks and then I met Mark and I had the feeling, okay, here’s a guy that I’ll never catch up to. – 38:49
  • There’s methyl B-12, right, so methylcobalamin, just much more available and a couple other compounds that really helped that process. – 42:01
  • The big epiphany was, “Hold it, if I change the amount of the choline donor, the nootropic, the antioxidant, right, the adaptogen. I change the ratios of those and maybe even add some elements like a pro hormone like a DHEA or pregnenolone or something like that, maybe I could get a different performance profile.  – 47:08
  • I wanted something that was a parasympathetic brain enhancer, which meant that it’s going to operate when you’re chill, right, or it’s going to operate and bring you to a chill state.  – 50:13
  • A lot of people don’t know what serotonin syndrome is. And if you’re using psychedelics, you might want to know about this, so just go off on that for a little bit.  – 53:42
  • So tell me why you guys are like fruit versus just give me a scoop of glucose?  – 58:31
  • We’ve talked about Brain Flow, the different formulas. There’s nine base blends and each of these gets customized?  – 1:02:32

If you like today’s episode, check us out on Apple Podcasts at daveasprey.com/apple and leave us a (hopefully) 5-star rating and a creative review.

Go check out my new book Super Human: The Bulletproof Plan to Age Backward and Maybe Even Live Forever and also “Game Changers“, “Headstrong” and “The Bulletproof Diet” on Amazon and consider leaving a review!

Want to help others reach their full potential? Check out the incredible Human Potential Coach Training program I set up with Dr. Mark Atkinson.

Nutrition Goes Primal with Dr. Paul Saladino and Nora Gedgaudas – #860

IN THIS EPISODE OF BULLETPROOF RADIO…

You’ve been asking for experts who can talk about food that’s in line with the way we evolved as humans, so this episode brings together two guests who are experts on ancestral eating: Dr. Paul Saladino’s research on the carnivore diet, with Nora Gedgaudas decades of research on paleo and keto diets.

The conversation dives into the dangers of vegan and vegetarianism, why meat should be a core part of your diet, and how plants might be more harmful to eat than you think.

Both put chronic disease at the core of their research and have spent years of research and heart finding eating habits that give you the greatest quality of life.

Dr. Paul Saladino is a certified functional medicine practitioner who says yes to meat and no to plants. Dr. Saladino’s work promotes the use of science-based information to deeply understand the root causes of illness and provide individualized care that goes beyond traditional pharmacological treatments.

“Eat nose to tail with organ meats, with well-raised red meat and organs, and you will thrive,” Dr. Saladino says. “Plants hate us and if we ignore the fact that plants exist on a toxicity spectrum and make plant toxins, which are defended chemicals, we are abandoning a whole bunch of people who could get really well by eliminating the most toxic plants from their diet.”

Want to learn more from Dr. Saladino? Listen to two full podcasts with him and check out his book:

Nora Gedgaudus is an internationally keto and ancestrally based nutrition specialist and author. She combines extensive research with evolutionary physiology, biochemistry, metabolism, nutrition, and chronic and degenerative disease for mind-body health and longevity.

She’s created her own program called PRIMALGENIC, based on her 20 years of knowledge of ancestral and modern eating, and the paleo and keto diets.

“What’s incumbent upon us in the face of so many things we feel like we can’t control is to take control of what we can, be aware, understand as much of this as we can and find ways of strategizing our way around the system and develop that firsthand knowing of where your food comes from, as much as humanly possible,” Nora says. “And, educate yourself and take responsibility for as much as you possibly can.”

Want to learn more from Nora? Listen to two full podcasts with her and check out her books:

Enjoy! And get more resources at Dave.Asprey/podcasts. Got a comment, idea or question for the podcast? Submit via this form.

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Nutrition Goes Primal with Dr. Paul Saladino and Nora Gedgaudas – #860

Links/Resources

Dr. Paul Saladino

Website: paulsaladinomd.com
Facebook: facebook.com/Paul-Saladino-MD
Instagram: @paulsaladinomd
Twitter: @MdSaladino
YouTube: youtube.com/channel/UCgBg0LcHfnJDPmFTTf677Pw

Nora Gedgaudas

Website: https://www.primalbody-primalmind.com/about-nora-gedgaudas/
Instagram: @noragedgaudus
Twitter: @NoraGedgaudus

Dave Asprey blog:

Key Notes

  • Coming Soon!

If you like today’s episode, check us out on Apple Podcasts at daveasprey.com/apple and leave us a (hopefully) 5-star rating and a creative review.

Go check out my new book Super Human: The Bulletproof Plan to Age Backward and Maybe Even Live Forever and also “Game Changers“, “Headstrong” and “The Bulletproof Diet” on Amazon and consider leaving a review!

Want to help others reach their full potential? Check out the incredible Human Potential Coach Training program I set up with Dr. Mark Atkinson.

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